Base de dados : MEDLINE
Pesquisa : C02.782.580.250 [Categoria DeCS]
Referências encontradas : 126 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 13 ir para página                         

  1 / 126 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28542463
[Au] Autor:Albariño CG; Wiggleton Guerrero L; Jenks HM; Chakrabarti AK; Ksiazek TG; Rollin PE; Nichol ST
[Ad] Endereço:Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
[Ti] Título:Insights into Reston virus spillovers and adaption from virus whole genome sequences.
[So] Source:PLoS One;12(5):e0178224, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reston virus (family Filoviridae) is unique among the viruses of the Ebolavirus genus in that it is considered non-pathogenic in humans, in contrast to the other members which are highly virulent. The virus has however, been associated with several outbreaks of highly lethal hemorrhagic fever in non-human primates (NHPs), specifically cynomolgus monkeys (Macaca fascicularis) originating in the Philippines. In addition, Reston virus has been isolated from domestic pigs in the Philippines. To better understand virus spillover events and potential adaption to new hosts, the whole genome sequences of representative Reston virus isolates were obtained using a next generation sequencing (NGS) approach and comparative genomic analysis and virus fitness analyses were performed. Nine virus genome sequences were completed for novel and previously described isolates obtained from a variety of hosts including a human case, non-human primates and pigs. Results of phylogenetic analysis of the sequence differences are consistent with multiple independent introductions of RESTV from a still unknown natural reservoir into non-human primates and swine farming operations. No consistent virus genetic markers were found specific for viruses associated with primate or pig infections, but similar to what had been seen with some Ebola viruses detected in the large Western Africa outbreak in 2014-2016, a truncated version of VP30 was identified in a subgroup of Reston viruses obtained from an outbreak in pigs 2008-2009. Finally, the genetic comparison of two closely related viruses, one isolated from a human case and one from an NHP, showed amino acid differences in the viral polymerase and detectable differences were found in competitive growth assays on human and NHP cell lines.
[Mh] Termos MeSH primário: Filoviridae/genética
Genoma Viral/genética
[Mh] Termos MeSH secundário: Animais
Surtos de Doenças/veterinária
Ebolavirus/genética
Ebolavirus/patogenicidade
Filoviridae/patogenicidade
Infecções por Filoviridae/veterinária
Infecções por Filoviridae/virologia
Marcadores Genéticos/genética
Doença pelo Vírus Ebola/veterinária
Doença pelo Vírus Ebola/virologia
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Macaca fascicularis/virologia
Suínos/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178224


  2 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27638946
[Au] Autor:Kerber R; Krumkamp R; Diallo B; Jaeger A; Rudolf M; Lanini S; Bore JA; Koundouno FR; Becker-Ziaja B; Fleischmann E; Stoecker K; Meschi S; Mély S; Newman EN; Carletti F; Portmann J; Korva M; Wolff S; Molkenthin P; Kis Z; Kelterbaum A; Bocquin A; Strecker T; Fizet A; Castilletti C; Schudt G; Ottowell L; Kurth A; Atkinson B; Badusche M; Cannas A; Pallasch E; Bosworth A; Yue C; Pályi B; Ellerbrok H; Kohl C; Oestereich L; Logue CH; Lüdtke A; Richter M; Ngabo D; Borremans B; Becker D; Gryseels S; Abdellati S; Vermoesen T; Kuisma E; Kraus A; Liedigk B
[Ad] Endereço:Bernhard Nocht Institute for Tropical Medicine European Mobile Laboratory Consortium German Center for Infection Research, Hamburg-Munich-Marburg-Riems.
[Ti] Título:Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.
[So] Source:J Infect Dis;214(suppl 3):S250-S257, 2016 Oct 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015. METHODS: The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively. RESULTS: The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virus-malaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 10-19 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 5-14 years, malaria parasite coinfection were independent determinants of a poor EVD outcome. CONCLUSIONS: Virus load, age, and malaria parasite coinfection play a role in the outcome of EVD.
[Mh] Termos MeSH primário: Ebolavirus/isolamento & purificação
Epidemias
Infecções por Filoviridae/diagnóstico
Doença pelo Vírus Ebola/diagnóstico
Malária/complicações
Unidades Móveis de Saúde
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Serviços de Laboratório Clínico
Ebolavirus/genética
Feminino
Filoviridae
Infecções por Filoviridae/complicações
Infecções por Filoviridae/virologia
Guiné
Doença pelo Vírus Ebola/complicações
Doença pelo Vírus Ebola/virologia
Seres Humanos
Lactente
Malária/parasitologia
Masculino
Meia-Idade
RNA Viral/sangue
Carga Viral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE


  3 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27549586
[Au] Autor:Rieger T; Kerber R; El Halas H; Pallasch E; Duraffour S; Günther S; Ölschläger S
[Ad] Endereço:Department of Virology, Bernhard Nocht Institute for Tropical Medicine.
[Ti] Título:Evaluation of RealStar Reverse Transcription-Polymerase Chain Reaction Kits for Filovirus Detection in the Laboratory and Field.
[So] Source:J Infect Dis;214(suppl 3):S243-S249, 2016 Oct 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diagnosis of Ebola virus (EBOV) disease (EVD) requires laboratory testing. METHODS: The RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and the derived RealStar Zaire Ebolavirus RT-PCR kit were validated using in vitro transcripts, supernatant of infected cell cultures, and clinical specimens from patients with EVD. RESULTS: The Filovirus Screen kit detected EBOV, Sudan virus, Taï Forest virus, Bundibugyo virus, Reston virus, and Marburg virus and differentiated between the genera Ebolavirus and Marburgvirus The amount of filovirus RNA that could be detected with a probability of 95% ranged from 11 to 67 RNA copies/reaction on a LightCycler 480 II. The Zaire Ebolavirus kit is based on the Filovirus Screen kit but was optimized for detection of EBOV. It has an improved signal-to-noise ratio at low EBOV RNA concentrations and is somewhat more sensitive than the Filovirus kit. Both kits show significantly lower analytical sensitivity on a SmartCycler II. Clinical evaluation revealed that the SmartCycler II, compared with other real-time PCR platforms, decreases the clinical sensitivity of the Filovirus Screen kit to diagnose EVD at an early stage. CONCLUSIONS: The Filovirus Screen kit detects all human-pathogenic filoviruses with good analytical sensitivity if performed on an appropriate real-time PCR platform. High analytical sensitivity is important for early diagnosis of EVD.
[Mh] Termos MeSH primário: Ebolavirus/isolamento & purificação
Infecções por Filoviridae/diagnóstico
Filoviridae/isolamento & purificação
Doença pelo Vírus Ebola/diagnóstico
Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos
[Mh] Termos MeSH secundário: Ebolavirus/genética
Filoviridae/genética
Infecções por Filoviridae/virologia
Doença pelo Vírus Ebola/virologia
Seres Humanos
Patologia Molecular
RNA Viral/análise
RNA Viral/genética
Kit de Reagentes para Diagnóstico
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160824
[St] Status:MEDLINE


  4 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27489269
[Au] Autor:Kozak R; He S; Kroeker A; de La Vega MA; Audet J; Wong G; Urfano C; Antonation K; Embury-Hyatt C; Kobinger GP; Qiu X
[Ad] Endereço:Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
[Ti] Título:Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease.
[So] Source:J Virol;90(20):9209-23, 2016 Oct 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Bundibugyo virus (BDBV) is the etiological agent of a severe hemorrhagic fever in humans with a case-fatality rate ranging from 25 to 36%. Despite having been known to the scientific and medical communities for almost 1 decade, there is a dearth of studies on this pathogen due to the lack of a small animal model. Domestic ferrets are commonly used to study other RNA viruses, including members of the order Mononegavirales To investigate whether ferrets were susceptible to filovirus infections, ferrets were challenged with a clinical isolate of BDBV. Animals became viremic within 4 days and succumbed to infection between 8 and 9 days, and a petechial rash was observed with moribund ferrets. Furthermore, several hallmarks of human filoviral disease were recapitulated in the ferret model, including substantial decreases in lymphocyte and platelet counts and dysregulation of key biochemical markers related to hepatic/renal function, as well as coagulation abnormalities. Virological, histopathological, and immunohistochemical analyses confirmed uncontrolled BDBV replication in the major organs. Ferrets were also infected with Ebola virus (EBOV) to confirm their susceptibility to another filovirus species and to potentially establish a virus transmission model. Similar to what was seen with BDBV, important hallmarks of human filoviral disease were observed in EBOV-infected ferrets. This study demonstrates the potential of this small animal model for studying BDBV and EBOV using wild-type isolates and will accelerate efforts to understand filovirus pathogenesis and transmission as well as the development of specific vaccines and antivirals. IMPORTANCE: The 2013-2016 outbreak of Ebola virus in West Africa has highlighted the threat posed by filoviruses to global public health. Bundibugyo virus (BDBV) is a member of the genus Ebolavirus and has caused outbreaks in the past but is relatively understudied, likely due to the lack of a suitable small animal model. Such a model for BDBV is crucial to evaluating vaccines and therapies and potentially understanding transmission. To address this, we demonstrated that ferrets are susceptible models to BDBV infection as well as to Ebola virus infection and that no virus adaptation is required. Moreover, these animals develop a disease that is similar to that seen in humans and nonhuman primates. We believe that this will improve the ability to study BDBV and provide a platform to test vaccines and therapeutics.
[Mh] Termos MeSH primário: Ebolavirus/imunologia
Furões/virologia
Infecções por Filoviridae/microbiologia
Filoviridae/imunologia
[Mh] Termos MeSH secundário: África Ocidental
Animais
Anticorpos Monoclonais/imunologia
Anticorpos Antivirais/imunologia
Modelos Animais de Doenças
Feminino
Infecções por Filoviridae/virologia
Doença pelo Vírus Ebola/imunologia
Doença pelo Vírus Ebola/virologia
Seres Humanos
Vacinas Virais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Viral); 0 (Viral Vaccines)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE
[do] DOI:10.1128/JVI.01033-16


  5 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27354372
[Au] Autor:Miller MR; McMinn RJ; Misra V; Schountz T; Müller MA; Kurth A; Munster VJ
[Ad] Endereço:Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana.
[Ti] Título:Broad and Temperature Independent Replication Potential of Filoviruses on Cells Derived From Old and New World Bat Species.
[So] Source:J Infect Dis;214(suppl 3):S297-S302, 2016 Oct 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Filoviruses are strongly associated with several species of bats as their natural reservoirs. In this study, we determined the replication potential of all filovirus species: Marburg marburgvirus, Taï Forest ebolavirus, Reston ebolavirus, Sudan ebolavirus, Zaire ebolavirus, and Bundibugyo ebolavirus. Filovirus replication was supported by all cell lines derived from 6 Old and New World bat species: the hammer-headed fruit bat, Buettikofer's epauletted fruit bat, the Egyptian fruit bat, the Jamaican fruit bat, the Mexican free-tailed bat and the big brown bat. In addition, we showed that Marburg virus Angola and Ebola virus Makona-WPGC07 efficiently replicated at 37°C, 37°-41°C, or 41°C, contrary to the hypothesis that temporal elevation in temperature due to flight affects filovirus replication in bats.
[Mh] Termos MeSH primário: Quirópteros/virologia
Reservatórios de Doenças/virologia
Infecções por Filoviridae/virologia
Filoviridae/isolamento & purificação
Doença pelo Vírus Ebola/virologia
Doença do Vírus de Marburg/virologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Ebolavirus/imunologia
Ebolavirus/isolamento & purificação
Ebolavirus/fisiologia
Filoviridae/fisiologia
Seres Humanos
Marburgvirus/imunologia
Marburgvirus/isolamento & purificação
Marburgvirus/fisiologia
Temperatura Ambiente
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE


  6 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27268907
[Au] Autor:Burk R; Bollinger L; Johnson JC; Wada J; Radoshitzky SR; Palacios G; Bavari S; Jahrling PB; Kuhn JH
[Ad] Endereço:Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, USA.
[Ti] Título:Neglected filoviruses.
[So] Source:FEMS Microbiol Rev;40(4):494-519, 2016 07.
[Is] ISSN:1574-6976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eight viruses are currently assigned to the family Filoviridae Marburg virus, Sudan virus and, in particular, Ebola virus have received the most attention both by researchers and the public from 1967 to 2013. During this period, natural human filovirus disease outbreaks occurred sporadically in Equatorial Africa and, despite high case-fatality rates, never included more than several dozen to a few hundred infections per outbreak. Research emphasis shifted almost exclusively to Ebola virus in 2014, when this virus was identified as the cause of an outbreak that has thus far involved more than 28 646 people and caused more than 11 323 deaths in Western Africa. Consequently, major efforts are currently underway to develop licensed medical countermeasures against Ebola virus infection. However, the ecology of and mechanisms behind Ebola virus emergence are as little understood as they are for all other filoviruses. Consequently, the possibility of the future occurrence of a large disease outbreak caused by other less characterized filoviruses (i.e. Bundibugyo virus, Lloviu virus, Ravn virus, Reston virus and Taï Forest virus) is impossible to rule out. Yet, for many of these viruses, not even rudimentary research tools are available, let alone medical countermeasures. This review summarizes the current knowledge on these less well-characterized filoviruses.
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/virologia
Infecções por Filoviridae/virologia
Doenças Negligenciadas/virologia
[Mh] Termos MeSH secundário: África/epidemiologia
Doenças Transmissíveis Emergentes/epidemiologia
Doenças Transmissíveis Emergentes/prevenção & controle
Surtos de Doenças/prevenção & controle
Filoviridae
Infecções por Filoviridae/epidemiologia
Infecções por Filoviridae/prevenção & controle
Seres Humanos
Doenças Negligenciadas/epidemiologia
Doenças Negligenciadas/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1093/femsre/fuw010


  7 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27189922
[Au] Autor:Banadyga L; Dolan MA; Ebihara H
[Ad] Endereço:Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
[Ti] Título:Rodent-Adapted Filoviruses and the Molecular Basis of Pathogenesis.
[So] Source:J Mol Biol;428(17):3449-66, 2016 Aug 28.
[Is] ISSN:1089-8638
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ebola, Marburg, and Ravn viruses, all filoviruses, are the causative agents of severe hemorrhagic fever. Much of what we understand about the pathogenesis of filovirus disease is derived from work with animal models, including nonhuman primates, which are considered the "gold standard" filovirus model since they faithfully recapitulate the clinical hallmarks of filovirus disease. However, rodent models, including the mouse, guinea pig, and hamster, also exist for Ebola, Marburg, and Ravn viruses, and although they may not reproduce all the clinical signs of filovirus disease, thanks to their relative ease of use and low cost, they are often the first choice for initial descriptions of virus pathogenesis and evaluation of antiviral prophylactics and therapeutics. Since filoviruses do not cause significant disease in adult, immunocompetent rodents, these models rely on "rodent-adapted" viruses that have been passaged several times through their host until virulence and lethality are achieved. In the process of adaptation, the viruses acquire numerous nucleotide/amino acid mutations that contribute to virulence in their rodent host. Interestingly, virus protein 24 (VP24) and nucleoprotein (NP) appear to be major virulence factors for ebolaviruses in rodents, whereas VP40 appears to be the major virulence factor for marburgviruses. By characterizing these mutations and understanding the molecular mechanisms that lead to the acquisition of virulence, we can gain better insight into the pathogenic processes that underlie filovirus disease in humans. These processes, and the viral and/or cellular proteins that contribute to them, will make attractive targets for the development of novel therapeutics and counter-measures.
[Mh] Termos MeSH primário: Adaptação Biológica
Modelos Animais de Doenças
Infecções por Filoviridae/patologia
Infecções por Filoviridae/virologia
Filoviridae/genética
Filoviridae/patogenicidade
[Mh] Termos MeSH secundário: Animais
Cricetinae
Cobaias
Camundongos
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE


  8 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27103629
[Au] Autor:Yusim K; Yoon H; Foley B; Feng S; Macke J; Dimitrijevic M; Abfalterer W; Szinger J; Fischer W; Kuiken C; Korber B
[Ad] Endereço:Los Alamos National Laboratory, Los Alamos, NM, USA kyusim@lanl.gov.
[Ti] Título:Integrated sequence and immunology filovirus database at Los Alamos.
[So] Source:Database (Oxford);2016, 2016.
[Is] ISSN:1758-0463
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The Ebola outbreak of 2013-15 infected more than 28 000 people and claimed more lives than all previous filovirus outbreaks combined. Governmental agencies, clinical teams, and the world scientific community pulled together in a multifaceted response ranging from prevention and disease control, to evaluating vaccines and therapeutics in human trials. As this epidemic is finally coming to a close, refocusing on long-term prevention strategies becomes paramount. Given the very real threat of future filovirus outbreaks, and the inherent uncertainty of the next outbreak virus and geographic location, it is prudent to consider the extent and implications of known natural diversity in advancing vaccines and therapeutic approaches. To facilitate such consideration, we have updated and enhanced the content of the filovirus portion of Los Alamos Hemorrhagic Fever Viruses Database. We have integrated and performed baseline analysis of all family ITALIC! Filoviridaesequences deposited into GenBank, with associated immune response data, and metadata, and we have added new computational tools with web-interfaces to assist users with analysis. Here, we (i) describe the main features of updated database, (ii) provide integrated views and some basic analyses summarizing evolutionary patterns as they relate to geo-temporal data captured in the database and (iii) highlight the most conserved regions in the proteome that may be useful for a T cell vaccine strategy.Database URL:www.hfv.lanl.gov.
[Mh] Termos MeSH primário: Bases de Dados Genéticas
Infecções por Filoviridae/virologia
Filoviridae/genética
Filoviridae/imunologia
[Mh] Termos MeSH secundário: Infecções por Filoviridae/imunologia
Seres Humanos
Internet
New Mexico
Interface Usuário-Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160423
[St] Status:MEDLINE


  9 / 126 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27001679
[Au] Autor:Akpovwa H
[Ad] Endereço:Cardiff School of Biosciences, Cardiff University, Cardiff, UK.
[Ti] Título:Chloroquine could be used for the treatment of filoviral infections and other viral infections that emerge or emerged from viruses requiring an acidic pH for infectivity.
[So] Source:Cell Biochem Funct;34(4):191-6, 2016 Jun.
[Is] ISSN:1099-0844
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Viruses from the Filoviridae family, as many other virus families, require an acidic pH for successful infection and are therefore susceptible to the actions of 4-aminoquinolines, such as chloroquine. Although the mechanisms of action of chloroquine clearly indicate that it might inhibit filoviral infections, several clinical trials that attempted to use chloroquine in the treatment of other acute viral infections - including dengue and influenza A and B - caused by low pH-dependent viruses, have reported that chloroquine had no clinical efficacy, and these results demoted chloroquine from the potential treatments for other virus families requiring low pH for infectivity. The present review is aimed at investigating whether chloroquine could combat the present Ebola virus epidemic, and also at exploring the main reasons for the reported lack of efficacy. Literature was sourced from PubMed, Scopus, Google Scholar, reference list of articles and textbooks - Fields Virology (Volumes 1and 2), the cytokine handbook, Pharmacology in Medicine: Principles and Practice, and hydroxychloroquine and chloroquine retinopathy. The present analysis concludes that (1) chloroquine might find a place in the treatment of Ebola, either as a monotherapy or in combination therapies; (2) the ineffectiveness of chloroquine, or its analogue, hydroxychloroquine, at treating infections from low pH-dependent viruses is a result of the failure to attain and sustain a steady state concentration sufficient to increase and keep the pH of the acidic organelles to approximately neutral levels; (3) to successfully treat filoviral infections - or other viral infections that emerge or emerged from low pH-dependent viruses - a steady state chloroquine plasma concentration of at least 1 µg/mL(~3.125 µM/L) or a whole blood concentration of 16 µM/L must be achieved and be sustained until the patients' viraemia becomes undetectable. These concentrations, however, do not rule out the efficacy of other, higher, steady state concentrations - although such concentrations might be accompanied by severe adverse effects or toxicities. The feasibility of the conclusion in the preceding texts has recently been supported by a subsequent study that shows that amodiaquine, a derivative of CQ, is able to protect humans infected with Ebola from death.
[Mh] Termos MeSH primário: Cloroquina/uso terapêutico
Infecções por Filoviridae/tratamento farmacológico
Filoviridae/patogenicidade
[Mh] Termos MeSH secundário: Cloroquina/farmacologia
Filoviridae/efeitos dos fármacos
Concentração de Íons de Hidrogênio
Imunomodulação/efeitos dos fármacos
Organelas/efeitos dos fármacos
Organelas/metabolismo
Tropismo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.1002/cbf.3182


  10 / 126 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26512687
[Au] Autor:Bixler SL; Goff AJ
[Ad] Endereço:United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Frederick, MD 21702, USA. sandra.l.bixler.ctr@mail.mil.
[Ti] Título:The Role of Cytokines and Chemokines in Filovirus Infection.
[So] Source:Viruses;7(10):5489-507, 2015 Oct 23.
[Is] ISSN:1999-4915
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as other biological processes. Here we examine the role of cytokines in filovirus infection, with an emphasis on understanding how these molecules affect development of the antiviral immune response and influence pathology. These proteins may present targets for immune modulation by therapeutic agents and vaccines in an effort to boost the natural immune response to infection and/or reduce immunopathology.
[Mh] Termos MeSH primário: Citocinas/imunologia
Infecções por Filoviridae/imunologia
Infecções por Filoviridae/patologia
Filoviridae/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; REVIEW
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151124
[Lr] Data última revisão:
151124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151030
[St] Status:MEDLINE
[do] DOI:10.3390/v7102892



página 1 de 13 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde