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[PMID]:28381295
[Au] Autor:Mucksová J; Plachý J; Stanek O; Hejnar J; Kalina J; Benesová B; Trefil P
[Ad] Endereço:BIOPHARM, Research Institute of Biopharmacy and Veterinary Drugs, Jílové U Prahy, Czech Republic.
[Ti] Título:Cytokine response to the RSV antigen delivered by dendritic cell-directed vaccination in congenic chicken lines.
[So] Source:Vet Res;48(1):18, 2017 Apr 05.
[Is] ISSN:1297-9716
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Systems of antigen delivery into antigen-presenting cells represent an important novel strategy in chicken vaccine development. In this study, we verified the ability of Rous sarcoma virus (RSV) antigens fused with streptavidin to be targeted by specific biotinylated monoclonal antibody (anti-CD205) into dendritic cells and induce virus-specific protective immunity. The method was tested in four congenic lines of chickens that are either resistant or susceptible to the progressive growth of RSV-induced tumors. Our analyses confirmed that the biot-anti-CD205-SA-FITC complex was internalized by chicken splenocytes. In the cytokine expression profile, several significant differences were evident between RSV-challenged progressor and regressor chicken lines. A significant up-regulation of IL-2, IL-12, IL-15, and IL-18 expression was detected in immunized chickens of both regressor and progressor groups. Of these cytokines, IL-2 and IL-12 were most up-regulated 14 days post-challenge (dpc), while IL-15 and IL-18 were most up-regulated at 28 dpc. On the contrary, IL-10 expression was significantly down-regulated in all immunized groups of progressor chickens at 14 dpc. We detected significant up-regulation of IL-17 in the group of immunized progressors. LITAF down-regulation with iNOS up-regulation was especially observed in the progressor group of immunized chickens that developed large tumors. Based on the increased expression of cytokines specific for activated dendritic cells, we conclude that our system is able to induce partial stimulation of specific cell types involved in cell-mediated immunity.
[Mh] Termos MeSH primário: Antígenos Virais/imunologia
Galinhas/virologia
Citocinas/fisiologia
Células Dendríticas/imunologia
Vírus do Sarcoma de Rous/imunologia
Sarcoma Aviário/prevenção & controle
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Animais
Animais Congênicos/imunologia
Animais Congênicos/virologia
Anticorpos Biespecíficos/imunologia
Antígenos CD/imunologia
Galinhas/imunologia
Células Dendríticas/virologia
Imunidade Celular/imunologia
Lectinas Tipo C/imunologia
Antígenos de Histocompatibilidade Menor/imunologia
Receptores de Superfície Celular/imunologia
Sarcoma Aviário/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bispecific); 0 (Antigens, CD); 0 (Antigens, Viral); 0 (Cytokines); 0 (DEC-205 receptor); 0 (Lectins, C-Type); 0 (Minor Histocompatibility Antigens); 0 (Receptors, Cell Surface); 0 (Viral Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1186/s13567-017-0423-8


  2 / 810 MEDLINE  
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[PMID]:28184005
[Au] Autor:Pandey KK; Bera S; Shi K; Aihara H; Grandgenett DP
[Ad] Endereço:From the Department of Microbiology and Immunology, Institute for Molecular Virology, Saint Louis University, St. Louis, Missouri 63104 and.
[Ti] Título:A C-terminal "Tail" Region in the Rous Sarcoma Virus Integrase Provides High Plasticity of Functional Integrase Oligomerization during Intasome Assembly.
[So] Source:J Biol Chem;292(12):5018-5030, 2017 Mar 24.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The retrovirus integrase (IN) inserts the viral cDNA into the host DNA genome. Atomic structures of five different retrovirus INs complexed with their respective viral DNA or branched viral/target DNA substrates have indicated these intasomes are composed of IN subunits ranging from tetramers, to octamers, or to hexadecamers. IN precursors are monomers, dimers, or tetramers in solution. But how intasome assembly is controlled remains unclear. Therefore, we sought to unravel the functional mechanisms in different intasomes. We produced kinetically stabilized Rous sarcoma virus (RSV) intasomes with human immunodeficiency virus type 1 strand transfer inhibitors that interact simultaneously with IN and viral DNA within intasomes. We examined the ability of RSV IN dimers to assemble two viral DNA molecules into intasomes containing IN tetramers in contrast to one possessing IN octamers. We observed that the last 18 residues of the C terminus ("tail" region) of IN (residues 1-286) determined whether an IN tetramer or octamer assembled with viral DNA. A series of truncations of the tail region indicated that these 18 residues are critical for the assembly of an intasome containing IN octamers but not for an intasome containing IN tetramers. The C-terminally truncated IN (residues 1-269) produced an intasome that contained tetramers but failed to produce an intasome with octamers. Both intasomes have similar catalytic activities. The results suggest a high degree of plasticity for functional multimerization and reveal a critical role of the C-terminal tail region of IN in higher order oligomerization of intasomes, potentially informing future strategies to prevent retroviral integration.
[Mh] Termos MeSH primário: DNA Viral/metabolismo
Integrases/metabolismo
Vírus do Sarcoma de Rous/enzimologia
[Mh] Termos MeSH secundário: Animais
Aves
Cristalografia por Raios X
Seres Humanos
Integrases/química
Modelos Moleculares
Multimerização Proteica
Vírus do Sarcoma de Rous/química
Vírus do Sarcoma de Rous/fisiologia
Sarcoma Aviário/metabolismo
Sarcoma Aviário/virologia
Integração Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); EC 2.7.7.- (Integrases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.773382


  3 / 810 MEDLINE  
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[PMID]:26909909
[Au] Autor:Liu YP
[Ad] Endereço:Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya'an, Sichuan, China.
[Ti] Título:Reply to commentary by D. Elleder and J. Hejnar on the article "Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome" published in Genetics and Molecular Research 14 (4): 14379-14386 to the letter published in Genet. Mol. Res. 15 (1): gmr.15014956.
[So] Source:Genet Mol Res;15(1), 2016 Jan 22.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Sarcoma Aviário
Viverridae
[Mh] Termos MeSH secundário: Animais
Galinhas
Genes gag
Seres Humanos
Doenças das Aves Domésticas
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160225
[Lr] Data última revisão:
160225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.150149561


  4 / 810 MEDLINE  
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[PMID]:26909908
[Au] Autor:Elleder D; Hejnar J
[Ad] Endereço:Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
[Ti] Título:Avian sarcoma and leukosis virus gag gene--Genet. Mol. Res. 14 (4): 14379-14386 "Avian sarcoma and leukosis virus gag gene in the Anser anser domesticus genome".
[So] Source:Genet Mol Res;15(1), 2016 Jan 22.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Sarcoma Aviário
Viverridae
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Galinhas
Genes gag
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160225
[Lr] Data última revisão:
160225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160225
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15014956


  5 / 810 MEDLINE  
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[PMID]:26667572
[Au] Autor:Svoboda J
[Ad] Endereço:Institute of Molecular Genetics of the ASCR, v. v. i., Prague, Czech Republic.
[Ti] Título:Cell Association in Rous Sarcoma Virus (RSV) Rescue and Cell Infection.
[So] Source:Folia Biol (Praha);61(5):161-7, 2015.
[Is] ISSN:0015-5500
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:In my article I tried to present the results of early experiments suggesting a significant role for cell association in Rous sarcoma virus transformation of non-permissive cells and revealing that infectious virus can be efficiently rescued from such cells by their fusion with permissive chicken fibroblasts.
[Mh] Termos MeSH primário: Galinhas/virologia
Vírus do Sarcoma de Rous/patogenicidade
Sarcoma Aviário/virologia
[Mh] Termos MeSH secundário: Animais
Transformação Celular Viral
Provírus/patogenicidade
Provírus/fisiologia
Ratos
Vírus do Sarcoma de Rous/fisiologia
Replicação Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151216
[St] Status:MEDLINE


  6 / 810 MEDLINE  
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[PMID]:24403579
[Au] Autor:Lounková A; Dráberová E; Senigl F; Trejbalová K; Geryk J; Hejnar J; Svoboda J
[Ad] Endereço:Department of Viral and Cellular Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
[Ti] Título:Molecular events accompanying rous sarcoma virus rescue from rodent cells and the role of viral gene complementation.
[So] Source:J Virol;88(6):3505-15, 2014 Mar.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Transformation of rodent cells with avian Rous sarcoma virus (RSV) opened new ways to studying virus integration and expression in nonpermissive cells. We were interested in (i) the molecular changes accompanying fusion of RSV-transformed mammalian cells with avian cells leading to virus rescue and (ii) enhancement of this process by retroviral gene products. The RSV-transformed hamster RSCh cell line was characterized as producing only a marginal amount of env mRNA, no envelope glycoprotein, and a small amount of unprocessed Gag protein. Egress of viral unspliced genomic RNA from the nucleus was hampered, and its stability decreased. Cell fusion of the chicken DF-1 cell line with RSCh cells led to production of env mRNA, envelope glycoprotein, and processed Gag and virus-like particle formation. Proteosynthesis inhibition in DF-1 cells suppressed steps leading to virus rescue. Furthermore, new aberrantly spliced env mRNA species were found in the RSCh cells. Finally, we demonstrated that virus rescue efficiency can be significantly increased by complementation with the env gene and the highly expressed gag gene and can be increased the most by a helper virus infection. In summary, Env and Gag synthesis is increased after RSV-transformed hamster cell fusion with chicken fibroblasts, and both proteins provided in trans enhance RSV rescue. We conclude that the chicken fibroblast yields some factor(s) needed for RSV replication, particularly Env and Gag synthesis, in nonpermissive rodent cells. IMPORTANCE: One of the important issues in retrovirus heterotransmission is related to cellular factors that prevent virus replication. Rous sarcoma virus (RSV), a member of the avian sarcoma and leukosis family of retroviruses, is able to infect and transform mammalian cells; however, such transformed cells do not produce infectious virus particles. Using the well-defined model of RSV-transformed rodent cells, we established that the lack of virus replication is due to the absence of chicken factor(s), which can be supplemented by cell fusion. Cell fusion with permissive chicken cells led to an increase in RNA splicing and nuclear export of specific viral mRNAs, as well as synthesis of respective viral proteins and production of virus-like particles. RSV rescue by cell fusion can be potentiated by in trans expression of viral genes in chicken cells. We conclude that rodent cells lack some chicken factor(s) required for proper viral RNA processing and viral protein synthesis.
[Mh] Termos MeSH primário: Doenças das Aves Domésticas/virologia
Vírus do Sarcoma de Rous/genética
Sarcoma Aviário/virologia
[Mh] Termos MeSH secundário: Animais
Fusão Celular
Linhagem Celular Transformada
Transformação Celular Viral
Galinhas
Cricetinae
Produtos do Gene env/genética
Produtos do Gene env/metabolismo
Produtos do Gene gag/genética
Produtos do Gene gag/metabolismo
Teste de Complementação Genética
Vírus do Sarcoma de Rous/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gene Products, env); 0 (Gene Products, gag)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:150515
[Lr] Data última revisão:
150515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140110
[St] Status:MEDLINE
[do] DOI:10.1128/JVI.02761-13


  7 / 810 MEDLINE  
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[PMID]:24109216
[Au] Autor:Dick RA; Kamynina E; Vogt VM
[Ad] Endereço:Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
[Ti] Título:Effect of multimerization on membrane association of Rous sarcoma virus and HIV-1 matrix domain proteins.
[So] Source:J Virol;87(24):13598-608, 2013 Dec.
[Is] ISSN:1098-5514
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In most retroviruses, plasma membrane (PM) association of the Gag structural protein is a critical step in viral assembly, relying in part on interaction between the highly basic Gag MA domain and the negatively charged inner leaflet of the PM. Assembly is thought to begin with Gag dimerization followed by multimerization, resulting in a hexameric lattice. To directly address the role of multimerization in membrane binding, we fused the MA domains of Rous sarcoma virus (RSV) and HIV-1 to the chemically inducible dimerization domain FK506-binding protein (FKBP) or to the hexameric protein CcmK4 from cyanobacteria. The cellular localization of the resulting green fluorescent protein (GFP)-tagged chimeric proteins was examined by fluorescence imaging, and the association of the proteins with liposomes was quantified by flotation in sucrose gradients, following synthesis in a reticulocyte extract or as purified proteins. Four lipid compositions were tested, representative of liposomes commonly reported in flotation experiments. By themselves, GFP-tagged RSV and HIV-1 MA proteins were largely cytoplasmic, but both hexamerized proteins were highly concentrated at the PM. Dimerization led to partial PM localization for HIV-1 MA. These in vivo effects of multimerization were reproduced in vitro. In flotation analyses, the intact RSV and HIV-1 Gag proteins were more similar to multimerized MA than to monomeric MA. RNA is reported to compete with acidic liposomes for HIV-1 Gag binding, and thus we also examined the effects of RNase treatment or tRNA addition on flotation. tRNA competed with liposomes in the case of some but not all lipid compositions and ionic strengths. Taken together, our results further underpin the model that multimerization is critical for PM association of retroviral Gag proteins. In addition, they suggest that the modulation of membrane binding by RNA, as previously reported for HIV-1, may not hold for RSV.
[Mh] Termos MeSH primário: Membrana Celular/virologia
Produtos do Gene gag/química
Produtos do Gene gag/metabolismo
Infecções por HIV/virologia
HIV-1/metabolismo
Vírus do Sarcoma de Rous/metabolismo
Sarcoma Aviário/virologia
Produtos do Gene gag do Vírus da Imunodeficiência Humana/química
Produtos do Gene gag do Vírus da Imunodeficiência Humana/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Citoplasma/virologia
Produtos do Gene gag/genética
HIV-1/química
HIV-1/genética
Seres Humanos
Multimerização Proteica
Estrutura Terciária de Proteína
Codorniz
Vírus do Sarcoma de Rous/química
Vírus do Sarcoma de Rous/genética
Produtos do Gene gag do Vírus da Imunodeficiência Humana/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Gene Products, gag); 0 (gag Gene Products, Human Immunodeficiency Virus)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131011
[St] Status:MEDLINE
[do] DOI:10.1128/JVI.01659-13


  8 / 810 MEDLINE  
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[PMID]:23890476
[Au] Autor:Svoboda J
[Ti] Título:Rous sarcoma virus centennial in Folia Biologica.
[So] Source:Folia Biol (Praha);59(3):103-4, 2013.
[Is] ISSN:0015-5500
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Mh] Termos MeSH primário: Galinhas/virologia
Genes src
Doenças das Aves Domésticas/história
Vírus do Sarcoma de Rous/isolamento & purificação
Sarcoma Aviário/história
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Transformação Celular Viral
Tchecoslováquia
Xenoenxertos
História do Século XX
História do Século XXI
Maryland
Transplante de Neoplasias
Publicações Periódicas como Assunto/história
Doenças das Aves Domésticas/virologia
Provírus/genética
Provírus/fisiologia
Ratos
Vírus do Sarcoma de Rous/genética
Vírus do Sarcoma de Rous/fisiologia
Sarcoma Aviário/virologia
Integração Viral
[Pt] Tipo de publicação:AUTOBIOGRAPHY; BIOGRAPHY; EDITORIAL; HISTORICAL ARTICLE
[Ps] Nome de pessoa como assunto:Svoboda J; Rous FP
[Em] Mês de entrada:1408
[Cu] Atualização por classe:130729
[Lr] Data última revisão:
130729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130730
[St] Status:MEDLINE


  9 / 810 MEDLINE  
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[PMID]:23751005
[Au] Autor:Kumar P; Murphy FA
[Ad] Endereço:Mill Creek High School, Hoschton, Georgia 30548, USA. pras.sb@gmail.com
[Ti] Título:Who is this man? Francis Peyton Rous.
[So] Source:Emerg Infect Dis;19(4):661-3, 2013 Apr.
[Is] ISSN:1080-6059
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Galinhas/virologia
Vírus do Sarcoma de Rous/fisiologia
Sarcoma Aviário/história
[Mh] Termos MeSH secundário: Animais
História do Século XIX
História do Século XX
Vírus do Sarcoma de Rous/isolamento & purificação
Sarcoma Aviário/virologia
Estados Unidos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Rous FP
[Em] Mês de entrada:1310
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130612
[St] Status:MEDLINE
[do] DOI:10.3201/eid1904.130049


  10 / 810 MEDLINE  
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[PMID]:23678577
[Au] Autor:Wang Y; Chen H; Zhao P; Li J; Cui Z
[Ad] Endereço:Animal Science and Technology College, Shandong Agricultural University, Tai'an 271018, China. 07sdauwyx@163.com
[Ti] Título:[Detection of fps tumor antigen with mono-specific anti-fps serum in tumors induced by acute transforming ALV].
[So] Source:Wei Sheng Wu Xue Bao;53(3):299-305, 2013 Mar 04.
[Is] ISSN:0001-6209
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To prepare anti-fps mono-specific serum, and detect the fps antigen in tumors induced by acute transforming avian leukosis/sarcoma virus containing v-fps oncogene. METHODS: Two part of v-fps gene was amplified by RT-PCR using the Fu-J viral RNA as the template. Mono-specific serum was prepared by immuning Kunming white mouse with both two recombinant infusion proteins expressed by the prokaryotic expression system. Indirect immunofluorescent assay was used to detect fps antigen in tumor tissue suspension cells and CEF infected by sarcoma supernatant. Immunohistochemical method was used to detect fps antigen in tumor tissue. RESULTS: The mouse mono-specific serum was specific as it had no cross reaction with classical ALV-J strains. The result reveals that the tumor tissue suspension cells, the CEF infected by sarcoma supernatant, and the slice immunohistochemistry of the sarcoma showed positive results. CONCLUSION: The anti-fps mono-specific serum was prepared, and the detection method was established, which laid the foundation for the study of viral biological characteristics and mechanism of tumourgenesis of acute transforming avian leukosis/sarcoma virus containing v-fps oncogene.
[Mh] Termos MeSH primário: Vírus da Leucose Aviária/imunologia
Vírus do Sarcoma Aviário/imunologia
Galinhas
Fibrossarcoma/imunologia
Doenças das Aves Domésticas/imunologia
Proteínas Proto-Oncogênicas c-fes/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antivirais/imunologia
Especificidade de Anticorpos
Antígenos de Neoplasias/genética
Antígenos de Neoplasias/imunologia
Leucose Aviária/imunologia
Leucose Aviária/virologia
Transformação Celular Neoplásica
Fibrossarcoma/virologia
Camundongos
Doenças das Aves Domésticas/virologia
Proteínas Proto-Oncogênicas c-fes/genética
RNA Viral/genética
Sarcoma Aviário/imunologia
Sarcoma Aviário/virologia
Organismos Livres de Patógenos Específicos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Viral); 0 (Antigens, Neoplasm); 0 (RNA, Viral); EC 2.7.10.2 (Proto-Oncogene Proteins c-fes)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130518
[St] Status:MEDLINE



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