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[PMID]:29429163
[Au] Autor:Wu YL; Wu F; Yang L; Sun H; Yan XC; Duan GJ
[Ad] Endereço:Department of Pathology, the First Affiliated Hospital, Army Medical University (Third Military Medical University), PLA, Chongqing 400038, China.
[Ti] Título:[Clinicopathologic features and prognosis of inflammatory pseudotumor-like follicular dendritic cell sarcomas in liver and spleen: an analysis of seven cases].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):114-118, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathological features and prognostic parameters of the inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) of liver and spleen. Ninteen cases of inflammatory pseudotumor (IPT) and 5 cases of IPT-like FDCS of the liver and spleen were collected at the First Affiliated Hospital, Army Medical University from 2006 to 2016. HE sections, immunohistochemical staining, and Epstein-Barr virus encoded nuclear RNA (EBER) in situ hybridization were reviewed along with a summary of the literature. Among the previously diagnosed 19 cases of IPT of the liver and spleen, 2 cases were misdiagnosed (the ratio of 2/19). Among 7 new cases including 3 males and 4 females, 3 cases involved the liver and 4 cases involved the spleen. The age range was 37-64 years (mean 53 years). The maximum tumor diameter ranged from 3.0 to 11.0 cm (mean 6.5 cm). Surgical resections were performed in all patients with follow-up time ranging from 3 to 84 months.All patients were disease-free.7 new cases were all positive for EBER, and showed the expression of at least one of the FDC markers, including CD21, CD23, and CD35. The rest of 17 cases of IPT were all negative for EBER and essentially negative for FDC markers, but were all positive for SMA. IPT-like FDCS of the liver and spleen is a rare low-grade malignant tumor morphologically mimicking inflammatory pseudotumor, and is easy to be misdiagnosis due to under-recognition. EBER in situ hybridization and FDC markers are indispensable for confirming the diagnosis.
[Mh] Termos MeSH primário: Granuloma de Células Plasmáticas/patologia
Hepatopatias/patologia
Esplenopatias/patologia
[Mh] Termos MeSH secundário: Adulto
Sarcoma de Células Dendríticas Foliculares/patologia
Feminino
Herpesvirus Humano 4/genética
Seres Humanos
Hibridização In Situ
Masculino
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.007


  2 / 150 MEDLINE  
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[PMID]:28767565
[Au] Autor:Chang YC; Chau IY; Yeh YC; Chau GY
[Ad] Endereço:aSchool of Medicine, National Yang-Ming University, Taipei, Taiwan bPoznan University of Medical Science Medical Faculty II, Poznan, Poland cDivision of General Surgery, Department of Surgery dDepartment of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan.
[Ti] Título:Small intestine follicular dendritic cell sarcoma with liver metastasis: A case report.
[So] Source:Medicine (Baltimore);96(31):e7261, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Follicular dendritic cell sarcoma (FDCS) is a rare neoplasia composed of spindle or oval cells with follicular dendritic cell differentiation, usually occurring in lymphoid tissue. In this report, we present a case of FDCS of the small intestine with liver metastasis. PATIENT CONCERNS: A 19-year-old female presented with recent onset of left upper abdominal pain. Abdominal computed tomography scan showed a large tumor mass in the liver lateral segment with compression to the pancreas upper part, and a smaller mass in the terminal ileum, respectively. High serum levels of amylase and lipase were noted. Resection of the tumors was performed. Microscopically, both tumors consisted of ovoid to spindle-shaped nuclei cells admixed with some lymphocytes arranged in fascicles, whorls, storiform arrays. Immunohistochemistry demonstrated that the tumor cells were positive for follicular dendritic cell markers, including CD21, CD23, and CD35. Epstein-Barr virus encoding small RNA (EBER; Inform EBER probe; Ventana Medical Systems, Tucson, AZ) in situ hybridization was negative. DIAGNOSES: According to the clinicopathological features, diagnosis of FDCS of intestinal origin was made. INTERVENTIONS: Resection of tumors located in the liver and at the small intestine was performed. After the operation, patient received adjuvant vinblastin chemotherapy. OUTCOMES: There was no evidence of recurrence at 8-month follow-up. LESSONS: It was unusual for FDCS of intestinal origin with liver metastasis and expressing with high serum levels of pancreatic enzymes.
[Mh] Termos MeSH primário: Sarcoma de Células Dendríticas Foliculares/diagnóstico
Sarcoma de Células Dendríticas Foliculares/patologia
Neoplasias Intestinais/diagnóstico
Neoplasias Intestinais/patologia
Neoplasias Hepáticas/diagnóstico
Neoplasias Hepáticas/secundário
[Mh] Termos MeSH secundário: Sarcoma de Células Dendríticas Foliculares/tratamento farmacológico
Sarcoma de Células Dendríticas Foliculares/cirurgia
Diagnóstico Diferencial
Feminino
Seres Humanos
Neoplasias Intestinais/tratamento farmacológico
Neoplasias Intestinais/cirurgia
Intestino Delgado/patologia
Intestino Delgado/cirurgia
Fígado/patologia
Fígado/cirurgia
Neoplasias Hepáticas/tratamento farmacológico
Neoplasias Hepáticas/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007261


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[PMID]:28554574
[Au] Autor:Zhang L; Yang C; Lewis JS; El-Mofty SK; Chernock RD
[Ad] Endereço:Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
[Ti] Título:p16 expression in follicular dendritic cell sarcoma: a potential mimicker of human papillomavirus-related oropharyngeal squamous cell carcinoma.
[So] Source:Hum Pathol;66:40-47, 2017 Aug.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm that most commonly occurs in cervical lymph nodes. It has histologic and clinical overlap with the much more common p16-positive human papillomavirus (HPV)-related squamous cell carcinoma of the oropharynx, which characteristically has nonkeratinizing morphology and often presents as an isolated neck mass. Not surprisingly, follicular dendritic cell sarcomas are commonly misdiagnosed as squamous cell carcinoma. Immunohistochemistry is helpful in separating the 2 entities. Follicular dendritic cell sarcoma expresses dendritic markers such as CD21 and CD23 and is almost always cytokeratin negative. However, in many cases of HPV-related oropharyngeal carcinoma, only p16 immunohistochemistry as a prognostic and surrogate marker for HPV is performed. p16 expression in follicular dendritic cell sarcoma has not been characterized. Here, we investigate the expression of p16 in follicular dendritic cell sarcoma and correlate it with retinoblastoma protein expression. A pilot study of dendritic marker expression in HPV-related oropharyngeal squamous cell carcinoma was also performed. We found that 4 of 8 sarcomas expressed p16 with strong and diffuse staining in 2 cases. In 2 of the 4 cases, p16 expression corresponded to loss of retinoblastoma protein expression. Dendritic marker expression (CD21 and CD23) was not found in HPV-related oropharyngeal squamous cell carcinomas. As such, positive p16 immunohistochemistry cannot be used as supportive evidence for the diagnosis of squamous cell carcinoma as strong and diffuse p16 expression may also occur in follicular dendritic cell sarcoma. Cytokeratins and dendritic markers are critical in separating the two tumor types.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Carcinoma de Células Escamosas/química
Inibidor p16 de Quinase Dependente de Ciclina/análise
Sarcoma de Células Dendríticas Foliculares/metabolismo
Neoplasias de Cabeça e Pescoço/química
Neoplasias Orofaríngeas/química
Infecções por Papillomavirus/metabolismo
[Mh] Termos MeSH secundário: Adulto
Carcinoma de Células Escamosas/patologia
Carcinoma de Células Escamosas/virologia
Sarcoma de Células Dendríticas Foliculares/patologia
Diagnóstico Diferencial
Feminino
Neoplasias de Cabeça e Pescoço/patologia
Neoplasias de Cabeça e Pescoço/virologia
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Missouri
Neoplasias Orofaríngeas/patologia
Neoplasias Orofaríngeas/virologia
Infecções por Papillomavirus/patologia
Infecções por Papillomavirus/virologia
Projetos Piloto
Valor Preditivo dos Testes
Receptores de Complemento 3d/análise
Receptores de IgE/análise
Proteína do Retinoblastoma/análise
Tennessee
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Cyclin-Dependent Kinase Inhibitor p16); 0 (P16 protein, human); 0 (Receptors, Complement 3d); 0 (Receptors, IgE); 0 (Retinoblastoma Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28447898
[Au] Autor:Van Baeten C; Van Dorpe J
[Ti] Título:Splenic Epstein-Barr Virus-Associated Inflammatory Pseudotumor.
[So] Source:Arch Pathol Lab Med;141(5):722-727, 2017 May.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Splenic inflammatory pseudotumor (IPT) is an uncommon lesion with an inflammatory morphologic aspect that often poses a diagnostic challenge. The etiology of IPT can be infectious, autoimmune, reactive, or neoplastic. Splenic Epstein-Barr virus (EBV)-associated IPTs form a subset of splenic IPTs in which there is a spindle cell component infected by EBV. The best characterized and most frequent subgroup of splenic EBV-associated IPT is IPT-like follicular dendritic cell tumor. This review also focusses on EBV-associated splenic IPTs without follicular dendritic cell marker expression. These lesions are less well characterized, making the differential diagnosis with other splenic lesions even more difficult. Recently, increased numbers of immunoglobulin G4-positive plasma cells and the presence of numerous granulomas have been reported in EBV-associated IPTs, and this can add to the difficulties in recognizing the neoplastic nature of these lesions. Herein, we also review the epidemiology, clinical features, histologic morphology, immunohistochemistry, electron microscopy, and pathogenesis of EBV-associated IPTs.
[Mh] Termos MeSH primário: Sarcoma de Células Dendríticas Foliculares
Granuloma de Células Plasmáticas
Herpesvirus Humano 4/fisiologia
Esplenopatias
[Mh] Termos MeSH secundário: Sarcoma de Células Dendríticas Foliculares/diagnóstico
Sarcoma de Células Dendríticas Foliculares/epidemiologia
Sarcoma de Células Dendríticas Foliculares/patologia
Sarcoma de Células Dendríticas Foliculares/virologia
Granuloma de Células Plasmáticas/diagnóstico
Granuloma de Células Plasmáticas/epidemiologia
Granuloma de Células Plasmáticas/patologia
Granuloma de Células Plasmáticas/virologia
Seres Humanos
Baço/patologia
Baço/virologia
Esplenopatias/diagnóstico
Esplenopatias/epidemiologia
Esplenopatias/patologia
Esplenopatias/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0283-RS


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[PMID]:28382648
[Au] Autor:Jain P; Milgrom SA; Patel KP; Nastoupil L; Fayad L; Wang M; Pinnix CC; Dabaja BS; Smith GL; Yu J; Hu S; Bueso Ramos CE; Kanagal-Shamanna R; Medeiros LJ; Oki Y; Fowler N
[Ad] Endereço:Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX, USA.
[Ti] Título:Characteristics, management, and outcomes of patients with follicular dendritic cell sarcoma.
[So] Source:Br J Haematol;178(3):403-412, 2017 Aug.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dendritic cell sarcomas are rare tumours of antigen presenting cells. Data regarding their biology, management and outcomes are sparse. We analysed 66 patients with follicular dendritic cell sarcoma (FDCS). Six patients also had Castleman disease, 9 had another malignancy and 13 had an autoimmune disease. Fifty-four per cent of patients presented with localized disease and 46% with systemic involvement. The median progression-free (PFS) and overall survival (OS) following frontline therapy was 21 and 50 months, respectively. Survival outcomes were significantly inferior in patients with extranodal, bulky or intra-abdominal disease at presentation. Stage was not associated with survival. Management approaches were heterogeneous. Patients who underwent an upfront gross total resection (GTR) experienced better PFS and OS (both P < 0·0001). In patients who underwent a GTR, consolidative radiotherapy was associated with improved local control (P = 0·03), PFS (P = 0·04) and OS (P = 0·05). In patients with measureable disease, gemcitabine with a taxane yielded an overall response rate of 80%. The pattern of relapse was predominantly locoregional. Salvage rates after recurrence were poor. Studies are underway at our institution to define the genomic profile in FDCS and identify potential novel therapeutic targets.
[Mh] Termos MeSH primário: Sarcoma de Células Dendríticas Foliculares/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Terapia Combinada
Sarcoma de Células Dendríticas Foliculares/patologia
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Estadiamento de Neoplasias
Radioterapia/métodos
Recidiva
Terapia de Salvação
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.14672


  6 / 150 MEDLINE  
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[PMID]:28353378
[Au] Autor:Chen T; Gopal P
[Ti] Título:Follicular Dendritic Cell Sarcoma.
[So] Source:Arch Pathol Lab Med;141(4):596-599, 2017 Apr.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Follicular dendritic cell sarcoma is a rare tumor that typically arises within lymph nodes but can also occur extranodally. It is important to have a high index of suspicion, so follicular dendritic cell sarcoma is included in the differential diagnosis of a spindle cell neoplasm in the appropriate clinical and morphologic settings. When included in the differential diagnosis, immunohistochemistry is generally sufficient to substantiate the diagnosis of follicular dendritic cell sarcoma. In this review, we discuss the clinicopathologic features of follicular dendritic cell sarcoma, recent molecular and cytogenetic findings, prognosis, and current approaches to treatment.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Sarcoma de Células Dendríticas Foliculares/diagnóstico
Sarcoma de Células Dendríticas Foliculares/metabolismo
Imuno-Histoquímica/métodos
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/genética
Sarcoma de Células Dendríticas Foliculares/genética
Diagnóstico Diferencial
Predisposição Genética para Doença/genética
Seres Humanos
Mutação
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0126-RS


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[PMID]:28145886
[Au] Autor:Lorenzi L; Döring C; Rausch T; Benes V; Lonardi S; Bugatti M; Campo E; Cabeçadas J; Simonitsch-Klupp I; Borges A; Mehta J; Agostinelli C; Pileri SA; Facchetti F; Hansmann ML; Hartmann S
[Ad] Endereço:Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
[Ti] Título:Identification of novel follicular dendritic cell sarcoma markers, FDCSP and SRGN, by whole transcriptome sequencing.
[So] Source:Oncotarget;8(10):16463-16472, 2017 Mar 07.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Follicular dendritic cell (FDC)-sarcoma is a rare neoplasm with morphologic and phenotypic features of FDCs. It shows an extremely heterogeneous morphology, therefore, its diagnosis relys on the phenotype of tumor cells. Aim of the present study was the identification of new specific markers for FDC-sarcoma by whole transcriptome sequencing (WTS). Candidate markers were selected based on gene expression level and biological function. Immunohistochemistry was performed on reactive tonsils, on 22 cases of FDC-sarcomas and 214 control cases including 114 carcinomas, 87 soft tissue tumors, 5 melanomas, 5 thymomas and 3 interdigitating dendritic cell sarcomas. FDC secreted protein (FDCSP) and Serglycin (SRGN) proved to be specific markers of FDC and related tumor. They showed better specificity and sensitivity values than some well known markers used in FDC sarcoma diagnosis (specificity: 98.6%, and 100%, respectively; sensitivity: 72.73% and 68.18%, respectively). In our cohorts CXCL13, CD21, CD35, FDCSP and SRGN were the best markers for FDC-sarcoma diagnosis and could discriminate 21/22 FDC sarcomas from other mesenchymal tumors by linear discriminant analysis. In summary, by WTS we identified two novel FDC markers and by the analysis of a wide cohort of cases and controls we propose an efficient marker panel for the diagnosis of this rare and enigmatic tumor.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Sarcoma de Células Dendríticas Foliculares/genética
Proteínas/genética
Proteoglicanas/genética
Proteínas de Transporte Vesicular/genética
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/metabolismo
Sarcoma de Células Dendríticas Foliculares/metabolismo
Sarcoma de Células Dendríticas Foliculares/patologia
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Proteínas/metabolismo
Proteoglicanas/metabolismo
Análise Serial de Tecidos
Transcriptoma
Proteínas de Transporte Vesicular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (FDCSP protein, human); 0 (Proteins); 0 (Proteoglycans); 0 (Vesicular Transport Proteins); 0 (serglycin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.14864


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[PMID]:27299190
[Au] Autor:Kazemimood R; Saei Hamedani F; Sharif A; Gaitonde S; Wiley E; Giulianotti PC; Groth JV
[Ad] Endereço:Departments of *Pathology †Surgery, University of Illinois Hospital and Health Science System, Chicago, IL.
[Ti] Título:A Rare Case of Epstein-Barr Virus Negative Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Presenting as a Solitary Colonic Mass in a 53-Year-Old Woman; Case Report and Review of Literature.
[So] Source:Appl Immunohistochem Mol Morphol;25(5):e30-e33, 2017 May/Jun.
[Is] ISSN:1533-4058
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Follicular dendritic cell (FDC) sarcoma is a rare neoplasm that occurs predominantly in lymph nodes. One third of FDC sarcomas happens in extranodal sites. There are 2 morphologic variants of this tumor: conventional and inflammatory pseudotumor (IPT)-like. IPT-like FDC sarcomas are reported mostly in females and usually involve the spleen and liver. In all cases of IPT-like FDC sarcoma the Epstein-Barr virus (EBV) was positive by in situ hybridization except one instance. We report a case of 53-year-old woman who presented with abdominal discomfort. Colonoscopy identified a sessile polypoid mass. Microscopically, there was a prominent lymphoplasmacytic infiltrate. Interspersed among the reactive lymphoid cells were large, pleomorphic stromal cells with marked atypia, irregular and multilobed nuclei, and hyperchromatic smudged chromatin. Immunohistochemical studies demonstrated the atypical stromal cells to be strongly positive for CD10 and D2-40, but negative for CD21, CD23, Clusterin, and epidermal growth factor receptor. EBV-encoded mRNA was negative. A diagnosis of IPT-like FDC sarcoma was rendered. To our knowledge, this is the second case of EBV-negative IPT-like FDC sarcoma reported so far in the literature.
[Mh] Termos MeSH primário: Neoplasias do Colo/diagnóstico
Neoplasias do Colo/patologia
Sarcoma de Células Dendríticas Foliculares/diagnóstico
Sarcoma de Células Dendríticas Foliculares/patologia
[Mh] Termos MeSH secundário: Antígenos Virais/análise
Antígenos Virais/genética
Neoplasias do Colo/virologia
Sarcoma de Células Dendríticas Foliculares/virologia
Feminino
Herpesvirus Humano 4/genética
Seres Humanos
Inflamação/etiologia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antigens, Viral)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.1097/PAI.0000000000000405


  9 / 150 MEDLINE  
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[PMID]:26639109
[Au] Autor:Purkait S; Mallick S; Joshi PP; Mallick S; Murugan NV; Sharma MC; Suri V; Mishra B; Mathur SR
[Ad] Endereço:Departments of Pathology, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Título:Retroperitoneal and mediastinal follicular dendritic cell sarcoma: report of 3 cases with review of literature.
[So] Source:Hematol Oncol;35(3):374-379, 2017 Sep.
[Is] ISSN:1099-1069
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Follicular dendritic cell sarcoma (FDCS) is a rare malignant histiocytic proliferation of antigen presenting follicular dendritic cell. It is an uncommon primary malignancy first described by Monda et al. in 1986. Most commonly reported cases are lymph nodal. Occasional cases occur in extra nodal sites. Here, we describe the clinicopathological features, histomorphology and outcome of three patients with extranodal FDCS along with a concise review of literature on the topic. All three patients were adult females. Two patients were in third decade, and one had age of 50 years. Among the three cases, two cases are presented as retroperitoneal mass and one as mediastinal mass. CT scans revealed heterogeneously enhancing masses. All the cases showed ovoid to spindle neoplastic cells arranged predominantly in whorling, fascicular and storiform patterns with inflammatory infiltrate. Immunohistochemically, the tumor cells are positive for CD21, CD23, CD35 and Clustrin. In view of rarity and variable clinical presentation in FDCS, accurate diagnosis is necessary. Copyright © 2015 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Sarcoma de Células Dendríticas Foliculares/diagnóstico
Neoplasias do Mediastino/diagnóstico
Neoplasias Retroperitoneais/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia
Terapia Combinada
Sarcoma de Células Dendríticas Foliculares/terapia
Diagnóstico por Imagem
Evolução Fatal
Feminino
Seres Humanos
Imuno-Histoquímica
Linfonodos/patologia
Neoplasias do Mediastino/terapia
Meia-Idade
Neoplasias Retroperitoneais/terapia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151208
[St] Status:MEDLINE
[do] DOI:10.1002/hon.2275


  10 / 150 MEDLINE  
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[PMID]:27488020
[Au] Autor:Lemech CR; Williams R; Thompson SR; McCaughan B; Chin M
[Ad] Endereço:Scientia Clinical Research, UNSW, Sydney, NSW, 2052, Australia. c.lemech@unsw.edu.au.
[Ti] Título:Treatment of breast cancer 2 (BRCA2)-mutant follicular dendritic cell sarcoma with a poly ADP-ribose polymerase (PARP) inhibitor: a case report.
[So] Source:BMC Res Notes;9:386, 2016 Aug 03.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. Treatment recommendations are currently based on case reports and small series describing combinations of surgery, chemotherapy and radiotherapy providing the best patient outcomes. Recent knowledge on molecular aberrations in this disease have not yet impacted on therapeutic decisions. CASE PRESENTATION: We describe a case of progressive follicular dendritic cell sarcoma of the lung and pleura, treated based on knowledge of the tumour's molecular aberrations. The patient was initially treated with surgery, chemotherapy and radiotherapy and developed disease progression. Mutation testing by Caris molecular intelligence demonstrated a breast cancer 2 gene mutation and further treatment with carboplatin and veliparib achieved disease stabilisation. CONCLUSION: Understanding of the molecular profile of rare tumours is key to improve therapeutic decision making and patient outcomes.
[Mh] Termos MeSH primário: Proteína BRCA2/genética
Sarcoma de Células Dendríticas Foliculares/tratamento farmacológico
Sarcoma de Células Dendríticas Foliculares/genética
Mutação/genética
Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico
Poli(ADP-Ribose) Polimerases/metabolismo
[Mh] Termos MeSH secundário: Idoso
Sarcoma de Células Dendríticas Foliculares/diagnóstico por imagem
Sarcoma de Células Dendríticas Foliculares/patologia
Progressão da Doença
Feminino
Seres Humanos
Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (BRCA2 Protein); 0 (Poly(ADP-ribose) Polymerase Inhibitors); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-016-2189-x



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