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[PMID]:28722204
[Au] Autor:Magnusson L; Hansen N; Saba KH; Nilsson J; Fioretos T; Rissler P; Nord KH
[Ad] Endereço:Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
[Ti] Título:Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours.
[So] Source:J Pathol;243(2):160-164, 2017 Oct.
[Is] ISSN:1096-9896
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human brown fat tumours (hibernomas) show concomitant loss of the tumour suppressor genes MEN1 and AIP. We hypothesized that the brown fat phenotype is attributable to these mutations. Accordingly, in this study, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumours, loss of MEN1 was found both in white (one of 51 lipomas) and in brown fat tumours. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumours is mediated by the loss of AIP. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Tecido Adiposo Marrom/fisiologia
Genes Supressores de Tumor/fisiologia
Peptídeos e Proteínas de Sinalização Intracelular/genética
Lipoma/genética
Neoplasias Lipomatosas/genética
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Inativação Gênica/fisiologia
Seres Humanos
Peptídeos e Proteínas de Sinalização Intracelular/deficiência
Mutação/genética
Fenótipo
Proteínas Proto-Oncogênicas/deficiência
Proteínas Proto-Oncogênicas/genética
Proteína Desacopladora 1/metabolismo
Regulação para Cima/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Intracellular Signaling Peptides and Proteins); 0 (MEN1 protein, human); 0 (Proto-Oncogene Proteins); 0 (UCP1 protein, human); 0 (Uncoupling Protein 1); 0 (aryl hydrocarbon receptor-interacting protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1002/path.4945


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[PMID]:28515087
[Au] Autor:Lubarski-Gotliv I; Dey K; Kuznetsov Y; Kalchenco V; Asher C; Garty H
[Ad] Endereço:Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel; and ira.gotliv@gmail.com.
[Ti] Título:FXYD5 (dysadherin) may mediate metastatic progression through regulation of the ß-Na -K -ATPase subunit in the 4T1 mouse breast cancer model.
[So] Source:Am J Physiol Cell Physiol;313(1):C108-C117, 2017 Jul 01.
[Is] ISSN:1522-1563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:FXYD5 is a Na -K -ATPase regulator, expressed in a variety of normal epithelia. In parallel, it has been found to be associated with several types of cancer and effect lethal outcome by promoting metastasis. However, the molecular mechanism underlying FXYD5 mediated invasion has not yet been identified. In this study, using in vivo 4T1 murine breast cancer model, we found that FXYD5-specific shRNA significantly inhibited lung cancer metastasis, without having a substantial effect on primary tumor growth. Our study reveals that FXYD5 participates in multiple stages of metastatic development and exhibits more than one mode of E-cadherin regulation. We provide the first evidence that FXYD5-related morphological changes are mediated through its interaction with Na -K -ATPase. Experiments in cultured 4T1 cells have indicated that FXYD5 expression may downregulate the ß1 isoform of the pump. This behavior could have implications on both transcellular interactions and intracellular events. Further studies suggest that differential localization of the adaptor protein Annexin A2 in FXYD5-expressing cells may correlate with matrix metalloproteinase 9 secretion and adhesion changes in 4T1 wild-type cells.
[Mh] Termos MeSH primário: Regulação Neoplásica da Expressão Gênica
Neoplasias Pulmonares/genética
Neoplasias Mamárias Experimentais/genética
Proteínas de Membrana/genética
Neoplasias Lipomatosas/genética
ATPase Trocadora de Sódio-Potássio/genética
[Mh] Termos MeSH secundário: Animais
Anexina A2/genética
Anexina A2/metabolismo
Caderinas/genética
Caderinas/metabolismo
Adesão Celular
Linhagem Celular Tumoral
Movimento Celular
Modelos Animais de Doenças
Feminino
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/secundário
Glândulas Mamárias Animais/metabolismo
Glândulas Mamárias Animais/patologia
Neoplasias Mamárias Experimentais/metabolismo
Neoplasias Mamárias Experimentais/patologia
Metaloproteinase 9 da Matriz/genética
Metaloproteinase 9 da Matriz/metabolismo
Proteínas de Membrana/antagonistas & inibidores
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Neoplasias Lipomatosas/metabolismo
Neoplasias Lipomatosas/patologia
Subunidades Proteicas/genética
Subunidades Proteicas/metabolismo
RNA Interferente Pequeno/genética
RNA Interferente Pequeno/metabolismo
Transdução de Sinais
ATPase Trocadora de Sódio-Potássio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Annexin A2); 0 (Cadherins); 0 (E-cadherin protein, mouse); 0 (FXYD5 protein, mouse); 0 (Membrane Proteins); 0 (Protein Subunits); 0 (RNA, Small Interfering); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1152/ajpcell.00206.2016


  3 / 178 MEDLINE  
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[PMID]:28070099
[Au] Autor:Hayashi Y; Kaizaki Y; Utsunomiya M; Aritsuka A; Naito Y; Fujinaga H; Hasatani K; Aoyagi H; Ibe N; Miyanaga T
[Ad] Endereço:Department of Gastroenterology, Fukui Prefectural Hospital.
[Ti] Título:A case of Trousseau syndrome associated with a mucosa-associated lymphoid tissue lymphoma disseminated to the mesenteric adipose tissue.
[So] Source:Nihon Shokakibyo Gakkai Zasshi;114(1):84-90, 2017.
[Is] ISSN:0446-6586
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 66-year-old man with recurrent stroke within a short period of time was referred to our department from the neurology department to rule out any malignancy. An endoscopic examination revealed a white depressed lesion in the body of the stomach, and computed tomography revealed a high-density area in the mesentery around the stomach. A mucosa-associated lymphoid tissue (MALT) lymphoma was detected from both the stomach biopsy and resected mesenteric specimen. Systemic chemotherapy was administered for the MALT lymphoma (Lugano classification stage IV). Cerebral infarction did not occur after the treatment. We concluded that Trousseau syndrome associated with the MALT lymphoma disseminated to the mesenteric adipose tissue. A MALT lymphoma has a small probability of occurring in Trousseau syndrome.
[Mh] Termos MeSH primário: Linfoma de Zona Marginal Tipo Células B/complicações
Linfoma de Zona Marginal Tipo Células B/patologia
Mesentério
Neoplasias Lipomatosas/complicações
Neoplasias Lipomatosas/patologia
Neoplasias Peritoneais/complicações
Neoplasias Peritoneais/patologia
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Idoso
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Ciclofosfamida/administração & dosagem
Seres Humanos
Linfoma de Zona Marginal Tipo Células B/diagnóstico por imagem
Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico
Masculino
Mesentério/diagnóstico por imagem
Invasividade Neoplásica
Neoplasias Lipomatosas/diagnóstico por imagem
Neoplasias Lipomatosas/tratamento farmacológico
Neoplasias Peritoneais/diagnóstico por imagem
Neoplasias Peritoneais/tratamento farmacológico
Prednisona/administração & dosagem
Recidiva
Rituximab/administração & dosagem
Síndrome
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Vincristina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
4F4X42SYQ6 (Rituximab); 5J49Q6B70F (Vincristine); 8N3DW7272P (Cyclophosphamide); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.11405/nisshoshi.114.84


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[PMID]:28007292
[Au] Autor:Shah A; James SL; Davies AM; Botchu R
[Ad] Endereço:Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital, Birmingham, UK. Electronic address: doctigs@gmail.com.
[Ti] Título:A diagnostic approach to popliteal fossa masses.
[So] Source:Clin Radiol;72(4):323-337, 2017 Apr.
[Is] ISSN:1365-229X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is a myriad of potential mass lesions that occur in the popliteal fossa, which present as palpable masses or are found incidentally on imaging. With a thorough knowledge and understanding of the appearances and locations of these different entities, one can narrow the differential diagnoses in the majority of cases. This will eliminate unnecessary additional investigations and enable a more rapid management. We present a review of frequently encountered and less common entities using an anatomical sieve, with the aim of providing a diagnostic approach to popliteal fossa masses.
[Mh] Termos MeSH primário: Artropatias/diagnóstico por imagem
Articulação do Joelho/diagnóstico por imagem
Neoplasias Lipomatosas/diagnóstico por imagem
Neoplasias de Tecido Muscular/diagnóstico por imagem
Osteocondroma/diagnóstico por imagem
Neoplasias de Tecidos Moles/diagnóstico por imagem
[Mh] Termos MeSH secundário: Bolsa Sinovial/diagnóstico por imagem
Diagnóstico Diferencial
Diagnóstico por Imagem/métodos
Seres Humanos
Cápsula Articular/diagnóstico por imagem
Cisto Popliteal/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE


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[PMID]:26808135
[Au] Autor:Rao UN; Cieply K; Sherer C; Surti U; Gollin SM
[Ad] Endereço:*Department of Pathology, Presbyterian-Shadyside Hospitals ‡Pittsburgh Cytogenetics Laboratory, Magee-Womens Hospital, University of Pittsburgh Medical Center †Department of Pathology, University of Pittsburgh School of Medicine §Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA.
[Ti] Título:Correlation of Classic and Molecular Cytogenetic Alterations in Soft-Tissue Sarcomas: Analysis of 46 Tumors With Emphasis on Adipocytic Tumors and Synovial Sarcoma.
[So] Source:Appl Immunohistochem Mol Morphol;25(3):168-177, 2017 Mar.
[Is] ISSN:1533-4058
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Sarcomas are heterogeneous, and their treatment and prognosis are driven by the morphologic subtype and the clinical stage. Classic cytogenetics and fluorescence in situ hybridization (FISH) analysis play an important role in their diagnostic work up. MATERIALS AND METHODS: Forty-six cases of soft-tissue sarcoma were reviewed that underwent karyotyping and simultaneous FISH analysis at initial diagnosis. They included 10 dedifferentiated liposarcomas, 10 myxoid liposarcomas, and 14 synovial sarcomas. Six tumors were investigated for EWSR1 rearrangement. Six high-grade miscellaneous sarcomas were also examined. RESULTS: The dedifferentiated liposarcoma had complex karyotypes and MDM2 amplification by FISH, and of these, 5 tumors with myxoid changes also had complex signals for DDIT3. All but 4 myxoid liposarcomas had complex karyotypes, in addition to the characteristic translocation. FISH analysis displayed DD1T3 rearrangement. All synovial sarcomas except 1 recurrence had a t(X;18) translocation by karyotyping and FISH. The EWSR1 rearrangement was present in all extraskeletal myxoid chondrosarcomas, angiomatoid fibrous histiocytoma, atypical Ewing sarcoma, and a clear-cell sarcoma, all of which had characteristic karyotypes. Seven high-grade sarcomas had no specific karyotype or rearrangements for DDIT3, SS18, and EWSR1 by FISH. CONCLUSIONS: There is good correlation between karyotyping and FISH. Complex FISH signals found in dedifferentiated liposarcomas may be related to an increased chromosome 12 copy number and ploidy. Karyotyping is an important baseline standard for the quality assurance of newly developed FISH probes. It also provides a global view of chromosomal changes and the opportunity to investigate the role of other genetic alterations and potential therapeutic targets.
[Mh] Termos MeSH primário: Neoplasias Lipomatosas/patologia
Sarcoma Sinovial/patologia
Sarcoma/genética
[Mh] Termos MeSH secundário: Seres Humanos
Hibridização in Situ Fluorescente
Neoplasias Lipomatosas/genética
Estudos Retrospectivos
Sarcoma/patologia
Sarcoma Sinovial/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160126
[St] Status:MEDLINE
[do] DOI:10.1097/PAI.0000000000000294


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[PMID]:27866258
[Au] Autor:Sheybani EF; Eutsler EP; Navarro OM
[Ad] Endereço:Department of Medical Imaging, University of Toronto, Toronto, ON, Canada.
[Ti] Título:Fat-containing soft-tissue masses in children.
[So] Source:Pediatr Radiol;46(13):1760-1773, 2016 Dec.
[Is] ISSN:1432-1998
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The diagnosis of soft-tissue masses in children can be difficult because of the frequently nonspecific clinical and imaging characteristics of these lesions. However key findings on imaging can aid in diagnosis. The identification of macroscopic fat within a soft-tissue mass narrows the differential diagnosis considerably and suggests a high likelihood of a benign etiology in children. Fat can be difficult to detect with sonography because of the variable appearance of fat using this modality. Fat is easier to recognize using MRI, particularly with the aid of fat-suppression techniques. Although a large portion of fat-containing masses in children are adipocytic tumors, a variety of other tumors and mass-like conditions that contain fat should be considered by the radiologist confronted with a fat-containing mass in a child. In this article we review the sonographic and MRI findings in the most relevant fat-containing soft-tissue masses in the pediatric age group, including adipocytic tumors (lipoma, angiolipoma, lipomatosis, lipoblastoma, lipomatosis of nerve, and liposarcoma); fibroblastic/myofibroblastic tumors (fibrous hamartoma of infancy and lipofibromatosis); vascular anomalies (involuting hemangioma, intramuscular capillary hemangioma, phosphate and tensin homologue (PTEN) hamartoma of soft tissue, fibro-adipose vascular anomaly), and other miscellaneous entities, such as fat necrosis and epigastric hernia.
[Mh] Termos MeSH primário: Diagnóstico por Imagem
Neoplasias Lipomatosas/diagnóstico por imagem
Neoplasias de Tecidos Moles/diagnóstico por imagem
[Mh] Termos MeSH secundário: Criança
Diagnóstico Diferencial
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161121
[St] Status:MEDLINE


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[PMID]:26555178
[Au] Autor:Krishnan V; Clark R; Chekmareva M; Johnson A; George S; Shaw P; Seewaldt V; Rinker-Schaeffer C
[Ad] Endereço:Section of Urology, Department of Surgery, The University of Chicago.
[Ti] Título:In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose.
[So] Source:J Vis Exp;(105):e52721, 2015 Oct 14.
[Is] ISSN:1940-087X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:High-grade serous ovarian cancer (HGSC), the cause of widespread peritoneal metastases, continues to have an extremely poor prognosis; fewer than 30% of women are alive 5 years after diagnosis. The omentum is a preferred site of HGSC metastasis formation. Despite the clinical importance of this microenvironment, the contribution of omental adipose tissue to ovarian cancer progression remains understudied. Omental adipose is unusual in that it contains structures known as milky spots, which are comprised of B, T, and NK cells, macrophages, and progenitor cells surrounding dense nests of vasculature. Milky spots play a key role in the physiologic functions of the omentum, which are required for peritoneal homeostasis. We have shown that milky spots also promote ovarian cancer metastatic colonization of peritoneal adipose, a key step in the development of peritoneal metastases. Here we describe the approaches we developed to evaluate and quantify milky spots in peritoneal adipose and study their functional contribution to ovarian cancer cell metastatic colonization of omental tissues both in vivo and ex vivo. These approaches are generalizable to additional mouse models and cell lines, thus enabling the study of ovarian cancer metastasis formation from initial localization of cells to milky spot structures to the development of widespread peritoneal metastases.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Neoplasias Lipomatosas/secundário
Omento/patologia
Neoplasias Ovarianas/patologia
Neoplasias Peritoneais/secundário
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Feminino
Xenoenxertos
Seres Humanos
Camundongos
Metástase Neoplásica
Células-Tronco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171015
[Lr] Data última revisão:
171015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151112
[St] Status:MEDLINE
[do] DOI:10.3791/52721


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[PMID]:26418501
[Au] Autor:Álvarez-López MÁ; Salvatierra J; Sanz A
[Ad] Endereço:Department of Dermatology, Reina Sofía Hospital, Córdoba, Spain.
[Ti] Título:Thrombosis of multiple angiolipomas due to acenocumarol treatment.
[So] Source:J Cutan Pathol;42(11):919-20, 2015 Nov.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Acenocumarol/efeitos adversos
Angiolipoma/patologia
Anticoagulantes/efeitos adversos
Neoplasias Lipomatosas/patologia
Trombose/induzido quimicamente
Trombose/patologia
[Mh] Termos MeSH secundário: Acenocumarol/administração & dosagem
Adulto
Angiolipoma/sangue
Anticoagulantes/administração & dosagem
Feminino
Seres Humanos
Neoplasias Lipomatosas/sangue
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Anticoagulants); I6WP63U32H (Acenocoumarol)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150930
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12600


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[PMID]:26258278
[Au] Autor:Lin CC; Liao SL; Liou SW; Chen CC; Wu YY; Woung LC
[Ad] Endereço:*MD †PhD Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan (CCL, SWL, CCC, LCW); Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan (SLL); and Department of Pathology, Taipei City Hospital, Renai Branch, Taipei, Taiwan (YYW).
[Ti] Título:Subconjunctival Herniated Orbital Fat Mimicking Adipocytic Neoplasm.
[So] Source:Optom Vis Sci;92(10):1021-6, 2015 Oct.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To describe and discuss rare and benign conditions of subconjunctival orbital fat herniation that may mimic adipocytic neoplasm. METHODS: Sixteen eyes of 13 patients with subconjunctival orbital fat herniation were included. They all underwent transconjunctival excision owing to cosmesis, discomfort, or suspicion of malignancy. Histopathologic examination, postoperative complications, and recurrent conditions were analyzed. RESULTS: Eleven male and two female patients were included. The lesion was unilateral in 10 and bilateral in 3 cases. Excision was performed via conjunctival wound and removing the prolapsed orbital fat. The conjunctiva was then closed with two to three interrupted sutures. All the histopathologic specimens revealed Lochkern cells, floret cells, and mature adipocytes separated by fibrovascular septae without hyperchromatic cells, consistent with subconjunctival herniated orbital fat. All the patients were treated successfully with transconjunctival excision without recurrence at an average follow-up of 10.6 months (range, 6 to 16 months). CONCLUSIONS: Prolapse of subconjunctival orbital fat is an uncommon entity of intraorbital masses and may mimic adipocytic neoplasm. It is usually associated with a dehiscence in the Tenon capsule. Surgical excision is indicated and pathologic evaluation is necessary if any malignancy is suspected.
[Mh] Termos MeSH primário: Tecido Adiposo/patologia
Doenças da Túnica Conjuntiva/diagnóstico
Hérnia/diagnóstico
Neoplasias Lipomatosas/diagnóstico
Doenças Orbitárias/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doenças da Túnica Conjuntiva/cirurgia
Diagnóstico Diferencial
Feminino
Herniorrafia
Seres Humanos
Masculino
Meia-Idade
Doenças Orbitárias/cirurgia
Prolapso
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150924
[Lr] Data última revisão:
150924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150811
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000000693


  10 / 178 MEDLINE  
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[PMID]:26146844
[Au] Autor:Johnston EE; LeBlanc RE; Kim J; Chung J; Balagtas J; Kim YH; Link MP
[Ad] Endereço:Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
[Ti] Título:Subcutaneous panniculitis-like T-cell lymphoma: Pediatric case series demonstrating heterogeneous presentation and option for watchful waiting.
[So] Source:Pediatr Blood Cancer;62(11):2025-8, 2015 Nov.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and primary cutaneous gamma delta T-cell lymphoma (PCGD-TCL) were initially both classified as subcutaneous panniculitis-like T-cell lymphoma. In 2008, SPTCL with alpha-beta T-cell receptor subtype was separated from primary cutaneous gamma delta T-cell lymphomas (PCGD-TCL). We report four pediatric cases that demonstrate the heterogeneity of each disease and show that PCGD-TCL in children can have an indolent course, whereas SPTCL can behave aggressively. Three patients had spontaneous, durable remissions without treatment, whereas the one patient with disease progression was treated successfully. Watchful waiting may thus be appropriate for initial management of children.
[Mh] Termos MeSH primário: Linfoma de Células T/terapia
Neoplasias Lipomatosas/terapia
Paniculite
[Mh] Termos MeSH secundário: Adolescente
Pré-Escolar
Feminino
Seres Humanos
Linfoma de Células T/genética
Linfoma de Células T/patologia
Neoplasias Lipomatosas/genética
Neoplasias Lipomatosas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150925
[Lr] Data última revisão:
150925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.25626



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