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[PMID]:29262347
[Au] Autor:Harris NL; Loke P
[Ad] Endereço:Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address: nicola.harris@epfl.ch.
[Ti] Título:Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection.
[So] Source:Immunity;47(6):1024-1036, 2017 Dec 19.
[Is] ISSN:1097-4180
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Type-2-cell-mediated immune responses play a critical role in mediating both host-resistance and disease-tolerance mechanisms during helminth infections. Recently, type 2 cell responses have emerged as major regulators of tissue repair and metabolic homeostasis even under steady-state conditions. In this review, we consider how studies of helminth infection have contributed toward our expanding cellular and molecular understanding of type-2-cell-mediated immunity, as well as new areas such as the microbiome. By studying how these successful parasites form chronic infections without overt pathology, we are gaining additional insights into allergic and inflammatory diseases, as well as normal physiology.
[Mh] Termos MeSH primário: Helmintíase/imunologia
Imunidade Celular
Macrófagos/imunologia
Nematoides/imunologia
Células Th2/imunologia
Trematódeos/imunologia
[Mh] Termos MeSH secundário: Animais
Citocinas/genética
Citocinas/imunologia
Células Epiteliais/imunologia
Células Epiteliais/parasitologia
Regulação da Expressão Gênica/imunologia
Helmintíase/genética
Helmintíase/parasitologia
Homeostase/imunologia
Interações Hospedeiro-Parasita/imunologia
Seres Humanos
Macrófagos/parasitologia
Mastócitos/imunologia
Mastócitos/parasitologia
Microbiota/imunologia
Células Th2/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


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[PMID]:28449319
[Au] Autor:Janmohamed A; Doledec D
[Ad] Endereço:Independent Consultant, Mississauga, Canada.
[Ti] Título:Comparison of administrative and survey data for estimating vitamin A supplementation and deworming coverage of children under five years of age in Sub-Saharan Africa.
[So] Source:Trop Med Int Health;22(7):822-829, 2017 07.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare administrative coverage data with results from household coverage surveys for vitamin A supplementation (VAS) and deworming campaigns conducted during 2010-2015 in 12 African countries. METHODS: Paired t-tests examined differences between administrative and survey coverage for 52 VAS and 34 deworming dyads. Independent t-tests measured VAS and deworming coverage differences between data sources for door-to-door and fixed-site delivery strategies and VAS coverage differences between 6- to 11-month and 12- to 59-month age group. RESULTS: For VAS, administrative coverage was higher than survey estimates in 47 of 52 (90%) campaign rounds, with a mean difference of 16.1% (95% CI: 9.5-22.7; P < 0.001). For deworming, administrative coverage exceeded survey estimates in 31 of 34 (91%) comparisons, with a mean difference of 29.8% (95% CI: 16.9-42.6; P < 0.001). Mean ± SD differences in coverage between administrative and survey data were 12.2% ± 22.5% for the door-to-door delivery strategy and 25.9% ± 24.7% for the fixed-site model (P = 0.06). For deworming, mean ± SD differences in coverage between data sources were 28.1% ± 43.5% and 33.1% ± 17.9% for door-to-door and fixed-site distribution, respectively (P = 0.64). VAS administrative coverage was higher than survey estimates in 37 of 49 (76%) comparisons for the 6- to 11-month age group and 45 of 48 (94%) comparisons for the 12- to 59-month age group. CONCLUSION: Reliance on health facility data alone for calculating VAS and deworming coverage may mask low coverage and prevent measures to improve programmes. Countries should periodically validate administrative coverage estimates with population-based methods.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Suplementos Nutricionais/estatística & dados numéricos
Pesquisas sobre Serviços de Saúde/estatística & dados numéricos
Helmintíase/tratamento farmacológico
Deficiência de Vitamina A/terapia
Vitamina A/uso terapêutico
[Mh] Termos MeSH secundário: África ao Sul do Saara
Pré-Escolar
Feminino
Pesquisas sobre Serviços de Saúde/métodos
Seres Humanos
Lactente
Masculino
Vitaminas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Vitamins); 11103-57-4 (Vitamin A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12883


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[PMID]:29215223
[Au] Autor:Motora ZI
[Ti] Título:[FIRST RECORD OF RHADINORHYNCHUS COLOLABIS (ACANTHOCEPHALA: RHADINORHYNCHIDAE) FROM THE CHERRY SALMON IN THE SEA OF JAPAN].
[So] Source:Parazitologiia;50(6):426-31, 2016 Nov-Dec.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Drawing, description and characteristics of Rhadinorhynchus cololabis, registered for the first time from Oncorhynchus masou in the Sea of Japan (northern part of Primorye Territory) are given. Ten species of acanthocephalans from the cherry salmon in the Primorsky Territory were recorded.
[Mh] Termos MeSH primário: Acantocéfalos/classificação
Acantocéfalos/fisiologia
Doenças dos Peixes/parasitologia
Helmintíase/parasitologia
Oncorhynchus/parasitologia
[Mh] Termos MeSH secundário: Animais
Oceanos e Mares
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE


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[PMID]:29211424
[Au] Autor:Bakay YI
[Ti] Título:[ECOLOGICAL AND PARASITOLOGICAL CHARACTERISTICS OF THE SMALL REDFISH SEBASTES VIVIPARUS (PISCES: SCORPAENIDAE)].
[So] Source:Parazitologiia;50(5):345-56, 2016 Sep-Oct.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The results of the parasite fauna research represent peculiarities of formation and ecological, faunistic and zoogeographical characteristics of parasite fauna of the small redfish Sebastes viviparus Krayer. 1845. This species is distinguished among the other North Atlantic Sebastes by the richest fauna of myxosporidians, trematodes, nematodes and acanthocephalans. The parasite fauna of S. viviparus is formed mainly of boreal species and to a lesser extent of Arctic-boreal species. According to the vertical zonality of parasites in fishes of the North Atlantic they are mainly represented by mesobenthic and epicontinental species. The parasite fauna in small redfish possesses significantly more pronounced geographic specificity than that of other North Atlantic Sebastes species.
[Mh] Termos MeSH primário: Acantocéfalos/fisiologia
Doenças dos Peixes/parasitologia
Helmintíase/parasitologia
Nematoides/fisiologia
Perciformes/parasitologia
Trematódeos/fisiologia
[Mh] Termos MeSH secundário: Acantocéfalos/classificação
Animais
Oceano Atlântico
Nematoides/classificação
Trematódeos/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:29211417
[Au] Autor:Atrashkevich GI; Mikhailova EI; Orlovskaya OM; Pospekhov VV
[Ti] Título:[BIODIVERSITY OF ACANTHOCEPHALANS (ACANTHOCEPHALA) IN FRESHWATER FISHES OF ASIATIC SUB-ARCTIC REGION].
[So] Source:Parazitologiia;50(4):263-90, 2016 Jul-Aug.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The analysis of taxonomical and ecological diversity of acanthocephalans in fishes of Asiatic sub-Arctic region freshwaters, summarizing changes in modern views on species composition, life cycles, and ecology of background groups of these parasites is given. A priority role of studies provided by O. N. Bauer and his scientific school in organization and development of these aspects of acanthocephalology is demonstrated. Special attention is paid to the assessment of acanthocephalan biodiversity of the genus Neoechinorhynchus, the background group of freshwater fish parasites of the Asiatic sub-Arctic region, and an original key for their species is given. The distribution of acanthocephalans of the genus Acanthocephalus in northeastern Asia is analyzed and prospective study of this parasite group, evolutionary associated with freshwater isopods of the genus Asellus as intermediate hosts, is outlined. The absence of documented evidences on intermediate hosts of other background parasites of freshwater fishes in the region, acanthocephalans of the genus Metechinorhynchus, is revealed. It is assumed that subsequent taxonomic revisions based both on morphological and molecular genetic studies are necessary for the reliable revealing of species composition in each genus of the background acanthocephalans from freshwater fishes of Northern Asia. Theoretical significance of the study of acanthocephalan life cycles and revealing their natural intermediate hosts for the reliable estimation of structural and functional organization of their host-parasite systems in different parts of the range is substantiated and the possibility of the distribution of taxonomic conclusions in new territories is analyzed. A brief annotated taxonomical list of freshwater acanthocephalans of the Asiatic sub-Arctic region is given.
[Mh] Termos MeSH primário: Acantocéfalos
Biodiversidade
Doenças dos Peixes/parasitologia
Peixes/parasitologia
Helmintíase
[Mh] Termos MeSH secundário: Acantocéfalos/classificação
Acantocéfalos/fisiologia
Animais
Regiões Árticas
Sibéria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  6 / 5125 MEDLINE  
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[PMID]:29218962
[Ti] Título:Schistosomiasis and soil-transmitted helminthiases: number of people treated in 2016.
[Ti] Título:Schistosomiase et géohelminthiases: nombre de personnes traitées en 2016..
[So] Source:Wkly Epidemiol Rec;92(49):749-60, 2017 Dec 08.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Helmintíase/tratamento farmacológico
Helmintíase/epidemiologia
Mebendazol/uso terapêutico
Esquistossomose/tratamento farmacológico
Esquistossomose/epidemiologia
Solo/parasitologia
[Mh] Termos MeSH secundário: Adulto
África/epidemiologia
Albendazol/uso terapêutico
Américas/epidemiologia
Ásia/epidemiologia
Criança
Pré-Escolar
Feminino
Helmintíase/transmissão
Seres Humanos
Lactente
Masculino
Região do Mediterrâneo/epidemiologia
Praziquantel/uso terapêutico
Esquistossomose/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil); 6490C9U457 (Praziquantel); 81G6I5V05I (Mebendazole); F4216019LN (Albendazole)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171208
[Lr] Data última revisão:
171208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  7 / 5125 MEDLINE  
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[PMID]:28984120
[Ti] Título:Summary of global update on preventive chemotherapy implementation in 2016: crossing the billion.
[Ti] Título:Récapitulatif des données mondiales actualisées sur la mise en oeuvre de la chimioprévention en 2016: le seuil du milliard est franchi..
[So] Source:Wkly Epidemiol Rec;92(40):589-93, 2017 10 06.
[Is] ISSN:0049-8114
[Cp] País de publicação:Switzerland
[La] Idioma:eng; fre
[Mh] Termos MeSH primário: Anti-Helmínticos/provisão & distribuição
Saúde Global/estatística & dados numéricos
Helmintíase/prevenção & controle
Doenças Negligenciadas/prevenção & controle
Tracoma/prevenção & controle
[Mh] Termos MeSH secundário: Anti-Helmínticos/uso terapêutico
Filariose Linfática/prevenção & controle
Seres Humanos
Oncocercose/prevenção & controle
Esquistossomose/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28947636
[Au] Autor:Moser W; Schindler C; Keiser J
[Ad] Endereço:Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, PO Box, CH-4002 Basel, Switzerland.
[Ti] Título:Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis.
[So] Source:BMJ;358:j4307, 2017 Sep 25.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To evaluate efficacies of anthelmintic drugs against soil transmitted helminths in terms of cure rates and egg reduction rates. Systematic review and network meta-analysis. PubMed, ISI Web of Science, Embase, ScienceDirect, the Cochrane Central Register of Clinical Trials, and the World Health Organization library database from 1960 until 31 December 2016. Randomised controlled trials evaluating the efficacy of a single dose regimen of albendazole, mebendazole, levamisole, and pyrantel pamoate against , hookworm ( and ) and The primary outcomes included cure rates analysed by network meta-analysis with mixed logistic regression models and egg reduction rates with mixed linear models. 55 and 46 randomised controlled trials were included in the analysis of cure rates and egg reduction rates, respectively. All drugs were highly efficacious against Albendazole showed the highest efficacy against hookworm infections with a cure rate of 79.5% (95% confidence interval 71.5% to 85.6%) and an egg reduction rate of 89.6% (81.9% to 97.3%). All drugs had low efficacy against , with mebendazole showing the highest cure rate of 42.1% (25.9% to 60.2%) and egg reduction rate of 66.0% (54.6% to 77.3%). Estimates for the years 1995 and 2015 showed significant reductions in efficacy of albendazole against : by 2015 the egg reduction rates fell from 72.6% (53.7% to 91.5%) to 43.4% (23.5% to 63.3%; P=0.049) and the cure rates fell from 38.6% (26.2% to 52.7%) to 16.4 (7.7% to 31.3%; P=0.027). All four currently recommended drugs show limitations in their efficacy profile. While only albendazole showed good efficacy against hookworm infection, all drugs had low efficacy against The decrease in efficacy of albendazole against over the past two decades is of concern. The findings indicate the need for strengthening efforts to develop new drug treatments, with a particular focus on drugs against .
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Helmintíase/prevenção & controle
Helmintos/efeitos dos fármacos
Solo/parasitologia
[Mh] Termos MeSH secundário: Animais
Feminino
Helmintíase/transmissão
Seres Humanos
Masculino
Metanálise em Rede
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Soil)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j4307


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[PMID]:28938014
[Au] Autor:Pastille E; Frede A; McSorley HJ; Gräb J; Adamczyk A; Kollenda S; Hansen W; Epple M; Buer J; Maizels RM; Klopfleisch R; Westendorf AM
[Ad] Endereço:Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
[Ti] Título:Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.
[So] Source:PLoS Pathog;13(9):e1006649, 2017 Sep.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules and inducing regulatory T cells (Tregs). This immunosuppressive state provoked in the host has been considered as a novel and promising approach to treat IBD patients and alleviate acute intestinal inflammation. On the contrary, specific parasite infections are well known to be directly linked to carcinogenesis. Whether a helminth infection interferes with the development of colitis-associated colon cancer (CAC) is not yet known. In the present study, we demonstrate that the treatment of mice with the intestinal helminth Heligmosomoides polygyrus at the onset of tumor progression in a mouse model of CAC does not alter tumor growth and distribution. In contrast, H. polygyrus infection in the early inflammatory phase of CAC strengthens the inflammatory response and significantly boosts tumor development. Here, H. polygyrus infection was accompanied by long-lasting alterations in the colonic immune cell compartment, with reduced frequencies of colonic CD8+ effector T cells. Moreover, H. polygyrus infection in the course of dextran sulfate sodium (DSS) mediated colitis significantly exacerbates intestinal inflammation by amplifying the release of colonic IL-6 and CXCL1. Thus, our findings indicate that the therapeutic application of helminths during CAC might have tumor-promoting effects and therefore should be well-considered.
[Mh] Termos MeSH primário: Colite/complicações
Neoplasias do Colo/etiologia
Helmintíase/complicações
Enteropatias Parasitárias/complicações
Infecções por Strongylida/complicações
[Mh] Termos MeSH secundário: Animais
Carcinogênese/imunologia
Modelos Animais de Doenças
Feminino
Citometria de Fluxo
Helmintíase/imunologia
Enteropatias Parasitárias/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Nematospiroides dubius
Infecções por Strongylida/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006649


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[PMID]:28934198
[Au] Autor:Essé C; Koffi VA; Kouamé A; Dongo K; Yapi RB; Moro HM; Kouakou CA; Palmeirim MS; Bonfoh B; N'Goran EK; Utzinger J; Raso G
[Ad] Endereço:Unité de Formation et de Recherche des Sciences de l'Homme et de la Société, Université Félix Houphouët-Boigny, Abidjan, Côte d'Ivoire.
[Ti] Título:"Koko et les lunettes magiques": An educational entertainment tool to prevent parasitic worms and diarrheal diseases in Côte d'Ivoire.
[So] Source:PLoS Negl Trop Dis;11(9):e0005839, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Integrated control programs, emphasizing preventive chemotherapy along with health education, can reduce the incidence of soil-transmitted helminthiasis and schistosomiasis. The aim of this study was to develop an educational animated cartoon to improve school children's awareness regarding soil-transmitted helminthiasis, diarrheal diseases, and related hygiene practices in Côte d'Ivoire. The key messages included in the cartoon were identified through prior formative research to specifically address local knowledge gaps. METHODOLOGY: In a first step, preliminary research was conducted to assess the knowledge, attitudes, practices, and beliefs of school-aged children regarding parasitic worm infections and hygiene, to identify key health messages to be included in an animated cartoon. Second, an animated cartoon was produced, which included the drafting of the script and story board, and the production of the cartoon's initial version. Finally, the animated cartoon was pilot tested in eight selected schools and further fine-tuned. PRINCIPAL FINDINGS: According to the questionnaire results, children believed that the consumption of sweet food, eating without washing their hands, sitting on the floor, and eating spoiled food were the main causes of parasitic worm infections. Abdominal pain, diarrhea, lack of appetite, failure to grow, and general fatigue were mentioned as symptoms of parasitic worm infections. Most of the children knew that they should go to the hospital for treatment if they experienced symptoms of parasitic worm diseases. The animated cartoon titled "Koko et les lunettes magiques" was produced by Afrika Toon, in collaboration with a scientific team composed of epidemiologists, civil engineers, and social scientists, and the local school children and teachers. Pilot testing of the animated cartoon revealed that, in the short term, children grasped and kept key messages. Most of the children who were shown the cartoon reported to like it. Acceptance of the animated cartoon was high among children and teachers alike. The messaging was tailored to improve knowledge and practices for prevention of helminthiases and diarrheal diseases through prior identification of knowledge gaps. Integration of such education tools into the school curriculum, along with deworming campaigns, might improve sustainability of control and elimination efforts against helminthiases and diarrheal diseases.
[Mh] Termos MeSH primário: Desenhos Animados como Assunto
Diarreia/prevenção & controle
Helmintíase/prevenção & controle
[Mh] Termos MeSH secundário: Criança
Costa do Marfim/epidemiologia
Diarreia/epidemiologia
Conhecimentos, Atitudes e Prática em Saúde
Helmintíase/epidemiologia
Seres Humanos
Instituições Acadêmicas
Solo/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005839



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