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[PMID]:29368477
[Au] Autor:Miller MJ; Soberano; Tallaksen R
[Ti] Título:Endobronchial Hamartoma Causing Postobstructive Pneumonia.
[So] Source:W V Med J;112(5):38-9, 2016 Sep-Oct.
[Is] ISSN:0043-3284
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The current case highlights an uncommon cause of recurrent pneumonia. A 76 year old female presented to her primary care physician multiple times with recurrent left lower lobe pneumonia. After multiple chest radiographs continued to show no improvement despite antibiotics, a CT of the chest was performed and showed an intraluminal lesion in the left lower lobe bronchus. An endoscopic biopsy was performed and showed the lesion to be a hamartoma. The patient subsequently underwent resection of the lesion and her symptoms resolved. This case illustrates the need for further diagnostic testing when recurrent pneumonia presents with the same lobar distribution.
[Mh] Termos MeSH primário: Broncopatias/diagnóstico
Hamartoma/diagnóstico
Pneumonia/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Biópsia
Broncopatias/complicações
Broncopatias/cirurgia
Broncoscopia
Diagnóstico Diferencial
Feminino
Hamartoma/complicações
Seres Humanos
Pneumonia/etiologia
Recidiva
Tomografia Computadorizada por Raios X
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29227064
[Au] Autor:Usagawa Y; Mitoma C; Ito T; Ito S; Kiryu H; Uchi H; Furue M
[Ti] Título:A case of Basaloid Follicular Hamartoma.
[So] Source:Fukuoka Igaku Zasshi;107(8):155-60, 2016 08.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:We here describe a case of solitary basaloid follicular hamartoma (BFH) : the case developing in company with senile lentigo on the nose. BFH is a relatively rare benign follicular neoplasm of undetermined etiology. Histologically, the specimen consisted of small-sized squamoid or basaloid cells and follicular germ-like cells in the periphery of the tumor nests. There were no infundibular cysts. BFH should be differentiated from infundibulocystic basal cell carcinoma (BCC), which consists of squamoid or basaloid cells in company with infundibular cysts, tumor of follicular infundibulum or trichoepithelioma. We analyzed the immunohistochemical findings of the case in comparison with those of BCC and trichoepithelioma. An immunohistochemical examination revealed 1) that Bcl-2 and CD10 was preferentially expressed in the outermost cells in the tumor nests consisting of follicular germ-like cells, 2) that most of the tumor cells, especially germ-like cells, were strongly positive for Ber-EP4, and 3) that peritumoral stroma was positive for CD34. The immunohistochemical findings of our cases supported that BFH should be differentiated from BCC, a common malignant neoplasm.
[Mh] Termos MeSH primário: Hamartoma
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Imuno-Histoquímica
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; ENGLISH ABSTRACT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:29245328
[Au] Autor:Chen SS; Zhou H; Tong B; Yu LL; Fan SS; Xiao ZK
[Ad] Endereço:aDepartment of Respiratory and Critical Care Medicine, Jiangxi Provincial People's HospitalbDepartment of Cardiology, the Second Affiliated Hospital of Nanchang UniversitycDepartment of Pathology, Jiangxi Provincial People's Hospital, Nanchang, China.
[Ti] Título:Endobronchial hamartoma mimicking malignant lung tumor contralateral endobronchial metastasis: A case report.
[So] Source:Medicine (Baltimore);96(49):e9085, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Endobronchial hamartoma, the most common benign lung tumor, is located in the bronchus, and it easily mimics lung cancer or bronchial metastasis. Endobronchial hamartoma can cause coughing, hemoptysis, and pulmonary infection; thus, it should be treated right away by surgery or fiberoptic bronchoscopy. PATIENT CONCERNS: We report a rare case of endobronchial hamartoma in which the clinical symptoms and imaging overlapped strongly with malignant lung tumor contralateral endobronchial metastasis. DIAGNOSES: Endobronchial hamartoma coexisting with a malignant lung tumor. INTERVENTIONS: Fiberoptic bronchoscopy was conducted, and the pathologic diagnosis was hamartoma. A second fiberoptic bronchoscopy was conducted, and fine-needle aspiration cytology of the enlarged lymph nodes indicated squamous cell carcinoma. OUTCOMES: The clinical symptoms were relieved, and the treatment options were docetaxel, cis-dichlorodiamineplatinum, and endostatin. LESSONS: Fiberoptic bronchoscopy needs to be guided by imaging and can be considered an effective method for the diagnosis of endobronchial hamartoma.
[Mh] Termos MeSH primário: Broncopatias/diagnóstico
Carcinoma de Células Escamosas/diagnóstico
Hamartoma/diagnóstico
Neoplasias Pulmonares/diagnóstico
Neoplasias Primárias Múltiplas/diagnóstico
[Mh] Termos MeSH secundário: Biópsia por Agulha Fina
Broncopatias/patologia
Broncoscopia
Carcinoma de Células Escamosas/patologia
Diagnóstico Diferencial
Hamartoma/patologia
Seres Humanos
Neoplasias Pulmonares/patologia
Masculino
Meia-Idade
Neoplasias Primárias Múltiplas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009085


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[PMID]:29277811
[Au] Autor:Ponti G; Manfredini M; Pastorino L; Maccaferri M; Tomasi A; Pellacani G
[Ad] Endereço:Clinical Pathology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy giovanni.ponti@unimore.it.
[Ti] Título: Germline Mutations and the Basaloid Follicular Hamartoma Values in the Tumor Spectrum of Basal Cell Carcinoma Syndrome (NBCCS).
[So] Source:Anticancer Res;38(1):471-476, 2018 01.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominantly inherited disorder characterized by multiple basal cell carcinomas (BCC), odontogenic tumors and various skeletal anomalies. Basaloid follicular hamartomas (BFHs) constitute rare neoplasms that can be detected in sporadic and familial settings as in the Basaloid Follicular Hamartoma Syndrome (BFHS). Although BFHS shares clinical, histopathological and genetic overlapping with the NBCCS, they are still considered two distinctive entities. The aim of our single-institution study was the analysis of a cohort of PTCH1-mutated patients in order to define clinical and biomolecular relationship between NBCCS and BFHs. MATERIALS AND METHODS: In our study we evaluated PTCH1 gene-carrier probands affected by NBCCS to detect the incidence of BFHs and their correlation with this rare syndrome. RESULTS: Among probands we recognized 4 patients with BFHs. We found 15 germline PTCH1 mutations, uniformly distributed across the PTCH1 gene. Six of them had familial history of NBCCS, two of them were novel and have not been described previously. CONCLUSION: NBCCS and BFHS may be the same genetic entity and not two distinctive syndromes. The inclusion of BFH in the NBCCS cutaneous tumor spectrum might be useful for the recognition of misdiagnosed NBCCS cases that could benefit from tailored surveillance strategies.
[Mh] Termos MeSH primário: Síndrome do Nevo Basocelular/genética
Folículo Piloso/anormalidades
Hamartoma/genética
Receptor Patched-1/genética
Dermatopatias Genéticas/genética
Neoplasias Cutâneas/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Síndrome do Nevo Basocelular/diagnóstico
Síndrome do Nevo Basocelular/patologia
Feminino
Mutação em Linhagem Germinativa/genética
Folículo Piloso/patologia
Hamartoma/diagnóstico
Hamartoma/patologia
Seres Humanos
Masculino
Meia-Idade
Dermatopatias Genéticas/diagnóstico
Dermatopatias Genéticas/patologia
Neoplasias Cutâneas/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PTCH protein, human); 0 (Patched-1 Receptor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


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[PMID]:29245215
[Au] Autor:Zou BC; Wang FF; Zhao G; Lu XL; Zhang L; Zhao P; Shi HT; Qin B; Guo XD; Zhang J
[Ad] Endereço:aDepartment of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinabDepartment of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi, China.
[Ti] Título:A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach: Case report.
[So] Source:Medicine (Baltimore);96(49):e8466, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A solitary Peutz-Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach. PATIENT CONCERNS: A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. A gastroscopy showed a giant and extensive bulging lesion on the greater curvature and posterior and anterior walls of the gastric antrum, involving three-quarters of the gastric wall. Endoscopic ultrasonography showed a muscularis mucosa lesion. DIAGNOSES: A solitary Peutz-Jeghers-type polyp in the antrum of stomach. INTERVENTIONS: The patient underwent an endoscopic submucosal dissection (ESD). OUTCOMES: The patient recovered quickly, without any complications. LESSONS: This is the second largest gastric solitary Peutz-Jeghers-polyp reported until now, and the largest gastric solitary Peutz-Jeghers type-polyp treated by endoscope.
[Mh] Termos MeSH primário: Hamartoma/diagnóstico por imagem
Síndrome de Peutz-Jeghers/diagnóstico por imagem
Pólipos/diagnóstico por imagem
Neoplasias Gástricas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Hamartoma/patologia
Seres Humanos
Masculino
Meia-Idade
Síndrome de Peutz-Jeghers/patologia
Pólipos/patologia
Antro Pilórico/diagnóstico por imagem
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008466


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[PMID]:28463619
[Au] Autor:Brandmeir NJ; Sather MD
[Ad] Endereço:Penn State Health, Milton S. Hershey Medical Center, Hershey, PA.
[Ti] Título:Letter to the Editor. Stereotactic laser ablation for hypothalamic hamartomas after SRS failure.
[So] Source:Neurosurg Focus;42(5):E18, 2017 05.
[Is] ISSN:1092-0684
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hamartoma/cirurgia
Doenças Hipotalâmicas/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Terapia a Laser
Radiocirurgia
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.3171/2016.11.FOCUS16426


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[PMID]:29072946
[Au] Autor:Stanoszek LM; Wang GY; Harms PW
[Ad] Endereço:From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
[Ti] Título:Histologic Mimics of Basal Cell Carcinoma.
[So] Source:Arch Pathol Lab Med;141(11):1490-1502, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. OBJECTIVE: - To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. DATA SOURCES: - Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. CONCLUSIONS: - In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.
[Mh] Termos MeSH primário: Carcinoma Basocelular/diagnóstico
Neoplasias Cutâneas/diagnóstico
Pele/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/diagnóstico
Adenocarcinoma Sebáceo/imunologia
Adenocarcinoma Sebáceo/metabolismo
Adenocarcinoma Sebáceo/patologia
Biomarcadores Tumorais/metabolismo
Carcinoma Basocelular/imunologia
Carcinoma Basocelular/metabolismo
Carcinoma Basocelular/patologia
Diagnóstico Diferencial
Hamartoma/diagnóstico
Hamartoma/imunologia
Hamartoma/metabolismo
Hamartoma/patologia
Histiocitoma Fibroso Benigno/diagnóstico
Histiocitoma Fibroso Benigno/imunologia
Histiocitoma Fibroso Benigno/metabolismo
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
Imuno-Histoquímica/tendências
Imunofenotipagem/tendências
Pele/imunologia
Pele/metabolismo
Neoplasias Cutâneas/imunologia
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0222-RA


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[PMID]:28984778
[Au] Autor:Xiang Z; Ai Z; Zhong G; Deng Y; Malhi H; Palmer S; Zee C
[Ad] Endereço:aDepartment of Radiology, Panyu Central Hospital of Guangzhou, Guangzhou, P.R. China bDepartment of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China cDepartment of Radiology, Keck Medical Center of USC, Los Angeles, CA.
[Ti] Título:Diagnostic value of using multiplanar reformation images: Case report for rare endotracheal hamartomas.
[So] Source:Medicine (Baltimore);96(40):e8231, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Pulmonary hamartomas are the most common benign tumor of the lung. Two types of pathologically similar hamartomas exist based on their location. These tumors have a low incidence, are rarely reported and frequently misdiagnosed because of lack of familiarity and/or understanding concerning their imaging features. PATIENT CONCERNS: Seventeen patients received treatment between June 2007 and May 2013 and had complete medical records. All of them had different degrees of cough and expectoration. Other symptoms include fever (5 cases), hemoptysis (4 cases), chest pain (3 cases), shortness of breath (2 cases), and dyspnea (1 case). DIAGNOSES: These patients all have pathologically confirmed, and informed the diagnosis of endobronchial hamartoma. INTERVENTIONS: Unenhanced and enhanced CT scans were performed using Toshiba Aquilion 64-slice and GE Lightspeed 64-slice CT scanners. The scan was performed from the superior thoracic aperture to the lateral costophrenic angle. The transaxial CT data was inserted into a Volume Wizard workstation to reconstruct images using MPR technique. OUTCOMES: The relationship between the location of the tumor and bronchi was clearly displayed on the axial images in only 2 patients. In all 17 patients, reconstructed MPR images were able to display the tumor parallel to the long axis of bronchi, thus facilitating in tumor identification and positioning along the bronchial tree. LESSONS: MPR images are valuable tools in the diagnosis of endobronchial hamartomas. Chiefly, these reconstructions aid in the detection of intratumoral fat/calcification and clearly demonstrate the tumors relationship and effect with the adjacent bronchi.
[Mh] Termos MeSH primário: Broncopatias/diagnóstico por imagem
Hamartoma/diagnóstico por imagem
Processamento de Imagem Assistida por Computador/métodos
Tomografia Computadorizada por Raios X/métodos
Doenças da Traqueia/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Brônquios/diagnóstico por imagem
Broncopatias/complicações
Dor no Peito/diagnóstico por imagem
Dor no Peito/etiologia
Tosse/diagnóstico por imagem
Tosse/etiologia
Dispneia/diagnóstico por imagem
Dispneia/etiologia
Feminino
Hamartoma/complicações
Hemoptise/diagnóstico por imagem
Hemoptise/etiologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Traqueia/diagnóstico por imagem
Doenças da Traqueia/complicações
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008231


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[PMID]:28979620
[Au] Autor:Abaloun Y; Ajhoun Y
[Ad] Endereço:Université Mohammed V Souissi, Service d'Ophtalmologie de l'Hôpital Militaire Mohamed V, Hay Riad, Rabat, Maroc.
[Ti] Título:[Lisch nodule in neurofibromatosis type 1].
[Ti] Título:Nodules de lisch dans la neurofibromatose type 1..
[So] Source:Pan Afr Med J;27:218, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Neurofibromatosis type 1 (NF1) or Von Recklinghausen disease manifests as cutaneous café-au-lait spots and neurofibromas. It is one of the most common autosomal dominant genetic diseases. It is extremely variable in its individual manifestation. Cutaneous and neurologic symptoms are the most common manifestations but it can also affect other organs including eyes, bones and other areas. Lisch nodules are the most common ocular manifestations in NF-1. They are asymptomatic small pigmented iris tumors (iris hamartomas) which can help suggest the diagnosis of NF1 as they are characteristic of this disease and mostly occur in adult patients. We report the case of a 45-year old female patient followed for a neurofibromatosis type 1 retained on the presence of multiple cutaneous café-au-lait spots and neurofibromas. Ophthalmologic examination showed visual acuity of 10/10 P3 in both eyes. Biomicroscopic examination showed Lisch nodules of the iris in both eyes (A,B).
[Mh] Termos MeSH primário: Manchas Café com Leite/etiologia
Hamartoma/etiologia
Doenças da Íris/etiologia
Neurofibromatose 1/complicações
[Mh] Termos MeSH secundário: Manchas Café com Leite/patologia
Feminino
Hamartoma/patologia
Seres Humanos
Doenças da Íris/patologia
Meia-Idade
Neurofibroma/etiologia
Neurofibroma/patologia
Neurofibromatose 1/fisiopatologia
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.218.11517


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[PMID]:28792868
[Au] Autor:Shah U; Goldstein AM; Gee MS; Deshpande V
[Ad] Endereço:From the Departments of Pediatrics (U.S.), Pediatric Surgery (A.M.G.), Radiology (M.S.G.), and Pathology (V.D.), Massachusetts General Hospital, and the Departments of Pediatrics (U.S.), Surgery (A.M.G.), Radiology (M.S.G.), and Pathology (V.D.), Harvard Medical School - both in Boston.
[Ti] Título:Case 24-2017. An 8-Month-Old Girl with Fever and an Abdominal Mass.
[So] Source:N Engl J Med;377(6):574-582, 2017 Aug 10.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Abdome/patologia
Cistos/diagnóstico por imagem
Hamartoma/congênito
Pâncreas/patologia
Pancreatopatias/congênito
[Mh] Termos MeSH secundário: Abdome/diagnóstico por imagem
Diagnóstico Diferencial
Drenagem
Feminino
Febre/etiologia
Hamartoma/complicações
Hamartoma/diagnóstico
Seres Humanos
Lactente
Pancreatopatias/complicações
Pancreatopatias/diagnóstico
Radiografia
Staphylococcus aureus/isolamento & purificação
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1616393



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