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[PMID]:29267667
[Au] Autor:Silva LABD; Sá MAR; Melo RA; Pereira JDS; Silveira ÉJDD; Miguel MCDC
[Ad] Endereço:Universidade Federal do Rio Grande do Norte - UFRN, Postgraduate Program in Oral Pathology, Natal, RN, Brazil.
[Ti] Título:Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts.
[So] Source:Braz Oral Res;31:e106, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare the number of CD57+ natural killer (NK) cells and CD8+ T lymphocytes between periapical granulomas (PGs) and radicular cysts (RCs). Twenty-fives cases of PGs and 25 of RCs were submitted to histological analysis and immunohistochemistry using anti-CD57 and anti-CD8 biomarkers. Positive cells were counted in 10 fields (400× magnification) and the median value was calculated for each case. Statistical tests were used to evaluate differences in the number of CD57+ NK cells and CD8+ T lymphocytes according to type of lesion, intensity of the infiltrate and thickness of the lining epithelium. The number of CD57+ NK cells and CD8+ T lymphocytes was higher in PGs than in RCs (p = 0.129 and p = 0.541, respectively). Comparison of the number of CD57+ NK cells in atrophic and hyperplastic epithelium revealed a larger number of cells in the atrophic epithelium (p = 0.042). A larger number of CD57+ NK cells and CD8+ T lymphocytes were observed in grade III infiltrates compared to grade I/II (p = 0.145 and p = 0.725, respectively). CD8+ T lymphocytes were more prevalent than CD57+ NK cells in most cases when PGs and RCs were analyzed separately or in combination (p < 0.0001). CD57+ NK cells and CD8+ T lymphocytes play a key role in antiviral defense and the presence of these cells supports evidence suggesting the participation of these microorganisms in the pathogenesis of PGs and RCs. The response mediated by CD8+ T lymphocytes was more frequent, indicating greater participation of the adaptive immunity in these chronic lesions.
[Mh] Termos MeSH primário: Antígenos CD57/análise
Linfócitos T CD8-Positivos/patologia
Células Matadoras Naturais/patologia
Granuloma Periapical/patologia
Cisto Radicular/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Biomarcadores/análise
Contagem de Células
Epitélio
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Granuloma Periapical/imunologia
Cisto Radicular/imunologia
Valores de Referência
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (CD57 Antigens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:28678970
[Au] Autor:Álvares PR; Arruda JAA; Silva LPD; Nascimento GJFD; Silveira MFD; Sobral APV
[Ad] Endereço:Universidade de Pernambuco - UPE, School of Dentistry, Department of Oral Pathology, Camaragibe, PB, Brazil.
[Ti] Título:Immunohistochemical expression of TGF-ß1 and MMP-9 in periapical lesions.
[So] Source:Braz Oral Res;31:e51, 2017 Jul 03.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor beta (TGF-ß1) in periapical lesion samples correlated with the intensity of the inflammatory infiltrate and thickness of the epithelial lining. Forty-five cases of periapical lesions (23 periapical granulomas and 22 radicular cysts) were subjected to morphological and immunohistochemical analyses using anti-MMP-9 and anti-TGF-ß1 antibodies. The data were analyzed using the following tests: non-parametric Mann-Whitney, chi-square, Fisher's exact test and Spearman's correlation test (P<0.05). Analysis of inflammatory infiltrate revealed that 78% of periapical granulomas presented infiltrate grade III, in contrast with 32% of radicular cysts (P<0.001). Morphological evaluation of the epithelial thickness in radicular cysts revealed the presence of atrophic epithelium in 86% of the cysts. The immunostaining of MMP-9 was score 2 in 67% of the granulomas and 77% of the cysts. Both lesions were predominantly score 1 for TGF-ß1. Significant differences were confirmed between the expression scores of TGF-ß1 and MMP-9 in periapical granulomas (p = 0.004) and in radicular cysts (p < 0.001). Expression of TGF-ß1 was different for periapical granulomas and radicular cysts. This immunoregulatory cytokine seems more representative in asymptomatic lesions. The extracellular matrix remodeling process dependent on MMP-9 seems to be similar for both periapical granulomas and radicular cysts. TGF-ß1 and MMP-9 may play an important role in the maintenance of periapical lesions.
[Mh] Termos MeSH primário: Metaloproteinase 9 da Matriz/análise
Granuloma Periapical/metabolismo
Cisto Radicular/química
Fator de Crescimento Transformador beta1/análise
[Mh] Termos MeSH secundário: Adulto
Biópsia
Células Epiteliais/patologia
Feminino
Seres Humanos
Imuno-Histoquímica/métodos
Masculino
Granuloma Periapical/imunologia
Granuloma Periapical/patologia
Cisto Radicular/imunologia
Cisto Radicular/patologia
Índice de Gravidade de Doença
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transforming Growth Factor beta1); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


  3 / 1174 MEDLINE  
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[PMID]:28362997
[Au] Autor:Liang ZZ; Li J; Huang SG
[Ad] Endereço:Department of Dentistry, Faculty of Dentistry, Jinan University, Guangzhou, China.
[Ti] Título:Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
[So] Source:Genet Mol Res;16(1), 2017 Mar 30.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-ß1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to classified standards, namely, healthy control (N = 25), periapical granuloma (N = 25), and periapical cyst (N = 25). The samples were fixed in 10% buffered formalin for more than 48 h, dehydrated, embedded, and stained with hematoxylin and eosin for histopathology. Double immunofluorescence was conducted to analyze the expression of TGF-ß-CD14 double-positive MPs in periapical tissues. The number of double-positive cells (cells/mm ) were significantly higher in the chronic periapical disease tissues (P < 0.01) compared to that in the control tissue; in addition, the density of TGF-ß1-CD14 double positive cells was significantly higher in the periapical cyst group than in the periapical granuloma group (P < 0.01). The number of TGF-ß1 expressing macrophages varied with human chronic periapical diseases. The TGF-ß1-CD14 double-positive cells might play an important role in the pathology of human chronic periapical diseases.
[Mh] Termos MeSH primário: Macrófagos/metabolismo
Doenças Periapicais/metabolismo
Fator de Crescimento Transformador beta1/biossíntese
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Doença Crônica
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças Periapicais/genética
Doenças Periapicais/imunologia
Granuloma Periapical/genética
Granuloma Periapical/imunologia
Granuloma Periapical/metabolismo
Cisto Radicular/genética
Cisto Radicular/metabolismo
Fator de Crescimento Transformador beta1/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transforming Growth Factor beta1)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16019329


  4 / 1174 MEDLINE  
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[PMID]:28341450
[Au] Autor:Segna E; Artoni A; Sacco R; Giannì AB
[Ad] Endereço:Resident, Department of Maxillofacial Surgery and Odontostomatology, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy. Electronic address: elesegna@hotmail.it.
[Ti] Título:Oral Surgery in Patients With Glanzmann Thrombasthenia: A Case Series.
[So] Source:J Oral Maxillofac Surg;75(2):256-259, 2017 Feb.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glanzmann thrombasthenia is a severe defect of platelet function caused by an inherited deficiency or dysfunction of the glycoprotein IIb/IIIa complex, the platelet fibrinogen receptor. Patients with Glanzmann thrombasthenia experience lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis. Surgery is usually very challenging, requiring close cooperation among surgeons, hematologists, and anesthesiologists. For anatomic reasons, oral surgery is particularly difficult owing to the inherent risk of hemorrhage and the difficulty in achieving local hemostasis. In the present report, we describe 3 successful cases of oral surgery in patients with Glanzmann thrombasthenia and report the surgical and hematologic management of each case.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Bucais/efeitos adversos
Trombastenia/complicações
[Mh] Termos MeSH secundário: Adolescente
Perda Sanguínea Cirúrgica/prevenção & controle
Criança
Feminino
Seres Humanos
Masculino
Procedimentos Cirúrgicos Bucais/métodos
Cisto Radicular/complicações
Cisto Radicular/cirurgia
Extração Dentária/efeitos adversos
Extração Dentária/métodos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170419
[Lr] Data última revisão:
170419
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:170326
[St] Status:MEDLINE


  5 / 1174 MEDLINE  
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[PMID]:28302494
[Au] Autor:Gomes NR; Diniz MG; Pereira TD; Estrela C; de Macedo Farias L; de Andrade BA; Gomes CC; Gomez RS
[Ad] Endereço:Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal University de Minas Gerais, Belo Horizonte, Brazil.
[Ti] Título:Actinomyces israelii in radicular cysts: a molecular study.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;123(5):586-590, 2017 May.
[Is] ISSN:2212-4411
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate whether the microscopic filamentous aggregates observed in radicular cysts are associated with the molecular identification of Actinomyces israelii. Moreover, to verify whether this bacterium can be detected in radicular cyst specimens not presenting aggregates. STUDY DESIGN: Microscopic colonies suggestive of Actinomyces were found in 8 out of 279 radicular cyst samples (case group). The case and control groups (n = 12; samples without filamentous colonies) were submitted to the semi-nested polymerase chain reaction to test the presence of A israelii. DNA sequencing was performed to validate polymerase chain reaction results. RESULTS: Two and 3 samples in the case and control groups, respectively, did not present a functional genomic DNA template and were excluded from the study. A israelii was identified in all samples of the case group and in 3 out of 9 samples of the control group. CONCLUSIONS: Although A israelii is more commonly identified in radicular cysts presenting filamentous aggregates, it also appears to be detected in radicular cysts without this microscopic finding.
[Mh] Termos MeSH primário: Actinomyces/isolamento & purificação
Actinomicose/diagnóstico
Cisto Radicular/microbiologia
[Mh] Termos MeSH secundário: Actinomicose/microbiologia
Adolescente
Adulto
Criança
Feminino
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


  6 / 1174 MEDLINE  
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[PMID]:28290616
[Au] Autor:Shen SQ; Wang R; Huang SG
[Ti] Título:Expression of the stem cell factor in fibroblasts, endothelial cells, and macrophages in periapical tissues in human chronic periapical diseases.
[So] Source:Genet Mol Res;16(1), 2017 Mar 08.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Stem cell factor (SCF), an important stem cell cytokine, has multiple functions. Fibroblasts (FBs), mature mast cells, endothelial cells (ECs), and eosinophil granulocytes can produce SCF in the inflammatory process. Therefore, we aimed to observe SCF expression in FBs, ECs, and macrophages (MPs) in periapical tissues in human chronic periapical disease and investigate the effects of cells expressing SCF in pathogenesis of the disease. Healthy (N = 20), periapical cyst (N = 15), and periapical granuloma (N = 15) tissues were fixed in 10% formalin for 48 h, embedded in paraffin, and stained with hematoxylin and eosin to observe histological changes. SCF expression was observed in FBs, ECs, and MPs in periapical tissues by double immunofluorescence. CD334, CD31, and CD14 are specific markers of FBs, ECs, and MPs, respectively. Results showed that densities of CD334-SCF double-positive FBs, CD31-SCF double-positive ECs, and CD14-SCF double-positive MPs were significantly increased in periapical tissue groups (P < 0.01). There were no significant differences in CD334-SCF double-positive FB and CD31-SCF double-positive EC levels between the two periapical tissue groups (P > 0.05). CD14-SCF double-positive MP density was considerably higher in periapical granulomas than in cysts (P < 0.01). FB, EC, and MP levels were significantly high and densities of CD334-SCF double-positive FBs, CD31-SCF double-positive ECs, and CD14-SCF double-positive MPs improved considerably in chronic periapical tissues, suggesting that the cells might be related to occurrence, development, and pathogenesis of chronic periapical disease.
[Mh] Termos MeSH primário: Células Endoteliais/metabolismo
Fibroblastos/metabolismo
Macrófagos/metabolismo
Doenças Periapicais/metabolismo
Tecido Periapical/metabolismo
Fator de Células-Tronco/biossíntese
[Mh] Termos MeSH secundário: Adulto
Idoso
Citocinas/metabolismo
Células Endoteliais/patologia
Feminino
Fibroblastos/patologia
Seres Humanos
Macrófagos/patologia
Masculino
Mastócitos/metabolismo
Mastócitos/patologia
Meia-Idade
Doenças Periapicais/patologia
Granuloma Periapical/metabolismo
Granuloma Periapical/patologia
Tecido Periapical/patologia
Cisto Radicular/metabolismo
Cisto Radicular/patologia
Fator de Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Stem Cell Factor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16019394


  7 / 1174 MEDLINE  
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[PMID]:28153133
[Au] Autor:Bilodeau EA; Collins BM
[Ad] Endereço:Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, G-135 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: Elizabeth.bilodeau@dental.pitt.edu.
[Ti] Título:Odontogenic Cysts and Neoplasms.
[So] Source:Surg Pathol Clin;10(1):177-222, 2017 Mar.
[Is] ISSN:1875-9157
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article reviews a myriad of common and uncommon odontogenic cysts and tumors. The clinical presentation, gross and microscopic features, differential diagnosis, prognosis, and diagnostic pitfalls are addressed for inflammatory cysts (periapical cyst, mandibular infected buccal cyst/paradental cyst), developmental cysts (dentigerous, lateral periodontal, glandular odontogenic, orthokeratinized odontogenic cyst), benign tumors (keratocystic odontogenic tumor, ameloblastoma, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, ameloblastic fibroma and fibroodontoma, odontoma, squamous odontogenic tumor, calcifying cystic odontogenic tumor, primordial odontogenic tumor, central odontogenic fibroma, and odontogenic myxomas), and malignant tumors (clear cell odontogenic carcinoma, ameloblastic carcinoma, ameloblastic fibrosarcoma).
[Mh] Termos MeSH primário: Cistos Odontogênicos/diagnóstico
Tumores Odontogênicos/diagnóstico
[Mh] Termos MeSH secundário: Cisto Dentígero/diagnóstico
Cisto Dentígero/patologia
Diagnóstico Diferencial
Seres Humanos
Cistos Odontogênicos/patologia
Tumores Odontogênicos/patologia
Cisto Periodontal/diagnóstico
Cisto Periodontal/patologia
Prognóstico
Cisto Radicular/diagnóstico
Cisto Radicular/patologia
Radiografia Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


  8 / 1174 MEDLINE  
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[PMID]:27391558
[Au] Autor:Alaeddini M; Eshghyar N; Etemad-Moghadam S
[Ad] Endereço:Dental Research Center, Dentistry Research Institute, Tehran University of Medical Science, Tehran, Iran.
[Ti] Título:Expression of podoplanin and TGF-beta in glandular odontogenic cyst and its comparison with developmental and inflammatory odontogenic cystic lesions.
[So] Source:J Oral Pathol Med;46(1):76-80, 2017 Jan.
[Is] ISSN:1600-0714
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The number of studies investigating the immunohistochemical characteristics of glandular odontogenic cysts (GOCs) is limited, due to its rarity. TGF-beta has been suggested to induce podoplanin expression in some lesions. We aimed to evaluate and compare podoplanin and TGF-beta expression in GOC and other odontogenic cystic lesions. METHODS: A total of 43 samples including five GOCs, 10 dentigerous cysts (DCs), eight unicystic ameloblastoma (UAs), and 20 radicular cysts (RCs) were selected and subjected to immunohistochemical staining using monoclonal antibodies against podoplanin and TGF-beta. Kruskal-Wallis test and Mann-Whitney U-test were used for statistical analysis along with Bonferroni for adjusting P-values (P < 0.05). RESULTS: Podoplanin immunoreactivity was observed in 80%, 70%, and 100% of DCs, RCs, and UAs, respectively, while none of the GOCs were positive for this marker (P = 0.004). Significant differences were only found in the GOC specimens. TGF-beta positivity occurred in the capsule and epithelium of all GOCs and DCs, while RCs and UAs demonstrated different expression percentages in the capsular and epithelial tissues. Epithelial TGF-beta showed significant differences among the studied lesions (P = 0.007) with the main difference found between DCs with RCs and DCs with UAs. CONCLUSIONS: Lack of podoplanin expression might be involved in the characteristic histologic and behavioral features of GOC, which seems to be unrelated to TGF-beta expression.
[Mh] Termos MeSH primário: Doenças Maxilomandibulares/metabolismo
Glicoproteínas de Membrana/metabolismo
Cistos Odontogênicos/metabolismo
Fator de Crescimento Transformador beta/metabolismo
[Mh] Termos MeSH secundário: Ameloblastoma/metabolismo
Ameloblastoma/patologia
Cisto Dentígero/metabolismo
Cisto Dentígero/patologia
Seres Humanos
Neoplasias Maxilomandibulares/metabolismo
Cistos Odontogênicos/patologia
Cisto Radicular/metabolismo
Cisto Radicular/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Glycoproteins); 0 (PDPN protein, human); 0 (Transforming Growth Factor beta)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1111/jop.12475


  9 / 1174 MEDLINE  
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[PMID]:27406247
[Au] Autor:Paduano F; Marrelli M; Palmieri F; Tatullo M
[Ad] Endereço:Tecnologica Research Institute, Biomedical Section, St. E. Fermi, Crotone, Italy.
[Ti] Título:CD146 Expression Influences Periapical Cyst Mesenchymal Stem Cell Properties.
[So] Source:Stem Cell Rev;12(5):592-603, 2016 Oct.
[Is] ISSN:1558-6804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent studies have identified a new human dental derived progenitor cell population with multi-lineage differentiation potential referred to as human periapical cyst mesenchymal stem cells (hPCy-MSCs). In the present study, we compared two subpopulations of hPCy-MSCs characterised by the low or high expression of CD146 to establish whether this expression can regulate their stem cell properties. Using flow cytometry, we evaluated the stem cell marker profile of hPCy-MSCs during passaging. Furthermore, CD146 and CD146 cells were sorted by magnetic beads and subsequently both cell populations were evaluated for differences in their proliferation, self-renewal, stem cell surface markers, stemness genes expression and osteogenic differentiation potential.We found that hPCy-MSCs possessed a stable expression of several mesenchymal stem cell surface markers, whereas CD146 expression declined during passaging.In addition, sorted CD146 cells proliferated significantly faster, displayed higher colony-forming unit-fibroblast capacity and showed higher expression of Klf4 when compared to the CD146 subset. Significantly, the osteogenic potential of hPCy-MSCs was greater in the CD146 than in CD146 population. These results demonstrate that CD146 is spontaneously downregulated with passaging at both mRNA and protein levels and that the high expression of CD146 reduces the proliferative, self-renewal and osteogenic differentiation potential of hPCy-MSCs. In conclusion, our study demonstrates that changes in the expression of CD146 can influence the stem cell properties of hPCy-MSCs.
[Mh] Termos MeSH primário: Células Mesenquimais Estromais/metabolismo
Cisto Radicular/metabolismo
Células-Tronco/metabolismo
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/metabolismo
Antígeno CD146/metabolismo
Diferenciação Celular/fisiologia
Linhagem da Célula/fisiologia
Proliferação Celular/fisiologia
Fibroblastos/metabolismo
Citometria de Fluxo/métodos
Expressão Gênica/fisiologia
Seres Humanos
Osteogênese/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (CD146 Antigen); 0 (MCAM protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160714
[St] Status:MEDLINE


  10 / 1174 MEDLINE  
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[PMID]:27377433
[Au] Autor:von Arx T
[Ad] Endereço:Klinik für Oralchirurgie und Stomatologie, Zahnmedizinische Kliniken der Universität Bern, Bern Switzerland.
[Ti] Título:[Mineral trioxide aggregate (MTA) a success story in apical surgery].
[Ti] Título:Mineral Trioxide Aggregate (MTA) – eine Erfolgsgeschichte in der apikalen Chirurgie..
[So] Source:Swiss Dent J;126(6):573-95, 2016.
[Is] ISSN:2296-6498
[Cp] País de publicação:Switzerland
[La] Idioma:fre; ger
[Ab] Resumo:The objective of apical surgery is to retain teeth with persistent apical pathosis following orthograde root canal treatment if endodontic non-surgical revision is difficult or associated with risks, or is even declined by the patient. Since the most frequent cause of recurrent apical disease is bacterial reinfection from the (remaining) root canal system, the bacteria-tight root-end filling is the most important step in apical surgery. In the early 1990s, mineral trioxide aggregate (MTA) was developed at the Loma Linda University in California/USA. Preclinical studies clearly showed that MTA has a high sealing capability, a good material stability and an excellent biocompatbility. Multiple experimental studies in animals highlighted the mild tissue reactions observed adjacent to this material. Furthermore, histological analysis of the periapical regions demonstrated a frequent deposition of new cementum not only onto the resection plane (cut dentinal surface), but also directly onto MTA. For these reasons, MTA is considered a bioactive material. In 1997 MTA was cleared for clinical use in patients. Multiple prospective clinical and randomized studies have documented high and constant success rates of MTA-treated teeth in apical surgery. A recently published longitudinal study showed that MTA-treated teeth remained stable over five years; hence the high healed rates documented after one year are maintained during long-term observation.
[Mh] Termos MeSH primário: Compostos de Alumínio/administração & dosagem
Compostos de Cálcio/administração & dosagem
Reação a Corpo Estranho/cirurgia
Teste de Materiais
Óxidos/administração & dosagem
Periodontite Periapical/cirurgia
Cisto Radicular/cirurgia
Obturação do Canal Radicular/métodos
Silicatos/administração & dosagem
Ápice Dentário/cirurgia
[Mh] Termos MeSH secundário: Combinação de Medicamentos
Seres Humanos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Calcium Compounds); 0 (Drug Combinations); 0 (Oxides); 0 (Silicates); 0 (mineral trioxide aggregate)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160705
[Lr] Data última revisão:
160705
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE



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