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[PMID]:28805986
[Au] Autor:Hung YP; Lovitch SB; Qian X
[Ad] Endereço:Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
[Ti] Título:Histiocytic sarcoma: New insights into FNA cytomorphology and molecular characteristics.
[So] Source:Cancer;125(8):604-614, 2017 Aug.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic features of histiocytes. Molecular characteristics of HS and fine-needle aspiration (FNA) criteria for its diagnosis have not been established. METHODS: A case series of HS in 8 FNA samples from 6 patients was reviewed along with histopathologic and clinical data. Immunohistochemistry was performed on cell blocks (3 cases), core biopsies (5 cases), and surgical specimens (4 cases). Targeted-exome next-generation sequencing (NGS) was performed on surgical resection specimens in 4 cases. RESULTS: Four patients had a known history of hematolymphoid malignancy. Cytomorphologic features included variably cellular smears composed of large epithelioid cells with reniform nuclei and abundant vacuolated cytoplasm, in an inflammatory background, with occasional cytophagocytosis and lymphoglandular bodies. Marked pleomorphism, multinucleated monster cells, and binucleated histiocytoid cells with partially overlapping, eccentrically placed nuclei resembling Pac-Man were common. Most cases expressed histiocytic markers CD68 (6 of 7 cases), CD163 (5 of 5 cases), and PU.1 (3 of 4 cases). In 3 cases, NGS analysis revealed alterations in lysine methyltransferase 2D (KMT2D)/mixed-lineage leukemia 2 (MLL2), a gene involved in chromatin regulation and previously implicated in the pathogenesis of follicular lymphoma. CONCLUSIONS: Although diagnosing HS with FNA alone is extremely challenging, the presence of pleomorphic and epithelioid large cells with binucleation and/or multinucleation in an inflammatory background should prompt the diagnosis of HS with judicious use of confirmatory histiocytic lineage markers. The detection of recurrent KMT2D/MLL2 alterations implicates epigenetic regulation in the pathogenesis of HS and supports the notion of transdifferentiation from a genetically similar but phenotypically distinct tumor of a different lineage. Cancer Cytopathol 2017;125:604-14. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Neoplasias Ósseas/patologia
Sarcoma Histiocítico/patologia
Neoplasias Hepáticas/patologia
Neoplasias Pulmonares/patologia
Neoplasias Retroperitoneais/patologia
Escápula/patologia
Neoplasias de Tecidos Moles/patologia
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Antígenos CD/metabolismo
Antígenos de Diferenciação Mielomonocítica/metabolismo
Neoplasias Ósseas/genética
Neoplasias Ósseas/metabolismo
Neoplasias Ósseas/cirurgia
Proteínas de Ligação a DNA/genética
Epigênese Genética
Feminino
Sequenciamento de Nucleotídeos em Larga Escala
Sarcoma Histiocítico/genética
Sarcoma Histiocítico/metabolismo
Sarcoma Histiocítico/cirurgia
Seres Humanos
Imuno-Histoquímica
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/secundário
Neoplasias Hepáticas/cirurgia
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/cirurgia
Masculino
Meia-Idade
Pescoço
Proteínas de Neoplasias/genética
Proteínas Proto-Oncogênicas/metabolismo
Receptores de Superfície Celular/metabolismo
Neoplasias Retroperitoneais/genética
Neoplasias Retroperitoneais/metabolismo
Neoplasias Retroperitoneais/cirurgia
Escápula/metabolismo
Escápula/cirurgia
Análise de Sequência de DNA
Neoplasias de Tecidos Moles/metabolismo
Neoplasias de Tecidos Moles/secundário
Neoplasias de Tecidos Moles/cirurgia
Transativadores/metabolismo
Neoplasias Uterinas/genética
Neoplasias Uterinas/metabolismo
Neoplasias Uterinas/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, Differentiation, Myelomonocytic); 0 (CD163 antigen); 0 (CD68 antigen, human); 0 (DNA-Binding Proteins); 0 (MLL2 protein, human); 0 (Neoplasm Proteins); 0 (Proto-Oncogene Proteins); 0 (Receptors, Cell Surface); 0 (Trans-Activators); 0 (proto-oncogene protein Spi-1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170815
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21851


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[PMID]:28376906
[Au] Autor:Vaughn JL; Freitag CE; Hemminger JA; Jones JA
[Ad] Endereço:Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. John.Vaughn@osumc.edu.
[Ti] Título:BRAF expression in histiocytic sarcoma associated with splenic marginal zone lymphoma: a case report.
[So] Source:J Med Case Rep;11(1):92, 2017 Apr 05.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Histiocytic sarcoma is a rare histiocytic neoplasm of unknown etiology that constitutes less than 1% of hematologic malignancies. A few cases of histiocytic sarcoma harboring the BRAF mutation have been reported, but this finding has not been confirmed in all studies. CASE PRESENTATION: We report the case of a 63-year-old white woman with a history of splenic marginal zone lymphoma who presented with 2 weeks of right-sided neck swelling. Positron emission tomography revealed an intensely hypermetabolic and destructive soft tissue mass in her right skull base. A bone marrow biopsy was performed, which revealed an infiltrate of malignant cells characterized as large pleomorphic cells with frequent folded/irregular nuclei, variably prominent nucleoli, fine chromatin, and abundant amounts of eosinophilic cytoplasm. The malignant cells were positive for CD163, CD68 (granular), lysozyme (granular), CD4, and CD45 (partial). Based on the biopsy findings, she was diagnosed as having histiocytic sarcoma. The malignant cells tested positive for the BRAF protein using immunohistochemistry. Before treatment of her histiocytic sarcoma could be initiated, she developed disseminated intravascular coagulation and acute hypoxemic respiratory failure secondary to non-cardiogenic pulmonary edema. She decided to pursue comfort care and died in our hospital 2 weeks following admission. CONCLUSIONS: Our case illustrates the aggressive nature of histiocytic sarcoma, and provides rare evidence that histiocytic sarcoma associated with indolent lymphomas may harbor the BRAF mutation. Further research is needed to clarify the role of targeted therapies such as vemurafenib in the treatment of patients with this disorder.
[Mh] Termos MeSH primário: Sarcoma Histiocítico/diagnóstico
Linfoma de Zona Marginal Tipo Células B/diagnóstico
Proteínas Proto-Oncogênicas B-raf/metabolismo
Neoplasias da Base do Crânio/diagnóstico
Neoplasias Esplênicas/diagnóstico
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/metabolismo
Evolução Fatal
Feminino
Sarcoma Histiocítico/patologia
Sarcoma Histiocítico/terapia
Seres Humanos
Linfoma de Zona Marginal Tipo Células B/patologia
Linfoma de Zona Marginal Tipo Células B/terapia
Meia-Idade
Conforto do Paciente
Neoplasias da Base do Crânio/patologia
Neoplasias da Base do Crânio/terapia
Neoplasias Esplênicas/patologia
Neoplasias Esplênicas/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1253-z


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[PMID]:28247189
[Au] Autor:Iwabuchi H; Kawashima H; Umezu H; Takachi T; Imamura M; Saitoh A; Ogose A; Imai C
[Ad] Endereço:Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuou-ku, Niigata, Niigata, 951-8510, Japan.
[Ti] Título:Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child.
[So] Source:Int J Hematol;106(2):299-303, 2017 Aug.
[Is] ISSN:1865-3774
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Sarcoma Histiocítico/tratamento farmacológico
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Cladribina/administração & dosagem
Cladribina/efeitos adversos
Citarabina/administração & dosagem
Citarabina/efeitos adversos
Imagem de Difusão por Ressonância Magnética
Feminino
Sarcoma Histiocítico/diagnóstico por imagem
Sarcoma Histiocítico/patologia
Seres Humanos
Tomografia por Emissão de Pósitrons
Indução de Remissão
Terapia de Salvação
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
04079A1RDZ (Cytarabine); 47M74X9YT5 (Cladribine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1007/s12185-017-2202-8


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[PMID]:28178429
[Au] Autor:Thongtharb A; Uchida K; Chambers JK; Nakayama H
[Ad] Endereço:1 Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
[Ti] Título:Variations in Histiocytic Differentiation of Cell Lines From Canine Cerebral and Articular Histiocytic Sarcomas.
[So] Source:Vet Pathol;54(3):395-404, 2017 May.
[Is] ISSN:1544-2217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two newly established canine histiocytic sarcoma (HS) cell lines, designated as PWC-HS01 and FCR-HS02, were obtained from brain and articular tumors, respectively. These 2 HS cell lines had phagocytic ability and modal chromosome aberrations. Although morphologic features of both HS cells were similar, immunocytochemical examinations revealed that the PWC-HS01 cell line expressed both dendritic cell (ie, S100, CD208, CD1, and CD4) and macrophage (ie, CD68, CD163, and CD204) markers. In contrast, the FCR-HS02 cell line was immunonegative for CD204 and CD68 but consistently positive for the dendritic cell markers. Moreover, reverse transcription polymerase chain reaction analyses confirmed histiocytic differentiation of both HS cell lines. These results suggest that HS from the central nervous system may have a tendency to be more undifferentiated compared with cases from other organs. In addition, the 2 newly established HS cell lines were also tumorigenic and metastatic in immunodeficient mice, supporting that these cell lines can be used as new tumor models for investigating canine histiocytic diseases.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/veterinária
Doenças do Cão/patologia
Sarcoma Histiocítico/veterinária
Artropatias/veterinária
[Mh] Termos MeSH secundário: Animais
Biomarcadores Tumorais
Neoplasias Encefálicas/patologia
Linhagem Celular Tumoral
Células Dendríticas/patologia
Cães
Regulação Neoplásica da Expressão Gênica/genética
Sarcoma Histiocítico/patologia
Artropatias/patologia
Macrófagos/patologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1177/0300985817690211


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[PMID]:28160308
[Au] Autor:Warschau M; Hoffmann M; Dziallas P; Hansmann F; Baumgärtner W; Mischke R; Cichowski S; Fehr M
[Ad] Endereço:Clinic for Pets, Reptiles and Pet and Feral Birds, University of Veterinary Medicine, D-30559, Hannover, Germany.
[Ti] Título:Invasive histiocytic sarcoma of the lumbar spine in a ferret (Mustela putorius furo).
[So] Source:J Small Anim Pract;58(2):115-118, 2017 Feb.
[Is] ISSN:1748-5827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This report describes the history, clinical examination and histopathology of a histiocytic sarcoma in a domestic ferret. Clinical signs were acute paraplegia and dysuria. Physical examination revealed a firm, smooth, touch-sensitive mass in and around the lumbar vertebral column. Neurologic examination was consistent with a lesion between spinal cord segments T3 and L3. Magnetic resonance images revealed bone lesions of L2 and L3 combined with compression of the spinal cord due to a homogenous, isointense mass that was diagnosed as a malignant round cell tumour and the ferret was euthanased. Histopathology confirmed the diagnosis of an infiltrative histiocytic sarcoma.
[Mh] Termos MeSH primário: Furões
Sarcoma Histiocítico/veterinária
Vértebras Lombares
Neoplasias da Coluna Vertebral/veterinária
[Mh] Termos MeSH secundário: Animais
Disuria/veterinária
Feminino
Sarcoma Histiocítico/diagnóstico por imagem
Sarcoma Histiocítico/patologia
Imagem por Ressonância Magnética/veterinária
Paraplegia/veterinária
Compressão da Medula Espinal/diagnóstico por imagem
Compressão da Medula Espinal/patologia
Compressão da Medula Espinal/veterinária
Neoplasias da Coluna Vertebral/diagnóstico por imagem
Neoplasias da Coluna Vertebral/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE
[do] DOI:10.1111/jsap.12632


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[PMID]:28087030
[Au] Autor:Escandell I; Ramon MD; Sánchez S; Terradez L; Jorda E
[Ad] Endereço:Dermatology Department, Clinical University Hospital of Valencia, Valencia, Spain. Electronic address: iescandell@aedv.es.
[Ti] Título:Dermoscopic characteristics of a cutaneous histiocytic sarcoma in a young patient.
[So] Source:J Am Acad Dermatol;76(2S1):S5-S7, 2017 Feb.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Dermoscopia
Sarcoma Histiocítico/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


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[PMID]:27890406
[Au] Autor:Karim MR; Izawa T; Pervin M; Sasai H; Kuwamura M; Yamate J
[Ad] Endereço:Laboratory of Veterinary Pathology, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka, Japan.
[Ti] Título:Cutaneous Histiocytic Sarcoma with Regional Lymph Node Metastasis in a Netherland Dwarf Rabbit (Oryctolagus cuniculus).
[So] Source:J Comp Pathol;156(2-3):169-172, 2017 Feb - Apr.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 10-year-old male Netherland dwarf rabbit (Oryctolagus cuniculus) was presented with a red nodular mass (1 cm in diameter) with ulceration and hair loss in the skin of the left upper lip. Cytological examination revealed atypical round cells. The mass was excised surgically. Histologically, the mass was composed of large round to polyhedral neoplastic cells with marked cytological atypia. The neoplastic cells were often binucleated or multinucleated. Immunohistochemically, the neoplastic cells were intensely positive for Iba1 and vimentin, but fewer neoplastic cells expressed E-cadherin. Nuclear immunoreactivity for Ki67 was detected in approximately 41% of the neoplastic cells. Metastasis to the left cervical lymph nodes was detected 6 months after the surgical excision. Based on clinical, histopathological and immunohistochemical findings, the present case was diagnosed as cutaneous histiocytic sarcoma. To the authors' knowledge cutaneous histiocytic disease has not been reported previously in lagomorphs.
[Mh] Termos MeSH primário: Sarcoma Histiocítico/veterinária
Metástase Linfática/patologia
Neoplasias Cutâneas/veterinária
[Mh] Termos MeSH secundário: Animais
Biomarcadores Tumorais/análise
Imuno-Histoquímica
Masculino
Coelhos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE


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[PMID]:27860224
[Au] Autor:Pfankuche VM; Spitzbarth I; Lapp S; Ulrich R; Deschl U; Kalkuhl A; Baumgärtner W; Puff C
[Ad] Endereço:Department of Pathology, University of Veterinary Medicine, Hannover, Germany.
[Ti] Título:Reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma.
[So] Source:J Cell Mol Med;21(4):816-830, 2017 Apr.
[Is] ISSN:1582-4934
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Histiocytic sarcoma represents a rare malignant tumour with a short survival time, indicating the need of novel treatment strategies including oncolytic virotherapy. The underlying molecular mechanisms of viral oncolysis are largely unknown. As cancer in companion animals shares striking similarities with human counterparts, we chose a permanent canine histiocytic sarcoma cell line (DH82 cells) to identify global transcriptome changes following infection with canine distemper virus (CDV), a paramyxovirus closely related to human measles virus. Microarray analysis identified 3054 differentially expressed probe sets (DEPs), encoding for 892 up- and 869 down-regulated unique canine genes, respectively, in DH82 cells persistently infected with the vaccine strain Onderstepoort of CDV (DH82-Ond-pi), compared to non-infected DH82 cells. Up-regulated genes were predominantly related to immune processes, as demonstrated by functional enrichment analysis. Moreover, there was substantial enrichment of genes characteristic for classically activated M1 and alternatively activated M2 macrophages in DH82-Ond-pi; however, significant polarization into either of both categories was lacking. 'Angiogenesis' was the dominant enriched functional term for the down-regulated genes, highlighting decreased blood vessel generation as a potential mechanism of paramyxovirus-induced oncolysis in DH82 cells. The anti-angiogenic effect of infection was verified by immunohistochemistry, which revealed a lower blood vessel density in an in vivo mouse model, xenotransplanted with DH82-Ond-pi, compared to mice transplanted with non-infected DH82 cells. Reduction in angiogenesis appears to be an important oncolytic mechanism of CDV in DH82 cells, suggesting that similar mechanisms might account for human histiocytic sarcoma and maybe other tumours in conjunction with measles virus.
[Mh] Termos MeSH primário: Regulação Neoplásica da Expressão Gênica
Sarcoma Histiocítico/genética
Sarcoma Histiocítico/terapia
Morbillivirus/fisiologia
Neovascularização Patológica/genética
Terapia Viral Oncolítica
Pesquisa Médica Translacional
Ensaios Antitumorais Modelo de Xenoenxerto
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Análise por Conglomerados
Vírus da Cinomose Canina
Cães
Regulação para Baixo/genética
Perfilação da Expressão Gênica
Seres Humanos
Imunidade/genética
Macrófagos/metabolismo
Camundongos
Anotação de Sequência Molecular
Necrose
Neovascularização Patológica/patologia
Fenótipo
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Análise de Componente Principal
Indução de Remissão
Transcrição Genética
Transcriptoma/genética
Regulação para Cima/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Platelet Endothelial Cell Adhesion Molecule-1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/jcmm.13023


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[PMID]:27828780
[Au] Autor:Binesh F; Karimi-Zarchi M; Vahidfar MR; Hadgiabadi ZK
[Ti] Título:Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity.
[So] Source:Rom J Intern Med;55(1):53-56, 2017 Mar 01.
[Is] ISSN:1220-4749
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Histiocytic sarcoma (HS) is an extraordinary rare tumor and it has an offensive clinical course. HS of the uterine cervix is a far uncommon tumor with just a few cases described so far. Here we presented a case of primary HS of the uterine cervix in a 62-year-old female initially misdiagnosed as large cell non-keratinizing squamous cell carcinoma. To the best of our knowledge, this is the first reported case of HS of the uterine cervix from Iran. CASE REPORT: The patient presented with post-menopausal vaginal bleeding. Further evaluations revealed the presence of a relatively large cervical mass that was sampled. Under the preliminary diagnosis of large cell non-keratinizing squamous cell carcinoma, the patient underwent radical surgery. Postoperative pathological examination confirmed the diagnosis of HS of the uterine cervix. The patient received chemotherapy. CONCLUSION: Clinical presentations of HS of the uterine cervix are very similar to more common cervical tumors; as a result its diagnosis relies on immunohistochemical methods. A correct diagnose could lead to the proper and timely treatment.
[Mh] Termos MeSH primário: Sarcoma Histiocítico/diagnóstico
Neoplasias do Colo do Útero/diagnóstico
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Diagnóstico Diferencial
Feminino
Sarcoma Histiocítico/complicações
Sarcoma Histiocítico/terapia
Seres Humanos
Histerectomia
Metrorragia/etiologia
Meia-Idade
Resultado do Tratamento
Neoplasias do Colo do Útero/complicações
Neoplasias do Colo do Útero/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE


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[PMID]:27925661
[Au] Autor:Elliott J
[Ad] Endereço:Willows Veterinary Centre, Solihull B90 4NH.
[Ti] Título:Gastric histiocytic sarcoma in a dog.
[So] Source:J Small Anim Pract;57(12):719, 2016 Dec.
[Is] ISSN:1748-5827
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças do Cão/fisiopatologia
Sarcoma Histiocítico/veterinária
[Mh] Termos MeSH secundário: Animais
Cães
Feminino
Sarcoma Histiocítico/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1111/jsap.12602



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