Base de dados : MEDLINE
Pesquisa : C04.557.435 [Categoria DeCS]
Referências encontradas : 461 [refinar]
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[PMID]:28823575
[Au] Autor:Wang G; Huang H; Kamat AM; Siefker-Radtke A; Dinney CP; Troncoso P; Czerniak B; Guo CC
[Ad] Endereço:Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
[Ti] Título:High-grade neuroendocrine carcinoma of the urachus-report of 3 cases.
[So] Source:Hum Pathol;67:126-133, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most urachal malignancies are composed of pure adenocarcinoma with mucin production. Urachal neuroendocrine carcinoma (NEC) is extremely rare, with only a few cases reported in the literature. Here we report 3 cases of urachal NEC, the largest series of this rare disease from a single institution. The patients were young, with a mean age of 27 years (range, 23-34). The urachal tumors showed 2 distinct components: high-grade NEC and enteric-type adenocarcinoma. The urachal NECs were composed of small cell carcinoma (n=2) or large cell NEC (n=1). The subsequent resection specimens showed that all the tumors were at advanced Sheldon stages. All 3 patients developed metastases, which were composed of NEC exclusively. Two patients died from disease in 10 and 31 months, respectively, and the third patient was alive with widespread metastases at 21 months. Our findings suggest that urachal NEC is an aggressive variant with an overwhelming growth advantage over conventional adenocarcinoma. The presence of high-grade NEC in the urachus is associated with poor prognosis.
[Mh] Termos MeSH primário: Adenocarcinoma/secundário
Carcinoma Neuroendócrino/secundário
Neoplasias Complexas Mistas/patologia
Neoplasias da Bexiga Urinária/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/química
Adenocarcinoma/cirurgia
Adulto
Biomarcadores Tumorais/análise
Biópsia
Carcinoma Neuroendócrino/química
Carcinoma Neuroendócrino/cirurgia
Progressão da Doença
Evolução Fatal
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Gradação de Tumores
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/cirurgia
Fatores de Tempo
Resultado do Tratamento
Neoplasias da Bexiga Urinária/química
Neoplasias da Bexiga Urinária/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


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[PMID]:28716439
[Au] Autor:Sirohi D; Smith SC; Ohe C; Colombo P; Divatia M; Dragoescu E; Rao P; Hirsch MS; Chen YB; Mehra R; Amin MB
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
[Ti] Título:Renal cell carcinoma, unclassified with medullary phenotype: poorly differentiated adenocarcinomas overlapping with renal medullary carcinoma.
[So] Source:Hum Pathol;67:134-145, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Renal medullary carcinoma (RMC) is a highly aggressive renal cell carcinoma arising in the collecting system and requiring careful correlation with status of sickle cell trait. A panel of international experts has recently proposed provisional diagnostic terminology, renal cell carcinoma, unclassified, with medullary phenotype, based on encountering an extraordinarily rare tumor with RMC morphology and immunophenotype in an individual proven not to have a hemoglobinopathy. Herein, we extend this observation to a cohort of 5 such tumors, morphologically similar to RMC, lacking SMARCB1 expression by immunohistochemistry, but each without evidence of a hemoglobinopathy. The tumors arose in 4 men and 1 woman with a mean age of 44 years, occurring in 3 left and 2 right kidneys. Clinically, aggression was apparent with involvement of perinephric adipose tissue in all 5 cases, nodal metastasis in 4 of 5 cases, and death of disease in 4 of 5 cases within 3-27 months. Histologic sections showed poorly differentiated adenocarcinoma, often with solid and nested growth patterns, as well as infiltrative glandular, tubulopapillary, cribriform, or reticular growth. Rhabdoid and sarcomatoid cytomorphology was seen in a subset. All tumors showed PAX8 nuclear positivity and SMARCB1 loss, with OCT3/4 expression in 4 of 5 cases. In summary, this first series of renal cell carcinoma, unclassified, with medullary phenotype documents tumors with morphologic, immunophenotypic, and prognostic features of RMC occurring in individuals without sickle cell trait. Although greater biologic and molecular understanding is needed, the available evidence points to these cases representing a sporadic counterpart to sickle cell trait-associated RMC.
[Mh] Termos MeSH primário: Adenocarcinoma/secundário
Carcinoma Medular/secundário
Carcinoma de Células Renais/secundário
Diferenciação Celular
Neoplasias Renais/patologia
Neoplasias Complexas Mistas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/química
Adenocarcinoma/classificação
Adenocarcinoma/cirurgia
Adulto
Idoso
Biomarcadores Tumorais/análise
Biópsia com Agulha de Grande Calibre
Carcinoma Medular/química
Carcinoma Medular/classificação
Carcinoma Medular/cirurgia
Carcinoma de Células Renais/classificação
Carcinoma de Células Renais/cirurgia
Feminino
Seres Humanos
Imuno-Histoquímica
Neoplasias Renais/química
Neoplasias Renais/classificação
Neoplasias Renais/cirurgia
Metástase Linfática
Masculino
Meia-Idade
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/classificação
Neoplasias Complexas Mistas/cirurgia
Nefrectomia
Fenótipo
Tomografia por Emissão de Pósitrons
Estudos Retrospectivos
Terminologia como Assunto
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Imagem Corporal Total
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


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[PMID]:28551326
[Au] Autor:Wen KW; Hale G; Shafizadeh N; Hosseini M; Huang A; Kakar S
[Ad] Endereço:Department of Pathology, University of California, San Francisco, San Francisco, CA 91343, United States.
[Ti] Título:Appendiceal goblet cell carcinoid: common errors in staging and clinical interpretation with a proposal for an improved terminology.
[So] Source:Hum Pathol;65:187-193, 2017 Jul.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Goblet cell carcinoid (GCC) is staged and treated as adenocarcinoma (AC) and not as neuroendocrine tumor (NET) or neuroendocrine carcinoma. The term carcinoid may lead to incorrect interpretation as NET. The aim of the study was to explore pitfalls in staging and clinical interpretation of GCC and mixed GCC-AC, and propose strategies to avoid common errors. Diagnostic terminology, staging, and clinical interpretation were evaluated in 58 cases (27 GCCs, 31 mixed GCC-ACs). Opinions were collected from 23 pathologists using a survey. Clinical notes were reviewed to assess the interpretation of pathology diagnoses by oncologists. NET staging was incorrectly used for 25% of GCCs and 5% of mixed GCC-ACs. In the survey, 43% of pathologists incorrectly indicated that NET staging is applicable to GCCs, and 43% incorrectly responded that Ki-67 proliferation index is necessary for GCC grading. Two cases each of GCC and mixed GCC-AC were incorrectly interpreted as neuroendocrine neoplasms by oncologists, and platinum-based therapy was considered for 2 GCC-AC cases because of the mistaken impression of neuroendocrine carcinoma created by use of the World Health Organization 2010 term mixed adenoneuroendocrine carcinoma. The term carcinoid in GCC and use of mixed adenoneuroendocrine carcinoma for mixed GCC-AC lead to errors in staging and treatment. We propose that goblet cell carcinoid should be changed to goblet cell carcinoma, whereas GCC with AC should be referred to as mixed GCC-AC with a comment about the proportion of each component and the histologic subtype of AC. This terminology will facilitate appropriate staging and clinical management, and avoid errors in interpretation.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Neoplasias do Apêndice/patologia
Tumor Carcinoide/patologia
Carcinoma Neuroendócrino/patologia
Neoplasias Complexas Mistas/patologia
Terminologia como Assunto
[Mh] Termos MeSH secundário: Adenocarcinoma/química
Adenocarcinoma/classificação
Neoplasias do Apêndice/química
Neoplasias do Apêndice/classificação
Tumor Carcinoide/química
Tumor Carcinoide/classificação
Carcinoma Neuroendócrino/química
Carcinoma Neuroendócrino/classificação
Consenso
Bases de Dados Factuais
Diagnóstico Diferencial
Erros de Diagnóstico
Seres Humanos
Imuno-Histoquímica
Antígeno Ki-67/análise
Estadiamento de Neoplasias
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/classificação
Valor Preditivo dos Testes
Estudos Retrospectivos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ki-67 Antigen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28445692
[Au] Autor:Roth LM; Lyu B; Cheng L
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202. Electronic address: lroth@iupui.edu.
[Ti] Título:Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms.
[So] Source:Hum Pathol;65:1-14, 2017 Jul.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2% to 5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but have not been described in the ovary. In this article, we discuss recently described diagnostic entities as well as inconsistencies in nomenclature used in the recent World Health Organization classifications of SCSTs in the testis and ovary. We also thoroughly review the topic of neoplasms composed of both germ cells and sex cord derivatives with an emphasis on controversial aspects. These include "dissecting gonadoblastoma" and testicular mixed germ cell-sex cord stromal tumor (MGC-SCST). The former is a recently described variant of gonadoblastoma that sometimes is an immediate precursor of germinoma in the dysgenetic gonads of patients with a disorder of sex development. Although the relationship of dissecting gonadoblastoma to the previously described undifferentiated gonadal tissue is complex and not entirely resolved, we believe that it is preferable to continue to use the term undifferentiated gonadal tissue for those cases that are not neoplastic and are considered to be the precursor of classical gonadoblastoma. Although the existence of testicular MGC-SCST has been challenged, the most recent evidence supports its existence; however, testicular MGC-SCST differs significantly from ovarian examples due to both genetic and epigenetic factors.
[Mh] Termos MeSH primário: Neoplasias Complexas Mistas/patologia
Neoplasias Embrionárias de Células Germinativas/patologia
Neoplasias Ovarianas/patologia
Tumores do Estroma Gonadal e dos Cordões Sexuais/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Diferenciação Celular
Linhagem da Célula
Epigênese Genética
Feminino
Regulação Neoplásica da Expressão Gênica
Predisposição Genética para Doença
Seres Humanos
Masculino
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/classificação
Neoplasias Complexas Mistas/genética
Neoplasias Embrionárias de Células Germinativas/química
Neoplasias Embrionárias de Células Germinativas/classificação
Neoplasias Embrionárias de Células Germinativas/genética
Neoplasias Ovarianas/química
Neoplasias Ovarianas/classificação
Neoplasias Ovarianas/genética
Fenótipo
Tumores do Estroma Gonadal e dos Cordões Sexuais/química
Tumores do Estroma Gonadal e dos Cordões Sexuais/classificação
Tumores do Estroma Gonadal e dos Cordões Sexuais/genética
Neoplasias Testiculares/química
Neoplasias Testiculares/classificação
Neoplasias Testiculares/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE


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[PMID]:28431889
[Au] Autor:Chen J; He J; Deng M; Wu HY; Shi J; Mao L; Sun Q; Tang M; Fan XS; Qiu YD; Huang Q
[Ad] Endereço:Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
[Ti] Título:Clinicopathological, radiologic, and molecular study of 23 combined hepatocellular-cholangiocarcinomas with stem cell features, cholangiolocellular type.
[So] Source:Hum Pathol;64:118-127, 2017 Jun.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cholangiolocellular carcinoma is a type of intrahepatic cholangiocarcinoma (ICC). According to the 2010 World Health Organization classification, this carcinoma is a combined hepatocellular-cholangiocarcinoma with stem cell features, cholangiolocellular type (CHC-SC-CLC). The aim of this study was to compare the clinicopathological characteristics of CHC-SC-CLC and conventional ICC. Based on the gross and histologic characteristics, we divided consecutive ICC tumors into CHC-SC-CLC (n = 23), mass-forming (MF; n = 57), and non-MF (n = 22) groups. Compared with MF and non-MF groups, the CHC-SC-CLC group featured history of hepatolithiasis or bile duct operation in significantly fewer patients (4.3% versus 14.8% and 86.4%, respectively; P < .001) and was more common in the right lobe (70% versus 47% and 27%; P = .033) but lower frequency of invasive growth or peritumoral Glisson sheath invasion (61% and 22% versus 77% and 33% and 100% and 86%, respectively; P = .002 and P < .001) and absence of mucous production (0 versus 77% and 96%; P < .001). In CHC-SC-CLCs, the mutation rate of isocitrate dehydrogenase 1 (IDH1) or IDH2 was significantly higher (35%) than in MF (4%) or non-MF (0) ICCs (P < .001). The 1-, 3-, and 5-year postresection survival rates were also significantly better with CHC-SC-CLCs (93%, 79%, and 52%, respectively) than with MF (72%, 46%, and 40%) or non-MF (61%, 18%, and 0) ICCs (P = .041). Thus, CHC-SC-CLC tumors demonstrated an indolent growth pattern, more frequent IDH1/2 gene mutations, and better prognosis than did MF or non-MF ICC tumors.
[Mh] Termos MeSH primário: Neoplasias dos Ductos Biliares/diagnóstico
Carcinoma Hepatocelular/diagnóstico
Colangiocarcinoma/diagnóstico
Neoplasias Hepáticas/diagnóstico
Técnicas de Diagnóstico Molecular
Neoplasias Complexas Mistas/diagnóstico
Células-Tronco Neoplásicas/patologia
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias dos Ductos Biliares/diagnóstico por imagem
Neoplasias dos Ductos Biliares/genética
Neoplasias dos Ductos Biliares/patologia
Biomarcadores Tumorais/genética
Biópsia
Carcinoma Hepatocelular/diagnóstico por imagem
Carcinoma Hepatocelular/genética
Carcinoma Hepatocelular/patologia
Proliferação Celular
Colangiocarcinoma/diagnóstico por imagem
Colangiocarcinoma/genética
Colangiocarcinoma/patologia
Análise Mutacional de DNA
Feminino
Hepatectomia
Seres Humanos
Imuno-Histoquímica
Isocitrato Desidrogenase/genética
Estimativa de Kaplan-Meier
Neoplasias Hepáticas/diagnóstico por imagem
Neoplasias Hepáticas/genética
Neoplasias Hepáticas/patologia
Masculino
Meia-Idade
Mutação
Invasividade Neoplásica
Neoplasias Complexas Mistas/diagnóstico por imagem
Neoplasias Complexas Mistas/genética
Neoplasias Complexas Mistas/patologia
Valor Preditivo dos Testes
Modelos de Riscos Proporcionais
Fatores de Tempo
Resultado do Tratamento
Carga Tumoral
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 1.1.1.41 (Isocitrate Dehydrogenase); EC 1.1.1.41 (isocitrate dehydrogenase 2, human); EC 1.1.1.42. (IDH1 protein, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170423
[St] Status:MEDLINE


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[PMID]:28315695
[Au] Autor:Taher A; Denic N; Kalimuthu SN; Chetty R
[Ad] Endereço:Department of Pathology, Health Sciences Centre, Eastern Health and Memorial University Newfoundland, St John's, Newfoundland and Labrador A1B 3V6, Canada.
[Ti] Título:An unusual primary malignant tumor of the stomach: fetal gutlike gastric adenocarcinoma with "blastoma"-like component.
[So] Source:Hum Pathol;67:176-180, 2017 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An unusual case of a polypoid, malignant gastric tumor in a 62-year-old man is presented. Endoscopy and subsequent polypectomy revealed an 8.5 × 6.5 × 4.5-cm lesion in the body of the stomach. Microscopy showed surface dysplasia with an invasive adenocarcinoma displaying prominent tubulopapillary areas composed of large vacuolated cells, pleomorphic nuclei, and occasional cytoplasmic hyaline globules. This component then blended with tubular structures lined by more primitive-appearing vacuolated cells embedded within a stroma made up of cellular primitive, high-grade blastemalike areas and less cellular, more pleomorphic foci with spindle and several bizarre, large cells. Immunohistochemistry showed the adenocarcinoma and primitive tubules to be strongly SALL4 and epithelial marker positive but with only focal expression of α-fetoprotein and glypican-3. The stromal component made up of blastemalike areas displayed strong immunoreactivity for glypican-3. The pleomorphic stromal areas were negative for all markers, including epithelial and muscle markers. The overall morphology and expression of primitive oncofetal proteins, especially SALL4 and glypican-3, are in keeping with this being a primitive adenocarcinoma showing fetal gutlike differentiation with an accompanying blastomalike component, a combination not previously described in a primary gastric cancer.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Tumor do Seio Endodérmico/patologia
Neoplasias Complexas Mistas/patologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/química
Adenocarcinoma/cirurgia
Biomarcadores Tumorais/análise
Biópsia
Diferenciação Celular
Tumor do Seio Endodérmico/química
Tumor do Seio Endodérmico/cirurgia
Glipicanas/análise
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/cirurgia
Neoplasias Gástricas/química
Neoplasias Gástricas/cirurgia
Fatores de Transcrição/análise
alfa-Fetoproteínas/análise
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AFP protein, human); 0 (Biomarkers, Tumor); 0 (GPC3 protein, human); 0 (Glypicans); 0 (SALL4 protein, human); 0 (Transcription Factors); 0 (alpha-Fetoproteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE


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[PMID]:28202484
[Au] Autor:Tan CH; Phung TB; Xenos C
[Ad] Endereço:Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia.
[Ti] Título:Glioblastoma with primitive neuronal pattern in a girl aged 3 months: a rare diagnosis at an unusual age.
[So] Source:BMJ Case Rep;2017, 2017 Feb 15.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A girl aged 3 months presented with multiple seizures within 12 hours and was noted to have a palpable swelling over the right temporal region. MRI of the brain revealed a large right frontotemporal tumour, suggestive of supratentorial primitive neuroectodermal tumour. She underwent a stealth-guided craniotomy and debulking of the tumour. Histopathology and immunochemistry of the specimen, however, indicated a high-grade tumour with glioblastoma and neuroblastic components. She underwent adjuvant chemotherapy following the surgery and is well at 7-month follow-up. This case underscores the importance of considering the rare entity of glioblastoma with primitive neuronal pattern as a differential diagnosis in a young child.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Glioblastoma/patologia
Neoplasias Complexas Mistas/patologia
Tumores Neuroectodérmicos Primitivos/patologia
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/terapia
Feminino
Glioblastoma/diagnóstico por imagem
Glioblastoma/terapia
Seres Humanos
Lactente
Imagem por Ressonância Magnética
Neoplasias Complexas Mistas/diagnóstico por imagem
Neoplasias Complexas Mistas/terapia
Tumores Neuroectodérmicos Primitivos/diagnóstico por imagem
Tumores Neuroectodérmicos Primitivos/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE


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[PMID]:28196824
[Au] Autor:Ebrom P; Parizh D; Hajdu CH; Gadangi P
[Ad] Endereço:Department of General Surgery, NYU Lutheran, Brooklyn, New York, USA.
[Ti] Título:Paget's disease of the anus masking a mixed adenoneuroendocrine tumour of the rectum.
[So] Source:BMJ Case Rep;2017, 2017 Feb 14.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A man aged 83 years with vague perirectal symptoms had a delayed diagnosis of Paget's disease of the anus. A lack of thorough digital rectal examination failed to diagnose a mixed adenonueroendocrine tumour of the rectum in a timely matter.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Neoplasias do Ânus/patologia
Neoplasias Complexas Mistas/patologia
Neoplasias Primárias Múltiplas/patologia
Tumores Neuroendócrinos/patologia
Doença de Paget Extramamária/patologia
Neoplasias Retais/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico
Idoso de 80 Anos ou mais
Neoplasias do Ânus/diagnóstico
Diagnóstico Tardio
Seres Humanos
Masculino
Neoplasias Complexas Mistas/diagnóstico
Neoplasias Primárias Múltiplas/diagnóstico
Tumores Neuroendócrinos/diagnóstico
Doença de Paget Extramamária/diagnóstico
Neoplasias Retais/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE


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[PMID]:28193642
[Au] Autor:Cooper L; Srinivasan K; Nugent N
[Ad] Endereço:NHS, London, UK.
[Ti] Título:Basal cell carcinoma arising in a congenital melanocytic naevus in an adult.
[So] Source:BMJ Case Rep;2017, 2017 Feb 13.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. A case is described of a woman aged 52 years presenting with a slow-growing, symptomatic 3 cm lesion in the centre of a 10×5 cm CMN on her right upper back. Diagnostic core biopsy revealed an ulcerated, infiltrative basal cell carcinoma which was then further excised. The scar has healed with no evidence of local recurrence at 1-year follow-up.
[Mh] Termos MeSH primário: Carcinoma Basocelular/patologia
Neoplasias Complexas Mistas/patologia
Nevo Pigmentado/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Nevo Pigmentado/congênito
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


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[PMID]:28177962
[Au] Autor:Li Y; Pawel BR; Hill DA; Epstein JI; Argani P
[Ad] Endereço:Departments of *Pathology †Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD ‡Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA §Department of Pathology, Children's National Medical Center, Washington, DC.
[Ti] Título:Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma.
[So] Source:Am J Surg Pathol;41(4):472-481, 2017 Apr.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The term cystic nephroma has traditionally been used to refer to 2 neoplasms, a lesion in adults that is now thought to be part of the spectrum of mixed epithelial stromal tumor (MEST) and a pediatric lesion that has been associated with mutations in the DICER1 gene. A direct detailed morphologic, immunohistochemical, and genetic comparison of these 2 lesions has not been performed. In this study, we compare the morphologic features, immunoreactivity for estrogen receptor and inhibin, and DICER1 genetic status of 12 adult cystic nephroma/MEST (median age 50.5 y, all females) and 7 pediatric cystic nephroma (median age 1.3 y, male:female=6:1). Both lesions (11 of 12 adult cases, 6 of 7 pediatric cases) frequently demonstrated subepithelial accentuation of stromal cellularity, though the increased cellularity frequently included inflammatory cells in the pediatric cases. All adult and pediatric cases labeled for estrogen receptor; however, whereas most (83%) of adult cases labeled for inhibin at least focally, no pediatric case labeled for inhibin. Most adult cases (58%) demonstrated wavy, ropy collagen in association with cellular stroma, whereas this was not found in pediatric cases. 86% of pediatric cases demonstrated DICER1 mutations, whereas only 1 of 10 adult cases demonstrated a DICER1 mutation. In summary, although cellular stroma and estrogen receptor immunoreactivity are commonly present in both adult and pediatric cystic nephroma, ropy collagen and inhibin immunoreactivity are far more common in adult cystic nephroma/MEST, whereas DICER1 mutations are far more prevalent in pediatric cystic nephroma. These results support the current World Health Organization Classification's separation of adult and pediatric cystic nephromas as distinct entities.
[Mh] Termos MeSH primário: Biomarcadores Tumorais
Análise Mutacional de DNA
Imuno-Histoquímica
Neoplasias Renais/diagnóstico
Neoplasias Complexas Mistas/diagnóstico
Neoplasias Císticas, Mucinosas e Serosas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Pré-Escolar
Colágeno/análise
RNA Helicases DEAD-box/genética
Feminino
Seres Humanos
Lactente
Inibinas/análise
Neoplasias Renais/química
Neoplasias Renais/genética
Neoplasias Renais/patologia
Masculino
Meia-Idade
Mutação
Neoplasias Complexas Mistas/química
Neoplasias Complexas Mistas/genética
Neoplasias Complexas Mistas/patologia
Neoplasias Císticas, Mucinosas e Serosas/química
Neoplasias Císticas, Mucinosas e Serosas/genética
Neoplasias Císticas, Mucinosas e Serosas/patologia
Valor Preditivo dos Testes
Receptores Estrogênicos/análise
Ribonuclease III/genética
Células Estromais/química
Células Estromais/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Receptors, Estrogen); 57285-09-3 (Inhibins); 9007-34-5 (Collagen); EC 3.1.26.3 (DICER1 protein, human); EC 3.1.26.3 (Ribonuclease III); EC 3.6.4.13 (DEAD-box RNA Helicases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000816



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