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  1 / 1732 MEDLINE  
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[PMID]:29284011
[Au] Autor:Pajuelo MJ; Eguiluz M; Roncal E; Quiñones-García S; Clipman SJ; Calcina J; Gavidia CM; Sheen P; Garcia HH; Gilman RH; Gonzalez AE; Zimic M; Cysticercosis Working Group in Peru
[Ad] Endereço:Laboratorio de Bioinformática y Biología Molecular, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
[Ti] Título:Genetic variability of Taenia solium cysticerci recovered from experimentally infected pigs and from naturally infected pigs using microsatellite markers.
[So] Source:PLoS Negl Trop Dis;11(12):e0006087, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The adult Taenia solium, the pork tapeworm, usually lives as a single worm in the small intestine of humans, its only known definitive host. Mechanisms of genetic variation in T. solium are poorly understood. Using three microsatellite markers previously reported [1], this study explored the genetic variability of T. solium from cysts recovered from experimentally infected pigs. It then explored the genetic epidemiology and transmission in naturally infected pigs and adult tapeworms recovered from human carriers from an endemic rural community in Peru. In an initial study on experimental infection, two groups of three piglets were each infected with proglottids from one of two genetically different tapeworms for each of the microsatellites. After 7 weeks, pigs were slaughtered and necropsy performed. Thirty-six (92.3%) out of 39 cysts originated from one tapeworm, and 27 (100%) out of 27 cysts from the other had exactly the same genotype as the parental tapeworm. This suggests that the microsatellite markers may be a useful tool for studying the transmission of T. solium. In the second study, we analyzed the genetic variation of T. solium in cysts recovered from eight naturally infected pigs, and from adult tapeworms recovered from four human carriers; they showed genetic variability. Four pigs had cysts with only one genotype, and four pigs had cysts with two different genotypes, suggesting that multiple infections of genetically distinct parental tapeworms are possible. Six pigs harbored cysts with a genotype corresponding to one of the identified tapeworms from the human carriers. In the dendrogram, cysts appeared to cluster within the corresponding pigs as well as with the geographical origin, but this association was not statistically significant. We conclude that genotyping of microsatellite size polymorphisms is a potentially important tool to trace the spread of infection and pinpoint sources of infection as pigs spread cysts with a shared parental genotype.
[Mh] Termos MeSH primário: Cisticercose/veterinária
Repetições de Microssatélites/genética
Taenia solium/genética
Teníase/veterinária
[Mh] Termos MeSH secundário: Animais
Cisticercose/parasitologia
Cisticercose/transmissão
Cysticercus/genética
Cysticercus/isolamento & purificação
Cistos/parasitologia
Modelos Animais de Doenças
Feminino
Variação Genética/genética
Genótipo
Masculino
Peru
Sus scrofa
Suínos
Doenças dos Suínos/parasitologia
Taenia solium/isolamento & purificação
Teníase/parasitologia
Teníase/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006087


  2 / 1732 MEDLINE  
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[PMID]:28467600
[Au] Autor:Arora N; Tripathi S; Kumar P; Mondal P; Mishra A; Prasad A
[Ad] Endereço:School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, India.
[Ti] Título:Recent advancements and new perspectives in animal models for Neurocysticercosis immunopathogenesis.
[So] Source:Parasite Immunol;39(7), 2017 Jul.
[Is] ISSN:1365-3024
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Neurocysticercosis (NCC), one of the most common parasitic diseases of the central nervous system, is caused by Taenia solium. This parasite involves two hosts, intermediate hosts (pig and human) and a definitive host (human) and has various stages in its complex life cycle (eggs, oncosphere, cysticerci and adult tapeworm). Hence, developing an animal model for T. solium that mimics its natural course of infection is quite challenging. We have reviewed here the animal models frequently used to study immunopathogenesis of cysticercosis and also discussed their usefulness for NCC studies. We found that researchers have used mice, rats, guinea pigs, dogs, cats and pigs as models for this disease with varying degrees of success. Mice and rats models have been utilized extensively for immunopathogenesis studies due to their relative ease of handling and abundance of commercially available reagents to study these small animal models. These models have provided some very exciting results for in-depth understanding of the disease. Of late, the experimentally/naturally infected swine model is turning out to be the best animal model as the disease progression closely resembles human infection in pigs. However, handling large experimental animals has its own challenges and limitations.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Neurocisticercose/imunologia
Taenia solium/imunologia
Taenia/imunologia
Teníase/imunologia
[Mh] Termos MeSH secundário: Animais
Chinchila
Cricetinae
Seres Humanos
Estágios do Ciclo de Vida
Macaca mulatta
Neurocisticercose/parasitologia
Ratos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/pim.12439


  3 / 1732 MEDLINE  
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[PMID]:28945737
[Au] Autor:Navarrete-Perea J; Isasa M; Paulo JA; Corral-Corral R; Flores-Bautista J; Hernández-Téllez B; Bobes RJ; Fragoso G; Sciutto E; Soberón X; Gygi SP; Laclette JP
[Ad] Endereço:Dept. of Immunology, Institute for Biomedical Research, Universidad Nacional Autónoma de México, Ciudad de México, México.
[Ti] Título:Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs.
[So] Source:PLoS Negl Trop Dis;11(9):e0005962, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In human and porcine cysticercosis caused by the tapeworm Taenia solium, the larval stage (cysts) can infest several tissues including the central nervous system (CNS) and the skeletal muscles (SM). The cyst's proteomics changes associated with the tissue localization in the host tissues have been poorly studied. Quantitative multiplexed proteomics has the power to evaluate global proteome changes in response to different conditions. Here, using a TMT-multiplexed strategy we identified and quantified over 4,200 proteins in cysts obtained from the SM and CNS of pigs, of which 891 were host proteins. To our knowledge, this is the most extensive intermixing of host and parasite proteins reported for tapeworm infections.Several antigens in cysticercosis, i.e., GP50, paramyosin and a calcium-binding protein were enriched in skeletal muscle cysts. Our results suggested the occurrence of tissue-enriched antigen that could be useful in the improvement of the immunodiagnosis for cysticercosis. Using several algorithms for epitope detection, we selected 42 highly antigenic proteins enriched for each tissue localization of the cysts. Taking into account the fold changes and the antigen/epitope contents, we selected 10 proteins and produced synthetic peptides from the best epitopes. Nine peptides were recognized by serum antibodies of cysticercotic pigs, suggesting that those peptides are antigens. Mixtures of peptides derived from SM and CNS cysts yielded better results than mixtures of peptides derived from a single tissue location, however the identification of the 'optimal' tissue-enriched antigens remains to be discovered. Through machine learning technologies, we determined that a reliable immunodiagnostic test for porcine cysticercosis required at least five different antigenic determinants.
[Mh] Termos MeSH primário: Sistema Nervoso Central/parasitologia
Proteínas de Helminto/análise
Músculo Esquelético/parasitologia
Proteoma/análise
Doenças dos Suínos/parasitologia
Taenia solium/química
Teníase/veterinária
[Mh] Termos MeSH secundário: Animais
Proteômica
Suínos
Taenia solium/isolamento & purificação
Teníase/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Helminth Proteins); 0 (Proteome)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005962


  4 / 1732 MEDLINE  
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[PMID]:28892472
[Au] Autor:Donadeu M; Fahrion AS; Olliaro PL; Abela-Ridder B
[Ad] Endereço:The University of Melbourne, Faculty of Veterinary and Agricultural Sciences, Veterinary Clinical Centre, Werribee, Victoria, Australia.
[Ti] Título:Target product profiles for the diagnosis of Taenia solium taeniasis, neurocysticercosis and porcine cysticercosis.
[So] Source:PLoS Negl Trop Dis;11(9):e0005875, 2017 Sep.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Target Product Profiles (TPPs) are process tools providing product requirements to guide researchers, developers and manufacturers in their efforts to develop effective and useful products such as biologicals, drugs or diagnostics. During a WHO Stakeholders Meeting on Taenia solium diagnostics, several TPPs were initiated to address diagnostic needs for different stages in the parasite's transmission (taeniasis, human and porcine cysticercosis). Following the meeting, draft TPPs were completed and distributed for consultation to 100 people/organizations, including experts in parasitology, human and pig cysticercosis, diagnostic researchers and manufacturers, international organizations working with neglected or zoonotic diseases, Ministries of Health and Ministries of Livestock in some of the endemic countries, WHO regional offices and other interested parties. There were 53 respondents. All comments and feedback received were considered and discussions were held with different experts according to their area of expertise. The comments were consolidated and final TPPs are presented here. They are considered to be live documents which are likely to undergo review and updating in the future when new knowledge and technologies become available.
[Mh] Termos MeSH primário: Cisticercose/veterinária
Neurocisticercose/diagnóstico
Doenças dos Suínos/diagnóstico
Taenia solium/isolamento & purificação
Teníase/diagnóstico
[Mh] Termos MeSH secundário: Animais
Cisticercose/diagnóstico
Cisticercose/epidemiologia
Cisticercose/parasitologia
Seres Humanos
Neurocisticercose/epidemiologia
Neurocisticercose/parasitologia
Suínos
Doenças dos Suínos/epidemiologia
Doenças dos Suínos/parasitologia
Teníase/epidemiologia
Teníase/parasitologia
Organização Mundial da Saúde
Zoonoses
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005875


  5 / 1732 MEDLINE  
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[PMID]:28850668
[Au] Autor:Del Brutto OH; Arroyo G; Del Brutto VJ; Zambrano M; García HH
[Ad] Endereço:School of Medicine, Universidad Espiritu Santo-Ecuador, Guayaquil, Ecuador.
[Ti] Título:On the relationship between calcified neurocysticercosis and epilepsy in an endemic village: A large-scale, computed tomography-based population study in rural Ecuador.
[So] Source:Epilepsia;58(11):1955-1961, 2017 Nov.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Using a large-scale population-based study, we aimed to assess prevalence and patterns of presentation of neurocysticercosis (NCC) and its relationship with epilepsy in community-dwellers aged ≥20 years living in Atahualpa (rural Ecuador). METHODS: In a three-phase epidemiological study, individuals with suspected seizures were identified during a door-to-door survey and an interview (phase I). Then, neurologists evaluated suspected cases and randomly selected negative persons to estimate epilepsy prevalence (phase II). In phase III, all participants were offered noncontrast computed tomography (CT) for identifying NCC cases. The independent association between NCC (exposure) and epilepsy (outcome) was assessed by the use of multivariate logistic regression models adjusted for age, sex, level of education, and alcohol intake. CT findings were subsequently compared to archived brain magnetic resonance imaging in a sizable subgroup of participants. RESULTS: Of 1,604 villagers aged ≥20 years, 1,462 (91%) were enrolled. Forty-one persons with epilepsy (PWE) were identified, for a crude prevalence of epilepsy of 28 per 1,000 population (95% confidence interval [CI] = 20.7-38.2). A head CT was performed in 1,228 (84%) of 1,462 participants, including 39 of 41 PWE. CT showed lesions consistent with calcified parenchymal brain cysticerci in 118 (9.6%) cases (95% CI = 8.1-11.4%). No patient had other forms of NCC. Nine of 39 PWE, as opposed to 109 of 1,189 participants without epilepsy, had NCC (23.1% vs. 9.2%, p = 0.004). This difference persisted in the adjusted logistic regression model (odds ratio = 3.04, 95% CI = 1.35-6.81, p = 0.007). SIGNIFICANCE: This large CT-based study demonstrates that PWE had three times the odds of having NCC than those without epilepsy, providing robust epidemiological evidence favoring the relationship between NCC and epilepsy.
[Mh] Termos MeSH primário: Calcinose/diagnóstico por imagem
Epilepsia/diagnóstico por imagem
Neurocisticercose/diagnóstico por imagem
Vigilância da População
População Rural
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Animais
Calcinose/epidemiologia
Estudos Transversais
Equador/epidemiologia
Epilepsia/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Neurocisticercose/epidemiologia
Vigilância da População/métodos
Distribuição Aleatória
Suínos
Taenia solium/isolamento & purificação
Teníase/diagnóstico por imagem
Teníase/epidemiologia
Tomografia Computadorizada por Raios X/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13892


  6 / 1732 MEDLINE  
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[PMID]:28704366
[Au] Autor:Schneider-Crease I; Griffin RH; Gomery MA; Dorny P; Noh JC; Handali S; Chastain HM; Wilkins PP; Nunn CL; Snyder-Mackler N; Beehner JC; Bergman TJ
[Ad] Endereço:Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.
[Ti] Título:Identifying wildlife reservoirs of neglected taeniid tapeworms: Non-invasive diagnosis of endemic Taenia serialis infection in a wild primate population.
[So] Source:PLoS Negl Trop Dis;11(7):e0005709, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite the global distribution and public health consequences of Taenia tapeworms, the life cycles of taeniids infecting wildlife hosts remain largely undescribed. The larval stage of Taenia serialis commonly parasitizes rodents and lagomorphs, but has been reported in a wide range of hosts that includes geladas (Theropithecus gelada), primates endemic to Ethiopia. Geladas exhibit protuberant larval cysts indicative of advanced T. serialis infection that are associated with high mortality. However, non-protuberant larvae can develop in deep tissue or the abdominal cavity, leading to underestimates of prevalence based solely on observable cysts. We adapted a non-invasive monoclonal antibody-based enzyme-linked immunosorbent assay (ELISA) to detect circulating Taenia spp. antigen in dried gelada urine. Analysis revealed that this assay was highly accurate in detecting Taenia antigen, with 98.4% specificity, 98.5% sensitivity, and an area under the curve of 0.99. We used this assay to investigate the prevalence of T. serialis infection in a wild gelada population, finding that infection is substantially more widespread than the occurrence of visible T. serialis cysts (16.4% tested positive at least once, while only 6% of the same population exhibited cysts). We examined whether age or sex predicted T. serialis infection as indicated by external cysts and antigen presence. Contrary to the female-bias observed in many Taenia-host systems, we found no significant sex bias in either cyst presence or antigen presence. Age, on the other hand, predicted cyst presence (older individuals were more likely to show cysts) but not antigen presence. We interpret this finding to indicate that T. serialis may infect individuals early in life but only result in visible disease later in life. This is the first application of an antigen ELISA to the study of larval Taenia infection in wildlife, opening the doors to the identification and description of infection dynamics in reservoir populations.
[Mh] Termos MeSH primário: Doenças Endêmicas
Ensaio de Imunoadsorção Enzimática/métodos
Doenças dos Primatas/diagnóstico
Doenças dos Primatas/epidemiologia
Taenia/isolamento & purificação
Teníase/veterinária
Urina/parasitologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Helmintos/urina
Etiópia/epidemiologia
Feminino
Masculino
Prevalência
Curva ROC
Sensibilidade e Especificidade
Teníase/diagnóstico
Teníase/epidemiologia
Theropithecus/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005709


  7 / 1732 MEDLINE  
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[PMID]:28410387
[Au] Autor:Alva A; Cangalaya C; Quiliano M; Krebs C; Gilman RH; Sheen P; Zimic M
[Ad] Endereço:Unidad de Bioinformática, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.
[Ti] Título:Mathematical algorithm for the automatic recognition of intestinal parasites.
[So] Source:PLoS One;12(4):e0175646, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lacking in many of the areas where these infections are most prevalent. In response to this public health issue, we developed a software based on pattern recognition analysis from microscopi digital images of fecal smears, capable of automatically recognizing and diagnosing common human intestinal parasites. To this end, we selected 229, 124, 217, and 229 objects from microscopic images of fecal smears positive for Taenia sp., Trichuris trichiura, Diphyllobothrium latum, and Fasciola hepatica, respectively. Representative photographs were selected by a parasitologist. We then implemented our algorithm in the open source program SCILAB. The algorithm processes the image by first converting to gray-scale, then applies a fourteen step filtering process, and produces a skeletonized and tri-colored image. The features extracted fall into two general categories: geometric characteristics and brightness descriptions. Individual characteristics were quantified and evaluated with a logistic regression to model their ability to correctly identify each parasite separately. Subsequently, all algorithms were evaluated for false positive cross reactivity with the other parasites studied, excepting Taenia sp. which shares very few morphological characteristics with the others. The principal result showed that our algorithm reached sensitivities between 99.10%-100% and specificities between 98.13%- 98.38% to detect each parasite separately. We did not find any cross-positivity in the algorithms for the three parasites evaluated. In conclusion, the results demonstrated the capacity of our computer algorithm to automatically recognize and diagnose Taenia sp., Trichuris trichiura, Diphyllobothrium latum, and Fasciola hepatica with a high sensitivity and specificity.
[Mh] Termos MeSH primário: Algoritmos
Helmintíase/diagnóstico
[Mh] Termos MeSH secundário: Animais
Difilobotríase/diagnóstico
Diphyllobothrium/crescimento & desenvolvimento
Fasciola hepatica/crescimento & desenvolvimento
Fasciolíase/diagnóstico
Seres Humanos
Processamento de Imagem Assistida por Computador
Microscopia
Óvulo/patologia
Reconhecimento Automatizado de Padrão
Sensibilidade e Especificidade
Taenia/crescimento & desenvolvimento
Teníase/diagnóstico
Tricuríase/diagnóstico
Trichuris/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175646


  8 / 1732 MEDLINE  
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[PMID]:28322765
[Au] Autor:Trevisan C; Montillo M; Prandi A; Mkupasi EM; Ngowi HA; Johansen MV
[Ad] Endereço:Department of Veterinary and Animal Sciences, University of Copenhagen, Dyrlægevej 100, 1870 Frederiksberg C, Denmark.
[Ti] Título:Hair cortisol and dehydroepiandrosterone concentrations in naturally Taenia solium infected pigs in Tanzania.
[So] Source:Gen Comp Endocrinol;246:23-28, 2017 May 15.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to measure hair cortisol and dehydroepiandrosterone (DHEA) concentrations in naturally Taenia solium infected and non-infected control pigs and assess the effect of an environmental change on the aforementioned parameters. Three hair patches were obtained from 13 T. solium infected and 15 non-infected controls sows, respectively corresponding to 3 time points (prior to, at and approximately two weeks after arrival at the research facility). Cortisol and DHEA were extracted using methanol and analysed by radio immune assay. Mean hair cortisol concentrations were significantly lower (p<0.001) in T. solium infected (4.7±3.0pg/mg) compared to control pigs (9.0±3.7pg/mg) prior to arrival at the research facility, however no significant difference was observed between the two groups at arrival and after approximately two weeks. Similar patterns were also observed for DHEA concentrations (infected pigs 253.9±82.3pg/mg, control pigs 387.7±116.4pg/mg) (p<0.001). Results showed that lean animals had significantly higher cortisol concentrations in both groups, infected and controls pigs, while DHEA was not significantly different between lean and normal animals. Results of this study have shown that an environmental change could have an effect on pigs' hormonal levels suggesting an undergoing adaptation process. After the pigs were kept under the same conditions, fed and watered ad libitum, no significant differences were observed between the groups, but a drop in DHEA concentrations was observed in all the pigs. Weight however had an effect on cortisol levels as lean animals had significantly higher cortisol concentrations in both groups, compared to normal pigs.
[Mh] Termos MeSH primário: Desidroepiandrosterona/metabolismo
Cabelo/química
Hidrocortisona/metabolismo
Doenças dos Suínos/metabolismo
Taenia solium/isolamento & purificação
Teníase/veterinária
[Mh] Termos MeSH secundário: Animais
Feminino
Radioimunoensaio
Suínos
Doenças dos Suínos/epidemiologia
Doenças dos Suínos/transmissão
Taenia solium/fisiologia
Teníase/epidemiologia
Teníase/metabolismo
Tanzânia/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
459AG36T1B (Dehydroepiandrosterone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


  9 / 1732 MEDLINE  
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[PMID]:28320455
[Au] Autor:Ng-Nguyen D; Stevenson MA; Traub RJ
[Ad] Endereço:Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, 3052, Australia. ngocn4@student.unimelb.edu.au.
[Ti] Título:A systematic review of taeniasis, cysticercosis and trichinellosis in Vietnam.
[So] Source:Parasit Vectors;10(1):150, 2017 Mar 21.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Taeniasis, cysticercosis and trichinellosis have been ranked as the most important food-borne parasites of humans in terms of public health, socioeconomic and trade impact. Despite this, information on these food-borne zoonoses in Vietnam is scarce and fragmented, and many local reports remain inaccessible to the international research community. This study aims to conduct comprehensive literature searches to report on the incidence and estimate the true prevalence of taeniasis in humans and T. solium cysticercosis in humans and pigs in Vietnam utilizing Bayesian models; in addition, to report the incidence and the distribution of trichinellosis. A Bayesian approach was used to estimate the true prevalence of taeniasis and cysticercosis based on published diagnostic test characteristics used in each published cross-sectional survey. The utilization of coproscopic-based examination of Taenia eggs in stool, although highly specific for genus-level detection, has poor sensitivity and led to an underestimation of the prevalence of human taeniasis. Similarly, post-mortem-based surveys of T. solium cysticercosis in pigs also led to the underestimation of prevalence of porcine cysticercosis. On the other hand, the low specificity of immunodiagnostic methods, in particular Ab-ELISA, led to a likely overestimation of T. solium cysticercosis in humans. Due to the use of imperfect diagnosis tests combined with poor descriptions of sampling methods, our ability to draw solid conclusions from these data is limited. We estimate that the true prevalence of taeniasis and T. solium cysticercosis in rural 'hotspots', is as high as 13% for each, in humans. Taeniasis and T. solium cysticercosis occurs in 60 of the 63 provinces of Vietnam. Most of the information relating to the distribution and prevalence of porcine cysticercosis is limited to commercial abattoir surveys. In Vietnam, Taenia asiatica appears to be confined to the north where it occurs sympatrically with T. solium and Taenia saginata. The status of T. asiatica in Central and South Vietnam remains unascertained. To date, five outbreaks of trichinellosis have been reported in the north and northwest of Vietnam, affecting a total of 114 people and responsible for eight fatalities. In the same region, studies of free-roaming pigs showed evidence of high levels of exposure to Trichinella and, in cases where larvae were recovered, the species present were identified as Trichinella spiralis. Based on five studies, the main risk factors for pork-borne zoonoses in Vietnam include the consumption of undercooked/raw meat and vegetables and the use of night-soil for fertilization of local produce. This systematic review draws attention to the importance of these pork-borne zoonoses.
[Mh] Termos MeSH primário: Cisticercose/parasitologia
Cisticercose/veterinária
Doenças Transmitidas por Alimentos/parasitologia
Carne Vermelha/parasitologia
Doenças dos Suínos/parasitologia
Teníase/parasitologia
Teníase/veterinária
[Mh] Termos MeSH secundário: Animais
Cisticercose/epidemiologia
Doenças Transmitidas por Alimentos/epidemiologia
Seres Humanos
Suínos
Doenças dos Suínos/epidemiologia
Teníase/epidemiologia
Vietnã/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2085-9


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[PMID]:28288753
[Au] Autor:Zheng Y
[Ad] Endereço:State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address: zhengyadong@caas.cn.
[Ti] Título:Proteomic analysis of Taenia ovis metacestodes by high performance liquid chromatography-coupled tandem mass spectrometry.
[So] Source:Vet Parasitol;236:113-116, 2017 Mar 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Taenia ovis metacestodes reside in the muscle of sheep and goats, and may cause great economic loss due to condemnation of carcasses if not effectively controlled. Although advances have been made in the control of T. ovis infection, our knowledge of T. ovis biology is limited. Herein the protein profiling of T. ovis metacestodes was determined by liquid chromatography-linked tandem mass spectrometry. A total of 966 proteins were identified and 25.1% (188/748) were annotated to be associated with metabolic pathways. Consistently, GO analysis returned a metabolic process (16.27%) as one of two main biological process terms. Moreover, it was found that 24 proteins, including very low-density lipoprotein receptor, enolase, paramyosin and endophilin B1, were abundant in T. ovis metacestodes. These proteins may be associated with motility, metabolism, signaling, stress, drug resistance and immune responses. Furthermore, comparative analysis of 5 cestodes revealed the presence of Taenia-specific enolases. These data provide clues for better understanding of T. ovis biology, which is informative for effective control of infection.
[Mh] Termos MeSH primário: Proteínas de Helminto/genética
Proteoma/genética
Taenia/genética
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/veterinária
Larva/genética
Ovinos
Doenças dos Ovinos/parasitologia
Taenia/crescimento & desenvolvimento
Teníase/parasitologia
Teníase/veterinária
Espectrometria de Massas em Tandem/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Helminth Proteins); 0 (Proteome)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE



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