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  1 / 1982 MEDLINE  
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[PMID]:28452706
[Au] Autor:Rowan NR; Wang EW; Kanaan A; Sahu N; Williams JV; Phillips CD; Lee SE
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
[Ti] Título:Respiratory viral detection in the paranasal sinuses of patients with cystic fibrosis.
[So] Source:Am J Rhinol Allergy;31(2):105-108, 2017 Mar 01.
[Is] ISSN:1945-8932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pulmonary colonization with antibiotic-resistant organisms in patients with cystic fibrosis (CF) is often preceded by upper-airway infections. Although there is a well-described relationship between pulmonary respiratory viral infections and overall disease progression of CF, the pathogenicity of respiratory viral infections in the paranasal sinuses of patients with CF remains unknown. With recent advances in respiratory virus detection techniques, this study sought to detect the presence of respiratory viruses in the paranasal sinuses of patients with CF in comparison with healthy controls and to correlate the viral presence with clinical measures of sinonasal disease. METHODS: This prospective individual cohort study compared 24 patients with CF with 14 healthy controls. Basic demographics, clinical measures of disease and respiratory viral screens (commercial multiplex) obtained directly from the paranasal sinuses were compared between the two groups. RESULTS: Respiratory viruses were detected in 33% of patients with CF (8/24) compared with 0% of the healthy controls (0/14) (p = 0.017). Respiratory viruses were only detected during the winter months, and the most commonly identified were influenza A and human rhinovirus strains. There was no statistical difference in the 22-Item Sino-Nasal Outcome Test (SNOT-22) scores (p = 0.93) or modified Lund-Kennedy scores (p = 0.74) between patients with CF with a positive viral test and those without a positive result. CONCLUSIONS: Respiratory viral detection is more commonly detected in the paranasal sinuses of patients with CF compared with healthy controls. Although respiratory viral presence did not correlate with a worse clinical severity of sinonasal disease, these findings may provide insight into the pathophysiology of CF and open new avenues for potential targeted therapy.
[Mh] Termos MeSH primário: Fibrose Cística/epidemiologia
Fibrose Cística/virologia
Vírus da Influenza A/fisiologia
Influenza Humana/epidemiologia
Seios Paranasais/virologia
Infecções por Picornaviridae/epidemiologia
Rhinovirus/fisiologia
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Progressão da Doença
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Estações do Ano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.2500/ajra.2017.31.4422


  2 / 1982 MEDLINE  
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[PMID]:28459437
[Au] Autor:Toussaint M; Jackson DJ; Swieboda D; Guedán A; Tsourouktsoglou TD; Ching YM; Radermecker C; Makrinioti H; Aniscenko J; Bartlett NW; Edwards MR; Solari R; Farnir F; Papayannopoulos V; Bureau F; Marichal T; Johnston SL
[Ad] Endereço:Airway Disease Infection Section, National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
[Ti] Título:Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
[So] Source:Nat Med;23(6):681-691, 2017 06.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
[Mh] Termos MeSH primário: Asma/imunologia
Citocinas/imunologia
DNA/imunologia
Armadilhas Extracelulares/imunologia
Infecções por Picornaviridae/imunologia
Hipersensibilidade Respiratória/imunologia
Infecções Respiratórias/imunologia
Células Th2/imunologia
[Mh] Termos MeSH secundário: Adulto
Animais
Estudos de Casos e Controles
Dermatophagoides farinae/imunologia
Modelos Animais de Doenças
Feminino
Seres Humanos
Interferon gama/imunologia
Interleucina-13/imunologia
Interleucina-4/imunologia
Interleucina-5/imunologia
Masculino
Camundongos
Meia-Idade
Rhinovirus
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Interleukin-13); 0 (Interleukin-5); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4332


  3 / 1982 MEDLINE  
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[PMID]:29246347
[Au] Autor:Droz N; Enouf V; Bidet P; Mohamed D; Behillil S; Simon AL; Bachy M; Caseris M; Bonacorsi S; Basmaci R
[Ad] Endereço:Pediatric-Emergency Department, Louis-Mourier Hospital, AP-HP, Colombes, France.
[Ti] Título:Temporal Association Between Rhinovirus Activity and Kingella kingae Osteoarticular Infections.
[So] Source:J Pediatr;192:234-239.e2, 2018 Jan.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France. The Spearman rank correlation was used to assess a correlation between weekly distributions, with P < .05 denoting a significant correlation. RESULTS: During the 7-year study period, 322 children were diagnosed with K kingae osteoarticular infection, and 317 testing episodes were K kingae-negative. We observed high activity for both K kingae osteoarticular infection and human rhinovirus (HRV) during the fall (98 [30.4%] and 2401 [39.1%] cases, respectively) and low activity during summer (59 [18.3%] and 681 [11.1%] cases, respectively). Weekly distributions of K kingae osteoarticular infection and rhinovirus activity were significantly correlated (r = 0.30; P = .03). In contrast, no significant correlation was found between the weekly distribution of K kingae osteoarticular infection and other respiratory viruses (r = -0.17, P = .34 compared with respiratory syncytial virus; r = -0.13, P = .34 compared with influenza virus; and r = -0.22, P = .11 compared with metapneumovirus). CONCLUSION: A significant temporal association was observed between HRV circulation and K kingae osteoarticular infection, strengthening the hypothesis of a role of viral infections in the pathophysiology of K kingae invasive infection.
[Mh] Termos MeSH primário: Artrite Infecciosa/epidemiologia
Kingella kingae
Infecções por Neisseriaceae/epidemiologia
Infecções por Picornaviridae/epidemiologia
Rhinovirus
Estações do Ano
[Mh] Termos MeSH secundário: Artrite Infecciosa/diagnóstico
Artrite Infecciosa/virologia
Pré-Escolar
França/epidemiologia
Seres Humanos
Lactente
Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/diagnóstico
Infecções por Neisseriaceae/virologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


  4 / 1982 MEDLINE  
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[PMID]:28886185
[Au] Autor:Chiang GPK; Chen Z; Chan MCW; Lee SHM; Kwok AK; Yeung ACM; Nelson EAS; Hon KL; Leung TF; Chan PKS
[Ad] Endereço:Departments of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.
[Ti] Título:Clinical features and seasonality of parechovirus infection in an Asian subtropical city, Hong Kong.
[So] Source:PLoS One;12(9):e0184533, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The epidemiology of human parechovirus (HPeV) in Asia remains obscure. We elucidated the prevalence, seasonality, type distribution and clinical presentation of HPeV among children in Hong Kong. METHODS: A 24-month prospective study to detect HPeV in children ≤36 months hospitalized for acute viral illnesses. RESULTS: 2.3% of the 3911 children examined had HPeV infection, with most (87.5%) concentrated in September-January (autumn-winter). 81.3% were HPeV1 and 12.5% were HPeV4, while HPeV3 was rare (2.5%). HPeV was a probable cause of the disease in 47.7% (42/88), mostly self-limiting including acute gastroenteritis, upper respiratory tract infection and maculopapular rash. A neonate developed severe sepsis-like illness with HPeV3 as the only pathogen detected. A high proportion (60.0%) of children coinfected with HPeV and other respiratory virus(es) had acute bronchiolitis or pneumonia. Six children with HPeV coinfections developed convulsion / pallid attack. Most rash illnesses exhibited a generalized maculopapular pattern involving the trunk and limbs, and were more likely associated with HPeV4 compared to other syndrome groups (36.4% vs. 3.1%, p = 0.011). CONCLUSIONS: In Hong Kong, HPeV exhibits a clear seasonality (autumn-winter) and was found in a small proportion (2.3%) of young children (≤36 months) admitted with features of acute viral illnesses. The clinical presentation ranged from mild gastroenteritis, upper respiratory tract infection and febrile rash to convulsion and severe sepsis-like illness. HPeV3, which is reported to associate with more severe disease in neonates, is rare in Hong Kong. HPeV coinfection might associate with convulsion and aggravate other respiratory tract infections.
[Mh] Termos MeSH primário: Parechovirus
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/virologia
Estações do Ano
Clima Tropical
[Mh] Termos MeSH secundário: Pré-Escolar
Diarreia/epidemiologia
Diarreia/virologia
Fezes/virologia
Feminino
Gastroenterite/epidemiologia
Gastroenterite/virologia
Hong Kong/epidemiologia
Hospitalização
Seres Humanos
Lactente
Recém-Nascido
Masculino
Parechovirus/classificação
Parechovirus/genética
Filogenia
Estudos Prospectivos
RNA Viral
Infecções Respiratórias/epidemiologia
Infecções Respiratórias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184533


  5 / 1982 MEDLINE  
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[PMID]:28884666
[Au] Autor:Zell R; Delwart E; Gorbalenya AE; Hovi T; King AMQ; Knowles NJ; Lindberg AM; Pallansch MA; Palmenberg AC; Reuter G; Simmonds P; Skern T; Stanway G; Yamashita T; Ictv Report Consortium
[Ad] Endereço:1​Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
[Ti] Título:ICTV Virus Taxonomy Profile: Picornaviridae.
[So] Source:J Gen Virol;98(10):2421-2422, 2017 Oct.
[Is] ISSN:1465-2099
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The family Picornaviridae comprises small non-enveloped viruses with RNA genomes of 6.7 to 10.1 kb, and contains >30 genera and >75 species. Most of the known picornaviruses infect mammals and birds, but some have also been detected in reptiles, amphibians and fish. Many picornaviruses are important human and veterinary pathogens and may cause diseases of the central nervous system, heart, liver, skin, gastrointestinal tract or upper respiratory tract. Most picornaviruses are transmitted by the faecal-oral or respiratory routes. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Picornaviridae, which is available at www.ictv.global/report/picornaviridae.
[Mh] Termos MeSH primário: Infecções por Picornaviridae/transmissão
Infecções por Picornaviridae/veterinária
Picornaviridae/classificação
Picornaviridae/genética
[Mh] Termos MeSH secundário: Anfíbios/virologia
Animais
Aves/virologia
Peixes/virologia
Seres Humanos
Mamíferos/virologia
Infecções por Picornaviridae/virologia
Répteis/virologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1099/jgv.0.000911


  6 / 1982 MEDLINE  
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[PMID]:28859129
[Au] Autor:Upton N; Jackson DJ; Nikonova AA; Hingley-Wilson S; Khaitov M; Del Rosario A; Traub S; Trujillo-Torralbo MB; Habibi M; Elkin SL; Kon OM; Edwards MR; Mallia P; Footitt J; Macintyre J; Stanciu LA; Johnston SL; Sykes A
[Ad] Endereço:Airway Disease Infection Section, National Heart & Lung Institute, Imperial College London, London, United Kingdom.
[Ti] Título:Rhinovirus induction of fractalkine (CX3CL1) in airway and peripheral blood mononuclear cells in asthma.
[So] Source:PLoS One;12(8):e0183864, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhinovirus infection is associated with the majority of asthma exacerbations. The role of fractalkine in anti-viral (type 1) and pathogenic (type 2) responses to rhinovirus infection in allergic asthma is unknown. To determine whether (1) fractalkine is produced in airway cells and in peripheral blood leucocytes, (2) rhinovirus infection increases production of fractalkine and (3) levels of fractalkine differ in asthmatic compared to non-asthmatic subjects. Fractalkine protein and mRNA levels were measured in bronchoalveolar lavage (BAL) cells and peripheral blood mononuclear cells (PBMCs) from non-asthmatic controls (n = 15) and mild allergic asthmatic (n = 15) subjects. Protein levels of fractalkine were also measured in macrophages polarised ex vivo to give M1 (type 1) and M2 (type 2) macrophages and in BAL fluid obtained from mild (n = 11) and moderate (n = 14) allergic asthmatic and non-asthmatic control (n = 10) subjects pre and post in vivo rhinovirus infection. BAL cells produced significantly greater levels of fractalkine than PBMCs. Rhinovirus infection increased production of fractalkine by BAL cells from non-asthmatic controls (P<0.01) and in M1-polarised macrophages (P<0.05), but not in BAL cells from mild asthmatics or in M2 polarised macrophages. Rhinovirus induced fractalkine in PBMCs from asthmatic (P<0.001) and healthy control subjects (P<0.05). Trends towards induction of fractalkine in moderate asthmatic subjects during in vivo rhinovirus infection failed to reach statistical significance. Fractalkine may be involved in both immunopathological and anti-viral immune responses to rhinovirus infection. Further investigation into how fractalkine is regulated across different cell types and into the effect of stimulation including rhinovirus infection is warranted to better understand the precise role of this unique dual adhesion factor and chemokine in immune cell recruitment.
[Mh] Termos MeSH primário: Asma/imunologia
Quimiocina CX3CL1/imunologia
Interações Hospedeiro-Patógeno
Leucócitos Mononucleares/imunologia
Infecções por Picornaviridae/imunologia
Rhinovirus/imunologia
[Mh] Termos MeSH secundário: Adulto
Asma/complicações
Asma/genética
Asma/virologia
Líquido da Lavagem Broncoalveolar/química
Líquido da Lavagem Broncoalveolar/imunologia
Líquido da Lavagem Broncoalveolar/virologia
Estudos de Casos e Controles
Quimiocina CX3CL1/genética
Feminino
Expressão Gênica
Seres Humanos
Leucócitos Mononucleares/patologia
Leucócitos Mononucleares/virologia
Macrófagos Alveolares/imunologia
Macrófagos Alveolares/patologia
Macrófagos Alveolares/virologia
Masculino
Infecções por Picornaviridae/complicações
Infecções por Picornaviridae/genética
Infecções por Picornaviridae/virologia
RNA Mensageiro/genética
RNA Mensageiro/imunologia
Sistema Respiratório/imunologia
Sistema Respiratório/patologia
Sistema Respiratório/virologia
Rhinovirus/crescimento & desenvolvimento
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CX3CL1 protein, human); 0 (Chemokine CX3CL1); 0 (RNA, Messenger)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183864


  7 / 1982 MEDLINE  
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[PMID]:28855493
[Au] Autor:Yamakawa T; Mizuta K; Kurokawa K; Nagasawa H; Yamada T; Suzuki E; Wada M
[Ad] Endereço:Department of Neurology, Yamagata Prefectural Central Hospital.
[Ti] Título:Clinical characteristics of 17 adult patients with epidemic myalgia associated with human parechovirus type 3 infection.
[So] Source:Rinsho Shinkeigaku;57(9):485-491, 2017 09 30.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients. Tendon reflexes were preserved, and serum creatine kinase level increased in all but 1 patient. Spinal MRI was performed for 3 patients, with normal results. Musculoskeletal MRI scans showed abnormal signals in the femoral muscles in 2 of 5 patients. In a nerve conduction test, the frequency of F wave appearance in the median nerve was 40% or less in 5 of 9 patients, and repeater F waves were seen in 2 patients. Of these, 7 patients had infants in their families, and developed fever around the same time; they may have been infected by these infants. All patients recovered within 1-2 weeks. HPeV3 infection is characterized by severe myalgia, and is frequently observed in summer every 2-3 years.
[Mh] Termos MeSH primário: Parechovirus
Infecções por Picornaviridae/complicações
Infecções por Picornaviridae/virologia
Pleurodinia Epidêmica/etiologia
Pleurodinia Epidêmica/virologia
[Mh] Termos MeSH secundário: Adulto
Surtos de Doenças
Feminino
Febre
Seres Humanos
Lactente
Japão/epidemiologia
Angiografia por Ressonância Magnética
Masculino
Meia-Idade
Debilidade Muscular
Músculo Esquelético/diagnóstico por imagem
Condução Nervosa
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/fisiopatologia
Pleurodinia Epidêmica/epidemiologia
Pleurodinia Epidêmica/fisiopatologia
Reflexo de Estiramento
Estações do Ano
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001035


  8 / 1982 MEDLINE  
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[PMID]:28849871
[Au] Autor:Singh M; Singh M; Jaiswal N; Chauhan A
[Ad] Endereço:Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh, India, 160012.
[Ti] Título:Heated, humidified air for the common cold.
[So] Source:Cochrane Database Syst Rev;8:CD001728, 2017 08 29.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Heated, humidified air has long been used by people with the common cold. The theoretical basis is that steam may help congested mucus drain better and that heat may destroy the cold virus as it does in vitro. This is an update of a review last published in 2013. OBJECTIVES: To assess the effects of inhaling heated water vapour (steam) in the treatment of the common cold by comparing symptoms, viral shedding, and nasal resistance. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (to February 2017), MEDLINE (1966 to 24 February 2017), Embase (1990 to 24 February 2017), and Current Contents (1998 to 24 February 2017). We also searched World Health Organization International Clinical Trials Registry Platform (WHO ICTRP) (8 March 2017) and ClinicalTrials.gov (8 March 2017) as well as reference lists of included studies. SELECTION CRITERIA: Randomised controlled trials using heated water vapour in participants with the common cold or experimentally induced common cold were eligible for inclusion. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures expected by Cochrane. Three review authors independently screened titles and abstracts for inclusion of potential studies identified from the search. We recorded the selection process in sufficient detail to complete a PRISMA flow diagram. We used a data collection form for study characteristics and outcome data that was developed and used for previous versions of this review. Two review authors independently extracted data, and a third review author resolved any disagreements. We used Review Manager 5 software to analyse data. MAIN RESULTS: We included six trials from five publications involving a total of 387 participants. We included no new studies in this 2017 update. The 'Risk of bias' assessment suggested an unclear risk of bias in the domain of randomisation and a low risk of bias in performance, detection, attrition, and reporting.It was uncertain whether heated, humidified air provides symptomatic relief for the common cold, as the fixed-effect analysis showed evidence of an effect (odds ratio (OR) 0.30, 95% confidence interval (CI) 0.16 to 0.56; 2 studies, 149 participants), but the random-effects analysis showed no significant difference in the results (OR 0.22, 95% CI 0.03 to 1.95). There is an argument for using either form of analysis. No studies demonstrated an exacerbation of clinical symptom scores. One study conducted in the USA demonstrated worsened nasal resistance, but an earlier Israeli study showed improvement. One study examined viral shedding in nasal washings, finding no significant difference between treatment and placebo groups (OR 0.47, 95% CI 0.04 to 5.19). As judged by the subjective response to therapy (i.e. therapy did not help), the number of participants reporting resolution of symptoms was not significantly higher in the heated humidified group (OR 0.58, 95% CI 0.28 to 1.18; 2 studies, 124 participants). There was significant heterogeneity in the effects of heated, humidified air on different outcomes, therefore we graded the quality of the evidence as low. Some studies reported minor adverse events (including discomfort or irritation of the nose). AUTHORS' CONCLUSIONS: The current evidence does not show any benefits or harms from the use of heated, humidified air delivered via the RhinoTherm device for the treatment of the common cold. There is a need for more double-blind, randomised trials that include standardised treatment modalities.
[Mh] Termos MeSH primário: Ar
Resfriado Comum/terapia
Terapia Respiratória/métodos
Vapor
[Mh] Termos MeSH secundário: Resfriado Comum/virologia
Calefação
Seres Humanos
Umidade
Infecções por Picornaviridae/terapia
Ensaios Clínicos Controlados Aleatórios como Assunto
Rhinovirus/fisiologia
Vapor/efeitos adversos
Eliminação de Partículas Virais
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Steam)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD001728.pub6


  9 / 1982 MEDLINE  
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Alfieri, Alice Fernandes
Alfieri, Amauri Alcindo
Texto completo
[PMID]:28849283
[Au] Autor:Ribeiro J; Lorenzetti E; Júnior JCR; da Silva Medeiros TN; Alfieri AF; Alfieri AA
[Ad] Endereço:Laboratory of Animal Virology, Molecular Biology Unit, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, Campus Universitário, PO Box 10011, CEP 86057-970, Londrina, PR, Brazil.
[Ti] Título:Phylogenetic analysis of VP1 and RdRP genes of Brazilian aichivirus B strains involved in a diarrhea outbreak in dairy calves.
[So] Source:Arch Virol;162(12):3691-3696, 2017 Dec.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Aichivirus B has been reported worldwide in calves and adult cattle with and without diarrhea. The aim of this study was to describe the molecular characteristics of the RdRP and VP1 genes of aichivirus B strains identified as the most frequent etiologic agent in a neonatal diarrhea outbreak in a high-production Brazilian dairy cattle herd. Preliminary laboratory analysis ruled out important enteropathogens (Cryptosporidium spp; Eimeria spp., E. coli F5, and bovine coronavirus). Fecal samples from diarrheic (n = 24) and asymptomatic (n = 5) calves up to 30 days old were collected for virological analysis. RT-PCR assays were performed for the detection of aichivirus B RdRP and VP1 genes and for rotavirus A VP7 and VP4 genes in fecal samples. Asymptomatic calves (control group) were negative for both viruses. Aichivirus B and rotavirus A G10P[11] genotypes were found in 54.2% (13/24) and 25% (6/24) of the diarrheic fecal samples, respectively. Aichivirus B was only identified (83.3%, 10/12) in calves up to two weeks old. Phylogenetic analysis based on the RdRP gene grouped the Brazilian strains in a new branch within the aichivirus B group. Comparative analysis of the nucleotide sequence of the VP1 gene of Brazilian and Chinese aichivirus B strains allowed the strains identified in this study to be classified in the putative lineage 1. This is the first description of a high rate of aichivirus B detection in a diarrhea outbreak in dairy calves, and the first phylogenetic study of the VP1 gene of aichivirus B wild-type strains performed in South America.
[Mh] Termos MeSH primário: Doenças dos Bovinos/virologia
Diarreia/veterinária
Surtos de Doenças
Kobuvirus/classificação
Kobuvirus/isolamento & purificação
Filogenia
Infecções por Picornaviridae/veterinária
[Mh] Termos MeSH secundário: Animais
Brasil/epidemiologia
Bovinos
Doenças dos Bovinos/epidemiologia
Diarreia/epidemiologia
Diarreia/virologia
Kobuvirus/genética
Infecções por Picornaviridae/epidemiologia
Infecções por Picornaviridae/virologia
RNA Replicase/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Homologia de Sequência
Proteínas Estruturais Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Viral Structural Proteins); EC 2.7.7.48 (RNA Replicase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3531-x


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[PMID]:28827284
[Au] Autor:Song DJ; Miller M; Beppu A; Rosenthal P; Das S; Karta M; Vuong C; Mehta AK; Croft M; Broide DH
[Ad] Endereço:Department of Medicine, University of California, San Diego, La Jolla, CA 92093.
[Ti] Título:Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation.
[So] Source:J Immunol;199(7):2215-2224, 2017 Oct 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Orosomucoid like 3 (ORMDL3), a gene localized to chromosome 17q21, has been linked in epidemiologic studies to childhood asthma and rhinovirus (RV) infections. As the single nucleotide polymorphisms linking ORMDL3 to asthma are associated with increased expression of ORMDL3, we have used hORMDL3 mice (which have universal increased expression of human ORMDL3) to determine whether infection of these transgenic mice with RV influences levels of airway inflammation or RV viral load. RV infection of hORMDL3 mice resulted in reduced RV viral load assessed by quantitative real-time PCR (lung and airway epithelium), as well as reduced airway inflammation (total bronchoalveolar lavage cells, neutrophils, macrophages, and lymphocytes) compared with RV-infected wild-type mice. Levels of the antiviral pathways including IFNs (IFN-α, IFN-ß, IFN-λ) and RNAse L were significantly increased in the lungs of RV-infected hORMDL3 mice. Levels of the antiviral mouse oligoadenylate synthetase (mOas)1g pathway and RNAse L were upregulated in the lungs of unchallenged hORMDL3 mice. In addition, levels of mOas2, but not mOas1 (mOas1a, mOas1b, mOas1g), or mOas3 pathways were significantly more upregulated by IFNs (IFN-α, IFN-ß, IFN-λ) in epithelial cells from hORMDL3 mice compared with RV-infected wild-type mouse epithelial cells. RNAse L-deficient mice infected with RV had increased RV viral load. Overall, these studies suggest that increased levels of ORMDL3 contribute to antiviral defense to RV infection in mice through pathways that may include IFNs (IFN-α, IFN-ß, IFN-λ), OAS, and RNAse L.
[Mh] Termos MeSH primário: Pulmão/virologia
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Infecções por Picornaviridae/imunologia
Infecções por Picornaviridae/virologia
Rhinovirus/isolamento & purificação
[Mh] Termos MeSH secundário: 2',5'-Oligoadenilato Sintetase/genética
2',5'-Oligoadenilato Sintetase/metabolismo
Animais
Asma/imunologia
Asma/virologia
Endorribonucleases/deficiência
Endorribonucleases/genética
Endorribonucleases/metabolismo
Células Epiteliais/virologia
Inflamação/imunologia
Inflamação/virologia
Interferon beta/biossíntese
Interferon beta/genética
Interferon beta/imunologia
Interferons/biossíntese
Interferons/genética
Interferons/imunologia
Pulmão/imunologia
Camundongos
Camundongos Transgênicos
Infecções por Picornaviridae/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (ORMDL3 protein, human); 77238-31-4 (Interferon-beta); 9008-11-1 (Interferons); EC 2.7.7.- (Oasl1 protein, mouse); EC 2.7.7.84 (2',5'-Oligoadenylate Synthetase); EC 3.1.- (Endoribonucleases); EC 3.1.26.- (2-5A-dependent ribonuclease)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601412



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