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[PMID]:28193741
[Au] Autor:Calvopina M; Aguirre C; Cevallos W; Castillo A; Abbasi I; Warburg A
[Ad] Endereço:Carrera de Medicina, Universidad De Las Americas (UDLA), Quito, Ecuador.
[Ti] Título:Coinfection of and Human Immunodeficiency Virus-Acquired Immune Deficiency Syndrome: Report of a Case of Disseminated Cutaneous Leishmaniasis in Ecuador.
[So] Source:Am J Trop Med Hyg;96(5):1151-1154, 2017 May.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractReported herein is the first case of -human immunodeficiency virus (HIV) coinfection in Ecuador. In Ecuador, HIV infections overlap endemic areas of leishmaniasis. Immunosuppression is a well-established risk factor for developing severe disease. This is a severe case of a 32-year-old man presenting with disseminated pleomorphic ulcers, papules, and cutaneous plaque-like lesions over his whole body. Numerous amastigotes were observed in both skin scrapings and biopsies. The sequence of the gene confirmed the presence of . The patient was treated but failed to respond to meglumine antimoniate and amphotericin B. Six months later, the patient died due to bacterial septic shock.
[Mh] Termos MeSH primário: Infecções por HIV/virologia
Leishmaniose Tegumentar Difusa/parasitologia
Choque Séptico/patologia
[Mh] Termos MeSH secundário: Adulto
Anfotericina B/uso terapêutico
Antiprotozoários/uso terapêutico
Coinfecção
Citocromos b/genética
Evolução Fatal
HIV/crescimento & desenvolvimento
Infecções por HIV/diagnóstico
Infecções por HIV/patologia
Seres Humanos
Leishmania guyanensis/efeitos dos fármacos
Leishmania guyanensis/genética
Leishmania guyanensis/isolamento & purificação
Leishmaniose Tegumentar Difusa/diagnóstico
Leishmaniose Tegumentar Difusa/tratamento farmacológico
Leishmaniose Tegumentar Difusa/patologia
Masculino
Meglumina/uso terapêutico
Compostos Organometálicos/uso terapêutico
Proteínas de Protozoários/genética
Análise de Sequência de DNA
Choque Séptico/diagnóstico
Choque Séptico/parasitologia
Choque Séptico/virologia
Pele/parasitologia
Pele/patologia
Pele/virologia
Falha de Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Organometallic Compounds); 0 (Protozoan Proteins); 6HG8UB2MUY (Meglumine); 75G4TW236W (meglumine antimoniate); 7XU7A7DROE (Amphotericin B); 9035-37-4 (Cytochromes b)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0431


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[PMID]:28138050
[Au] Autor:Supsrisunjai C; Kootiratrakarn T; Puangpet P; Bunnag T; Chaowalit P; Wessagowit V
[Ad] Endereço:Department of Medical Services, Ministry of Public Health, Institute of Dermatology, Bangkok, Thailand.
[Ti] Título:Disseminated Autochthonous Dermal Leishmaniasis Caused by (PCM2 Trang) in a Patient from Central Thailand Infected with Human Immunodeficiency Virus.
[So] Source:Am J Trop Med Hyg;96(5):1160-1163, 2017 May.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractSeveral case reports of autochthonous leishmaniasis in Thailand have been published since 1996. Most of the previous cases presented with visceral leishmaniasis (VL) and were mostly reported in southern part of Thailand. Recently, it has been evident that is the main cause of infection in Thailand. However, (PCM2 Trang isolate) was found to be of a separate lineage with restricted distribution in southern Thailand and also a cause of disseminated dermal and visceral leishmaniasis in one published case. Here we report the first patient from central Thailand with human immunodeficiency virus infection presenting with disseminated dermal leishmaniasis. Polymerase chain reaction and DNA sequencing analysis (large subunit of RNA polymerase II and 18S ribosomal RNA internal transcribed spacer 1) from the tissue biopsy sample revealed the pathogen sequences to be highly homologous to PCM2 Trang strain previously reported from southern Thailand.
[Mh] Termos MeSH primário: Antiprotozoários/uso terapêutico
Antivirais/uso terapêutico
Derme/patologia
Infecções por HIV/virologia
Leishmaniose Tegumentar Difusa/parasitologia
[Mh] Termos MeSH secundário: Adulto
Anfotericina B/uso terapêutico
Coinfecção
DNA Espaçador Ribossômico/genética
Derme/efeitos dos fármacos
Derme/parasitologia
Derme/virologia
Feminino
HIV/efeitos dos fármacos
HIV/crescimento & desenvolvimento
Infecções por HIV/diagnóstico
Infecções por HIV/tratamento farmacológico
Infecções por HIV/patologia
Seres Humanos
Itraconazol/uso terapêutico
Leishmania/efeitos dos fármacos
Leishmania/genética
Leishmania/isolamento & purificação
Leishmaniose Tegumentar Difusa/diagnóstico
Leishmaniose Tegumentar Difusa/tratamento farmacológico
Leishmaniose Tegumentar Difusa/patologia
Proteínas de Protozoários/genética
RNA Polimerase II/genética
Análise de Sequência de DNA
Tailândia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Antiviral Agents); 0 (DNA, Ribosomal Spacer); 0 (Protozoan Proteins); 304NUG5GF4 (Itraconazole); 7XU7A7DROE (Amphotericin B); EC 2.7.7.- (RNA Polymerase II)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0472


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[PMID]:28128815
[Au] Autor:Blum-Domínguez SD; Martínez-Vázquez A; Núñez-Oreza LA; Martínez-Hernández F; Villalobos G; Tamay-Segovia P
[Ad] Endereço:Laboratorio de Enfermedades Tropicales, Centro de Investigaciones Biomédicas, Universidad Autónoma de Campeche, Campeche, Camp., México.
[Ti] Título:[Diffuse cutaneous leishmaniasis (DCL) and visceral leishmaniasis (VL) concurrent with cancer: Presentation of a case].
[Ti] Título:Leishmaniasis cutánea difusa (LCD) y visceral (LV) concurrentes con cáncer: Presentación de un caso..
[So] Source:Gac Med Mex;153(1):121-124, 2017 Jan-Feb.
[Is] ISSN:0016-3813
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Male of 52 year old with chronic alcoholism and ulcerated lesion on the face and disseminated nodular skin lesions, underwent to biopsy of ulcer edges where was observed a concomitant epidermoid malignancy with Leishmania (L.). Besides others, biopsies of nodule in the periumbilical region, lymph node and bone marrow were assayed, and all biopsies had abundant amastigotes. The amplified Polymerase Chain Reaction (PCR) products from nodule were sequenced and the alignment analysis demonstrated homology with L. mexicana confirming the infection by this parasite. This is considered the first case of visceral and diffuse cutaneous leishmaniasis concurrent with epidermoid cancer in the state of Campeche.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/complicações
Leishmaniose Tegumentar Difusa/complicações
Leishmaniose Visceral/complicações
Neoplasias Cutâneas/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE


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[PMID]:27546158
[Au] Autor:Bezerra-Souza A; Yamamoto ES; Laurenti MD; Ribeiro SP; Passero LF
[Ad] Endereço:Laboratory of Pathology of Infectious Diseases (LIM-50), Medical School, University of São Paulo, Avenida Dr. Arnaldo 455, 01246903 Cerqueira César, SP, Brazil.
[Ti] Título:The antifungal compound butenafine eliminates promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis.
[So] Source:Parasitol Int;65(6 Pt A):702-707, 2016 Dec.
[Is] ISSN:1873-0329
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The production of ergosterol lipid, important for the Leishmania membrane homeostasis, involves different enzymes. This pathway can be blocked to azoles and allylamines drugs, such as Butenafine. The aim of the present work was to evaluate the anti-leishmanicidal activity of this drug in 2 major species of Leishmania responsible for causing the American tegumentar leishmaniasis (L. (L.) amazonensis and L. (V.) braziliensis). Butenafine eliminated promastigote forms of L. amazonensis and L. braziliensis with efficacy similar to miltefosine, a standard anti-leishmania drug. In addition, butenafine induced alterations in promastigote forms of L. amazonensis that resemble programmed cell death. Butenafine as well as miltefosine presented mild toxicity in peritoneal macrophages, however, butenafine was more effective to eliminate intracellular amastigotes of both L. amazonensis and L. braziliensis, and this effect was not associated with elevated levels of nitric oxide or hydrogen peroxide. Taken together, data presented herein suggests that butenafine can be considered as a prototype drug able to eliminate L. amazonensis and L. braziliensis, etiological agents of anergic diffuse and mucocutaneous leishmaniasis, respectively.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Antiprotozoários/uso terapêutico
Benzilaminas/uso terapêutico
Leishmania braziliensis/efeitos dos fármacos
Leishmaniose Tegumentar Difusa/tratamento farmacológico
Leishmaniose Mucocutânea/tratamento farmacológico
Naftalenos/uso terapêutico
Fosforilcolina/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Reposicionamento de Medicamentos
Feminino
Leishmania braziliensis/classificação
Leishmaniose Tegumentar Difusa/parasitologia
Leishmaniose Mucocutânea/parasitologia
Macrófagos/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos BALB C
Testes de Sensibilidade Parasitária
Fosforilcolina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Antiprotozoal Agents); 0 (Benzylamines); 0 (Naphthalenes); 107-73-3 (Phosphorylcholine); 53EY29W7EC (miltefosine); 91Y494NL0X (butenafine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160823
[St] Status:MEDLINE


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[PMID]:27251586
[Au] Autor:Zgheib E; Habib R; Moukarbel R; Khalifeh I
[Ad] Endereço:Department of Plastic Reconstructive and Aesthetic Surgery, American University of Beirut Medical Center, Beirut, Lebanon.
[Ti] Título:Old World Leishmaniasis: an ancient disease with nonstandardized microscopic and clinical classifications.
[So] Source:J Cutan Pathol;43(10):815-20, 2016 Oct.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Microscopic and clinical classifications of cutaneous leishmania have been set in the 1980s. Since then, they have been used invariably. Lebanon, a nonendemic country, is suffering from a leishmaniasis epidemic because of the massive population influx from endemic Syria. DESIGN: Patients diagnosed and speciated with leishmania (n = 169) using molecular and microscopic analysis were studied. General demographic data, microscopic data [Ridley's pattern (RP), microscopic pattern, Parasitic Index (PI)] and clinical stage were documented. Clinical score was scored as: 1: inflammatory; 2: proliferative/reorganization; 3: healed phases. The three patterns were studied in comparison to the lesion age and PI. RESULTS: At low PI, the clinical score and microscopic pattern showed healing scores (scores 3 and 4, respectively). In contrast, RP showed variable distribution at low PI. The same pattern is noted when correlating the different patterns with high PI. In comparison to lesion age, none of the three patterns showed the predicted linear correlation with lesion progression. CONCLUSION: In the studied population, the previously adopted classifications did not correlate with the disease progression. Such findings may raise the possibility of evolving disease. The proposed clinical and microscopic patterns showed better correlation with the disease progression.
[Mh] Termos MeSH primário: Emigração e Imigração
Leishmaniose Tegumentar Difusa/epidemiologia
Leishmaniose Tegumentar Difusa/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Líbano/epidemiologia
Masculino
Meia-Idade
Síria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12745


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[PMID]:27031998
[Au] Autor:Fernández-Figueroa EA; Imaz-Rosshandler I; Castillo-Fernández JE; Miranda-Ortíz H; Fernández-López JC; Becker I; Rangel-Escareño C
[Ad] Endereço:Unidad de Investigación en Medicina Experimental, Centro de Medicina Tropical, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, C.P.04510 México, D.F., México.
[Ti] Título:Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana.
[So] Source:PLoS Negl Trop Dis;10(3):e0004570, 2016 Mar.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfunction in patients with DCL, this study aimed at identifying differences in the NK-cell response towards Leishmania mexicana lipophosphoglycan (LPG) between patients with localized and diffuse cutaneous leishmaniasis through gene expression profiling. Our results indicate that important genes involved in the innate immune response to Leishmania are down-regulated in NK cells from DCL patients, particularly TLR and JAK/STAT signaling pathways. This down-regulation showed to be independent of LPG stimulation. The study sheds new light for understanding the mechanisms that undermine the correct effector functions of NK cells in patients with diffuse cutaneous leishmaniasis contributing to a better understanding of the pathobiology of leishmaniasis.
[Mh] Termos MeSH primário: Janus Quinases/metabolismo
Células Matadoras Naturais/fisiologia
Leishmania mexicana
Leishmaniose Tegumentar Difusa/metabolismo
Fatores de Transcrição STAT/metabolismo
Receptores Toll-Like/metabolismo
[Mh] Termos MeSH secundário: Regulação para Baixo
Regulação da Expressão Gênica/fisiologia
Seres Humanos
Janus Quinases/genética
Fatores de Transcrição STAT/genética
Transdução de Sinais/fisiologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (STAT Transcription Factors); 0 (Toll-Like Receptors); EC 2.7.10.2 (Janus Kinases)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0004570


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[PMID]:26239973
[Au] Autor:de Macedo-Silva ST; Visbal G; Urbina JA; de Souza W; Rodrigues JC
[Ad] Endereço:Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janerio, Brazil Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, Brazil.
[Ti] Título:Potent In Vitro Antiproliferative Synergism of Combinations of Ergosterol Biosynthesis Inhibitors against Leishmania amazonensis.
[So] Source:Antimicrob Agents Chemother;59(10):6402-18, 2015 Oct.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmaniases comprise a spectrum of diseases caused by protozoan parasites of the Leishmania genus. Treatments available have limited safety and efficacy, high costs, and difficult administration. Thus, there is an urgent need for safer and more-effective therapies. Most trypanosomatids have an essential requirement for ergosterol and other 24-alkyl sterols, which are absent in mammalian cells. In previous studies, we showed that Leishmania amazonensis is highly susceptible to aryl-quinuclidines, such as E5700, which inhibit squalene synthase, and to the azoles itraconazole (ITZ) and posaconazole (POSA), which inhibit C-14α-demethylase. Herein, we investigated the antiproliferative, ultrastructural, and biochemical effects of combinations of E5700 with ITZ and POSA against L. amazonensis. Potent synergistic antiproliferative effects were observed against promastigotes, with fractional inhibitory concentration (FIC) ratios of 0.0525 and 0.0162 for combinations of E5700 plus ITZ and of E5700 plus POSA, respectively. Against intracellular amastigotes, FIC values were 0.175 and 0.1125 for combinations of E5700 plus ITZ and E5700 plus POSA, respectively. Marked alterations of the ultrastructure of promastigotes treated with the combinations were observed, in particular mitochondrial swelling, which was consistent with a reduction of the mitochondrial transmembrane potential, and an increase in the production of reactive oxygen species. We also observed the presence of vacuoles similar to autophagosomes in close association with mitochondria and an increase in the number of lipid bodies. Both growth arrest and ultrastructural/biochemical alterations were strictly associated with the depletion of the 14-desmethyl endogenous sterol pool. These results suggest the possibility of a novel combination therapy for the treatment of leishmaniasis.
[Mh] Termos MeSH primário: Inibidores de 14-alfa Desmetilase/farmacologia
Ergosterol/antagonistas & inibidores
Itraconazol/farmacologia
Leishmania mexicana/efeitos dos fármacos
Piridinas/farmacologia
Quinuclidinas/farmacologia
Triazóis/farmacologia
Tripanossomicidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Meios de Cultura/química
Sinergismo Farmacológico
Quimioterapia Combinada
Ergosterol/biossíntese
Farnesil-Difosfato Farnesiltransferase/antagonistas & inibidores
Farnesil-Difosfato Farnesiltransferase/metabolismo
Seres Humanos
Leishmania mexicana/isolamento & purificação
Leishmania mexicana/metabolismo
Leishmania mexicana/ultraestrutura
Leishmaniose Tegumentar Difusa/parasitologia
Gotículas Lipídicas/efeitos dos fármacos
Gotículas Lipídicas/ultraestrutura
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Mitocôndrias/ultraestrutura
Testes de Sensibilidade Parasitária
Espécies Reativas de Oxigênio/agonistas
Espécies Reativas de Oxigênio/metabolismo
Esterol 14-Desmetilase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (14-alpha Demethylase Inhibitors); 0 (3-((2-benzyl-6-(3-hydroxy-4-methoxypyrrolidin-1-yl)pyridin-3-yl)ethynyl)quinuclidin-3-ol); 0 (Culture Media); 0 (Pyridines); 0 (Quinuclidines); 0 (Reactive Oxygen Species); 0 (Triazoles); 0 (Trypanocidal Agents); 304NUG5GF4 (Itraconazole); 6TK1G07BHZ (posaconazole); EC 1.14.13.70 (Sterol 14-Demethylase); EC 2.5.1.21 (Farnesyl-Diphosphate Farnesyltransferase); Z30RAY509F (Ergosterol)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150805
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.01150-15


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[PMID]:26149864
[Au] Autor:Shaw J; Pratlong F; Floeter-Winter L; Ishikawa E; El Baidouri F; Ravel C; Dedet JP
[Ad] Endereço:Parasitology Department, Biomedical Sciences Institute, São Paulo University, São Paulo, Brazil; French National Reference Centre on Leishmaniasis, Montpellier University, Montpellier, France; Biology Department, BioSciences Institute, São Paulo University, São Paulo, Brazil; Tropical Medicine Nucle
[Ti] Título:Characterization of Leishmania (Leishmania) waltoni n.sp. (Kinetoplastida: Trypanosomatidae), the Parasite Responsible for Diffuse Cutaneous Leishmaniasis in the Dominican Republic.
[So] Source:Am J Trop Med Hyg;93(3):552-8, 2015 Sep.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmania parasites isolated, between 1979 and 1988 by the late Bryce Walton, from Dominican Republic (DR) patients with diffuse cutaneous leishmaniasis, were characterized using a panel of 12 isoenzymes, 23 monoclonal antibodies, small subunit ribosomal DNA (SSu rDNA), and multilocus sequence analysis (MLSA). The isoenzyme and monoclonal antibody profiles and the MLSA results showed that the Dominican Republic parasites were distinct from other described Leishmania species. This new species belongs to the mexicana complex, which is distributed in central and parts of northern South America. It is suggested that the parasites uniqueness from other members of the mexicana complex is related to it being isolated on an island for millions of years. If Leishmania (Leishmania) waltoni fails to adapt to some imported mammal, such as the house rat, it will be the only Leishmania to be classified as an endangered species. The excessive destruction of habitats on Hispaniola threatens the survival of its vectors and presumed natural reservoirs, such as the rodent hutias and the small insectivorous mammal solenodon. The concept of Leishmania species is discussed in the light of recent evaluations on criteria for defining bacterial species.
[Mh] Termos MeSH primário: Leishmania
Leishmaniose Tegumentar Difusa/parasitologia
[Mh] Termos MeSH secundário: Anticorpos Antiprotozoários/imunologia
Sequência de Bases
República Dominicana/epidemiologia
Técnica Indireta de Fluorescência para Anticorpo
Seres Humanos
Isoenzimas/genética
Leishmania/enzimologia
Leishmania/genética
Leishmania/isolamento & purificação
Leishmania/fisiologia
Leishmaniose Tegumentar Difusa/epidemiologia
Dados de Sequência Molecular
Tipagem de Sequências Multilocus
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Isoenzymes)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150708
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.14-0774


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[PMID]:26143433
[Au] Autor:Kevric I; Cappel MA; Keeling JH
[Ad] Endereço:Department of Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA.
[Ti] Título:New World and Old World Leishmania Infections: A Practical Review.
[So] Source:Dermatol Clin;33(3):579-93, 2015 Jul.
[Is] ISSN:1558-0520
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmaniasis is a parasitic infection endemic to more than 90 countries worldwide. As travel to endemic areas increases, dermatologists need to keep this entity in the differential for any chronic skin lesion in persons who may have had a possible exposure for any duration. It can be difficult to diagnose because manifestations are varied and sometimes subclinical. This article discusses the current state of epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment options. A special focus is placed on cutaneous manifestations and their treatment.
[Mh] Termos MeSH primário: Leishmaniose Tegumentar Difusa/diagnóstico
Leishmaniose Mucocutânea/diagnóstico
Leishmaniose Visceral/diagnóstico
[Mh] Termos MeSH secundário: Anfotericina B/uso terapêutico
Gluconato de Antimônio e Sódio/uso terapêutico
Antiprotozoários/uso terapêutico
Ácido Desoxicólico/uso terapêutico
Combinação de Medicamentos
Seres Humanos
Incidência
Leishmania braziliensis/genética
Leishmania donovani/genética
Leishmania mexicana/genética
Leishmania tropica/genética
Leishmaniose Tegumentar Difusa/tratamento farmacológico
Leishmaniose Tegumentar Difusa/epidemiologia
Leishmaniose Mucocutânea/tratamento farmacológico
Leishmaniose Mucocutânea/epidemiologia
Leishmaniose Visceral/tratamento farmacológico
Leishmaniose Visceral/epidemiologia
Fosforilcolina/análogos & derivados
Fosforilcolina/uso terapêutico
Reação em Cadeia da Polimerase
Viagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Drug Combinations); 0 (liposomal amphotericin B); 005990WHZZ (Deoxycholic Acid); 107-73-3 (Phosphorylcholine); 53EY29W7EC (miltefosine); 7XU7A7DROE (Amphotericin B); 87687-70-5 (amphotericin B, deoxycholate drug combination); V083S0159D (Antimony Sodium Gluconate)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150706
[Lr] Data última revisão:
150706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150706
[St] Status:MEDLINE


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[PMID]:25692783
[Au] Autor:Teixeira PC; Velasquez LG; Lepique AP; de Rezende E; Bonatto JM; Barcinski MA; Cunha-Neto E; Stolf BS
[Ad] Endereço:Heart Institute (InCor), University of São Paulo School of Medicine, São Paulo, São Paulo, Brazil.
[Ti] Título:Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB/c and BALB/c nude mice.
[So] Source:PLoS Negl Trop Dis;9(2):e0003411, 2015 Feb.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmaniasis is an important disease that affects 12 million people in 88 countries, with 2 million new cases every year. Leishmania amazonensis is an important agent in Brazil, leading to clinical forms varying from localized (LCL) to diffuse cutaneous leishmaniasis (DCL). One interesting issue rarely analyzed is how host immune response affects Leishmania phenotype and virulence. Aiming to study the effect of host immune system on Leishmania proteins we compared proteomes of amastigotes isolated from BALB/c and BALB/c nude mice. The athymic nude mice may resemble patients with diffuse cutaneous leishmaniasis, considered T-cell hyposensitive or anergic to Leishmania's antigens. This work is the first to compare modifications in amastigotes' proteomes driven by host immune response. Among the 44 differentially expressed spots, there were proteins related to oxidative/nitrosative stress and proteases. Some correspond to known Leishmania virulence factors such as OPB and tryparedoxin peroxidase. Specific isoforms of these two proteins were increased in parasites from nude mice, suggesting that T cells probably restrain their posttranslational modifications in BALB/c mice. On the other hand, an isoform of HSP70 was increased in amastigotes from BALB/c mice. We believe our study may allow identification of potential virulence factors and ways of regulating their expression.
[Mh] Termos MeSH primário: Proteínas de Choque Térmico HSP70/biossíntese
Leishmania mexicana/metabolismo
Leishmaniose Tegumentar Difusa/parasitologia
Peroxidases/biossíntese
Proteínas de Protozoários/biossíntese
Serina Endopeptidases/biossíntese
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Antígenos de Protozoários/imunologia
Brasil
Modelos Animais de Doenças
Feminino
Seres Humanos
Leishmania mexicana/isolamento & purificação
Leishmania mexicana/patogenicidade
Leishmaniose Tegumentar Difusa/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Isoformas de Proteínas/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (HSP70 Heat-Shock Proteins); 0 (Protein Isoforms); 0 (Protozoan Proteins); EC 1.11.1.- (Peroxidases); EC 1.11.1.- (tryparedoxin peroxidase); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.83 (oligopeptidase B)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150219
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0003411



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