| [PMID]: | 27921286 |
| [Au] Autor: | Abadi P; Johansen A; Godballe C; Gerke O; Høilund-Carlsen PF; Thomassen A |
| [Ad] Endereço: | Department of Nuclear Medicine, Odense University Hospital, Søndre Boulevard 29, 5000, Odense C, Denmark. pey.abadi@gmail.com. |
| [Ti] Título: | F-FDG PET/CT to differentiate malignant necrotic lymph node from benign cystic lesions in the neck. |
| [So] Source: | Ann Nucl Med;31(2):101-108, 2017 Feb. |
| [Is] ISSN: | 1864-6433 |
| [Cp] País de publicação: | Japan |
| [La] Idioma: | eng |
| [Ab] Resumo: | OBJECTIVE: Patients presenting with cystic lesions in the neck without obvious signs of malignancy constitute a diagnostic challenge since fine needle aspiration is often insufficient and a diagnosis may not be reached until surgical resection/biopsy is performed. The differential diagnosis of a cystic cervical mass comprises a variety of benign conditions, but malignancy must be ruled out. We examined the diagnostic performance of fluorine-18 fluorodeoxyglucose ( F-FDG) PET/CT to identify malignancy. METHODS: We retrospectively included consecutive patients referred from the Department of ENT Head and Neck Surgery for F-FDG PET/CT-scans because of a solitary neck cyst. Scan results were compared to histopathology and follow-up. RESULTS: The study comprised 58 patients. Twenty patients (34%) were diagnosed with cancer during follow-up. PET/CT suggested malignancy in 34 patients (19 true positive, 15 false positive) and showed no malignancy in 24 (23 true negative, 1 false negative). The sensitivity, specificity, accuracy, positive and negative predictive values were 95% (76-99%), 61% (45-74%), 72% (60-82%), 56% (39-71%), and 96% (80-99%), respectively (95% confidence intervals in brackets). The primary tumor was identified in 14 out of the 20 patients with confirmed cancer. Increased metabolism, as evaluated by PET, was the only imaging characteristic among several others, which associated independently with malignancy in the cystic neck lesions, odds ratio 1.27 (1.07-1.50), p = 0.006. CONCLUSION: F-FDG PET/CT could reliably rule out malignancy (NPV 96%), albeit with a high frequency of false positive scans, requiring further diagnostic work-up. Increased metabolism was the best imaging parameter to differentiate between malignant and benign lesions. |
| [Mh] Termos MeSH primário: |
Fluordesoxiglucose F18
Linfonodos/diagnóstico por imagem
Linfocele/diagnóstico por imagem
Linfoma/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos
|
| [Mh] Termos MeSH secundário: |
Adulto
Idoso
Idoso de 80 Anos ou mais
Diagnóstico Diferencial
Feminino
Seguimentos
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Linfonodos/patologia
Linfocele/patologia
Linfoma/patologia
Masculino
Meia-Idade
Necrose
Estudos Retrospectivos
Sensibilidade e Especificidade
Adulto Jovem
|
| [Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18) |
| [Em] Mês de entrada: | 1702 |
| [Cu] Atualização por classe: | 170206 |
[Lr] Data última revisão:
| 170206 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 161207 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1007/s12149-016-1142-3 |
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