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[PMID]:26797482
[Au] Autor:Madokoro Y; Mizuno M; Ookita K; Hagiwara S; Ito A; Matsukawa N
[Ad] Endereço:Department of Neurology, Nagoya City University Hospital.
[Ti] Título:[Angioimmunoblastic T-cell lymphoma suspected to recur in the cranium after complete remission: A case report].
[So] Source:Rinsho Shinkeigaku;56(2):112-5, 2016.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 46-year-old woman presenting to the Department of Hematology with swelling of the mandibular lymph nodes was diagnosed with angioimmunoblastic T-cell lymphoma (AITL) in June 2013. The patient went into complete remission in December 2013 with chemotherapy; however, she was re-evaluated because of mental confusion during May 2014. In addition to the memory disturbances, elevated cerebrospinal fluid cell count and protein were noted. Fluid attenuated inversion recovery cranial magnetic resonance imaging revealed multiple hyperintense areas in both the mammillary bodies and thalamus accompanied by contrast-enhancing in some areas. The diagnosis of recurrent AITL was made based on the brain biopsy. AITL recurrence in the cranium should be considered in patients exhibiting central nervous system symptoms although such recurrences have not been reported previously.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico
Linfoma Imunoblástico de Células Grandes/diagnóstico
Linfoma de Células T/diagnóstico
Recidiva Local de Neoplasia
Indução de Remissão
[Mh] Termos MeSH secundário: Encéfalo/diagnóstico por imagem
Encéfalo/patologia
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/patologia
Neoplasias Encefálicas/terapia
Terapia Combinada
Feminino
Seres Humanos
Linfoma Imunoblástico de Células Grandes/diagnóstico por imagem
Linfoma Imunoblástico de Células Grandes/patologia
Linfoma Imunoblástico de Células Grandes/terapia
Linfoma de Células T/diagnóstico por imagem
Linfoma de Células T/patologia
Linfoma de Células T/terapia
Imagem por Ressonância Magnética
Metotrexato/administração & dosagem
Meia-Idade
Radioterapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-000804


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[PMID]:26607603
[Au] Autor:Qing X; Enbom E; Qing A; French S; Cai J
[Ad] Endereço:Department of Pathology, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA. Electronic address: drqingx@yahoo.com.
[Ti] Título:Plasmablastic lymphoma presenting as a large intracardiac mass and bilateral pleural effusions.
[So] Source:Exp Mol Pathol;100(1):79-81, 2016 Feb.
[Is] ISSN:1096-0945
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Plasmablastic lymphoma (PBL) is a rare aggressive lymphoma arising most frequently in the oral cavity of HIV-infected patients. Rare cases of PBL have been reported in extra-oral sites, as well as in HIV-negative patients. Cardiac involvement by lymphoma is very rare. The most common primary cardiac lymphoma is diffuse large B-cell lymphoma. We report an unusual case of PBL in a 49-year-old, HIV-positive man presenting with a large intracardiac mass and bilateral pleural effusions. Histological examination of the cardiac mass biopsy and cytological evaluation of the pleural fluid demonstrated large lymphoma cells with plasmablastic differentiation. By immunohistochemistry, the large lymphoma cells expressed CD30, CD45, CD138, MUM1, and kappa light chain, were weakly positive for EMA, and were negative for T-cell and B-cell markers, lambda light chain, and human herpes virus 8 (HHV8). In situ hybridization for Epstein Barr Virus-encoded RNA (EBER) was negative in large lymphoma cells. To our knowledge, in the English literature, this is the second reported case of PBL with cardiac origin and the first reported case of PBL that presents as a combination of intracardiac mass and pleural effusions.
[Mh] Termos MeSH primário: Linfoma Plasmablástico/patologia
[Mh] Termos MeSH secundário: Linfócitos B/citologia
Linfócitos B/virologia
Diagnóstico Diferencial
Herpesvirus Humano 8
Seres Humanos
Imuno-Histoquímica/métodos
Linfoma Difuso de Grandes Células B/diagnóstico
Linfoma Difuso de Grandes Células B/virologia
Linfoma Imunoblástico de Células Grandes/diagnóstico
Linfoma Imunoblástico de Células Grandes/virologia
Masculino
Meia-Idade
Linfoma Plasmablástico/virologia
Derrame Pleural/diagnóstico
Derrame Pleural/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE


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[PMID]:26756053
[Au] Autor:Debord C; Eveillard M
[Ti] Título:Leukemic phase of a large B-cell lymphoma arising in KSHV-associated multicentric Castleman disease.
[So] Source:Blood;126(16):1966, 2015 Oct 15.
[Is] ISSN:1528-0020
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doença de Castleman
Infecções por Herpesviridae
Herpesvirus Humano 8
Leucemia
Linfoma Imunoblástico de Células Grandes
[Mh] Termos MeSH secundário: Doença de Castleman/sangue
Doença de Castleman/patologia
Doença de Castleman/virologia
Feminino
Infecções por Herpesviridae/sangue
Infecções por Herpesviridae/patologia
Seres Humanos
Leucemia/sangue
Leucemia/patologia
Leucemia/virologia
Linfoma Imunoblástico de Células Grandes/sangue
Linfoma Imunoblástico de Células Grandes/patologia
Linfoma Imunoblástico de Células Grandes/virologia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1601
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160113
[St] Status:MEDLINE


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[PMID]:26617922
[Au] Autor:Churchill H; Naina H; Boriack R; Rakheja D; Chen W
[Ad] Endereço:Department of Pathology, University of Texas Southwestern Medical Center Dallas, Texas.
[Ti] Título:Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma.
[So] Source:Int J Clin Exp Pathol;8(9):11753-9, 2015.
[Is] ISSN:1936-2625
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive peripheral T-cell lymphoma with mutations in genes encoding isocitrate dehydrogenase1 and 2 (IDH1 and IDH2). Mutant IDH generates the oncometabolite D-2-hydroxyglutarate (D-2HG). We report the first case of discordant intracellular and plasma D-2HG levels in a patient with IDH2 R172S mutated AITL. METHODS: An 87-year-old woman was diagnosed with AITL in the groin lymph node by morphologic and immunophenotypic analyses, and molecular studies by DNA sequencing. D-2HG was measured in both tumoral tissue and in pre-treatment plasma by liquid chromatography-tandem mass spectrometry. RESULTS: While D-2HG was markedly elevated in the tissue sample, its level in plasma was normal. We discuss this discordant D-2HG result within the context of previously reported discordant 2HG results in other IDH mutated tumors, and its implication for using circulating D-2HG as a biomarker of IDH mutation. In addition, this case also harbored mutations in RHOA, TET2, and TP53. The molecular pathogenesis is briefly discussed. CONCLUSION: While our case suggests that circulating D-2HG is not a reliable marker of IDH mutation in AITL, more cases need to be studied to arrive at a definite conclusion.
[Mh] Termos MeSH primário: Glutaratos/metabolismo
Isocitrato Desidrogenase/genética
Linfoma Imunoblástico de Células Grandes/genética
Linfoma Imunoblástico de Células Grandes/metabolismo
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Neoplasias da Mama/patologia
Cromatografia Líquida
Proteínas de Ligação a DNA/genética
Feminino
Glutaratos/análise
Seres Humanos
Mutação
Segunda Neoplasia Primária/patologia
Proteínas Proto-Oncogênicas/genética
Espectrometria de Massas em Tandem
Proteína Supressora de Tumor p53/genética
Proteína rhoA de Ligação ao GTP/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (Glutarates); 0 (Proto-Oncogene Proteins); 0 (TET2 protein, human); 0 (Tumor Suppressor Protein p53); 124671-05-2 (RHOA protein, human); 2889-31-8 (alpha-hydroxyglutarate); EC 1.1.1.41 (Isocitrate Dehydrogenase); EC 1.1.1.41 (isocitrate dehydrogenase 2, human); EC 3.6.5.2 (rhoA GTP-Binding Protein)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151202
[Lr] Data última revisão:
151202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151201
[St] Status:MEDLINE


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[PMID]:25916641
[Au] Autor:Wang G; Gao X; Zhao W; Zhang D; Li Y; Li W
[Ad] Endereço:Department of Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
[Ti] Título:[Presence of B-cell clones in angioimmunoblastic T cell lymphoma].
[So] Source:Zhonghua Bing Li Xue Za Zhi;44(2):106-10, 2015 Feb.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the significance of B-cell clones in angioimmunoblastic T cell lymphoma (AITL) and the correlation with Epstein-Barr virus (EBV) and prognosis. METHOD: The histopathologic features, T cell clonality and EBV positivity in 33 cases of AITL and 10 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) collected from May 2010 to February 2014 were analyzed by immunohistochemistry, PCR gene rearrangement and in situ hybridization. Follow-up data were also collected. RESULTS: Of the 33 cases with AITL, seven cases (21.2%) exhibited clonal rearrangement of Ig genes; 21 cases (63.6%) were EBV positive. Seven cases had B-cell clones and all (7/7) were EBV positive; 14 of the 26 (53.8%) cases without B-cell clones were EBV positive. The difference between the two groups was statistically significant (P = 0.032). Four levels were made according to the number of EBV-labeled cells, Ig gene rearrangements, but there was no significant difference among levels 1, 2 and 3. There was no correlation between B-cell clones and prognosis (P = 0.263). CONCLUSION: Clonal rearrangement of Ig genes is a common finding in AITL, and it is highly associated with EBV positivity, but not with the number of EBV-labeled cells. The clinical significance remains unclear; further study with more samples is warranted.
[Mh] Termos MeSH primário: Linfócitos B/patologia
Rearranjo Gênico
Linfoma Imunoblástico de Células Grandes/genética
Linfoma Imunoblástico de Células Grandes/patologia
Linfoma de Células T Periférico/genética
[Mh] Termos MeSH secundário: Feminino
Genes de Imunoglobulinas
Herpesvirus Humano 4/isolamento & purificação
Seres Humanos
Imuno-Histoquímica
Hibridização In Situ
Linfoma de Células T Periférico/patologia
Masculino
Reação em Cadeia da Polimerase
Prognóstico
Linfócitos T
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1507
[Cu] Atualização por classe:160818
[Lr] Data última revisão:
160818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE


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[PMID]:25229766
[Au] Autor:Horn H; Staiger AM; Vöhringer M; Hay U; Campo E; Rosenwald A; Ott G; Ott MM
[Ad] Endereço:*Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology †Department of Internal Medicine II, Hematology and Oncology, Robert-Bosch-Krankenhaus ‡Department of Ear, Nose and Throat Surgery, Marienhospital, Stuttgart ∥Institute of Pathology, University of Würzburg, Comprehensive Cancer Center Mainfranken (CCCM), Würzburg ¶Institute of Pathology, Caritas-Hospital, Bad Mergentheim, Germany §Hematopathology Unit, Pathology Department, Hospital Clínic and University of Barcelona, Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
[Ti] Título:Diffuse large B-cell lymphomas of immunoblastic type are a major reservoir for MYC-IGH translocations.
[So] Source:Am J Surg Pathol;39(1):61-6, 2015 Jan.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The immunoblastic variant of diffuse large B-cell lymphoma (IB-DLBCL) has recently been recognized as an aggressive lymphoma type with inferior prognosis as compared with other DLBCL variants. At the same time, the presence of MYC rearrangements in DLBCL has been shown to indicate shorter survival in R-CHOP-treated patients. In this study, we investigated the occurrence of MYC gene rearrangements in IB-DLBCL versus non-IB-DLBCL in a large series. Using fluorescence in situ hybridization with an MYC break-apart and MYC-IGH fusion probe, we found that 13/39 evaluable IB-DLBCLs (33%) harbor translocations involving MYC, in contrast with only 5/68 (7%) in the non-IB-DLBCL group (P<0.01). The immunoglobulin heavy chain gene (IGH) was the translocation partner in all rearrangements (100%) involving MYC in IB-DLBCL, which is in contrast to what has been reported for DLBCL in the literature (50% to 70%). Moreover, MYC rearrangements occurred as the sole translocation in the majority of cases (77%), whereas across all DLBCLs the majority of MYC-rearranged cases carry additional rearrangements of either BCL2 and/or BCL6 genes (between 58% and 83% of cases). Finally, MYC-rearranged IB-DLBCLs were CD10 positive in 62% (8/13), whereas this was an uncommon feature in MYC germline IB-DLBCLs (15%). In conclusion, IB-DLBCLs are genetically characterized by frequent MYC-IGH translocations that often occur without additional BCL2 and/or BCL6 translocations. The activation of MYC, therefore, may be an important pathogenetic feature in IB-DLBCL.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Genes de Cadeia Pesada de Imunoglobulina
Linfoma Difuso de Grandes Células B/genética
Linfoma Imunoblástico de Células Grandes/genética
Proteínas Proto-Oncogênicas c-myc/genética
Translocação Genética
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biópsia
Testes Genéticos
Alemanha
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Linfoma Difuso de Grandes Células B/imunologia
Linfoma Difuso de Grandes Células B/patologia
Linfoma Imunoblástico de Células Grandes/imunologia
Linfoma Imunoblástico de Células Grandes/patologia
Neprilisina/análise
Fenótipo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (MYC protein, human); 0 (Proto-Oncogene Proteins c-myc); EC 3.4.24.11 (Neprilysin)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140918
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000319


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[PMID]:24712980
[Au] Autor:Cattaneo C; Re A; Ungari M; Peli A; Casari S; Castelnuovo F; Fisogni S; Lonardi S; Pellegrini V; Petullà M; Facchetti F; Rossi G
[Ad] Endereço:Department of Hematology , Spedali Civili, Brescia , Italy.
[Ti] Título:Plasmablastic lymphoma among human immunodeficiency virus-positive patients: results of a single center's experience.
[So] Source:Leuk Lymphoma;56(1):267-9, 2015 Jan.
[Is] ISSN:1029-2403
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Soropositividade para HIV/complicações
Linfoma Imunoblástico de Células Grandes/complicações
[Mh] Termos MeSH secundário: Soropositividade para HIV/diagnóstico
Soropositividade para HIV/tratamento farmacológico
Soropositividade para HIV/mortalidade
Seres Humanos
Linfoma Imunoblástico de Células Grandes/diagnóstico
Linfoma Imunoblástico de Células Grandes/mortalidade
Linfoma Imunoblástico de Células Grandes/terapia
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150203
[Lr] Data última revisão:
150203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140410
[St] Status:MEDLINE
[do] DOI:10.3109/10428194.2014.911867


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[PMID]:25358953
[Au] Autor:Yasuhara R; Irié T; Shiozawa E; Yamochi T; Tanaka J; Kohno Y; Fujikura M; Kimura Y; Hanazawa T; Seki K; Sano T; Shirota T; Kushima M; Takimoto M; Mishima K
[Ad] Endereço:Division of Pathology, Showa University, Tokyo, Japan.
[Ti] Título:Plasmablastic lymphoma of the maxillary sinus with intraoral manifestation caused by direct alveolar bone infiltration in an HIV-negative patient.
[So] Source:Pathol Int;64(11):588-90, 2014 Nov.
[Is] ISSN:1440-1827
[Cp] País de publicação:Australia
[La] Idioma:eng
[Mh] Termos MeSH primário: Herpesvirus Humano 4/isolamento & purificação
Infiltração Leucêmica/etiologia
Linfoma Difuso de Grandes Células B/patologia
Linfoma Imunoblástico de Células Grandes/patologia
Linfoma Imunoblástico de Células Grandes/virologia
Seio Maxilar/patologia
[Mh] Termos MeSH secundário: Feminino
Infecções por HIV/diagnóstico
Seres Humanos
Infiltração Leucêmica/diagnóstico
Infiltração Leucêmica/patologia
Linfoma Difuso de Grandes Células B/complicações
Linfoma Difuso de Grandes Células B/diagnóstico
Linfoma Difuso de Grandes Células B/virologia
Linfoma Imunoblástico de Células Grandes/complicações
Linfoma Imunoblástico de Células Grandes/diagnóstico
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141114
[Lr] Data última revisão:
141114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1111/pin.12212


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[PMID]:25228125
[Au] Autor:Witzig TE; Maurer MJ; Habermann TM; Link BK; Micallef IN; Nowakowski GS; Ansell SM; Colgan JP; Inwards DJ; Porrata LF; Markovic SN; Johnston PB; Lin Y; Thompson C; Gupta M; Katzmann JA; Cerhan JR
[Ad] Endereço:Division of Hematology, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B- and T-cell non-Hodgkin lymphoma.
[So] Source:Am J Hematol;89(12):1116-20, 2014 Dec.
[Is] ISSN:1096-8652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The serum immunoglobulin free light chain (FLC) assay quantitates free kappa (κ) and lambda (λ) light chains. FLC elevations in patients with diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and chronic lymphocytic leukemia (CLL) are associated with an inferior survival. These increases in FLC can be monoclonal (as in myeloma) or polyclonal. The goal was to estimate the frequency of these elevations within distinct types of B-cell and T-cell non-Hodgkin lymphoma (NHL) and whether the FLC measurements are associated with event-free survival (EFS). We studied serum for FLC abnormalities using normal laboratory reference ranges to define an elevated κ or λ FLC. Elevations were further classified as polyclonal or monoclonal. Four hundred ninety-two patients were studied: 453 B-cell and 34 T-cell NHL patients. Twenty-nine % (142/453) of patients had an elevated FLC of which 10% were monoclonal elevations. Within B-cell NHL, FLC abnormalities were most common in lymphoplasmacytic (79%), mantle cell (68%), and lymphomas of mucosa associated lymphoid tissue (31%); they were least common in follicular (15%). The hazard ratio (HR) for EFS in all patients was 1.41 (95% CI; 1.11-1.81); in all B-cell NHL the HR was 1.44 (95% CI 1.11-1.96); in all T-cell NHL the HR was 1.17 (95% CI 0.55-2.49). FLC abnormalities predicted an inferior OS (HR = 2.75, 95% CI: 1.93-3.90, P < 0.0001). The serum FLC assay is useful for prognosis in both B-cell and T-cell types of NHL. In B-cell NHL further discrimination between a monoclonal and polyclonal elevation may be helpful and should be analyzed in prospective clinical trials.
[Mh] Termos MeSH primário: Cadeias kappa de Imunoglobulina/sangue
Cadeias lambda de Imunoglobulina/sangue
Linfoma de Células B/sangue
Linfoma Folicular/sangue
Linfoma Imunoblástico de Células Grandes/sangue
Linfoma de Célula do Manto/sangue
Linfoma de Células T/sangue
[Mh] Termos MeSH secundário: Idoso
Linfócitos B/imunologia
Linfócitos B/metabolismo
Linfócitos B/patologia
Células Clonais
Feminino
Seres Humanos
Linfoma de Células B/diagnóstico
Linfoma de Células B/mortalidade
Linfoma de Células B/patologia
Linfoma Folicular/diagnóstico
Linfoma Folicular/mortalidade
Linfoma Folicular/patologia
Linfoma Imunoblástico de Células Grandes/diagnóstico
Linfoma Imunoblástico de Células Grandes/mortalidade
Linfoma Imunoblástico de Células Grandes/patologia
Linfoma de Célula do Manto/diagnóstico
Linfoma de Célula do Manto/mortalidade
Linfoma de Célula do Manto/patologia
Linfoma de Células T/diagnóstico
Linfoma de Células T/mortalidade
Linfoma de Células T/patologia
Masculino
Meia-Idade
Prognóstico
Análise de Sobrevida
Linfócitos T/imunologia
Linfócitos T/metabolismo
Linfócitos T/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Immunoglobulin kappa-Chains); 0 (Immunoglobulin lambda-Chains)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:161019
[Lr] Data última revisão:
161019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140918
[St] Status:MEDLINE
[do] DOI:10.1002/ajh.23839


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[PMID]:25223592
[Au] Autor:Gheith S; Cornfield D; Chen W; Singh-Kahlon P; Ahmed B
[Ad] Endereço:Hematopathology Section, Department of Pathology, Health Network Laboratories/Lehigh Valley Health Network, Allentown, PA, 18103. Electronic address: Shereen_M.Gheith@lvhn.org.
[Ti] Título:Immunoblastic follicular lymphoma: a very unusual transformation of low-grade follicular lymphoma.
[So] Source:Hum Pathol;45(11):2359-63, 2014 Nov.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 73-year-old man, in clinical remission 17 years after radiation therapy for a localized low-grade follicular lymphoma (FL), developed extensive lymphadenopathy, ascites, and splenomegaly with splenic masses. Axillary lymph node biopsy showed FL composed of nodules of centrocytes side by side with nodules of immunoblasts rather than centroblasts. Immunophenotyping revealed conventional FL markers (BCL-2, BCL-6, and CD10) as well as MUM-1 in the immunoblastic component, suggesting postgerminal center differentiation. Fluorescence in situ hybridization showed t(14;18) in both centrocytic and immunoblastic components and a copy gain of BCL-6 predominantly in the immunoblastic component. Areas of centrocytic and of immunoblastic nodules were macrodissected separately and underwent molecular evaluation for immunoglobulin heavy chain gene rearrangement. Identical base-pair peaks were found, attesting to their clonal identity. This case represents a very unusual example of transformation of a low-grade FL to a nodular immunoblastic FL.
[Mh] Termos MeSH primário: Transformação Celular Neoplásica/patologia
Linfoma Folicular/patologia
Linfoma Imunoblástico de Células Grandes/patologia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1501
[Cu] Atualização por classe:141202
[Lr] Data última revisão:
141202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140917
[St] Status:MEDLINE



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