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Pesquisa : C02.782.350.675.100 [Categoria DeCS]
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[PMID]:27761745
[Au] Autor:Caruso C; Peletto S; Cerutti F; Modesto P; Robetto S; Domenis L; Masoero L; Acutis PL
[Ad] Endereço:Department of Virology, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Via Bologna 148, 10154, Torino (TO), Italy. claudio.caruso@izsto.it.
[Ti] Título:Evidence of circulation of the novel border disease virus genotype 8 in chamois.
[So] Source:Arch Virol;162(2):511-515, 2017 Feb.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Evidence of association between the novel putative border disease virus genotype 8 (BDV-8) and fatal disease in an Alpine chamois (Rupicapra rupicapra) is reported. Diagnostically, we also demonstrated, as already previously reported, the failure of BDV-specific primers (PDB1 and PDB2) to detect BDV-8.
[Mh] Termos MeSH primário: Doença da Fronteira/epidemiologia
Vírus da Doença da Fronteira/genética
Vírus da Doença da Fronteira/patogenicidade
Genoma Viral
RNA Viral/genética
Rupicapra/virologia
[Mh] Termos MeSH secundário: Animais
Doença da Fronteira/patologia
Doença da Fronteira/transmissão
Doença da Fronteira/virologia
Vírus da Doença da Fronteira/classificação
Vírus da Doença da Fronteira/isolamento & purificação
Genótipo
Itália/epidemiologia
Filogenia
Filogeografia
Espanha/epidemiologia
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-3112-4


  2 / 172 MEDLINE  
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[PMID]:28033381
[Au] Autor:Luzzago C; Ebranati E; Cabezón O; Fernández-Sirera L; Lavín S; Rosell R; Veo C; Rossi L; Cavallero S; Lanfranchi P; Marco I; Zehender G
[Ad] Endereço:Department of Veterinary Medicine, University of Milan, Milano, Italy.
[Ti] Título:Spatial and Temporal Phylogeny of Border Disease Virus in Pyrenean Chamois (Rupicapra p. pyrenaica).
[So] Source:PLoS One;11(12):e0168232, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Border disease virus (BDV) affects a wide range of ruminants worldwide, mainly domestic sheep and goat. Since 2001 several outbreaks of disease associated to BDV infection have been described in Pyrenean chamois (Rupicapra pyrenaica pyrenaica) in Spain, France and Andorra. In order to reconstruct the most probable places of origin and pathways of dispersion of BDV among Pyrenean chamois, a phylogenetic analysis of 95 BDV 5'untranslated sequences has been performed on chamois and domestic ungulates, including novel sequences and retrieved from public databases, using a Bayesian Markov Chain Monte Carlo method. Discrete and continuous space phylogeography have been applied on chamois sequences dataset, using centroid positions and latitude and longitude coordinates of the animals, respectively. The estimated mean evolutionary rate of BDV sequences was 2.9×10-3 subs/site/year (95% HPD: 1.5-4.6×10-3). All the Pyrenean chamois isolates clustered in a unique highly significant clade, that originated from BDV-4a ovine clade. The introduction from sheep (dated back to the early 90s) generated a founder effect on the chamois population and the most probable place of origin of Pyrenean chamois BDV was estimated at coordinates 42.42 N and 1.9 E. The pathways of virus dispersion showed two main routes: the first started on the early 90s of the past century with a westward direction and the second arise in Central Pyrenees. The virus spread westward for more than 125 km and southward for about 50km and the estimated epidemic diffusion rate was about 13.1 km/year (95% HPD 5.2-21.4 km/year). The strong spatial structure, with strains from a single locality segregating together in homogeneous groups, and the significant pathways of viral dispersion among the areas, allowed to reconstruct both events of infection in a single area and of migrations, occurring between neighboring areas.
[Mh] Termos MeSH primário: Regiões 5´ não Traduzidas/genética
Doença da Fronteira/epidemiologia
Vírus da Doença da Fronteira/genética
Vírus da Doença da Fronteira/isolamento & purificação
Surtos de Doenças/veterinária
Rupicapra/virologia
Doenças dos Ovinos/transmissão
Ovinos/virologia
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Teorema de Bayes
Doença da Fronteira/virologia
Vírus da Doença da Fronteira/classificação
Filogenia
Filogeografia
RNA Viral/genética
Análise de Sequência de RNA
Doenças dos Ovinos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (RNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168232


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[PMID]:27451496
[Au] Autor:Glotov AG; Glotova TI; Shulyak AF
[Ti] Título:[PESTIVIRUSES IN RUMINANTS].
[So] Source:Vopr Virusol;61(2):59-62, 2016.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The genus Pestivirus includes four species: bovine viral diarrhea virus 1, bovine viral diarrhea virus 2, classical swine fever disease virus, and ovine border disease virus. Pestiviruses infect many species of domestic and wild animals. Bovine viral diarrhea virus is a prototypical representative of the pestiviruses of ruminant animals. Recently, new candidates appeared for including in this genus: two viruses of the wild ruminant animals that have not been officially classified and one HoBi-like virus discovered for the first time in the bovine fetal serum. The circulation of the ruminant animal pestiviruses within population of domestic and wild animals, the presence of these viruses in bioproducts stimulates studies of the infection reservoirs and their influence on the effect of the bovine viral diarrhea control programs.
[Mh] Termos MeSH primário: Doença da Fronteira/epidemiologia
Doença das Mucosas por Vírus da Diarreia Viral Bovina/epidemiologia
Peste Suína Clássica/epidemiologia
Síndrome Hemorrágica Bovina/epidemiologia
Pestivirus/genética
[Mh] Termos MeSH secundário: Animais
Doença da Fronteira/patologia
Doença da Fronteira/virologia
Doença das Mucosas por Vírus da Diarreia Viral Bovina/patologia
Doença das Mucosas por Vírus da Diarreia Viral Bovina/virologia
Bovinos
Peste Suína Clássica/patologia
Peste Suína Clássica/virologia
Síndrome Hemorrágica Bovina/patologia
Síndrome Hemorrágica Bovina/virologia
Pestivirus/classificação
Pestivirus/patogenicidade
Filogenia
Ruminantes
Ovinos
Suínos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161109
[Lr] Data última revisão:
161109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


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[PMID]:26851587
[Au] Autor:Mishra N; Rajukumar K; Vilcek S; Kalaiyarasu S; Behera SP; Dubey P; Nema RK; Gavade VB; Dubey SC; Kulkarni DD
[Ad] Endereço:National Institute of High Security Animal Diseases, Indian Council of Agricultural Research, Anand Nagar, Bhopal 462022, Madhya Pradesh, India. Electronic address: mishranir@rediffmail.com.
[Ti] Título:Identification and molecular characterization of border disease virus (BDV) from sheep in India.
[So] Source:Comp Immunol Microbiol Infect Dis;44:1-7, 2016 Feb.
[Is] ISSN:1878-1667
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pestiviruses isolated from sheep and goats in India thus far have been bovine viral diarrhoea virus 1 (BVDV-1) or BVDV-2. During routine genetic typing of pestiviruses in the years 2009-10, border disease virus (BDV) was detected in eight Indian sheep of a flock showing clinical signs of BD by real time RT-PCR. All the samples yielded positive virus isolates in cell culture but were found negative by a BVDV antigen ELISA. A representative BDV isolate was characterized at genetic and antigenic level. Phylogenetic analysis carried out in 5'-UTR, N(pro) and E2 regions of genome typed the Indian BDV isolate as BDV-3. A more detailed analysis in N(pro) and entire region coding structural proteins showed that the N(pro) (168), C (100 aa), E(rns) (227 aa), E1 (195 aa) and E2 (373 aa) proteins were of size characteristic for BDV reference strain X818. Antigenic differences were evident between the BDV-3 isolate and previously reported BDV-1, BDV-5 and BDV-7 strains. Although origin of BDV-3 in India is not clear, the results reflect probable introduction through trade in sheep between India and other countries or BDV-3 may be more widely distributed. Additionally, this study suggests that for diagnosis of BDV infection, the commercial BVDV Ag-ELISA should be used with caution. This is the first identification of BDV in sheep in India which highlights the need for continued pestivirus surveillance and assessing its impact on sheep and goat production.
[Mh] Termos MeSH primário: Doença da Fronteira/virologia
Vírus da Doença da Fronteira/genética
Vírus da Doença da Fronteira/isolamento & purificação
[Mh] Termos MeSH secundário: Regiões 5' não Traduzidas
Animais
Antígenos Virais/sangue
Antígenos Virais/imunologia
Doença da Fronteira/diagnóstico
Doença da Fronteira/epidemiologia
Bovinos
Ensaio de Imunoadsorção Enzimática
Genoma Viral
Genótipo
Cabras/virologia
Índia/epidemiologia
Filogenia
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Ovinos
Carneiro Doméstico/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (Antigens, Viral)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160207
[St] Status:MEDLINE


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[PMID]:26597186
[Au] Autor:Peletto S; Caruso C; Cerutti F; Modesto P; Zoppi S; Dondo A; Acutis PL; Masoero L
[Ad] Endereço:Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, via Bologna 148, 10154, Turin (TO), Italy. simone.peletto@izsto.it.
[Ti] Título:A new genotype of border disease virus with implications for molecular diagnostics.
[So] Source:Arch Virol;161(2):471-7, 2016 Feb.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Border disease virus (BDV) is a (+) single-stranded RNA pestivirus affecting mainly sheep and goats worldwide. Genetic typing of BDV has led to the identification of at least seven major genotypes. This study reports the detection of a BDV strain from a goat in northwestern Italy during routine investigations. Sequence analysis revealed mutations in the 5'-UTR of the virus with implications for BDV molecular diagnostics. Moreover, subsequent phylogenetic analysis based on the combined 5'-UTR and Npro/partial C genes, showed divergence from known BDV genotypes, revealing the detection of a novel pestivirus group, for which we propose the name BDV genotype 8.
[Mh] Termos MeSH primário: Regiões 5´ não Traduzidas
Doença da Fronteira/diagnóstico
Doença da Fronteira/virologia
Vírus da Doença da Fronteira/classificação
Vírus da Doença da Fronteira/genética
Genótipo
RNA Viral/genética
[Mh] Termos MeSH secundário: Animais
Vírus da Doença da Fronteira/isolamento & purificação
Análise por Conglomerados
Cabras
Itália
Dados de Sequência Molecular
Mutação
Patologia Molecular
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (5' Untranslated Regions); 0 (RNA, Viral)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160123
[Lr] Data última revisão:
160123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151125
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-015-2696-4


  6 / 172 MEDLINE  
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[PMID]:26208716
[Au] Autor:Beaunée G; Gilot-Fromont E; Garel M; Ezanno P
[Ad] Endereço:INRA, Oniris, LUNAM Université, UMR1300 BioEpAR, CS40706, F-44307 Nantes, France. gael.beaunee@gmail.com.
[Ti] Título:A novel epidemiological model to better understand and predict the observed seasonal spread of Pestivirus in Pyrenean chamois populations.
[So] Source:Vet Res;46:86, 2015 Jul 24.
[Is] ISSN:1297-9716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seasonal variations in individual contacts give rise to a complex interplay between host demography and pathogen transmission. This is particularly true for wild populations, which highly depend on their natural habitat. These seasonal cycles induce variations in pathogen transmission. The seasonality of these biological processes should therefore be considered to better represent and predict pathogen spread. In this study, we sought to better understand how the seasonality of both the demography and social contacts of a mountain ungulate population impacts the spread of a pestivirus within, and the dynamics of, this population. We propose a mathematical model to represent this complex biological system. The pestivirus can be transmitted both horizontally through direct contact and vertically in utero. Vertical transmission leads to abortion or to the birth of persistently infected animals with a short life expectancy. Horizontal transmission involves a complex dynamics because of seasonal variations in contact among sexes and age classes. We performed a sensitivity analysis that identified transmission rates and disease-related mortality as key parameters. We then used data from a long-term demographic and epidemiological survey of the studied population to estimate these mostly unknown epidemiological parameters. Our model adequately represents the system dynamics, observations and model predictions showing similar seasonal patterns. We show that the virus has a significant impact on population dynamics, and that persistently infected animals play a major role in the epidemic dynamics. Modeling the seasonal dynamics allowed us to obtain realistic prediction and to identify key parameters of transmission.
[Mh] Termos MeSH primário: Doença da Fronteira/transmissão
Vírus da Doença da Fronteira/fisiologia
Rupicapra
[Mh] Termos MeSH secundário: Animais
Doença da Fronteira/epidemiologia
Demografia
Feminino
França/epidemiologia
Masculino
Modelos Biológicos
Dinâmica Populacional
Prevalência
Rupicapra/fisiologia
Estudos Soroepidemiológicos
Comportamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150729
[Lr] Data última revisão:
150729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150726
[St] Status:MEDLINE
[do] DOI:10.1186/s13567-015-0218-8


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[PMID]:26117151
[Au] Autor:Mao L; Li W; Liu X; Hao F; Yang L; Deng J; Zhang W; Wei J; Jiang J
[Ad] Endereço:Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing 210014, China. Electronic address: jeason0725@126.com.
[Ti] Título:Chinese border disease virus strain JSLS12-01 infects piglets and down-regulates the antibody responses of classical swine fever virus C strain vaccination.
[So] Source:Vaccine;33(32):3918-22, 2015 Jul 31.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:During 2012 and 2013, several border disease virus (BDV) strains were identified from Chinese goat and sheep herds. At the same time, pigs from the same areas were found to be seropositive to BDV by ELISA, without showing clinical signs (unpublished data). To examine the susceptibility of pigs to the Chinese BDV strains, BDV isolate JSLS12-01, isolated from naturally infected sheep, was used to infect pigs. Antibody responses, viremia, clinical signs and pathological changes of the infected animals were examined. It confirmed that the current BDV strain could infect the domestic pigs, the animals showed viremia during 4 to 14 days post infection (dpi) and sero-conversion from 14dpi; no clinical and pathological changes were observed. In addition, CSFV maternal antibody did not influence BDV infection. Subsequently, pigs were infected with the BDV isolate and vaccinated with Hog cholera lapinized virus (HCLV) 21 days later to determine the effect of BDV infection on antibody induction of CSFV vaccination. The specific CSFV antibody and neutralizing antibody titers of the BDV infected group remained negative after the primary vaccination. Even after the boost vaccination, they were still significantly lower than those of the uninfected groups (p<0.05). These results indicated that BDV infection could down-regulate the antibody responses of CSFV C-strain vaccination. It should be paid attention that BDV prevalence in pig herds and in live vaccines might hamper the vaccination of CSF.
[Mh] Termos MeSH primário: Formação de Anticorpos
Infecções Assintomáticas
Doença da Fronteira/imunologia
Vírus da Doença da Fronteira/fisiologia
Vírus da Febre Suína Clássica/imunologia
Doenças dos Suínos/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/sangue
Anticorpos Antivirais/sangue
Vírus da Doença da Fronteira/isolamento & purificação
China
Cabras
Ovinos
Suínos
Doenças dos Suínos/virologia
Vacinas Virais/administração & dosagem
Vacinas Virais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (Viral Vaccines)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150720
[Lr] Data última revisão:
150720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150629
[St] Status:MEDLINE


  8 / 172 MEDLINE  
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[PMID]:26050575
[Au] Autor:Marco I; Cabezón O; Velarde R; Fernández-Sirera L; Colom-Cadena A; Serrano E; Rosell R; Casas-Díaz E; Lavín S
[Ad] Endereço:Servei d'Ecopatologia de Fauna Salvatge,Departament de Medicina i Cirurgia Animals,Facultat de Veterinària,Universitat Autònoma de Barcelona,08193-Bellaterra,Spain.
[Ti] Título:The two sides of border disease in Pyrenean chamois (Rupicapra pyrenaica): silent persistence and population collapse.
[So] Source:Anim Health Res Rev;16(1):70-7, 2015 Jun.
[Is] ISSN:1475-2654
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In 2001, border disease virus (BDV) was identified as the cause of a previously unreported disease in Pyrenean chamois (Rupicapra pyrenaica) in Spain. Since then, the disease has caused a dramatic decrease, and in some cases collapse, of chamois populations and has expanded to nearly the entire distribution area in the Pyrenees. Chamois BDV was characterized as BDV-4 genotype and experimental studies confirmed that it was the primary agent of the disease. The infection has become endemic in the Central and Eastern Pyrenees. However, while most Pyrenean chamois populations have been severely affected by the disease, others have not, despite the circulation of BDV in apparently healthy individuals, suggesting the existence of different viral strategies for persisting in the host population. Changes in the interplay of pathogen, host and environmental factors may lead to the formation of different disease patterns. A key factor influencing disease emergence may be pathogen invasiveness through viral mutation. Host factors, such as behavior, immunity at the population level and genetic variability, may also have driven different epidemiological scenarios. Climatic and other ecological factors may have favored secondary infections, such as pneumonia, that under particular circumstances have been major contributing factors in the high mortality observed in some areas.
[Mh] Termos MeSH primário: Doença da Fronteira/epidemiologia
Vírus da Doença da Fronteira/patogenicidade
Rupicapra/virologia
[Mh] Termos MeSH secundário: Animais
Doença da Fronteira/diagnóstico
Doença da Fronteira/transmissão
Genótipo
Interações Hospedeiro-Patógeno
Espanha/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1602
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150609
[St] Status:MEDLINE
[do] DOI:10.1017/S1466252315000055


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[PMID]:25890073
[Au] Autor:Mao L; Liu X; Li W; Yang L; Zhang W; Jiang J
[Ad] Endereço:Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences; Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture; National Center for Engineering Research of Veterinary Bio-products, Nanjing, 210014, China. jeason0725@126.com.
[Ti] Título:Characterization of one sheep border disease virus in China.
[So] Source:Virol J;12:15, 2015 Feb 08.
[Is] ISSN:1743-422X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Border disease virus (BDV) causes border disease (BD) affecting mainly sheep and goats worldwide. BDV in goat herds suffering diarrhea was recently reported in China, however, infection in sheep was undetermined. Here, BDV infections of sheep herds in Jiangsu, China were screened; a BDV strain was isolated and identified from the sheep flocks in China. The genomic characteristics and pathogenesis of this new isolate were studied. RESULTS: In 2012, samples from 160 animals in 5 regions of Jiangsu province of China were screened for the presence of BDV genomic RNA and antibody by RT-PCR and ELISA, respectively. 44.4% of the sera were detected positively, and one slowly grown sheep was analyzed to be pestivirus RNA positive and antibody-negative. The sheep kept virus positive and antibody negative in the next 6 months of whole fattening period, and was defined as persistent infection (PI). The virus was isolated in MDBK cells without cytopathic effect (CPE) and named as JSLS12-01. Near-full-length genome sequenced was 12,227 nucleotides (nt). Phylogenetic analysis based on 5'-UTR and N(pro) fragments showed that the strain belonged to genotype 3, and shared varied homology with the other 3 BDV strains previously isolated from Chinese goats. The genome sequence of JSLS12-01 also had the highest homology with genotype BDV-3 (the strain Gifhorn). Experimental infections of sheep had mild clinical signs as depression and short-period mild fever (5 days). Viremia was detected in 1-7 days post-infection (dpi), and seroconversion began after 14 dpi. CONCLUSIONS: This study reported the genomic and pathogenesis characterizations of one sheep BDV strain, which confirmed the occurrence of BDV infection in Chinese sheep. This sheep derived BDV strain was classified as BDV-3, together with the goat derived strains in China. These results might be helpful for further understanding of BDV infection in China and useful for prevention and control of BDV infections in the future.
[Mh] Termos MeSH primário: Doença da Fronteira/virologia
Vírus da Doença da Fronteira/classificação
Vírus da Doença da Fronteira/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Doença da Fronteira/epidemiologia
Vírus da Doença da Fronteira/genética
China/epidemiologia
Cães
Ensaio de Imunoadsorção Enzimática
Genoma Viral
Genótipo
Células Madin Darby de Rim Canino
Filogenia
Prevalência
RNA Viral/isolamento & purificação
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Análise de Sequência de DNA
Homologia de Sequência
Ovinos
Cultura de Vírus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (RNA, Viral)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150420
[Lr] Data última revisão:
150420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150419
[St] Status:MEDLINE
[do] DOI:10.1186/s12985-014-0217-9


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[PMID]:25889936
[Au] Autor:Braun U; Hilbe M; Janett F; Hässig M; Zanoni R; Frei S; Schweizer M
[Ad] Endereço:Department of Farm Animals, Vetsuisse-Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057, Zurich, Switzerland. ubraun@vetclinics.uzh.ch.
[Ti] Título:Transmission of border disease virus from a persistently infected calf to seronegative heifers in early pregnancy.
[So] Source:BMC Vet Res;11:43, 2015 Feb 22.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study describes the transmission of border disease virus (BDV) from a persistently infected calf to seronegative heifers in early pregnancy, resulting in persistently infected fetuses. On day 50 of pregnancy (= day 0 of the infection phase), six heifers were co-housed in a free stall with a bull calf persistently infected with BDV (pi BVD) for 60 days. The heifers underwent daily clinical examination, and blood samples were collected regularly for detection of pestiviral RNA and anti-pestivirus antibodies. After day 60 (= day 110 of pregnancy), the heifers were slaughtered, and the fetuses and placentae underwent post-mortem and immunohistochemical examination and RT-PCR for viral RNA detection. RESULTS: Three heifers had mild viraemia from day 8 to day 14, and by day 40 all heifers had pestivirus antibodies identified as anti-BDV antibodies in the serum neutralisation test. The placenta of the three viraemic heifers had histological evidence of inflammation, and fetal organs from these heifers were positive for pestivirus antigen by immunohistochemical examination and for BD viral RNA by RT-PCR and sequencing. Thus, co-housing of heifers in early pregnancy with a pi-BDV calf led to seroconversion in all heifers and persistent fetal infection in three. CONCLUSIONS: Considering that pi-BDV cattle can infect other cattle and lead to persistent infection of the fetus in pregnant cows, BDV should not be ignored in the context of the mandatory BVDV eradication and monitoring program. This strongly suggests that BDV should be taken into account in BVD eradication and control programs.
[Mh] Termos MeSH primário: Doença da Fronteira/transmissão
Vírus da Doença da Fronteira/fisiologia
Doenças dos Bovinos/transmissão
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos/virologia
Anticorpos Antivirais/sangue
Doença da Fronteira/virologia
Vírus da Doença da Fronteira/patogenicidade
Bovinos
Doenças dos Bovinos/virologia
Feminino
Feto/virologia
Masculino
Testes de Neutralização/veterinária
Placenta/virologia
Gravidez
Complicações Infecciosas na Gravidez/veterinária
Complicações Infecciosas na Gravidez/virologia
Útero/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150420
[Lr] Data última revisão:
150420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150419
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-014-0275-7



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