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[PMID]:28829831
[Au] Autor:Hohn O; Norley S; Kücherer C; Bazarbachi A; El Hajj H; Marcus U; Zimmermann R; Bannert N
[Ad] Endereço:Department of Infectious Diseases, Division for HIV and Other Retroviruses, Robert Koch Institute, Berlin, Germany.
[Ti] Título:No significant HTLV seroprevalence in German people who inject drugs.
[So] Source:PLoS One;12(8):e0183496, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Although human T-lymphotropic virus (HTLV) is transmitted via the same routes as human immunodeficiency virus (HIV), its worldwide seroprevalence differs drastically because HTLV is transmitted mainly via infected cells rather than free virus. The sharing of needles and other equipment places people who inject drugs (PWID) at particularly high-risk for such blood-borne diseases. METHODS: To validate the methodology used to process and analyze the dried blood spots (DBS) utilized in the study, dried serum spots (DSS) with dilutions of sera from known HTLV infected individuals were analyzed by ELISA and Western blot. DBS collected between 2011 and 2015 from 2,077 PWID in eight German cities recruited by respondent-driven sampling were tested for HTLV-specific antibodies. RESULTS: The validation demonstrated that the use of DSS allowed identification of samples with even low titers of HTLV-specific antibodies, although a confirmatory Western blot with an additional venous blood sample would often be required. Despite numerous HIV and HCV positive individuals being identified within the study population, none tested positive for HTLV. CONCLUSION: While the HIV and HCV prevalences in German PWID are comparable to those in other European countries, the very low prevalence of HTLV reflects the situation in the general population.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/sangue
Abuso de Substâncias por Via Intravenosa/complicações
[Mh] Termos MeSH secundário: Anticorpos Antideltaretrovirus/sangue
Infecções por Deltaretrovirus/complicações
Ensaio de Imunoadsorção Enzimática
Alemanha/epidemiologia
Seres Humanos
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Deltaretrovirus Antibodies)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183496


  2 / 1121 MEDLINE  
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[PMID]:28298599
[Au] Autor:Mossoun A; Calvignac-Spencer S; Anoh AE; Pauly MS; Driscoll DA; Michel AO; Nazaire LG; Pfister S; Sabwe P; Thiesen U; Vogler BR; Wiersma L; Muyembe-Tamfum JJ; Karhemere S; Akoua-Koffi C; Couacy-Hymann E; Fruth B; Wittig RM; Leendertz FH; Schubert G
[Ad] Endereço:Université Felix Houphouët Boigny, Abidjan, Côte d'Ivoire.
[Ti] Título:Bushmeat Hunting and Zoonotic Transmission of Simian T-Lymphotropic Virus 1 in Tropical West and Central Africa.
[So] Source:J Virol;91(10), 2017 May 15.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Simian T-lymphotropic virus 1 (STLV-1) enters human populations through contact with nonhuman primate (NHP) bushmeat. We tested whether differences in the extent of contact with STLV-1-infected NHP bushmeat foster regional differences in prevalence of human T-lymphotropic virus 1 (HTLV-1). Using serological and PCR assays, we screened humans and NHPs at two Sub-Saharan African sites where subsistence hunting was expected to be less (Taï region, Côte d'Ivoire [CIV]) or more (Bandundu region, Democratic Republic of the Congo [DRC]) developed. Only 0.7% of human participants were infected with HTLV-1 in CIV ( = 574), and 1.3% of humans were infected in DRC ( = 302). Two of the Ivorian human virus sequences were closely related to simian counterparts, indicating ongoing zoonotic transmission. Multivariate analysis of human demographic parameters and behavior confirmed that participants from CIV were less often exposed to NHPs than participants from DRC through direct contact, e.g., butchering. At the same time, numbers of STLV-1-infected NHPs were higher in CIV (39%; = 111) than in DRC (23%; = 39). We conclude that similar ultimate risks of zoonotic STLV-1 transmission-defined as the product of prevalence in local NHP and human rates of contact to fresh NHP carcasses-contribute to the observed comparable rates of HTLV-1 infection in humans in CIV and DRC. We found that young adult men and mature women are most likely exposed to NHPs at both sites. In view of the continued difficulties in controlling zoonotic disease outbreaks, the identification of such groups at high risk of NHP exposure may guide future prevention efforts. Multiple studies report a high risk for zoonotic transmission of blood-borne pathogens like retroviruses through contact with NHPs, and this risk seems to be particularly high in tropical Africa. Here, we reveal high levels of exposure to NHP bushmeat in two regions of Western and Central tropical Africa. We provide evidence for continued zoonotic origin of HTLV-1 in humans at CIV, and we found that young men and mature women represent risk groups for zoonotic transmission of pathogens from NHPs. Identifying such risk groups can contribute to mitigation of not only zoonotic STLV-1 transmission but also transmission of any blood-borne pathogen onto humans in Sub-Saharan Africa.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/transmissão
Infecções por HTLV-I/epidemiologia
Carne/virologia
Primatas/virologia
Vírus 1 Linfotrópico T de Símios/isolamento & purificação
Zoonoses
[Mh] Termos MeSH secundário: Adulto
África Central
África do Norte/epidemiologia
Animais
Animais Selvagens/virologia
Costa do Marfim/epidemiologia
Infecções por Deltaretrovirus/epidemiologia
Infecções por Deltaretrovirus/prevenção & controle
Infecções por Deltaretrovirus/virologia
República Democrática do Congo/epidemiologia
Surtos de Doenças/prevenção & controle
Feminino
Infecções por HTLV-I/prevenção & controle
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Masculino
Filogenia
Prevalência
Adulto Jovem
Zoonoses/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171028
[Lr] Data última revisão:
171028
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


  3 / 1121 MEDLINE  
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[PMID]:28034804
[Au] Autor:Turpin J; Alais S; Marçais A; Bruneau J; Melamed A; Gadot N; Tanaka Y; Hermine O; Melot S; Lacoste R; Bangham CR; Mahieux R
[Ad] Endereço:International Center for Research in Infectiology, Retroviral Oncogenesis Laboratory, INSERM U1111 - Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007, Lyon, France; Equipe labellisée "Ligue Nationale Contre le Cancer", France; Section of Vir
[Ti] Título:Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity.
[So] Source:Cancer Lett;389:78-85, 2017 Mar 28.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:HTLV-1 causes Adult T cell Leukemia/Lymphoma (ATLL) in humans. We describe an ATL-like disease in a 9 year-old female baboon naturally infected with STLV-1 (the simian counterpart of HTLV-1), with a lymphocyte count over 10 /L, lymphocytes with abnormal nuclear morphology, and pulmonary and skin lesions. The animal was treated with a combination of AZT and alpha interferon. Proviral load (PVL) was measured every week. Because the disease continued to progress, the animal was euthanized. Abnormal infiltrates of CD3 CD25 lymphocytes and Tax-positive cells were found by histological analyses in both lymphoid and non-lymphoid organs. PVL was measured and clonal diversity was assessed by LM-PCR (Ligation-Mediated Polymerase Chain Reaction) and high throughput sequencing, in blood during treatment and in 14 different organs. The highest PVL was found in lymph nodes, spleen and lungs. One major clone and a number of intermediate abundance clones were present in blood throughout the course of treatment, and in organs. These results represent the first multi-organ clonality study in ATLL. We demonstrate a previously undescribed clonal complexity in ATLL. Our data reinforce the usefulness of natural STLV-1 infection as a model of ATLL.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/veterinária
Doenças dos Macacos/patologia
Vírus 1 Linfotrópico T de Símios
[Mh] Termos MeSH secundário: Animais
Infecções por Deltaretrovirus/tratamento farmacológico
Infecções por Deltaretrovirus/patologia
Infecções por Deltaretrovirus/virologia
Modelos Animais de Doenças
Feminino
Interferon-alfa/farmacologia
Leucemia-Linfoma de Células T do Adulto/patologia
Linfócitos/patologia
Doenças dos Macacos/tratamento farmacológico
Doenças dos Macacos/virologia
Papio
Carga Viral
Zidovudina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interferon-alpha); 4B9XT59T7S (Zidovudine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


  4 / 1121 MEDLINE  
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[PMID]:27519553
[Au] Autor:Enose-Akahata Y; Caruso B; Haner B; Charlip E; Nair G; Massoud R; Billioux BJ; Ohayon J; Switzer WM; Jacobson S
[Ad] Endereço:Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 5C-103, Bethesda, MD, 20892, USA.
[Ti] Título:Development of neurologic diseases in a patient with primate T lymphotropic virus type 1 (PTLV-1).
[So] Source:Retrovirology;13(1):56, 2016 Aug 12.
[Is] ISSN:1742-4690
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Virus transmission from various wild and domestic animals contributes to an increased risk of emerging infectious diseases in human populations. HTLV-1 is a human retrovirus associated with acute T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 originated from ancient zoonotic transmission from nonhuman primates, although cases of zoonotic infections continue to occur. Similar to HTLV-1, the simian counterpart, STLV-1, causes chronic infection and leukemia and lymphoma in naturally infected monkeys, and combined are called primate T-lymphotropic viruses (PTLV-1). However, other clinical syndromes typically seen in humans such as a chronic progressive myelopathy have not been observed in nonhuman primates. Little is known about the development of neurologic and inflammatory diseases in human populations infected with STLV-1-like viruses following nonhuman primate exposure. RESULTS: We performed detailed laboratory analyses on an HTLV-1 seropositive patient with typical HAM/TSP who was born in Liberia and now resides in the United States. Using a novel droplet digital PCR for the detection of the HTLV-1 tax gene, the proviral load in PBMC and cerebrospinal fluid cells was 12.98 and 51.68 %, respectively; however, we observed a distinct difference in fluorescence amplitude of the positive droplet population suggesting possible mutations in proviral DNA. A complete PTLV-1 proviral genome was amplified from the patient's PBMC DNA using an overlapping PCR strategy. Phylogenetic analysis of the envelope and LTR sequences showed the virus was highly related to PTLV-1 from sooty mangabey monkeys (smm) and humans exposed via nonhuman primates in West Africa. CONCLUSIONS: These results demonstrate the patient is infected with a simian variant of PTLV-1, suggesting for the first time that PTLV-1smm infection in humans may be associated with a chronic progressive neurologic disease.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/complicações
Infecções por Deltaretrovirus/virologia
Paraparesia Espástica Tropical/virologia
Vírus 1 Linfotrópico T de Primatas/isolamento & purificação
[Mh] Termos MeSH secundário: África Ocidental
Idoso
Animais
Infecções por Deltaretrovirus/transmissão
Genes pX
Haplorrinos/virologia
Seres Humanos
Leucócitos Mononucleares/virologia
Masculino
Filogenia
Reação em Cadeia da Polimerase
Vírus 1 Linfotrópico T de Primatas/genética
Vírus 1 Linfotrópico T de Primatas/patogenicidade
Provírus/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160814
[St] Status:MEDLINE
[do] DOI:10.1186/s12977-016-0290-9


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[PMID]:27310836
[Au] Autor:Switzer WM; Tang S; Zheng H; Shankar A; Sprinkle PS; Sullivan V; Granade TC; Heneine W
[Ad] Endereço:Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, United States of America.
[Ti] Título:Dual Simian Foamy Virus/Human Immunodeficiency Virus Type 1 Infections in Persons from Côte d'Ivoire.
[So] Source:PLoS One;11(6):e0157709, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zoonotic transmission of simian retroviruses in West-Central Africa occurring in primate hunters has resulted in pandemic spread of human immunodeficiency viruses (HIVs) and human T-lymphotropic viruses (HTLVs). While simian foamy virus (SFV) and simian T- lymphotropic virus (STLV)-like infection were reported in healthy persons exposed to nonhuman primates (NHPs) in West-Central Africa, less is known about the distribution of these viruses in Western Africa and in hospitalized populations. We serologically screened for SFV and STLV infection using 1,529 specimens collected between 1985 and 1997 from Côte d'Ivoire patients with high HIV prevalence. PCR amplification and analysis of SFV, STLV, and HIV/SIV sequences from PBMCs was used to investigate possible simian origin of infection. We confirmed SFV antibodies in three persons (0.2%), two of whom were HIV-1-infected. SFV polymerase (pol) and LTR sequences were detected in PBMC DNA available for one HIV-infected person. Phylogenetic comparisons with new SFV sequences from African guenons showed infection likely originated from a Chlorocebus sabaeus monkey endemic to Côte d'Ivoire. 4.6% of persons were HTLV seropositive and PCR testing of PBMCs from 15 HTLV seroreactive persons identified nine with HTLV-1 and one with HTLV-2 LTR sequences. Phylogenetic analysis showed that two persons had STLV-1-like infections, seven were HTLV-1, and one was an HTLV-2 infection. 310/858 (53%), 8/858 (0.93%), and 18/858 (2.1%) were HIV-1, HIV-2, and HIV-positive but undifferentiated by serology, respectively. No SIV sequences were found in persons with HIV-2 antibodies (n = 1) or with undifferentiated HIV results (n = 7). We document SFV, STLV-1-like, and dual SFV/HIV infection in Côte d'Ivoire expanding the geographic range for zoonotic simian retrovirus transmission to West Africa. These findings highlight the need to define the public health consequences of these infections. Studying dual HIV-1/SFV infections in immunocompromised populations may provide a new opportunity to better understand SFV pathogenicity and transmissibility in humans.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/diagnóstico
Infecções por HIV/diagnóstico
HIV-1/isolamento & purificação
Infecções por Retroviridae/diagnóstico
Vírus Espumoso dos Símios/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/sangue
Cercopithecus aethiops
Coinfecção
Costa do Marfim/epidemiologia
DNA Viral/genética
Infecções por Deltaretrovirus/epidemiologia
Infecções por Deltaretrovirus/virologia
Infecções por HIV/epidemiologia
Infecções por HIV/virologia
HIV-1/classificação
HIV-1/genética
HIV-2/classificação
HIV-2/genética
HIV-2/isolamento & purificação
Vírus 1 Linfotrópico T Humano/classificação
Vírus 1 Linfotrópico T Humano/genética
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Vírus 2 Linfotrópico T Humano/classificação
Vírus 2 Linfotrópico T Humano/genética
Vírus 2 Linfotrópico T Humano/isolamento & purificação
Seres Humanos
Leucócitos Mononucleares/virologia
Doenças dos Macacos/diagnóstico
Doenças dos Macacos/epidemiologia
Doenças dos Macacos/virologia
Filogenia
Infecções por Retroviridae/epidemiologia
Infecções por Retroviridae/virologia
Vírus Espumoso dos Símios/classificação
Vírus Espumoso dos Símios/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (DNA, Viral)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0157709


  6 / 1121 MEDLINE  
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[PMID]:27245152
[Au] Autor:Reid MJ; Switzer WM; Schillaci MA; Ragonnet-Cronin M; Joanisse I; Caminiti K; Lowenberger CA; Galdikas BM; Sandstrom PA; Brooks JI
[Ad] Endereço:Department of Anthropology, University of Toronto Scarborough, 1265 Military Trail, Scarborough, Ontario M1C 1A4, Canada; Department of Anthropology, University of Toronto, 19 Russell Street, Toronto, Ontario M5S 2S2, Canada. Electronic address: mj.reid@utoronto.ca.
[Ti] Título:Detailed phylogenetic analysis of primate T-lymphotropic virus type 1 (PTLV-1) sequences from orangutans (Pongo pygmaeus) reveals new insights into the evolutionary history of PTLV-1 in Asia.
[So] Source:Infect Genet Evol;43:434-50, 2016 09.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:While human T-lymphotropic virus type 1 (HTLV-1) originates from ancient cross-species transmission of simian T-lymphotropic virus type 1 (STLV-1) from infected nonhuman primates, much debate exists on whether the first HTLV-1 occurred in Africa, or in Asia during early human evolution and migration. This topic is complicated by a lack of representative Asian STLV-1 to infer PTLV-1 evolutionary histories. In this study we obtained new STLV-1 LTR and tax sequences from a wild-born Bornean orangutan (Pongo pygmaeus) and performed detailed phylogenetic analyses using both maximum likelihood and Bayesian inference of available Asian PTLV-1 and African STLV-1 sequences. Phylogenies, divergence dates and nucleotide substitution rates were co-inferred and compared using six different molecular clock calibrations in a Bayesian framework, including both archaeological and/or nucleotide substitution rate calibrations. We then combined our molecular results with paleobiogeographical and ecological data to infer the most likely evolutionary history of PTLV-1. Based on the preferred models our analyses robustly inferred an Asian source for PTLV-1 with cross-species transmission of STLV-1 likely from a macaque (Macaca sp.) to an orangutan about 37.9-48.9kya, and to humans between 20.3-25.5kya. An orangutan diversification of STLV-1 commenced approximately 6.4-7.3kya. Our analyses also inferred that HTLV-1 was first introduced into Australia ~3.1-3.7kya, corresponding to both genetic and archaeological changes occurring in Australia at that time. Finally, HTLV-1 appears in Melanesia at ~2.3-2.7kya corresponding to the migration of the Lapita peoples into the region. Our results also provide an important future reference for calibrating information essential for PTLV evolutionary timescale inference. Longer sequence data, or full genomes from a greater representation of Asian primates, including gibbons, leaf monkeys, and Sumatran orangutans are needed to fully elucidate these evolutionary dates and relationships using the model criteria suggested herein.
[Mh] Termos MeSH primário: Evolução Biológica
Infecções por Deltaretrovirus/transmissão
Vírus 1 Linfotrópico T Humano/genética
Filogenia
Vírus 1 Linfotrópico T de Primatas/genética
Vírus 1 Linfotrópico T de Símios/genética
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Teorema de Bayes
Infecções por Deltaretrovirus/epidemiologia
Infecções por Deltaretrovirus/história
Infecções por Deltaretrovirus/virologia
Produtos do Gene tax/genética
História Antiga
Vírus 1 Linfotrópico T Humano/classificação
Seres Humanos
Macaca/virologia
Taxa de Mutação
Paleontologia
Pongo pygmaeus/virologia
Vírus 1 Linfotrópico T de Primatas/classificação
Vírus 1 Linfotrópico T de Símios/classificação
Sequências Repetidas Terminais
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gene Products, tax)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE


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[PMID]:27137686
[Au] Autor:Schwob A; Mahieux R; Journo C
[Ad] Endereço:CIRI (Centre International de Recherche en Infectiologie), équipe Oncogenèse Rétrovirale labellisée Ligue contre le Cancer, université de Lyon, Lyon, France - Inserm U1111, Lyon, France - École Normale Supérieure de Lyon, 46, allée d'Italie, Lyon, France - Université Claude Bernard Lyon 1, Centre International de Recherche en Infectiologie, Lyon, France - CNRS UMR5308, Lyon, France.
[Ti] Título:[Unanchored ubiquitin chains: a new viral target for NF-κB activation].
[Ti] Título:Les chaînes libres d'ubiquitine - Une nouvelle cible virale pour l'induction de la voie NF-κB..
[So] Source:Med Sci (Paris);32(4):329-32, 2016 Apr.
[Is] ISSN:1958-5381
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/metabolismo
Vírus 1 Linfotrópico T Humano/fisiologia
NF-kappa B/metabolismo
Ubiquitina/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Leucemia/etiologia
Leucemia/metabolismo
Leucemia/virologia
Transdução de Sinais
Ubiquitina/química
Ubiquitinação
Viroses/metabolismo
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (NF-kappa B); 0 (Ubiquitin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160504
[St] Status:MEDLINE
[do] DOI:10.1051/medsci/20163204006


  8 / 1121 MEDLINE  
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[PMID]:26984729
[Au] Autor:Castro I; Giret TM; Magnani DM; Maxwell HS; Umland O; Perry JK; Pecotte JK; Brasky KM; Barber GN; Desrosiers RC; Watkins DI
[Ad] Endereço:Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA.
[Ti] Título:Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons.
[So] Source:J Virol;90(11):5280-91, 2016 Jun 01.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: There are currently 5 million to 10 million human T-lymphotropic virus type 1 (HTLV-1)-infected people, and many of them will develop severe complications resulting from this infection. A vaccine is urgently needed in areas where HTLV-1 is endemic. Many vaccines are best tested in nonhuman primate animal models. As a first step in designing an effective HTLV-1 vaccine, we defined the CD8(+) and CD4(+) T cell response against simian T-lymphotropic virus type 1 (STLV-1), a virus closely related to HTLV-1, in olive baboons (Papio anubis). Consistent with persistent antigenic exposure, we observed that STLV-1-specific CD8(+) T cells displayed an effector memory phenotype and usually expressed CD107a, gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α). To assess the viral targets of the cellular immune response in STLV-1-infected animals, we used intracellular cytokine staining to detect responses against overlapping peptides covering the entire STLV-1 proteome. Our results show that, similarly to humans, the baboon CD8(+) T cell response narrowly targeted the Tax protein. Our findings suggest that the STLV-1-infected baboon model may recapitulate some of the important aspects of the human response against HTLV-1 and could be an important tool for the development of immune-based therapy and prophylaxis. IMPORTANCE: HTLV-1 infection can lead to many different and often fatal conditions. A vaccine deployed in areas of high prevalence might reduce the incidence of HTLV-1-induced disease. Unfortunately, there are very few animal models of HTLV-1 infection useful for testing vaccine approaches. Here we describe cellular immune responses in baboons against a closely related virus, STLV-1. We show for the first time that the immune response against STLV-1 in naturally infected baboons is largely directed against the Tax protein. Similar findings in humans and the sequence similarity between the human and baboon viruses suggest that the STLV-1-infected baboon model might be useful for developing a vaccine against HTLV-1.
[Mh] Termos MeSH primário: Infecções por Deltaretrovirus/imunologia
Produtos do Gene tax/imunologia
Imunidade Celular
Vírus 1 Linfotrópico T de Símios/imunologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Infecções por Deltaretrovirus/virologia
Modelos Animais de Doenças
Descoberta de Drogas
Seres Humanos
Memória Imunológica
Interferon gama/genética
Papio
Proteoma
Fator de Necrose Tumoral alfa/genética
Carga Viral
Vacinas Virais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gene Products, tax); 0 (Proteome); 0 (Tumor Necrosis Factor-alpha); 0 (Viral Vaccines); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE
[do] DOI:10.1128/JVI.00281-16


  9 / 1121 MEDLINE  
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[PMID]:26932456
[Au] Autor:Yee JL; Vanderford TH; Didier ES; Gray S; Lewis A; Roberts J; Taylor K; Bohm RP
[Ad] Endereço:California National Primate Research Center, University of California, Davis, CA, USA.
[Ti] Título:Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management.
[So] Source:J Med Primatol;45(2):55-78, 2016 Apr.
[Is] ISSN:1600-0684
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.
[Mh] Termos MeSH primário: Macaca
Doenças dos Macacos/diagnóstico
Viroses/veterinária
[Mh] Termos MeSH secundário: Algoritmos
Animais
Betaretrovirus/isolamento & purificação
Infecções por Deltaretrovirus/diagnóstico
Infecções por Deltaretrovirus/veterinária
Infecções por Herpesviridae/diagnóstico
Infecções por Herpesviridae/veterinária
Herpesvirus Cercopitecino 1/isolamento & purificação
Modelos Animais
Doenças dos Macacos/virologia
Controle de Qualidade
Infecções por Retroviridae/diagnóstico
Infecções por Retroviridae/veterinária
Síndrome de Imunodeficiência Adquirida dos Símios/diagnóstico
Vírus da Imunodeficiência Símia/isolamento & purificação
Vírus 1 Linfotrópico T de Símios/isolamento & purificação
Organismos Livres de Patógenos Específicos
Viroses/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; REVIEW
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1111/jmp.12209


  10 / 1121 MEDLINE  
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[PMID]:26546777
[Au] Autor:de Sá KS; Santana BB; de Souza Ferreira TC; Sousa RC; Caldas CA; Azevedo VN; Feitosa RN; Machado LF; de Oliveira Guimarães Ishak M; Ishak R; Vallinoto AC
[Ad] Endereço:Laboratory of Virology (Laboratório de Virologia), Institute of Biological Sciences (Instituto de Ciências Biológicas), Federal University of Pará (Universidade Federal do Pará), Guamá, 66075-110 Belém, Pará, Brazil.
[Ti] Título:IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy.
[So] Source:Cytokine;77:79-87, 2016 Jan.
[Is] ISSN:1096-0023
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The present study is the first investigation of the association between single nucleotide polymorphisms (SNPs - rs8099917, rs12979860 and rs8103142) of the IL28B gene and the development of human T-lymphotropic virus (HTLV)-associated arthropathy (HAA). Individuals with HAA exhibited low interleukin (IL) 6 (p<0.05) and high IL-10 (p<0.05) levels compared with asymptomatic patients. TNF-α/CD4(+) T cell count, TNF-α/CD8(+) T cell count and IFN-γ/proviral load positively correlated in asymptomatic patients. The allelic and genotypic frequencies did not differ between patients with HAA and asymptomatic patients. Seven haplotypes were detected in the investigated population, with haplotype CCT (p<0.05) being the most frequent among the HTLV-infected individuals, while haplotype TTG (p<0.05) was detected in the group with HAA only. Compared with asymptomatic patients, individuals with HAA and genotype TT (rs8099917) exhibited larger numbers of CD8(+) T cells (p<0.05) and higher proviral load levels (p<0.05). Those patients with HAA and genotypes CC (rs12979860) and TT (rs8103142) exhibited high TNF-ß (p<0.05) and IFN-γ (p<0.05) levels. Those patients with HAA and genotype CT/TT (rs12979860) exhibited high IL-10 levels (p<0.05). These results suggest that haplotypes CCT and TTG might be associated with susceptibility to HTLV infection and progression to HAA, respectively. Genotype TT (rs8099917) might be a risk factor for elevation of the proviral load and CD8(+) T cell count. In addition, genotypes CC (rs12979860) and TT (rs8103142) seem to be associated with increased TNF-ß and IFN-γ levels.
[Mh] Termos MeSH primário: Artrite Infecciosa/virologia
Citocinas/metabolismo
Infecções por Deltaretrovirus/virologia
Deltaretrovirus/fisiologia
Interleucinas/genética
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Alelos
Artrite Infecciosa/genética
Artrite Infecciosa/metabolismo
Linfócitos T CD4-Positivos/metabolismo
Linfócitos T CD8-Positivos/metabolismo
Infecções por Deltaretrovirus/genética
Infecções por Deltaretrovirus/metabolismo
Feminino
Frequência do Gene
Genótipo
Haplótipos
Interações Hospedeiro-Patógeno
Seres Humanos
Interferon gama/metabolismo
Interleucina-10/metabolismo
Interleucina-6/metabolismo
Contagem de Linfócitos
Masculino
Células Th1/metabolismo
Células Th2/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (IL28B protein, human); 0 (Interleukin-6); 0 (Interleukins); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151130
[Lr] Data última revisão:
151130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151108
[St] Status:MEDLINE



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