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[PMID]:28767708
[Au] Autor:McMichael L; Edson D; Smith C; Mayer D; Smith I; Kopp S; Meers J; Field H
[Ad] Endereço:University of Queensland, School of Veterinary Science, Gatton, Queensland, Australia.
[Ti] Título:Physiological stress and Hendra virus in flying-foxes (Pteropus spp.), Australia.
[So] Source:PLoS One;12(8):e0182171, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pteropid bats (flying-foxes) are the natural reservoir of Hendra virus, an emergent paramyxovirus responsible for fatal infection in horses and humans in Australia. Pteropus alecto (the Black flying-fox) and the paraphyletic P. conspicillatus (the Spectacled flying-fox) appear to be the primary reservoir hosts. Previous studies have suggested that physiological and ecological factors may underpin infection dynamics in flying-foxes, and subsequent spillover to horses and in turn humans. We sought to examine temporal trends in urinary cortisol concentration in wild Australian flying-fox populations, to elucidate the putative relationship between Hendra virus infection and physiological stress. Pooled and individual urine samples were non-invasively collected from under roosting flying-foxes at two latitudinally disparate regions in the eastern Australian state of Queensland. Hendra virus detection, and (in individual urine samples) sex and species determination were PCR-based. Urinary cortisol measurement used a validated enzyme immunoassay. We found no direct correlation between increased urinary cortisol and Hendra virus excretion, but our findings do suggest a biologically plausible association between low winter temperatures and elevated cortisol levels in P. alecto in the lower latitude Southeast Queensland roosts. We hypothesize an indirect association between low winter temperatures and increased Hendra virus infection and excretion, mediated by the physiological cost of thermoregulation. Our findings and our approach are directly relevant to elaboration of the disease ecology of Nipah virus and other emerging henipaviruses in bats. More broadly, they inform investigation of emerging disease infection dynamics across the wildlife/livestock/human interface.
[Mh] Termos MeSH primário: Quirópteros/virologia
Vírus Hendra/fisiologia
Infecções por Henipavirus/diagnóstico
Hidrocortisona/urina
[Mh] Termos MeSH secundário: Animais
Austrália
Quirópteros/urina
Reservatórios de Doenças
Feminino
Infecções por Henipavirus/urina
Masculino
Especificidade da Espécie
Estresse Fisiológico
Urina/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182171


  2 / 379 MEDLINE  
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[PMID]:28636633
[Au] Autor:Goyen KA; Wright JD; Cunneen A; Henning J
[Ad] Endereço:School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland, Australia.
[Ti] Título:Playing with fire - What is influencing horse owners' decisions to not vaccinate their horses against deadly Hendra virus infection?
[So] Source:PLoS One;12(6):e0180062, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hendra virus is a zoonotic paramyxovirus, which causes severe respiratory and neurological disease in horses and humans. Since 2012, the Hendra virus sub-unit G vaccine has been available for horse vaccination in Australia. Uptake of the vaccine has been limited and spill-over events of Hendra virus infection in horses continue to occur. We conducted an online, questionnaire-based cross-sectional study of 376 horse owners belonging to a variety of different equestrian clubs in Queensland, Australia, to identify risk factors for non-vaccination against Hendra virus. A total of 43.1% (N = 162) of horse owners indicated that they currently did not vaccinate against Hendra virus infection, while 56.9% (N = 214) currently vaccinated against Hendra virus infection. A total of 52 risk factors were evaluated relating to equestrian activities, horse management, perceived risk and severity of horse and human infection with Hendra virus, side effects of Hendra vaccination, other vaccinations conducted by horse owners and horse owners' attitudes towards veterinarians. The final multivariable logistics regression model identified the following risk factors associated with increased odds of non-vaccination against Hendra virus: 1) perceived low risk (compared to high) of Hendra virus infection to horses (considering the horse owners' location and management practices) or horse owners were unsure about the risk of infection, 2) perceived moderate severity (compared to very severe or severe) of Hendra virus infection in humans, 3) horse owners non-vaccination of their pets, 4) horse owners non-vaccination against strangles disease in horses, 5) handling of more than three horses per week (compared to one horse only) and 6) perceived attitude that veterinarians had a high motivation of making money from Hendra virus vaccination (compared to veterinarians having a low motivation of making money from Hendra virus vaccination). Horse owners were more likely to vaccinate against Hendra virus if horses were used for dressage, show jumping or eventing. The study also identified horse owners' concerns about side-effects and about the lack of evidence on vaccine efficacy.
[Mh] Termos MeSH primário: Vírus Hendra/imunologia
Infecções por Henipavirus/prevenção & controle
Doenças dos Cavalos/prevenção & controle
Vacinação
[Mh] Termos MeSH secundário: Animais
Austrália
Estudos Transversais
Conhecimentos, Atitudes e Prática em Saúde
Infecções por Henipavirus/virologia
Doenças dos Cavalos/virologia
Cavalos
Seres Humanos
Internet
Razão de Chances
Propriedade
Fatores de Risco
Inquéritos e Questionários
Vacinação/efeitos adversos
Vacinação/economia
Médicos Veterinários/economia
Médicos Veterinários/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180062


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[PMID]:28539439
[Au] Autor:Escaffre O; Saito TB; Juelich TL; Ikegami T; Smith JK; Perez DD; Atkins C; Levine CB; Huante MB; Nusbaum RJ; Endsley JJ; Freiberg AN; Rockx B
[Ad] Endereço:Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
[Ti] Título:Contribution of Human Lung Parenchyma and Leukocyte Influx to Oxidative Stress and Immune System-Mediated Pathology following Nipah Virus Infection.
[So] Source:J Virol;91(15), 2017 Aug 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nipah virus (NiV) is a zoonotic emerging paramyxovirus that can cause fatal respiratory illness or encephalitis in humans. Despite many efforts, the molecular mechanisms of NiV-induced acute lung injury (ALI) remain unclear. We previously showed that NiV replicates to high titers in human lung grafts in NOD-SCID/γ mice, resulting in a robust inflammatory response. Interestingly, these mice can undergo human immune system reconstitution by the bone marrow, liver, and thymus (BLT) reconstitution method, in addition to lung tissue engraftment, giving altogether a realistic model to study human respiratory viral infections. Here, we characterized NiV Bangladesh strain (NiV-B) infection of human lung grafts from human immune system-reconstituted mice in order to identify the overall effect of immune cells on NiV pathogenesis of the lung. We show that NiV-B replicated to high titers in human lung grafts and caused similar cytopathic effects irrespective of the presence of human leukocytes in mice. However, the human immune system interfered with virus spread across lung grafts, responded to infection by leukocyte migration to small airways and alveoli of the lung grafts, and accelerated oxidative stress in lung grafts. In addition, the presence of human leukocytes increased the expression of cytokines and chemokines that regulate inflammatory influx to sites of infection and tissue damage. These results advance our understanding of how the immune system limits NiV dissemination and contributes to ALI and inform efforts to identify therapeutic targets. Nipah virus (NiV) is an emerging paramyxovirus that can cause a lethal respiratory and neurological disease in humans. Only limited data are available on NiV pathogenesis in the human lung, and the relative contribution of the innate immune response and NiV to acute lung injury (ALI) is still unknown. Using human lung grafts in a human immune system-reconstituted mouse model, we showed that the NiV Bangladesh strain induced cytopathic lesions in lung grafts similar to those described in patients irrespective of the donor origin or the presence of leukocytes. However, the human immune system interfered with virus spread, responded to infection by leukocyte infiltration in the small airways and alveolar area, induced oxidative stress, and triggered the production of cytokines and chemokines that regulate inflammatory influx by leukocytes in response to infection. Understanding how leukocytes interact with NiV and cause ALI in human lung xenografts is crucial for identifying therapeutic targets.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/patologia
Infecções por Henipavirus/patologia
Leucócitos/imunologia
Pulmão/patologia
Vírus Nipah/crescimento & desenvolvimento
Estresse Oxidativo
[Mh] Termos MeSH secundário: Animais
Citocinas/análise
Modelos Animais de Doenças
Seres Humanos
Camundongos
Camundongos SCID
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE


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[PMID]:28407738
[Au] Autor:Manyweathers J; Field H; Longnecker N; Agho K; Smith C; Taylor M
[Ad] Endereço:Centre for Health Research, Western Sydney University, Sydney, Australia. jmanyweathers@csu.edu.au.
[Ti] Título:"Why won't they just vaccinate?" Horse owner risk perception and uptake of the Hendra virus vaccine.
[So] Source:BMC Vet Res;13(1):103, 2017 Apr 13.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hendra virus is a paramyxovirus that causes periodic serious disease and fatalities in horses and humans in Australia first identified in 1994. Pteropid bats (commonly known as flying-foxes) are the natural host of the virus, and the putative route of infection in horses is by ingestion or inhalation of material contaminated by flying-fox urine or other bodily fluids. Humans become infected after close contact with infected horses. Horse owners in Australia are encouraged to vaccinate their horses against Hendra virus to reduce the risk of Hendra virus infection, and to prevent potential transmission to humans. After the vaccine was released in 2012, uptake by horse owners was slow, with some estimated 11-17% of horses in Australia vaccinated. This study was commissioned to examine barriers to vaccine uptake and potential drivers to future adoption of vaccination by horse owners. METHODS: This study examined qualitative comments from respondents to an on-line survey, reporting reasons for not vaccinating their horses. The study also investigated scenarios in which respondents felt they might consider vaccinating their horses. RESULTS: Self-reported barriers to uptake of the Hendra virus vaccine by horse owners (N = 150) included concerns about vaccine safety, cost, and effectiveness. Reduction in vaccination costs and perception of immediacy of Hendra virus risk were reported as being likely to change future behaviour. However, the data also indicated that horse owners generally would not reconsider vaccinating their horses if advised by their veterinarian. CONCLUSION: While changes to vaccine costs and the availability data supporting vaccine safety and efficacy may encourage more horse owners to vaccinate, this study highlights the importance of protecting the relationship between veterinarians and horse owners within the risk management strategies around Hendra virus. Interactions and trust between veterinarians and animal owners has important implications for management of and communication around Hendra virus and other zoonotic disease outbreaks.
[Mh] Termos MeSH primário: Conhecimentos, Atitudes e Prática em Saúde
Infecções por Henipavirus/veterinária
Doenças dos Cavalos/prevenção & controle
Cavalos/virologia
Vacinas/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Austrália
Quirópteros/virologia
Vírus Hendra
Infecções por Henipavirus/prevenção & controle
Seres Humanos
Risco
Inquéritos e Questionários
Vacinas/economia
Médicos Veterinários
Zoonoses/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1006-7


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[PMID]:28388650
[Au] Autor:Cong Y; Lentz MR; Lara A; Alexander I; Bartos C; Bohannon JK; Hammoud D; Huzella L; Jahrling PB; Janosko K; Jett C; Kollins E; Lackemeyer M; Mollura D; Ragland D; Rojas O; Solomon J; Xu Z; Munster V; Holbrook MR
[Ad] Endereço:NIAID Integrated Research Facility, Ft. Detrick, Frederick, Maryland, United States of America.
[Ti] Título:Loss in lung volume and changes in the immune response demonstrate disease progression in African green monkeys infected by small-particle aerosol and intratracheal exposure to Nipah virus.
[So] Source:PLoS Negl Trop Dis;11(4):e0005532, 2017 Apr.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nipah virus (NiV) is a paramyxovirus (genus Henipavirus) that emerged in the late 1990s in Malaysia and has since been identified as the cause of sporadic outbreaks of severe febrile disease in Bangladesh and India. NiV infection is frequently associated with severe respiratory or neurological disease in infected humans with transmission to humans through inhalation, contact or consumption of NiV contaminated foods. In the work presented here, the development of disease was investigated in the African Green Monkey (AGM) model following intratracheal (IT) and, for the first time, small-particle aerosol administration of NiV. This study utilized computed tomography (CT) and magnetic resonance imaging (MRI) to temporally assess disease progression. The host immune response and changes in immune cell populations over the course of disease were also evaluated. This study found that IT and small-particle administration of NiV caused similar disease progression, but that IT inoculation induced significant congestion in the lungs while disease following small-particle aerosol inoculation was largely confined to the lower respiratory tract. Quantitative assessment of changes in lung volume found up to a 45% loss in IT inoculated animals. None of the subjects in this study developed overt neurological disease, a finding that was supported by MRI analysis. The development of neutralizing antibodies was not apparent over the 8-10 day course of disease, but changes in cytokine response in all animals and activated CD8+ T cell numbers suggest the onset of cell-mediated immunity. These studies demonstrate that IT and small-particle aerosol infection with NiV in the AGM model leads to a severe respiratory disease devoid of neurological indications. This work also suggests that extending the disease course or minimizing the impact of the respiratory component is critical to developing a model that has a neurological component and more accurately reflects the human condition.
[Mh] Termos MeSH primário: Encéfalo/patologia
Infecções por Henipavirus/imunologia
Imunidade Celular
Pulmão/patologia
[Mh] Termos MeSH secundário: Aerossóis
Animais
Encéfalo/virologia
Linfócitos T CD8-Positivos/imunologia
Cercopithecus aethiops/virologia
Citocinas/sangue
Modelos Animais de Doenças
Progressão da Doença
Feminino
Infecções por Henipavirus/veterinária
Seres Humanos
Pulmão/virologia
Imagem por Ressonância Magnética
Masculino
Vírus Nipah
RNA Viral/análise
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aerosols); 0 (Cytokines); 0 (RNA, Viral)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005532


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[PMID]:28214468
[Au] Autor:Mendez DH; Büttner P; Kelly J; Nowak M; Speare Posthumously R
[Ad] Endereço:College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4811, Australia. Diana.Mendez@jcu.edu.au.
[Ti] Título:Difficulties experienced by veterinarians when communicating about emerging zoonotic risks with animal owners: the case of Hendra virus.
[So] Source:BMC Vet Res;13(1):56, 2017 Feb 18.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Communication skills are essential for veterinarians who need to discuss animal health related matters with their clients. When dealing with an emerging zoonosis, such as Hendra virus (HeV), veterinarians also have a legal responsibility to inform their clients about the associated risks to human health. Here we report on part of a mixed methods study that examined the preparedness of, and difficulties experienced by, veterinarians communicating about HeV-related risks with their clients. METHODS: Phase 1 was an exploratory, qualitative study that consisted of a series of face-to-face, semi-structured interviews with veterinary personnel from Queensland, Australia (2009-10) to identify the barriers to HeV management in equine practices. Phase 2a was a quantitative study that surveyed veterinarians from the same region (2011) and explored the veterinarians' preparedness and willingness to communicate about HeV-related risks, and the reactions of their clients that they experienced. The second study included both multiple choice and open-ended questions. RESULTS: The majority of the participants from Phase 2a (83.1%) declared they had access to a HeV management plan and over half (58.6%) had ready-to-use HeV information available for clients within their practice. Most (87%) reported "always or sometimes" informing clients about HeV-related risks when a horse appeared sick. When HeV was suspected, 58.1% of participants reported their clients were receptive to their safety directives and 24.9% of clients were either initially unreceptive, overwhelmed by fear, or in denial of the associated risks. The thematic analysis of the qualitative data from Phases 1 and 2a uncovered similar themes in relation to HeV-related communication issues experienced by veterinarians: "clients' intent to adhere"; "adherence deemed redundant"; "misunderstanding or denial of risk"; "cost"; "rural culture"; "fear for reputation". The theme of "emotional state of clients" was only identified during Phase 1. CONCLUSION: Warning horse owners about health and safety issues that may affect them when present in a veterinary work environment is a legal requirement for veterinarians. However, emerging zoonoses are unpredictable events that may require a different communication approach. Future training programs addressing veterinary communication skills should take into account the particular issues inherent to managing an emerging zoonosis and emphasise the importance of maintaining human safety. Veterinary communication skills and approaches required when dealing with emerging zoonoses should be further investigated.
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/transmissão
Vírus Hendra/fisiologia
Infecções por Henipavirus/veterinária
Doenças dos Cavalos/virologia
Médicos Veterinários
Zoonoses
[Mh] Termos MeSH secundário: Adulto
Animais
Comunicação
Feminino
Infecções por Henipavirus/epidemiologia
Infecções por Henipavirus/virologia
Doenças dos Cavalos/epidemiologia
Doenças dos Cavalos/transmissão
Cavalos
Seres Humanos
Masculino
Meia-Idade
Queensland/epidemiologia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170220
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-0970-2


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[PMID]:28128262
[Au] Autor:Butler D
[Ti] Título:Billion-dollar project aims to prep vaccines before epidemics hit.
[So] Source:Nature;541(7638):444-445, 2017 01 18.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Surtos de Doenças/prevenção & controle
Vacinas/economia
Vacinas/provisão & distribuição
[Mh] Termos MeSH secundário: Animais
Infecções por Coronavirus/prevenção & controle
Surtos de Doenças/economia
Doença pelo Vírus Ebola/epidemiologia
Doença pelo Vírus Ebola/prevenção & controle
Infecções por Henipavirus/prevenção & controle
Seres Humanos
Cooperação Internacional
Febre Lassa/prevenção & controle
Vírus Nipah
Fatores de Tempo
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Vaccines)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1038/nature.2017.21329


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[PMID]:28104849
[Au] Autor:Cohen J
[Ti] Título:A half-billion-dollar bid to head off emerging diseases.
[So] Source:Science;355(6322):237, 2017 Jan 20.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Transmissíveis Emergentes/prevenção & controle
Infecções por Coronavirus/prevenção & controle
Saúde Global/economia
Infecções por Henipavirus/prevenção & controle
Febre Lassa/prevenção & controle
Vacinas Virais/economia
[Mh] Termos MeSH secundário: Financiamento de Capital
Doenças Transmissíveis Emergentes/virologia
Seres Humanos
Investimentos em Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Vaccines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1126/science.355.6322.237


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[PMID]:28103156
[Au] Autor:de Araujo J; Lo MK; Tamin A; Ometto TL; Thomazelli LM; Nardi MS; Hurtado RF; Nava A; Spiropoulou CF; Rota PA; Durigon EL
[Ad] Endereço:1 Institute of Biomedical Sciences, University of Sao Paulo , Sao Paulo, Brazil .
[Ti] Título:Antibodies Against Henipa-Like Viruses in Brazilian Bats.
[So] Source:Vector Borne Zoonotic Dis;17(4):271-274, 2017 Apr.
[Is] ISSN:1557-7759
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bats are reservoir hosts for many paramyxoviruses, some of which cause human and zoonotic diseases of public health importance. We developed a Nipah virus nucleoprotein enzyme-linked immunosorbent assay to detect cross-reactive antibodies in serum samples from several bat species in Brazil. Our results warrant further investigation of henipa-like virus reservoirs in the Western hemisphere.
[Mh] Termos MeSH primário: Quirópteros/virologia
Infecções por Henipavirus/veterinária
Henipavirus/imunologia
[Mh] Termos MeSH secundário: Animais
Brasil/epidemiologia
Infecções por Henipavirus/epidemiologia
Infecções por Henipavirus/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1089/vbz.2016.2051


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[PMID]:28088124
[Au] Autor:Clayton BA
[Ad] Endereço:Commonwealth Scientific and Industrial Research Organisation, Australian Animal Health Laboratory, East Geelong, Victoria 3219, Australia. Electronic address: Bronwyn.Clayton@csiro.au.
[Ti] Título:Nipah virus: transmission of a zoonotic paramyxovirus.
[So] Source:Curr Opin Virol;22:97-104, 2017 Feb.
[Is] ISSN:1879-6265
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Nipah virus is a recently-recognised, zoonotic paramyxovirus that causes severe disease and high fatality rates in people. Outbreaks have occurred in Malaysia, Singapore, India and Bangladesh, and a putative Nipah virus was also recently associated with human disease in the Philippines. Worryingly, human-to-human transmission is common in Bangladesh, where outbreaks occur with near-annual frequency. Onward human transmission of Nipah virus in Bangladesh is associated with close contact with clinically-unwell patients or their infectious secretions. While Nipah virus isolates associated with outbreaks of human infection have not resulted in sustained transmission to date, specific exposures carry a high risk of person-to-person transmission, an observation which is supported by recent findings in animal models. Novel paramyxoviruses continue to emerge from wildlife hosts, and represent an ongoing threat to human health globally.
[Mh] Termos MeSH primário: Transmissão de Doença Infecciosa
Infecções por Henipavirus/transmissão
Vírus Nipah/isolamento & purificação
Zoonoses/transmissão
[Mh] Termos MeSH secundário: Animais
Ásia/epidemiologia
Infecções por Henipavirus/epidemiologia
Seres Humanos
Zoonoses/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde