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  1 / 3903 MEDLINE  
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[PMID]:28462731
[Au] Autor:Pettey WBP; Carter ME; Toth DJA; Samore MH; Gundlapalli AV
[Ad] Endereço:University of Utah School of Medicine,Salt Lake City, Utah,USA.
[Ti] Título:Constructing Ebola transmission chains from West Africa and estimating model parameters using internet sources.
[So] Source:Epidemiol Infect;145(10):1993-2002, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:During the recent Ebola crisis in West Africa, individual person-level details of disease onset, transmissions, and outcomes such as survival or death were reported in online news media. We set out to document disease transmission chains for Ebola, with the goal of generating a timely account that could be used for surveillance, mathematical modeling, and public health decision-making. By accessing public web pages only, such as locally produced newspapers and blogs, we created a transmission chain involving two Ebola clusters in West Africa that compared favorably with other published transmission chains, and derived parameters for a mathematical model of Ebola disease transmission that were not statistically different from those derived from published sources. We present a protocol for responsibly gleaning epidemiological facts, transmission model parameters, and useful details from affected communities using mostly indigenously produced sources. After comparing our transmission parameters to published parameters, we discuss additional benefits of our method, such as gaining practical information about the affected community, its infrastructure, politics, and culture. We also briefly compare our method to similar efforts that used mostly non-indigenous online sources to generate epidemiological information.
[Mh] Termos MeSH primário: Ebolavirus/fisiologia
Doença pelo Vírus Ebola/transmissão
Modelos Teóricos
Saúde Pública/métodos
[Mh] Termos MeSH secundário: África Ocidental
Doença pelo Vírus Ebola/virologia
Seres Humanos
Internet
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180303
[Lr] Data última revisão:
180303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000760


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[PMID]:29215269
[Au] Autor:Yang SP; Zhao W; Hu PP; Wu KY; Jiang ZH; Bai LP; Li MM; Chen JX
[Ad] Endereço:Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Southern Medical University , Guangzhou 510515, People's Republic of China.
[Ti] Título:Lanthanum-Based Metal-Organic Frameworks for Specific Detection of Sudan Virus RNA Conservative Sequences down to Single-Base Mismatch.
[So] Source:Inorg Chem;56(24):14880-14887, 2017 Dec 18.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reactions of La(NO ) ·6H O with the polar, tritopic quaternized carboxylate ligands N-carboxymethyl-3,5-dicarboxylpyridinium bromide (H CmdcpBr) and N-(4-carboxybenzyl)-3,5-dicarboxylpyridinium bromide (H CbdcpBr) afford two water-stable metal-organic frameworks (MOFs) of {[La (Cmdcp) (H O) ]} (1, 3D) and {[La (Cbdcp) (H O) ]} (2, 2D). MOFs 1 and 2 absorb the carboxyfluorescein (FAM)-tagged probe DNA (P-DNA) and quench the fluorescence of FAM via a photoinduced electron transfer (PET) process. The nonemissive P-DNA@MOF hybrids thus formed in turn function as sensing platforms to distinguish conservative linear, single-stranded RNA sequences of Sudan virus with high selectivity and low detection limits of 112 and 67 pM, respectively (at a signal-to-noise ratio of 3). These hybrids also exhibit high specificity and discriminate down to single-base mismatch RNA sequences.
[Mh] Termos MeSH primário: Ebolavirus/isolamento & purificação
Doença pelo Vírus Ebola/virologia
Lantânio/química
Estruturas Metalorgânicas/química
RNA Viral/análise
[Mh] Termos MeSH secundário: Sequência de Bases
Cristalografia por Raios X
Fluoresceínas/química
Corantes Fluorescentes/química
Doença pelo Vírus Ebola/diagnóstico
Seres Humanos
Limite de Detecção
Modelos Moleculares
Espectrometria de Fluorescência/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoresceins); 0 (Fluorescent Dyes); 0 (Metal-Organic Frameworks); 0 (RNA, Viral); 3301-79-9 (6-carboxyfluorescein); 6I3K30563S (Lanthanum)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1021/acs.inorgchem.7b02107


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[PMID]:29389094
[Au] Autor:Myers N
[Ti] Título:Policy Making to Build Relationships: A Grounded Theory Analysis of Interviews and Documents Relating to H1N1, Ebola, and the U.S. Public Health Preparedness Network.
[So] Source:J Health Hum Serv Adm;39(3):313-56, 2016.
[Is] ISSN:1079-3739
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the last five years, the American public health emergency preparedness and response system has been tested by two significant threats, H1N1 and Ebola. While neither proved as dangerous as initially feared, these viruses highlighted on-going issues with collaborations in the field of public health and health care. Strengths were identified within the network, but also challenges that must be resolved before the U.S. faces a major pandemic. Employing interview data from public health emergency response practitioners and documentary evidence from the H1N1 and Ebola responses, this qualitative analysis uses the grounded theory approach to identify key areas for collaborative improvement. The grounded theory developed calls for a stronger policy framework at the federal level to facilitate more collaboration between U.S. agencies and facilitate more collaboration at the state and local level.
[Mh] Termos MeSH primário: Defesa Civil
Teoria Fundamentada
Doença pelo Vírus Ebola/prevenção & controle
Influenza Humana/prevenção & controle
Formulação de Políticas
Administração em Saúde Pública
[Mh] Termos MeSH secundário: Comportamento Cooperativo
Documentação
Planejamento em Saúde
Doença pelo Vírus Ebola/epidemiologia
Seres Humanos
Vírus da Influenza A Subtipo H1N1
Influenza Humana/epidemiologia
Comunicação Interdisciplinar
Entrevistas como Assunto
Pandemias/prevenção & controle
Pesquisa Qualitativa
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:H
[Da] Data de entrada para processamento:180202
[St] Status:MEDLINE


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[PMID]:29194245
[Au] Autor:McNiel PL; Elertson KM
[Ad] Endereço:About the Authors Paula L. McNiel, DNP, RN, APHN-BC, is an assistant professor, University of Wisconsin-Oshkosh College of Nursing. Kathleen M. Elertson, DNP, RN, CPNP, FNP-BC, is an assistant professor, University of Wisconsin-Oshkosh College of Nursing. For more information, write to Dr. McNiel at mcnielp@uwosh.edu.
[Ti] Título:Reality Check: Preparing Nursing Students to Respond to Ebola and Other Infectious Diseases.
[So] Source:Nurs Educ Perspect;38(1):42-43, 2017 Jan/Feb.
[Is] ISSN:1536-5026
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Escalating uncertainty regarding the international impact of Ebola virus disease and other infectious diseases prompted educators to develop interactive, multidisciplinary training for senior-level baccalaureate nursing students. A three-hour clinical learning session was scheduled within the curriculum. Nurse faculty utilized 11 activities to increase students' awareness and understanding of the potential and actual impact of Ebola virus disease and other infectious diseases. Feedback reflected a positive student experience highlighting several key areas related to increased knowledge and confidence. This session highlighted the importance of adjusting focus and priorities within curricula to meet core baccalaureate essentials and address current public health needs.
[Mh] Termos MeSH primário: Bacharelado em Enfermagem
Doença pelo Vírus Ebola/enfermagem
[Mh] Termos MeSH secundário: Currículo
Retroalimentação
Seres Humanos
Pesquisa em Educação de Enfermagem
Desenvolvimento de Programas
Estudantes de Enfermagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1097/01.NEP.0000000000000076


  5 / 3903 MEDLINE  
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[PMID]:28460340
[Au] Autor:Medaglini D; Siegrist CA
[Ad] Endereço:Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
[Ti] Título:Immunomonitoring of human responses to the rVSV-ZEBOV Ebola vaccine.
[So] Source:Curr Opin Virol;23:88-94, 2017 04.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The rVSV-ZEBOV vaccine is currently the only Ebola vaccine with demonstrated clinical efficacy in a ring-vaccination clinical trial. It has been shown to be reactogenic but immunogenic and safe in several Phase I clinical studies. However, its mechanisms of protection are unknown and available immunogenicity data are mostly limited to classical serological analysis; it is now of paramount importance to apply cutting-edge technologies, including transcriptomic and metabolomic analyses, and to perform integrative analyses with standard serology and clinical data to comprehensively profile the rVSV-ZEBOV immune signature.
[Mh] Termos MeSH primário: Vacinas contra Ebola/imunologia
Ebolavirus/imunologia
Doença pelo Vírus Ebola/prevenção & controle
[Mh] Termos MeSH secundário: Portadores de Fármacos
Vacinas contra Ebola/administração & dosagem
Perfilação da Expressão Gênica
Seres Humanos
Imunoensaio
Metaboloma
Vacinas Sintéticas/administração & dosagem
Vacinas Sintéticas/imunologia
Vesiculovirus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Ebola Vaccines); 0 (Vaccines, Synthetic)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


  6 / 3903 MEDLINE  
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[PMID]:27771389
[Au] Autor:Welch SR; Guerrero LW; Chakrabarti AK; McMullan LK; Flint M; Bluemling GR; Painter GR; Nichol ST; Spiropoulou CF; Albariño CG
[Ad] Endereço:Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MG G-14, Atlanta, GA, 30329, USA.
[Ti] Título:Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems.
[So] Source:Antiviral Res;136:9-18, 2016 12.
[Is] ISSN:1872-9096
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Lassa virus (LASV) and Ebola virus (EBOV) infections are important global health issues resulting in significant morbidity and mortality. While several promising drug and vaccine trials for EBOV are ongoing, options for LASV infection are currently limited to ribavirin treatment. A major factor impeding the development of antiviral compounds to treat these infections is the need to manipulate the virus under BSL-4 containment, limiting research to a few institutes worldwide. Here we describe the development of a novel LASV minigenome assay based on the ambisense LASV S segment genome, with authentic terminal untranslated regions flanking a ZsGreen (ZsG) fluorescent reporter protein and a Gaussia princeps luciferase (gLuc) reporter gene. This assay, along with a similar previously established EBOV minigenome, was optimized for high-throughput screening (HTS) of potential antiviral compounds under BSL-2 containment. In addition, we rescued a recombinant LASV expressing ZsG, which, in conjunction with a recombinant EBOV reporter virus, was used to confirm any potential antiviral hits in vitro. Combining an initial screen to identify potential antiviral compounds at BSL-2 containment before progressing to HTS with infectious virus will reduce the amount of expensive and technically challenging BSL-4 containment research. Using these assays, we identified 6-azauridine as having anti-LASV activity, and demonstrated its anti-EBOV activity in human cells. We further identified 2'-deoxy-2'-fluorocytidine as having potent anti-LASV activity, with an EC value 10 times lower than that of ribavirin.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Ebolavirus/efeitos dos fármacos
Ebolavirus/genética
Vírus Lassa/efeitos dos fármacos
Vírus Lassa/genética
[Mh] Termos MeSH secundário: Antivirais/química
Azauridina/farmacologia
Desoxicitidina/análogos & derivados
Desoxicitidina/farmacologia
Descoberta de Drogas/métodos
Genes Reporter
Genoma Viral
Proteínas de Fluorescência Verde/genética
Doença pelo Vírus Ebola
Ensaios de Triagem em Larga Escala/métodos
Seres Humanos
Febre Lassa
Luciferases/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antiviral Agents); 0W860991D6 (Deoxycytidine); 147336-22-9 (Green Fluorescent Proteins); 7BVB29RCPR (Azauridine); EC 1.13.12.- (Luciferases); LCY080JPY9 (2'-fluoro-2'-deoxycytidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


  7 / 3903 MEDLINE  
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[PMID]:29304039
[Au] Autor:Raftery P; Condell O; Wasunna C; Kpaka J; Zwizwai R; Nuha M; Fallah M; Freeman M; Harris V; Miller M; Baller A; Massaquoi M; Katawera V; Saindon J; Bemah P; Hamblion E; Castle E; Williams D; Gasasira A; Nyenswah T
[Ad] Endereço:EVD Response Team, World Health Organization, Monrovia, Montserrado, Liberia.
[Ti] Título:Establishing Ebola Virus Disease (EVD) diagnostics using GeneXpert technology at a mobile laboratory in Liberia: Impact on outbreak response, case management and laboratory systems strengthening.
[So] Source:PLoS Negl Trop Dis;12(1):e0006135, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The 2014-16 Ebola Virus Disease (EVD) outbreak in West Africa highlighted the necessity for readily available, accurate and rapid diagnostics. The magnitude of the outbreak and the re-emergence of clusters of EVD cases following the declaration of interrupted transmission in Liberia, reinforced the need for sustained diagnostics to support surveillance and emergency preparedness. We describe implementation of the Xpert Ebola Assay, a rapid molecular diagnostic test run on the GeneXpert platform, at a mobile laboratory in Liberia and the subsequent impact on EVD outbreak response, case management and laboratory system strengthening. During the period of operation, site coordination, management and operational capacity was supported through a successful collaboration between Ministry of Health (MoH), World Health Organization (WHO) and international partners. A team of Liberian laboratory technicians were trained to conduct EVD diagnostics and the laboratory had capacity to test 64-100 blood specimens per day. Establishment of the laboratory significantly increased the daily testing capacity for EVD in Liberia, from 180 to 250 specimens at a time when the effectiveness of the surveillance system was threatened by insufficient diagnostic capacity. During the 18 months of operation, the laboratory tested a total of 9,063 blood specimens, including 21 EVD positives from six confirmed cases during two outbreaks. Following clearance of the significant backlog of untested EVD specimens in November 2015, a new cluster of EVD cases was detected at the laboratory. Collaboration between surveillance and laboratory coordination teams during this and a later outbreak in March 2016, facilitated timely and targeted response interventions. Specimens taken from cases during both outbreaks were analysed at the laboratory with results informing clinical management of patients and discharge decisions. The GeneXpert platform is easy to use, has relatively low running costs and can be integrated into other national diagnostic algorithms. The technology has on average a 2-hour sample-to-result time and allows for single specimen testing to overcome potential delays of batching. This model of a mobile laboratory equipped with Xpert Ebola test, staffed by local laboratory technicians, could serve to strengthen outbreak preparedness and response for future outbreaks of EVD in Liberia and the region.
[Mh] Termos MeSH primário: Surtos de Doenças/prevenção & controle
Monitoramento Epidemiológico
Doença pelo Vírus Ebola/diagnóstico
Doença pelo Vírus Ebola/epidemiologia
Unidades Móveis de Saúde
[Mh] Termos MeSH secundário: Administração de Caso
Ebolavirus/isolamento & purificação
Doença pelo Vírus Ebola/virologia
Seres Humanos
Libéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006135


  8 / 3903 MEDLINE  
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[PMID]:29323843
[Au] Autor:Borisevich IV; Chemikova NK; Markov VI; Krasnianskiy VP; Borisevich SV; Rozhdestvenskiy EV
[Ti] Título:An experience in the clinical use of specific immunoglobulin from horse blood serum for prophylaxis of Ebola haemorrhagic fever.
[So] Source:Vopr Virusol;62(1):25-9, 2017.
[Is] ISSN:0507-4088
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to estimate the efficacy and safety of single intramuscular introduction of specific heterologous immunoglobulin as prophylactic drug against Ebola hemorrhagic fever. Materials and methods. The specific heterologous immunoglobulin was introduced as a special prophylactic drug to 28 patients in epidemic situations, after skin hurt with infectious materials or contact with infectious blood. Clinico-laboratory observation was performed in 24 subjects after single intramuscular introduction of heterologous immunoglobulin Ebola. The samples of blood serum were investigated for immunoglobulin Ebola and antibodies to horse gamma-globulin on the 30th and 60th days after prophylaxis. Results. None of the subjects of the study contracted Ebola fever. There were no anaphylactic reactions after special prophylaxis with specific heterologous immunoglobulin. Among the subjects with normal allergic state 31% responded with local reactions; 13%, with a general reaction (mild case of the serum disease). Almost no reaction was observed in patients with unfavorable allergic state subjected to desensitizing therapy; in the absence of desensitizing therapy, 50% of patients with unfavorable allergic state exhibited local reactions; 17%, mild cases of the serum disease; 33%, moderate cases of the serum disease. In summary, if the tactics of immunoglobulin application was right, the quantity of local allergic reactions was 28%; of wide spread reactions, 6%. Weak serum disease was observed in 11% of the subjects. The prognostic period of resistance to Ebola fever was less than 30 days. Conclusion. The prophylactic use of specific immunoglobulin from horse blood serum against hemorrhagic Ebola fever is effective and relatively safe in patients subjected to desensitizing therapy.
[Mh] Termos MeSH primário: Anticorpos Antivirais/administração & dosagem
Ebolavirus/imunologia
Doença pelo Vírus Ebola/prevenção & controle
Imunoglobulina G/administração & dosagem
Profilaxia Pré-Exposição/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Anticorpos Antivirais/efeitos adversos
Anticorpos Antivirais/sangue
Criança
Busca de Comunicante
Dessensibilização Imunológica
Ebolavirus/patogenicidade
Feminino
Doença pelo Vírus Ebola/imunologia
Doença pelo Vírus Ebola/transmissão
Doença pelo Vírus Ebola/virologia
Cavalos/sangue
Cavalos/imunologia
Seres Humanos
Hipersensibilidade/imunologia
Hipersensibilidade/fisiopatologia
Imunização Passiva
Imunoglobulina G/efeitos adversos
Imunoglobulina G/sangue
Injeções Intramusculares
Masculino
Meia-Idade
Ferimentos Penetrantes Produzidos por Agulha/imunologia
Segurança do Paciente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Immunoglobulin G)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE


  9 / 3903 MEDLINE  
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[PMID]:28468673
[Au] Autor:Haddow AD; Nasar F; Schellhase CW; Moon RD; Padilla SL; Zeng X; Wollen-Roberts SE; Shamblin JD; Grimes EC; Zelko JM; Linthicum KJ; Bavari S; Pitt ML; Trefry JC
[Ad] Endereço:United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA. andrew.d.haddow.ctr@mail.mil.
[Ti] Título:Low potential for mechanical transmission of Ebola virus via house flies (Musca domestica).
[So] Source:Parasit Vectors;10(1):218, 2017 May 03.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ebola virus (EBOV) infection results in high morbidity and mortality and is primarily transmitted in communities by contact with infectious bodily fluids. While clinical and experimental evidence indicates that EBOV is transmitted via mucosal exposure, the ability of non-biting muscid flies to mechanically transmit EBOV following exposure to the face had not been assessed. RESULTS: To investigate this transmission route, house flies (Musca domestica Linnaeus) were used to deliver an EBOV/blood mixture to the ocular/nasal/oral facial mucosa of four cynomolgus macaques (Macaca fascicularis Raffles). Following exposure, macaques were monitored for evidence of infection through the conclusion of the study, days 57 and 58. We found no evidence of systemic infection in any of the exposed macaques. CONCLUSIONS: The results of this study indicate that there is a low potential for the mechanical transmission of EBOV via house flies - the conditions in this study were not sufficient to initiate infection.
[Mh] Termos MeSH primário: Ebolavirus/isolamento & purificação
Doença pelo Vírus Ebola/transmissão
Moscas Domésticas/virologia
Insetos Vetores/virologia
[Mh] Termos MeSH secundário: Animais
Olho/virologia
Face/virologia
Fezes/virologia
Doença pelo Vírus Ebola/sangue
Doença pelo Vírus Ebola/virologia
Macaca fascicularis
Mucosa Bucal/virologia
Membrana Mucosa/virologia
Nariz/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2149-x


  10 / 3903 MEDLINE  
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[PMID]:29298314
[Au] Autor:Nic Lochlainn LM; Gayton I; Theocharopoulos G; Edwards R; Danis K; Kremer R; Kleijer K; Tejan SM; Sankoh M; Jimissa A; Greig J; Caleo G
[Ad] Endereço:European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden.
[Ti] Título:Improving mapping for Ebola response through mobilising a local community with self-owned smartphones: Tonkolili District, Sierra Leone, January 2015.
[So] Source:PLoS One;13(1):e0189959, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: During the 2014-16 Ebola virus disease (EVD) outbreak, the Magburaka Ebola Management Centre (EMC) operated by Médecins Sans Frontières (MSF) in Tonkolili District, Sierra Leone, identified that available district maps lacked up-to-date village information to facilitate timely implementation of EVD control strategies. In January 2015, we undertook a survey in chiefdoms within the MSF EMC catchment area to collect mapping and village data. We explore the feasibility and cost to mobilise a local community for this survey, describe validation against existing mapping sources and use of the data to prioritise areas for interventions, and lessons learned. METHODS: We recruited local people with self-owned Android smartphones installed with open-source survey software (OpenDataKit (ODK)) and open-source navigation software (OpenStreetMap Automated Navigation Directions (OsmAnd)). Surveyors were paired with local motorbike drivers to travel to eligible villages. The collected mapping data were validated by checking for duplication and comparing the village names against a pre-existing village name and location list using a geographic distance and text string-matching algorithm. RESULTS: The survey teams gained sufficient familiarity with the ODK and OsmAnd software within 1-2 hours. Nine chiefdoms in Tonkolili District and three in Bombali District were surveyed within two weeks. Following de-duplication, the surveyors collected data from 891 villages with an estimated 127,021 households. The overall survey cost was €3,395; €3.80 per village surveyed. The MSF GIS team (MSF-OCG) created improved maps for the MSF Magburaka EMC team which were used to support surveillance, investigation of suspect EVD cases, hygiene-kit distribution and EVD survivor support. We shared the mapping data with OpenStreetMap, the local Ministry of Health and Sanitation and Sierra Leone District and National Ebola Response Centres. CONCLUSIONS: Involving local community and using accessible technology allowed rapid implementation, at moderate cost, of a survey to collect geographic and essential village information, and creation of updated maps. These methods could be used for future emergencies to facilitate response.
[Mh] Termos MeSH primário: Surtos de Doenças
Doença pelo Vírus Ebola/epidemiologia
Smartphone
[Mh] Termos MeSH secundário: Doença pelo Vírus Ebola/prevenção & controle
Seres Humanos
Propriedade
Serra Leoa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189959



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