Base de dados : MEDLINE
Pesquisa : C04.557.435.500 [Categoria DeCS]
Referências encontradas : 1530 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 153 ir para página                         

  1 / 1530 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28796040
[Au] Autor:Yang Z; Yang X; Lu X; Gao L; Li G; Zhang X
[Ad] Endereço:aDepartment of General Surgery, The Second Hospital of Jilin University, Changchun City, Jilin Province bDepartment of Urology, Dezhou People Hospital, Dezhou City, Shandong Province cDepartment of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin City dDepartment of Urology, Weihai Central Hospital, Weihai City, Shandong Province, China.
[Ti] Título:Primary malignant mesenchymoma of bladder: Case report and review of the literature.
[So] Source:Medicine (Baltimore);96(32):e7579, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Malignant mesenchymoma (MM) is defined as a heterogeneous malignant soft tissue tumor that consists of 2 or more distinctly different mesenchymal components in addition to fibrosarcomatous elements. Bladder MM was rarely reported in the literature and there are only 5 cases of primary bladder MM documented in English literature to date. PATIENT CONCERNS: A 58-year-old male complained of difficulty in urination and intermittent gross hematuria for 3 months. Doppler ultrasound scan revealed an avascular and homogeneous hypoechoic mass measured 6.5 × 9 cm in the bladder. Computed tomography showed a homogeneous solid mass in the bladder. DIAGNOSES: Pathology revealed spindle-shaped tumor and proliferation of poorly differentiated immature mesenchymal cells rich in eosinophilic cytoplasm with hyperchromatic sticklike nuclei. Immunohistochemical examinations were positive for CD117. INTERVENTIONS: The patient was diagnosed with presence of bladder tumor and underwent radical cystectomy; the optimal treatment strategy was reviewed and discussed. OUTCOMES: There was no recurrence or metastasis during a 16-month follow-up. LESSONS: Our case study demonstrated bladder MM with a relatively indolent clinical course. A multidisciplinary approach including surgery, radiotherapy, and chemotherapy may be useful. Radical resection is the most important determinant of clinical outcome. Generally, the clinical outcome and prognosis of mesenchymoma are favorable.
[Mh] Termos MeSH primário: Mesenquimoma/patologia
Neoplasias da Bexiga Urinária/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Mesenquimoma/cirurgia
Meia-Idade
Neoplasias da Bexiga Urinária/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170827
[Lr] Data última revisão:
170827
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007579


  2 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28699109
[Au] Autor:Mentzel T; Brenn T
[Ad] Endereço:Dermatopathologie Bodensee, Siemensstrasse 6/1, 88048, Friedrichshafen, Germany. mentzel@dermpath.de.
[Ti] Título:Malignant mesenchymal neoplasms of the dermis and subcutis mimicking benign lesions: a case-based review.
[So] Source:Virchows Arch;471(5):565-574, 2017 Nov.
[Is] ISSN:1432-2307
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this short review, malignant mesenchymal neoplasms of the dermis and subcutis mimicking benign lesions and their differential diagnoses are discussed. These include plaque-like dermatofibrosarcoma protuberans, superficial low-grade fibromyxoid sarcoma, low-grade superficial malignant peripheral nerve sheath tumour, epithelioid sarcoma, pseudomyogenic haemangioendothelioma, Kaposi sarcoma mimicking cavernous haemangioma and benign lymphangioendothelioma, and rare forms of angiosarcoma mimicking a benign vascular lesion.
[Mh] Termos MeSH primário: Mesenquimoma/diagnóstico
Neoplasias Cutâneas/diagnóstico
Neoplasias de Tecidos Moles/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1007/s00428-017-2187-y


  3 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28614212
[Au] Autor:Agaimy A; Michal M; Chiosea S; Petersson F; Hadravsky L; Kristiansen G; Horch RE; Schmolders J; Hartmann A; Haller F; Michal M
[Ad] Endereço:*Institute of Pathology ††Department of Hand & Plastic Surgery, University Hospital, Erlangen **Institute of Pathology ‡‡Department of Orthopedic & Traumatology, Section for Tumor Orthopedics, University Hospital, Bonn, Germany †Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Prague ‡Biomedical Center of the Faculty of Medicine in Pilsen, Pilsen, Czech Republic §Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA ∥Department of Pathology, National University Health System, Singapore ¶Department of Pathology, 3rd Medical Faculty in Prague, Charles University, Prague, Czech Republic.
[Ti] Título:Phosphaturic Mesenchymal Tumors: Clinicopathologic, Immunohistochemical and Molecular Analysis of 22 Cases Expanding their Morphologic and Immunophenotypic Spectrum.
[So] Source:Am J Surg Pathol;41(10):1371-1380, 2017 Oct.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount of FGF23 which results in TIO via uncontrolled renal loss of phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have been reported. Although there is increasing evidence that PMT can be diagnosed by reproducible histopathologic features, firm diagnosis has been often restricted to cases associated with TIO and, hence, diagnosis of "nonphosphaturic variants" remained challenging. Recently, FGFR1/FN1 gene fusions were detected in roughly half of cases. We herein reviewed the clinicopathologic features of 22 PMTs (15 cases not published before), stained them with an extended immunohistochemical marker panel and examined them by fluorescence in situ hybridization for FGFR1 gene fusions. Patients were 12 males and 9 females (one of unknown sex) aged 33 to 83 years (median: 52 y). Lesions affected the soft tissues (n=11), bones (n=6), sinonasal tract (n=4), and unspecified site (n=1). Most lesions originated in the extremities (9 in the lower and 4 in the upper extremities). Acral sites were involved in 10 patients (6 foot/heel, 3 fingers/hands, and 1 in unspecified digit). Phosphaturia and TIO were recorded in 10/11 and 9/14 patients with detailed clinical data, respectively. Limited follow-up (5 mo to 14 y; median: 16 mo) was available for 14 patients. Local recurrence was noted in one patient and metastasis in another patient. Histologically, 11 tumors were purely of conventional mixed connective tissue type, 3 were chondromyxoid fibroma-like, 2 were hemangio-/glomangiopericytoma-like with giant cells, and 1 case each angiomyolipoma-like and reparative giant cell granuloma-like. Four tumors contained admixture of patterns (predominantly cellular with variable conventional component). Immunohistochemistry showed consistent expression of CD56 (11/11; 100%), ERG (19/21; 90%), SATB2 (19/21; 90%), and somatostatin receptor 2A (15/19; 79%), while other markers tested negative: DOG1 (0/17), beta-catenin (0/14), S100 protein (0/14), and STAT6 (0/7). FGFR1 fluorescence in situ hybridization was positive in 8/17 (47%) evaluable cases. These results add to the phenotypic delineation of PMT reporting for the first time consistent expression of SATB2 and excluding any phenotypic overlap with solitary fibrous tumor or sinonasal glomangiopericytoma. The unifying immunophenotype of the neoplastic cells irrespective of the histologic pattern suggests a specific disease entity with diverse morphotypes/variants rather than different neoplasms unified by TIO.
[Mh] Termos MeSH primário: Mesenquimoma/genética
Mesenquimoma/patologia
Neoplasias de Tecido Conjuntivo/genética
Neoplasias de Tecido Conjuntivo/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Masculino
Meia-Idade
Técnicas de Diagnóstico Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000890


  4 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28492717
[Au] Autor:Sun LJ; Chen X; Dai YN; Xu CF; Ji F; Chen LH; Chen HT; Chen CX
[Ad] Endereço:Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University, Zhejiang, China.
[Ti] Título:Endoscopic Ultrasonography in the Diagnosis and Treatment Strategy Choice of Esophageal Leiomyoma.
[So] Source:Clinics (Sao Paulo);72(4):197-201, 2017 Apr.
[Is] ISSN:1980-5322
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES:: Esophageal leiomyoma is the most common benign tumor of the esophagus, and it originates from mesenchymal tissue. This study analyzed the clinicopathological characteristics of esophageal leiomyoma and aimed to evaluate the role of endoscopic ultrasonography in the diagnosis and treatment selection for these lesions. METHODS:: Two hundred and twenty-five patients who had suspected esophageal leiomyomas in endoscopic ultrasonography were enrolled at the Endoscopy Center of The First Affiliated Hospital, Zhejiang University from January 1st, 2009 to May 31th, 2015. The main outcomes included the demographic and morphological characteristics, symptoms, comparisons of diagnosis and treatment methods, adverse events, and prognosis. RESULTS:: One hundred and sixty-seven patients were diagnosed as having an esophageal leiomyoma by pathological examination. The mean patient age was 50.57±9.983 years. In total, 62.9% of the lesions originated from the muscularis mucosa, and the others originated from the muscularis propria. The median distance to the incisors was 30±12 cm. The median diameter was 0.72±0.99 cm. As determined by endoscopic ultrasonography, most existing leiomyomas were homogeneous, endophytic, and spherical. The leiomyomas from the muscularis mucosa were smaller than those from the muscularis propria and much closer to the incisors (p<0.05). SMA (smooth muscle antibody) (97.2%) and desmin (94.5%) were positive in the majority of patients. In terms of treatments, patients preferred endoscopic therapies, which led to less adverse events (e.g., intraoperative bleeding, local infection, pleural effusion) than surgical operations (p<0.05). The superficial leiomyomas presented less adverse events and better recovery (p<0.05) than deep leiomyomas. CONCLUSION:: Endoscopic ultrasonography has demonstrated high accuracy in the diagnosis of esophageal leiomyomas and provides great support in selecting treatments; however, EUS cannot completely avoid misdiagnosis, so combining it with other examinations may be a good strategy to solve this problem.
[Mh] Termos MeSH primário: Endossonografia/métodos
Neoplasias Esofágicas/diagnóstico por imagem
Leiomioma/diagnóstico por imagem
Mesenquimoma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Acurácia dos Dados
Desmina/metabolismo
Ressecção Endoscópica de Mucosa/métodos
Endossonografia/normas
Neoplasias Esofágicas/patologia
Neoplasias Esofágicas/terapia
Feminino
Seres Humanos
Leiomioma/patologia
Leiomioma/terapia
Masculino
Mesenquimoma/patologia
Mesenquimoma/terapia
Meia-Idade
Músculo Liso/metabolismo
Estudos Retrospectivos
Tomografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Desmin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


  5 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28445300
[Au] Autor:Qiu S; Cao LL; Qiu Y; Yan P; Li ZX; Du J; Sun LM; Zhang QF
[Ad] Endereço:aDepartment of Orthopedic Surgery bDepartment of Medical Oncology cDepartment of Ultrasonography, the First Affiliated Hospital of China Medical University, Shenyang dDepartment of Pathology, Fushun Hospital of Traditional Chinese Medicine, Fushun eDepartment of Radiology and Key Laboratory of Diagnostic Imaging and Interventional Radiology, the First Affiliated Hospital of China Medical University fDepartment of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, PR China.
[Ti] Título:Malignant phosphaturic mesenchymal tumor with pulmonary metastasis: A case report.
[So] Source:Medicine (Baltimore);96(17):e6750, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Phosphaturic mesenchymal tumor (PMT) is a new tumor entity of soft tissue and bone tumor recently accepted by the World Health Organization, which typically causes the paraneoplastic syndrome of tumor-induced osteomalacia (TIO). The majority of PMTs follow a benign clinical course and local recurrence occurs in < 10% of cases, malignant PMTs with distant organ metastasis are extremely uncommon. PATIENT CONCERNS: We reported a 41-year-old woman who was diagnosed with PMT 10 years ago with a repeated recurrence and pulmonary metastasis. DIAGNOSES: Based on clinical manifestations, MRI scan, serum biochemical indicators evaluation, followed by histopathological examination, the patient was diagnosed as malignant PMT with pulmonary metastasis. INTERVENTIONS: The patient was treated with calcium, phosphorus, and vitamin D after surgical resection and measured the serum ion concentrations every 3 months. OUTCOMES: The patient had a favorable outcome for 10 months without recurrence. LESSONS: PMTs lack of characteristic histological morphology, some recurrence cases may appear benign morphologically; the malignant PMTs are easily overlooked. Patients with PMT should be carefully evaluated and monitored, in order to early identify its malignant potential.
[Mh] Termos MeSH primário: Neoplasias Ósseas/patologia
Neoplasias Hepáticas/diagnóstico
Neoplasias Pulmonares/secundário
Mesenquimoma/diagnóstico
Neoplasias de Tecido Conjuntivo/patologia
[Mh] Termos MeSH secundário: Adulto
Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/terapia
Diagnóstico Diferencial
Feminino
Seres Humanos
Hipofosfatemia/etiologia
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/secundário
Neoplasias Pulmonares/diagnóstico
Neoplasias Pulmonares/terapia
Mesenquimoma/patologia
Mesenquimoma/secundário
Neoplasias de Tecido Conjuntivo/diagnóstico
Neoplasias de Tecido Conjuntivo/terapia
Osteomalacia/etiologia
Síndromes Paraneoplásicas/diagnóstico
Síndromes Paraneoplásicas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006750


  6 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27939009
[Au] Autor:Tatencloux S; Mosseri V; Papillard-Maréchal S; Mesples B; Pellegrino B; Belloy M; Jimènez I; Algret N; Levy D; Michon J; Orbach D
[Ad] Endereço:AP-HP, hôpital Ambroise-Paré, service de pédiatrie générale, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
[Ti] Título:[Care pathways before diagnosis in children and adolescents with malignancies].
[Ti] Título:Parcours prédiagnostique des enfants et adolescents atteints de tumeurs solides..
[So] Source:Bull Cancer;104(2):128-138, 2017 Feb.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:OBJECTIVE: to describe medical care pathways between first symptoms and first oncologic consultation in children and adolescents with solid cancers in order to analyze a possible relationship between delayed diagnosis and its potential consequences. METHODS: Retrospective study on patients aged less than 25 years at first consultation in the oncology department of pediatric, adolescent and young adult in Institut Curie during one year. Were collected data on cancer characteristics, components of care pathways, and sociodemographic parents' characteristics. RESULTS: Hundred and six patients were selected, with median age of 6 years. Most represented tumor was low-grade cerebral tumor (17.0%). Pain was the most frequent type of disorder observed as first sign (34.3% of patients). First signs were unspecific in only 27.6% of cases. Most patients were first seen by a general practitioner (29.3%). Median total time to diagnosis was one month [ranges: 0-64]. Median number of consultations before referral to oncology expert was 2 [0-7]. Retrospective analysis found a possible delayed diagnosis in 44.3% of patients, with potential vital and functional risks estimated respectively at 14.1 and 20.7% of overall population. Time to diagnosis was shorter if father was of foreign nationality vs. French (34 days vs. 72 days, P<0.05), and longer if parents were separated (74.5 days vs. 42.5 days, P<0.03). CONCLUSIONS: Overall time to diagnosis is quite fast, even if first signs of pediatric cancers are very polymorphic. Some medical and sociodemographic factors could influence characteristics of care pathways.
[Mh] Termos MeSH primário: Diagnóstico Tardio/efeitos adversos
Neoplasias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Neoplasias Ósseas/complicações
Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/epidemiologia
Neoplasias Encefálicas/complicações
Neoplasias Encefálicas/diagnóstico
Neoplasias Encefálicas/epidemiologia
Institutos de Câncer
Dor do Câncer/etiologia
Criança
Pré-Escolar
Diagnóstico Tardio/estatística & dados numéricos
Emigrantes e Imigrantes/estatística & dados numéricos
Características da Família
Feminino
França
Medicina Geral/estatística & dados numéricos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Mesenquimoma/complicações
Mesenquimoma/diagnóstico
Mesenquimoma/epidemiologia
Neoplasias/complicações
Neoplasias/epidemiologia
Estudos Retrospectivos
Sarcoma/diagnóstico
Sarcoma/epidemiologia
Fatores Socioeconômicos
Avaliação de Sintomas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


  7 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27659744
[Au] Autor:Chazal T; Khanine V; Lidove O; Godot S; Ziza JM
[Ad] Endereço:Service de médecine interne et rhumatologie, groupe hospitalier diaconesses Croix-Saint-Simon, 125, rue d'Avron, 75020 Paris, France. Electronic address: thibchazal@gmail.com.
[Ti] Título:[Tumor-induced osteomalacia caused by a late-revealing phosphaturic mesenchymal tumor].
[Ti] Título:Ostéomalacie secondaire à une tumeur mésenchymateuse phosphaturique de révélation tardive..
[So] Source:Rev Med Interne;38(6):412-415, 2017 Jun.
[Is] ISSN:1768-3122
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Osteomalacia is associated with diffuse pain and multiple fractures and therefore, diagnosis and treatment of this condition are necessary. Clinicians should be aware of an uncommon mechanism of osteomalacia where hypophosphataemia is secondary to renal phosphaturia because of the production by a mesenchymal phosphaturic tumor of FGF-23. This tumor should be localized and removed to cure this tumor-induced osteomalacia. OBSERVATION: A 70-year-old female patient was admitted to explore diffuse pain caused by multiple fractures secondary to osteomalacia. Despite vitamin D supplementation, she remained profoundly hypophosphoremic with major renal phosphaturia. A tumor-induced mechanism was suspected because of high level of FGF-23. It took more than three years of investigation to spot the causal phosphaturic mesenchymal tumor despite annual repetition of indium-labelled scintigraphy and PET-scan. The resection of the tumor, located between two phalanges of the right foot, cured the patient with sustained normal rate of serum level of phosphorus after two years. CONCLUSION: Tumor-induced osteomalacia is a diagnostic challenge because the localization of the tumor may be a long process. Patients should be monitored clinically and imaging studies repeated until a diagnosis is made and the causal tumor removed.
[Mh] Termos MeSH primário: Hipofosfatemia Familiar/etiologia
Mesenquimoma/complicações
Neoplasias de Tecido Conjuntivo/etiologia
Neoplasias de Tecidos Moles/complicações
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Tardio
Feminino

Seres Humanos
Hipofosfatemia/complicações
Hipofosfatemia Familiar/diagnóstico
Mesenquimoma/diagnóstico
Neoplasias de Tecido Conjuntivo/diagnóstico
Neoplasias de Tecidos Moles/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


  8 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27821035
[Au] Autor:Arcega R; Wu JX; Magaki S; Donahue TR; Wang HL
[Ti] Título:A hitherto undescribed benign mesenchymal polyp of the gallbladder: edematous angiomyolipoma-like polyp.
[So] Source:Acta Gastroenterol Belg;79(3):245-250, 2016 Jul-Sep.
[Is] ISSN:1784-3227
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:We report a case of two peculiar gallbladder polyps in a sixty-four year old male who presented with symptomatic cholelithiasis. Cholecystectomy was performed, which revealed two polyps measuring 0.6 cm and 1.9 cm, located in the body of the gallbladder. Microscopic examination of the polyps showed composite mesenchymal lesions with vascular proliferation of small-to-medium sized arterioles, myoid stroma, and lipomatous periphery. The myoid component was characterized by wisps of bland smooth muscle fibers loosely separated by proteinaceous and focally myxoid matrix. The surface of the polyps was lined by a single layer of bland epithelial cells. The unique histomorphologic features differentiate the lesions from other known mesenchymal polyps of the gallbladder. We propose the name "edematous angiomyolipoma-like polyp" for these rare lesions given their histomorphologic similarity to angiomyolipoma. (Acta gastroenterol. belg., 2016, 79, 371-374).
[Mh] Termos MeSH primário: Angiomiolipoma/diagnóstico
Colelitíase/diagnóstico
Neoplasias da Vesícula Biliar/diagnóstico
Vesícula Biliar
Mesenquimoma/diagnóstico
Pólipos
[Mh] Termos MeSH secundário: Colecistectomia/métodos
Diagnóstico Diferencial
Vesícula Biliar/diagnóstico por imagem
Vesícula Biliar/patologia
Vesícula Biliar/cirurgia
Seres Humanos
Imuno-Histoquímica/métodos
Masculino
Meia-Idade
Pólipos/diagnóstico
Pólipos/patologia
Pólipos/fisiopatologia
Pólipos/cirurgia
Resultado do Tratamento
Ultrassonografia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE


  9 / 1530 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27667176
[Au] Autor:Kling T; Ferrarese R; Ó hAilín D; Johansson P; Heiland DH; Dai F; Vasilikos I; Weyerbrock A; Jörnsten R; Carro MS; Nelander S
[Ad] Endereço:Sahlgrenska Cancer Center, Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
[Ti] Título:Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma.
[So] Source:EBioMedicine;12:72-85, 2016 Oct.
[Is] ISSN:2352-3964
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Glioblastomas are characterized by transcriptionally distinct subtypes, but despite possible clinical relevance, their regulation remains poorly understood. The commonly used molecular classification systems for GBM all identify a subtype with high expression of mesenchymal marker transcripts, strongly associated with invasive growth. We used a comprehensive data-driven network modeling technique (augmented sparse inverse covariance selection, aSICS) to define separate genomic, epigenetic, and transcriptional regulators of glioblastoma subtypes. Our model identified Annexin A2 (ANXA2) as a novel methylation-controlled positive regulator of the mesenchymal subtype. Subsequent evaluation in two independent cohorts established ANXA2 expression as a prognostic factor that is dependent on ANXA2 promoter methylation. ANXA2 knockdown in primary glioblastoma stem cell-like cultures suppressed known mesenchymal master regulators, and abrogated cell proliferation and invasion. Our results place ANXA2 at the apex of a regulatory cascade that determines glioblastoma mesenchymal transformation and validate aSICS as a general methodology to uncover regulators of cancer subtypes.
[Mh] Termos MeSH primário: Anexina A2/metabolismo
Epigênese Genética
Regulação Neoplásica da Expressão Gênica
Glioblastoma/genética
Glioblastoma/metabolismo
Mesenquimoma/genética
Mesenquimoma/metabolismo
[Mh] Termos MeSH secundário: Algoritmos
Anexina A2/genética
Biomarcadores Tumorais
Linhagem Celular Tumoral
Biologia Computacional/métodos
Metilação de DNA
Bases de Dados de Ácidos Nucleicos
Transição Epitelial-Mesenquimal
Perfilação da Expressão Gênica
Técnicas de Silenciamento de Genes
Glioblastoma/mortalidade
Glioblastoma/patologia
Seres Humanos
Mesenquimoma/mortalidade
Mesenquimoma/patologia
Anotação de Sequência Molecular
Gradação de Tumores
Células-Tronco Neoplásicas/metabolismo
Prognóstico
Regiões Promotoras Genéticas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Annexin A2); 0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


  10 / 1530 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:27602604
[Au] Autor:Rommel B; Holzmann C; Bullerdiek J
[Ad] Endereço:a Center for Human Genetics , University of Bremen , Bremen , Germany.
[Ti] Título:Malignant mesenchymal tumors of the uterus - time to advocate a genetic classification.
[So] Source:Expert Rev Anticancer Ther;16(11):1155-1166, 2016 Nov.
[Is] ISSN:1744-8328
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Sarcomas are rare uterine tumors with leiomyosarcomas and endometrial stromal sarcomas constituting the predominant entities often making their first appearance in young and middle-aged women. By histology combined with immunostaining alone some of these tumors can offer diagnostic challenges e.g. for the differential diagnosis between leiomyosarcomas and smooth muscle tumors of uncertain malignant potential (STUMP). Areas covered: Recent advances in the genetic classification and subclassification, respectively, have shown that genetic markers can offer a valuable adjunct to conventional diagnostic tools. Herein, we will review these recent data from the literature also referring to genetic alterations found in STUMP, endometrial stromal nodules, and leiomyomas including their variants. Expert commentary: For the future, we consider genetic classification as a necessary step in the clinical management of these tumors which will help not only to improve the diagnosis but also the therapy of these malignancies often associated with a worse prognosis.
[Mh] Termos MeSH primário: Neoplasias do Endométrio/diagnóstico
Neoplasias Hepáticas/diagnóstico
Mesenquimoma/diagnóstico
Neoplasias Uterinas/diagnóstico
[Mh] Termos MeSH secundário: Animais
Diagnóstico Diferencial
Neoplasias do Endométrio/genética
Neoplasias do Endométrio/patologia
Feminino
Seres Humanos
Leiomiossarcoma/diagnóstico
Leiomiossarcoma/genética
Leiomiossarcoma/patologia
Neoplasias Hepáticas/genética
Neoplasias Hepáticas/patologia
Mesenquimoma/genética
Mesenquimoma/patologia
Prognóstico
Sarcoma do Estroma Endometrial/diagnóstico
Sarcoma do Estroma Endometrial/genética
Sarcoma do Estroma Endometrial/patologia
Tumor de Músculo Liso/diagnóstico
Tumor de Músculo Liso/genética
Tumor de Músculo Liso/patologia
Neoplasias Uterinas/genética
Neoplasias Uterinas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE



página 1 de 153 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde