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[PMID]:29088279
[Au] Autor:Schmidt K; Butt J; Mauter P; Vogel K; Erles-Kemna A; Pawlita M; Nicklas W
[Ad] Endereço:Microbiological Diagnostics, Center for Preclinical Research, German Cancer Research Center, Heidelberg, Germany.
[Ti] Título:Development of a multiplex serological assay reveals a worldwide distribution of murine astrovirus infections in laboratory mice.
[So] Source:PLoS One;12(10):e0187174, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Laboratory mice play a tremendous role in biomedical research in studies on immunology, infection, cancer and therapy. In the course of standardization of mice used in animal experiments, health monitoring constitutes an important instrument towards microbiological standardization. Infections with murine astroviruses (MuAstV) were only recently discovered and are, therefore, still relatively unknown in laboratory animal science. In rodent health monitoring viral infections within a population are commonly assessed in terms of specific antibodies by serological testing, as active infection and excretion of virus is often temporary and can easily be missed. So far only ongoing infections with astroviruses can be detected by PCR. The objective of this work was the development of a sensitive and specific MuAstV multiplex serological assay with a high-throughput capability to be used in routine testing of laboratory mice. Four different MuAstV proteins were recombinantly expressed and used as antigens. The best reacting antigen, the capsid spike protein VP27, was selected and tested with a panel of 400 sera of mice from units with a known MuAstV status. Assay sensitivity and specificity resulted in 98.5% and 100%, respectively, compared to RT-PCR results. Eventually this assay was used to test 5529 serum samples in total, during routine diagnostics at the German Cancer Research Center (DKFZ) in Heidelberg between 2015 and 2017. High sero-prevalence rates of up to 98% were detected in units with open cages indicating that the virus is highly infectious and circulates within these populations virtually infecting all animals regardless of the mouse strain. In addition, data collected from 312 mice purchased from commercial breeders and from 661 mice from 58 research institutes in 15 countries worldwide allowed the conclusion that MuAstV is widespread in contemporary laboratory mouse populations.
[Mh] Termos MeSH primário: Animais de Laboratório/virologia
Infecções por Astroviridae/veterinária
Astroviridae
Camundongos/virologia
Reação em Cadeia da Polimerase Multiplex
Testes Sorológicos/métodos
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/imunologia
Astroviridae/imunologia
Infecções por Astroviridae/epidemiologia
Infecções por Astroviridae/imunologia
Infecções por Astroviridae/virologia
Reação em Cadeia da Polimerase Multiplex/métodos
Reação em Cadeia da Polimerase Multiplex/veterinária
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Sensibilidade e Especificidade
Estudos Soroepidemiológicos
Testes Sorológicos/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171101
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187174


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Miagostovich, Marize Pereira
Leite, José Paulo Gagliardi
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[PMID]:28854225
[Au] Autor:Portes SAR; Carvalho-Costa FA; Rocha MS; Fumian TM; Maranhão AG; de Assis RM; Xavier MDPTP; Rocha MS; Miagostovich MP; Leite JPG; Volotão EM
[Ad] Endereço:Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:Enteric viruses in HIV-1 seropositive and HIV-1 seronegative children with diarrheal diseases in Brazil.
[So] Source:PLoS One;12(8):e0183196, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diarrheal diseases (DD) have distinct etiological profiles in immune-deficient and immune-competent patients. This study compares detection rates, genotype distribution and viral loads of different enteric viral agents in HIV-1 seropositive (n = 200) and HIV-1 seronegative (n = 125) children hospitalized with DD in Rio de Janeiro, Brazil. Except for group A rotavirus (RVA), which were detected through enzyme immunoassay, the other enteric viruses (norovirus [NoV], astrovirus [HAstV], adenovirus [HAdV] and bocavirus [HBoV]) were detected through PCR or RT-PCR. A quantitative PCR was performed for RVA, NoV, HAstV, HAdV and HBoV. Infections with NoV (19% vs. 9.6%; p<0.001), HBoV (14% vs. 7.2%; p = 0.042) and HAdV (30.5% vs. 14.4%; p<0.001) were significantly more frequent among HIV-1 seropositive children. RVA was significantly less frequent among HIV-1 seropositive patients (6.5% vs. 20%; p<0.001). Similarly, frequency of infection with HAstV was lower among HIV-1 seropositive children (5.5% vs. 12.8%; p = 0.018). Among HIV-1 seropositive children 33 (16.5%) had co-infections, including three enteric viruses, such as NoV, HBoV and HAdV (n = 2) and NoV, HAstV and HAdV (n = 2). The frequency of infection with more than one virus was 17 (13.6%) in the HIV-1 negative group, triple infection (NoV + HAstV + HBoV) being observed in only one patient. The median viral load of HAstV in feces was significantly higher among HIV-1 positive children compared to HIV-1 negative children. Concerning children infected with RVA, NoV, HBoV and HAdV, no statistically significant differences were observed in the medians of viral loads in feces, comparing HIV-1 seropositive and HIV-1 seronegative children. Similar detection rates were observed for RVA, HAstV and HAdV, whilst NoV and HBoV were significantly more prevalent among children with CD4+ T lymphocyte count below 200 cells/mm3. Enteric viruses should be considered an important cause of DD in HIV-1 seropositive children, along with pathogens more classically associated with intestinal infections in immunocompromised hosts.
[Mh] Termos MeSH primário: Infecções por Adenoviridae/epidemiologia
Infecções por Astroviridae/epidemiologia
Infecções por Caliciviridae/epidemiologia
Diarreia/epidemiologia
Gastroenterite/epidemiologia
Infecções por HIV/epidemiologia
Infecções por Parvoviridae/epidemiologia
Infecções por Rotavirus/epidemiologia
[Mh] Termos MeSH secundário: Adenoviridae/crescimento & desenvolvimento
Adenoviridae/isolamento & purificação
Infecções por Adenoviridae/imunologia
Infecções por Adenoviridae/virologia
Infecções por Astroviridae/imunologia
Infecções por Astroviridae/virologia
Brasil/epidemiologia
Contagem de Linfócito CD4
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD4-Positivos/virologia
Infecções por Caliciviridae/imunologia
Infecções por Caliciviridae/virologia
Criança
Pré-Escolar
Coinfecção
Diarreia/imunologia
Diarreia/virologia
Fezes/virologia
Feminino
Gastroenterite/imunologia
Gastroenterite/virologia
Infecções por HIV/imunologia
Infecções por HIV/virologia
HIV-1/crescimento & desenvolvimento
HIV-1/isolamento & purificação
Bocavirus Humano/crescimento & desenvolvimento
Bocavirus Humano/isolamento & purificação
Seres Humanos
Lactente
Masculino
Mamastrovirus/crescimento & desenvolvimento
Mamastrovirus/isolamento & purificação
Norovirus/crescimento & desenvolvimento
Norovirus/isolamento & purificação
Infecções por Parvoviridae/imunologia
Infecções por Parvoviridae/virologia
Prevalência
Rotavirus/crescimento & desenvolvimento
Rotavirus/isolamento & purificação
Infecções por Rotavirus/imunologia
Infecções por Rotavirus/virologia
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183196


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[PMID]:28715976
[Au] Autor:Cortez V; Meliopoulos VA; Karlsson EA; Hargest V; Johnson C; Schultz-Cherry S
[Ad] Endereço:Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; email: valerie.cortez@stjude.org , victoria.meliopoulos@stjude.org , erik.karlsson@stjude.org , virginia.hargest@stjude.org , cydney.johnson@stjude.org , stacey.schultz-cherry@stjude.org.
[Ti] Título:Astrovirus Biology and Pathogenesis.
[So] Source:Annu Rev Virol;4(1):327-348, 2017 Sep 29.
[Is] ISSN:2327-0578
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Astroviruses are nonenveloped, positive-sense single-stranded RNA viruses that cause gastrointestinal illness. Although a leading cause of pediatric diarrhea, human astroviruses are among the least characterized enteric RNA viruses. However, by using in vitro methods and animal models to characterize virus-host interactions, researchers have discovered several important properties of astroviruses, including the ability of the astrovirus capsid to act as an enterotoxin, disrupting the gut epithelial barrier. Improved animal models are needed to study this phenomenon, along with the pathogenesis of astroviruses, particularly in those strains that can cause extraintestinal disease. Much like for other enteric viruses, the current dogma states that astroviruses infect in a species-specific manner; however, this assumption is being challenged by growing evidence that these viruses have potential to cross species barriers. This review summarizes these remarkable facets of astrovirus biology, highlighting critical steps toward increasing our understanding of this unique enteric pathogen.
[Mh] Termos MeSH primário: Infecções por Astroviridae/virologia
Gastroenterite/virologia
Mamastrovirus/fisiologia
Mamastrovirus/patogenicidade
[Mh] Termos MeSH secundário: Animais
Infecções por Astroviridae/fisiopatologia
Infecções por Astroviridae/veterinária
Capsídeo/metabolismo
Galinhas/virologia
Diarreia/virologia
Modelos Animais de Doenças
Gastroenterite/fisiopatologia
Seres Humanos
Mucosa Intestinal/fisiopatologia
Mucosa Intestinal/virologia
Mamastrovirus/genética
Camundongos
Permeabilidade
Filogenia
Especificidade da Espécie
Suínos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-virology-101416-041742


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[PMID]:28537544
[Au] Autor:To KKW; Chan WM; Li KSM; Lam CSF; Chen Z; Tse H; Lau SKP; Woo PCY; Yuen KY
[Ad] Endereço:1​Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China 2​State Key Laboratory for Emerging Infectious Diseases, The University of Hong Kong, Hong Kong SAR, PR China 4​Research Centre of Infection and Immunology, The University of Hon
[Ti] Título:High prevalence of four novel astrovirus genotype species identified from rodents in China.
[So] Source:J Gen Virol;98(5):1004-1015, 2017 May.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astroviruses cause gastrointestinal and neurological infections in humans and animals. Since astrovirus is genetically diverse and different astrovirus genotypes can be found in the same animal species, astrovirus is a potential zoonotic threat to humans. In this study, we screened for astroviruses in rodents from Hong Kong, Hunan and Guangxi. Astrovirus was detected in 11.9 % (67/562) of rectal swab specimens. Phylogenetic analysis of the ORF1b region, which encodes the RdRp, showed that there were four distinct clusters (clusters A, B, C and D). Whole genome sequencing was performed for 11 representative strains from each of these four clusters. The mean amino acid genetic distances (p-dist) of full-length ORF2 were >0.634 between clusters A, B, C and other known astroviruses. The p-dist between clusters A and B, A and C, and B and C were 0.371-0.375, 0.517-0.549 and 0.524-0.555, respectively. Within cluster C, the p-dist between HN-014 and GX-006 was 0.372. Since strains with p-dist of ≥0.368 in ORF2 are now considered to be of separate genotypes species, cluster A, cluster B, cluster C-HN-014 and cluster C-GX-006 can be classified as novel genotype species. Cluster D was most closely related to the rodent astrovirus previously identified in Hong Kong. Since rodents live in close proximity to humans, interspecies jumping of these novel astroviruses may represent a threat to human health.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Astroviridae/classificação
Astroviridae/isolamento & purificação
Genótipo
Doenças dos Roedores/epidemiologia
Doenças dos Roedores/virologia
[Mh] Termos MeSH secundário: Animais
Astroviridae/genética
Infecções por Astroviridae/epidemiologia
Infecções por Astroviridae/virologia
Análise por Conglomerados
Genoma Viral
Hong Kong/epidemiologia
Filogenia
Prevalência
RNA Replicase/genética
Reto/virologia
Roedores
Análise de Sequência de DNA
Homologia de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000766


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[PMID]:28316017
[Au] Autor:Zhang Y; Wang F; Liu N; Yang L; Zhang D
[Ad] Endereço:College of Life Science, South China Agricultural University, Guangzhou, People's Republic of China.
[Ti] Título:Complete genome sequence of a novel avastrovirus in goose.
[So] Source:Arch Virol;162(7):2135-2139, 2017 Jul.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:We report the complete genome sequence of a new avastrovirus of goose-origin (FLX). The 7299-nt-long genome consisted of three overlapping open reading frames (ORFs) that were in different reading frames. Pairwise comparisons showed that the FLX genome was 59% identical to its closest relatives and that the levels of amino acid identity shared by FLX with other astroviruses did not exceed 54% in ORF1a, 66% in ORF1b, and 50% in ORF2, respectively. Phylogenetic analysis based on the amino acid sequence of the full-length ORF2 demonstrated that FLX was highly divergent from all other avastroviruses. At the amino acid level the complete capsid region of FLX shared genetic distances of 0.574-0.719 with three official avastrovirus species, suggesting that it can be classified as a member of a novel species in the genus Avastrovirus.
[Mh] Termos MeSH primário: Infecções por Astroviridae/virologia
Avastrovirus/classificação
Gansos/virologia
Filogenia
Doenças das Aves Domésticas/virologia
[Mh] Termos MeSH secundário: Animais
Avastrovirus/genética
Avastrovirus/isolamento & purificação
Proteínas do Capsídeo/genética
China
Genoma Viral
Fases de Leitura Aberta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3297-1


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[PMID]:28230787
[Au] Autor:Fischer K; Pinho Dos Reis V; Balkema-Buschmann A
[Ad] Endereço:Friedrich Loeffler Institut, Institute of Novel and Emerging Infectious Diseases, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. Kerstin.fischer@fli.de.
[Ti] Título:Bat Astroviruses: Towards Understanding the Transmission Dynamics of a Neglected Virus Family.
[So] Source:Viruses;9(2), 2017 Feb 21.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bats belong to the order Chiroptera that represents the second largest order of mammals with more than 1200 species and an almost global distribution. Environmental changes and deforestation have severely influenced many ecosystems, intensifying the contact between wildlife and humans. In recent years, bats have been found to harbor a number of different viruses with zoonotic potential, as well as a great diversity of astroviruses, for which the question of zoonotic potential remains unanswered to date. Human astroviruses have been identified as the causative agent for diarrhea in children and immunocompromised patients. For a long time, astroviruses have been considered to be strictly species-specific. However, a great genetic diversity has recently been discovered among animal and human astroviruses that might indicate the potential of these viruses to cross species barriers. Furthermore, our knowledge about the tissue tropism of astroviruses has been expanded to some neurotropic strains that have recently been shown to be responsible for encephalitis in humans and livestock. This review gives an overview on what is known about astroviruses in bats, humans and livestock, especially bovines and pigs. Future research activities are suggested to unravel astrovirus infection dynamics in bat populations to further assess the zoonotic potential of these viruses.
[Mh] Termos MeSH primário: Infecções por Astroviridae/transmissão
Infecções por Astroviridae/veterinária
Quirópteros/virologia
Mamastrovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Infecções por Astroviridae/virologia
Seres Humanos
Gado
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:28224712
[Au] Autor:Pfaff F; Schlottau K; Scholes S; Courtenay A; Hoffmann B; Höper D; Beer M
[Ad] Endereço:Friedrich-Loeffler-Institut, Greifswald - Insel Riems, Germany.
[Ti] Título:A novel astrovirus associated with encephalitis and ganglionitis in domestic sheep.
[So] Source:Transbound Emerg Dis;64(3):677-682, 2017 Jun.
[Is] ISSN:1865-1682
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In June 2013, a 4-year-old Welsh Mountain ewe and in March 2014 a 10-day-old lamb of the same breed and the same flock presented progressive neurological signs including depressed sensorium, tremor, and unusual behaviour. Neuropathological examination of the brain and spinal cord detected non-suppurative polioencephalomyelitis and dorsal root ganglionitis, characteristic of a neurotropic viral agent in both sheep. Metagenomic analysis of different tissue samples from both animals identified a novel Ovine Astrovirus (OvAstV). The presence of viral genome in the central nervous system was confirmed by RT-qPCR. Although the cases presented nine months apart, the identified OvAstV shared nearly identical sequences, differing in only three nucleotide positions across the complete genome. Phylogenetic analysis revealed a close relation of OvAstV to neurotropic bovine astroviruses and an enteric OvAstV. In conclusion, these are the first reported cases of astrovirus infection in domestic sheep that were associated with encephalitis and ganglionitis.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Encefalite Viral/veterinária
Mamastrovirus
Doenças dos Ovinos/virologia
[Mh] Termos MeSH secundário: Animais
Infecções por Astroviridae/patologia
Infecções por Astroviridae/virologia
Encéfalo/virologia
Encefalite Viral/virologia
Feminino
Genoma Viral
Mamastrovirus/genética
Metagenômica
Filogenia
Ovinos
Doenças dos Ovinos/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE
[do] DOI:10.1111/tbed.12623


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[PMID]:28189887
[Au] Autor:Ito M; Kuroda M; Masuda T; Akagami M; Haga K; Tsuchiaka S; Kishimoto M; Naoi Y; Sano K; Omatsu T; Katayama Y; Oba M; Aoki H; Ichimaru T; Mukono I; Ouchi Y; Yamasato H; Shirai J; Katayama K; Mizutani T; Nagai M
[Ad] Endereço:Ishikawa Nanbu Livestock Hygiene Service Center, Kanazawa, Ishikawa 920-3101, Japan.
[Ti] Título:Whole genome analysis of porcine astroviruses detected in Japanese pigs reveals genetic diversity and possible intra-genotypic recombination.
[So] Source:Infect Genet Evol;50:38-48, 2017 Jun.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Porcine astroviruses (PoAstVs) are ubiquitous enteric virus of pigs that are distributed in several countries throughout the world. Since PoAstVs are detected in apparent healthy pigs, the clinical significance of infection is unknown. However, AstVs have recently been associated with a severe neurological disorder in animals, including humans, and zoonotic potential has been suggested. To date, little is known about the epidemiology of PoAstVs among the pig population in Japan. In this report, we present an analysis of nearly complete genomes of 36 PoAstVs detected by a metagenomics approach in the feces of Japanese pigs. Based on a phylogenetic analysis and pairwise sequence comparison, 10, 5, 15, and 6 sequences were classified as PoAstV2, PoAstV3, PoAstV4, and PoAstV5, respectively. Co-infection with two or three strains was found in individual fecal samples from eight pigs. The phylogenetic trees of ORF1a, ORF1b, and ORF2 of PoAstV2 and PoAstV4 showed differences in their topologies. The PoAstV3 and PoAstV5 strains shared high sequence identities within each genotype in all ORFs; however, one PoAstV3 strain and one PoAstV5 strain showed considerable sequence divergence from the other PoAstV3 and PoAstV5 strains, respectively, in ORF2. Recombination analysis using whole genomes revealed evidence of multiple possible intra-genotype recombination events in PoAstV2 and PoAstV4, suggesting that recombination might have contributed to the genetic diversity and played an important role in the evolution of Japanese PoAstVs.
[Mh] Termos MeSH primário: Infecções por Astroviridae/veterinária
Diarreia/veterinária
Genoma Viral
Mamastrovirus/genética
Filogenia
Doenças dos Suínos/virologia
Proteínas Virais/genética
[Mh] Termos MeSH secundário: Animais
Infecções por Astroviridae/virologia
Evolução Biológica
Diarreia/virologia
Fezes/virologia
Variação Genética
Genótipo
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Japão
Mamastrovirus/classificação
Fases de Leitura Aberta
Recombinação Genética
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


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[PMID]:28117758
[Au] Autor:Johnson C; Hargest V; Cortez V; Meliopoulos VA; Schultz-Cherry S
[Ad] Endereço:Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Cydney.Johnson@stjude.org.
[Ti] Título:Astrovirus Pathogenesis.
[So] Source:Viruses;9(1), 2017 Jan 22.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.
[Mh] Termos MeSH primário: Infecções por Astroviridae/virologia
Astroviridae/fisiologia
Interações Hospedeiro-Patógeno
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:28106836
[Au] Autor:Arias CF; DuBois RM
[Ad] Endereço:Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexico. arias@ibt.unam.mx.
[Ti] Título:The Astrovirus Capsid: A Review.
[So] Source:Viruses;9(1), 2017 Jan 19.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Astroviruses are enterically transmitted viruses that cause infections in mammalian and avian species. Astroviruses are nonenveloped, icosahedral viruses comprised of a capsid protein shell and a positive-sense, single-stranded RNA genome. The capsid protein undergoes dramatic proteolytic processing both inside and outside of the host cell, resulting in a coordinated maturation process that affects cellular localization, virus structure, and infectivity. After maturation, the capsid protein controls the initial phases of virus infection, including virus attachment, endocytosis, and genome release into the host cell. The astrovirus capsid is the target of host antibodies including virus-neutralizing antibodies. The capsid protein also mediates the binding of host complement proteins and inhibits complement activation. Here, we will review our knowledge on the astrovirus capsid protein (CP), with particular attention to the recent structural, biochemical, and virological studies that have advanced our understanding of the astrovirus life cycle.
[Mh] Termos MeSH primário: Infecções por Astroviridae/virologia
Proteínas do Capsídeo/metabolismo
Mamastrovirus/metabolismo
[Mh] Termos MeSH secundário: Animais
Capsídeo/metabolismo
Proteínas do Capsídeo/genética
Seres Humanos
Mamastrovirus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Capsid Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE



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