[PMID]: | 28790105 |
[Au] Autor: | Lafage-Pochitaloff M; Baranger L; Hunault M; Cuccuini W; Lefebvre C; Bidet A; Tigaud I; Eclache V; Delabesse E; Bilhou-Nabéra C; Terré C; Chapiro E; Gachard N; Mozziconacci MJ; Ameye G; Porter S; Grardel N; Béné MC; Chalandon Y; Graux C; Huguet F; Lhéritier V; Ifrah N; Dombret H; Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) |
[Ad] Endereço: | Department of Genetics, University Hospital, Assistance Publique-Hôpitaux de Marseille, INSERM 1104, Aix-Marseille University, Marseille, France. |
[Ti] Título: | Impact of cytogenetic abnormalities in adults with Ph-negative B-cell precursor acute lymphoblastic leukemia. |
[So] Source: | Blood;130(16):1832-1844, 2017 Oct 19. |
[Is] ISSN: | 1528-0020 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-cell precursor (BCP) acute lymphoblastic leukemia (ALL), often comprising small numbers of patients. In this study, we aimed to reassess the prognostic value of cytogenetic abnormalities in a large series of 617 adult patients with Ph-negative BCP-ALL (median age, 38 years), treated in the intensified Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)-2003/2005 trials. Combined data from karyotype, DNA index, fluorescence in situ hybridization, and polymerase chain reaction screening for relevant abnormalities were centrally reviewed and were informative in 542 cases (88%), allowing classification in 10 exclusive primary cytogenetic subgroups and in secondary subgroups, including complex and monosomal karyotypes. Prognostic analyses focused on cumulative incidence of failure (including primary refractoriness and relapse), event-free survival, and overall survival. Only 2 subgroups, namely t(4;11)/ and 14q32/ translocations, displayed a significantly worse outcome in this context, still observed after adjustment for age and after censoring patients who received allogeneic stem cell transplantation (SCT) in first remission at SCT time. A worse outcome was also observed in patients with low hypodiploidy/near triploidy, but this was likely related to their higher age and worse tolerance to therapy. The other cytogenetic abnormalities, including complex and monosomal karyotypes, had no prognostic value in these intensive protocols designed for adult patients up to the age of 60 years. |
[Mh] Termos MeSH primário: |
Aberrações Cromossômicas Leucemia-Linfoma Linfoblástico de Células Precursoras B/diagnóstico Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética
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[Mh] Termos MeSH secundário: |
Adolescente Adulto Aberrações Cromossômicas/estatística & dados numéricos Ensaios Clínicos como Assunto/estatística & dados numéricos Análise Citogenética Feminino Seres Humanos Cariotipagem Masculino Meia-Idade Estudos Multicêntricos como Assunto/estatística & dados numéricos Cromossomo Filadélfia Leucemia-Linfoma Linfoblástico de Células Precursoras B/epidemiologia Leucemia-Linfoma Linfoblástico de Células Precursoras B/terapia Valor Preditivo dos Testes Prognóstico Estudos Retrospectivos Adulto Jovem
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Em] Mês de entrada: | 1710 |
[Cu] Atualização por classe: | 171031 |
[Lr] Data última revisão:
| 171031 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 170810 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1182/blood-2017-05-783852 |
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