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[PMID]:29429160
[Au] Autor:Zhao M; Wang YB; Yan YJ; Wang W; Ru GQ; He XL
[Ad] Endereço:Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.
[Ti] Título:[Clinicopathologic features of atypical spindle cell lipomatous tumor].
[So] Source:Zhonghua Bing Li Xue Za Zhi;47(2):99-104, 2018 Feb 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathologic characteristics, immunophenotype, differential and diagnostic features of atypical spindle cell lipomatous tumor (ASLT). Three cases of ASLT were collected from January 2010 to March 2017 at Zhejiang Provincial People's Hospital. The clinical and imaging features, histomorphology, immunophenotype and prognosis were analyzed. Fluorescence in situ hybridization (FISH) was used to detect MDM2 gene amplification, and relevant literature was reviewed. All three patients were adult males, aged 38, 43 and 54 years, respectively. One tumor originated in the subcutaneous soft tissue in the head and neck, one was located in the left primary bronchus and one in the latissimus dorsi muscle. Grossly, all three tumors were circumscribed and ranged from 4.0 to 5.8 cm in size. Microscopically, all showed a focally infiltrative front. These tumors were composed of variable proportions of spindle-shaped and adipocytic cells in a background of variable fibrous and edematous matrix. Scattered lipoblasts were easily seen. One tumor was composed predominately of spindle tumor cells, one of adipocytic cells, and one of equally mixed cell populations. The spindle tumor cells were generally bland-appearing with focal nuclear enlargement and hyperchromasia noted in one case. Mitosis was not seen in neither the spindle cells nor the adipocytic cells. By immunohistochemistry, diffuse and strong reactivity to CD34 of the spindle cells was noted in all cases, definite loss of Rb expression was noted in one of three cases, and S-100 protein was expressed only in the adipocytic cells. INI-1 was intact and Ki-67 index was 1% to 3%. All other markers including CDK4, MDM2, STAT6, SOX10, CD99, bcl-2, ß-catenin, CD117, GFAP, CK, EMA, SMA and desmin were negative. FISH of MDM2 was done in two cases, and both showed no amplification. The ASLT in the head and neck had two recurrences during 17 months of follow-up, whereas the tumor in the latissimus dorsi was free of disease during 33 months of follow-up. ASLT is a rare subtype of low-grade adipocytic neoplasm and is distinctive from atypical lipomatous tumor/well-differentiated liposarcoma. The histomorpholgy of ASLT has significant heterogeneity and forms a continuous spectrum. ASLT needs to be distinguished from a series of benign and malignant soft tissue tumors.
[Mh] Termos MeSH primário: Neoplasias Brônquicas/patologia
Neoplasias de Cabeça e Pescoço/patologia
Lipoma/patologia
Neoplasias Musculares/patologia
[Mh] Termos MeSH secundário: Adulto
Neoplasias Brônquicas/química
Neoplasias de Cabeça e Pescoço/química
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Lipoma/química
Lipossarcoma/química
Lipossarcoma/patologia
Masculino
Meia-Idade
Neoplasias Musculares/química
Recidiva Local de Neoplasia
Proteínas S100/análise
Fator de Transcrição STAT6/análise
Músculos Superficiais do Dorso
beta Catenina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CTNNB1 protein, human); 0 (S100 Proteins); 0 (STAT6 Transcription Factor); 0 (STAT6 protein, human); 0 (beta Catenin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2018.02.004


  2 / 10142 MEDLINE  
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[PMID]:29256430
[Au] Autor:Stimmelmayr R; Rotstein D; Seguel M; Gottdenker N
[Ad] Endereço:North Slope Borough Department of Wildlife Management, Barrow, Alaska 99723, USA.
[Ti] Título:Hepatic lipomas and myelolipomas in subsistence-harvested bowhead whales Balaena mysticetus, Alaska (USA): a case review 1980-2016.
[So] Source:Dis Aquat Organ;127(1):71-74, 2017 Dec 19.
[Is] ISSN:0177-5103
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We describe a case series of benign hepatic fatty tumors in 10 subsistence-harvested bowhead whales. Microscopic features included lipomatous and myelolipomatous masses. Extensive atrophy and/or destruction of hepatic parenchyma was not observed. No other significant disease was present except in an animal with unrelated chronic pleuritis. Based on our longitudinal case series (1980-2016) which identified 1-2 hepatic lipomas and myelolipomas in landed whales annually at Barrow, Alaska (USA), since 2012, hepatic lipomas and myelolipomas are occasionally seen in hunter-harvested bowhead whales. A conservative estimate for the percentage of bowhead whales with hepatic fatty tumors in landed whales in Barrow from 2012 to 2016 was 6% (7/111). The pathogenesis and exact cell origin of these benign fatty tumors in bowhead whales is undetermined. Assessment of further cases is warranted to better define the tissue distribution and pathogenesis of these tumors in bowhead whale liver.
[Mh] Termos MeSH primário: Lipoma/veterinária
Neoplasias Hepáticas/veterinária
Mielolipoma/veterinária
Baleias
[Mh] Termos MeSH secundário: Alaska
Animais
Feminino
Lipoma/epidemiologia
Lipoma/patologia
Neoplasias Hepáticas/epidemiologia
Masculino
Mielolipoma/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.3354/dao03186


  3 / 10142 MEDLINE  
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[PMID]:29181924
[Au] Autor:Vetrhus M; Fjetland L
[Ti] Título:Intravenøst lipom..
[So] Source:Tidsskr Nor Laegeforen;137(22), 2017 11 28.
[Is] ISSN:0807-7096
[Cp] País de publicação:Norway
[La] Idioma:nor
[Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada
Lipoma/diagnóstico por imagem
Neoplasias Vasculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Veias Braquiocefálicas/diagnóstico por imagem
Veias Braquiocefálicas/patologia
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.4045/tidsskr.17.0646


  4 / 10142 MEDLINE  
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[PMID]:29252657
[Au] Autor:Kojima K; Iwanami A; Mikami S; Ishii K; Matsumoto M; Nakamura M
[Ad] Endereço:Departments of Orthopedic Surgery (K.K., A.I., K.I., M.M., and M.N.) and Pathology (S.M.), Keio University School of Medicine, Tokyo, Japan.
[Ti] Título:An Intramedullary Osteolipoma of the Upper Thoracic Spinal Cord: A Case Report.
[So] Source:JBJS Case Connect;6(3):e80, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: We present a rare case of an intramedullary osteolipoma without any extramedullary connections or coexisting spinal dysraphism. A 48-year-old woman presented with back pain and pain around the lateral aspect of the left thigh. Magnetic resonance imaging (MRI) revealed a heterogeneous hyperintense and hypointense region on T1 and T2-weighted imaging. A cavernous hemangioma was suspected, and the patient was admitted for surgical resection. The histological diagnosis was an intramedullary osteolipoma. CONCLUSION: MRI with fat suppression and computed tomography are recommended for the diagnosis of an intramedullary osteolipoma, but a definitive diagnosis requires histological examination.
[Mh] Termos MeSH primário: Lipoma/diagnóstico
Neoplasias da Medula Espinal/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lipoma/patologia
Meia-Idade
Neoplasias da Medula Espinal/patologia
Vértebras Torácicas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00025


  5 / 10142 MEDLINE  
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[PMID]:29390483
[Au] Autor:Kim JH; Yoon HH; Jeong SH; Woo HS; Lee WS; Choi SJ; Kim SG; Ha SY; Kwon KA
[Ad] Endereço:Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon.
[Ti] Título:Spontaneous peeled ileal giant lipoma caused by lower gastrointestinal bleeding: A case report.
[So] Source:Medicine (Baltimore);96(51):e9253, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Gastrointestinal subepithelial tumors (SETs) with endoscopic features such as ulceration, a red color change, a peeled mucosal layer, and spontaneous bleeding could have malignant potential. However, we encountered a case of a lipoma that presented features different from the generally known features of gastrointestinal SETs. Therefore, we report an interesting rare case of a terminal ileal giant lipoma with a unique feature of spontaneous peeled ulceration on the surface on endoscopy that caused gastrointestinal bleeding. PATIENT: An 82-year-old woman with a 1-week history of abdominal pain and hematochezia presented to our hospital. DIAGNOSES: Ileocolonoscopy revealed a SET with a peeled surface and erythematous and ulcerative mucosal changes as well as exposed a submucosal mass at the terminal ileum. Macroscopically, the lesion appeared as a yellowish pedunculated polypoid mass measuring 3 × 2 cm with a peeled mucosal ulceration. Histopathological findings revealed a submucosal lipoma of the terminal ileum. INTERVENTION: We thought that the endoscopic finding indicated malignant SETs or those with malignant potential rather than benign SETs. Therefore, the patient underwent an elective laparoscopic ileocecectomy. LESSONS: We encountered a lipoma that did not present with the typical features of gastrointestinal SETs. Our findings suggest that clinicians should consider that benign SETs in the terminal ileum may present with various endoscopic findings similar to those of malignant SETs, which can cause fatal symptoms and signs.
[Mh] Termos MeSH primário: Hemorragia Gastrointestinal/etiologia
Íleo/cirurgia
Neoplasias Intestinais/patologia
Laparoscopia/métodos
Lipoma/patologia
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico
Dor Abdominal/etiologia
Idoso de 80 Anos ou mais
Endoscopia por Cápsula/métodos
Feminino
Seguimentos
Hemorragia Gastrointestinal/cirurgia
Seres Humanos
Íleo/patologia
Mucosa Intestinal/patologia
Mucosa Intestinal/cirurgia
Neoplasias Intestinais/complicações
Neoplasias Intestinais/diagnóstico por imagem
Neoplasias Intestinais/cirurgia
Lipoma/complicações
Lipoma/diagnóstico por imagem
Lipoma/cirurgia
Medição de Risco
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009253


  6 / 10142 MEDLINE  
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[PMID]:28468196
[Au] Autor:Trento GDS; Stringhini DJ; Rebellato NLB; Scariot R
[Ad] Endereço:*Department of Oral and Maxillofacial Surgery at Federal University of Paraná at Curitiba-UFPR † Department of Oral and Maxillofacial Surgery at Positivo University at Curitiba-UFPR, Curitiba, Brazil.
[Ti] Título:Extra-Oral Excision of a Buccal Fat Pad Lipoma.
[So] Source:J Craniofac Surg;28(3):e226-e227, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lipomas and its variants are common soft tissue tumors, and however occur infrequently in the oral and maxillofacial region. Their incidence in the oral cavity is low among all oral lesions. Oral lipoma is yellowish and soft to palpation, and histologically can be mistaken by other lipoma variants. The aim of this study is to report a case of a lipoma located at the buccal fat pad which was removed through an extra-oral access. A 43-year-old male is presenting an augmentation in the right buccal region, being a soft consistency mobile lesion with 1.5 cm of diameter, asymptomatic, and 2 years of growing. Computed tomography scan showed hypodensity compatible with adipose tissue. The lesion was removed through an extra-oral access. The lipoma described in this clinical report had an unusual location and once the lesion was very superficial an extra-oral access was the first treatment option despite the fact that was a benign tumor.
[Mh] Termos MeSH primário: Lipoma/cirurgia
Neoplasias Bucais/cirurgia
[Mh] Termos MeSH secundário: Adulto
Bochecha
Seres Humanos
Lipoma/diagnóstico por imagem
Lipoma/patologia
Masculino
Neoplasias Bucais/diagnóstico por imagem
Neoplasias Bucais/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003414


  7 / 10142 MEDLINE  
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[PMID]:29184599
[Au] Autor:Attifi H; Lagtoubi M
[Ad] Endereço:Service d'Otorhinolaryngologie et Chirurgie Cervico-faciale, Hôpital Militaire Moulay Ismaïl, Meknès, Maroc.
[Ti] Título:[Lipoma of the deep lobe of the parotid gland].
[Ti] Título:Lipome du lobe profond de la glande parotide..
[So] Source:Pan Afr Med J;28:47, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Lipomas of the parotid gland are benign tumors developing from the fatty tissue in the gland. They are rare, accounting for 0.6-4.4% of all benign tumors. Those located in the deep lobe of the gland are uncommon. Clinically, they are very difficult to diagnose. CT scan and especially MRI can support the diagnosis. Surgery is the treatment of choice but its modalities remain controversial. We report the case of a 52-year old female patient, with no particular past medical history, presenting with asymptomatic left preauricular mass evolving over 1 year and gradually increasing in volume. Clinical examination showed painless elastic swelling, measuring 2 × 1.5 × 1 cm, extending from the ear lobule to the left mandibular angle. Stensen duct wasn't obstructed and saliva was clear. The patient showed no facial paralysis. CT scan showed perfectly delimited unilobular hypodense homogeneous mass in the deep lobe of the parotid gland. No suspected cervical lymphadenopathy was detected. MRI confirmed the presence of homogeneous, lipomatous intraparotid tissue process. After superficial parotidectomy and translocation of the branches of the facial nerve, a yellowish mass appeared under the buccal and mandibular branches of the facial nerve. The patient underwent complete resection up to the left parapharyngeal space. The postoperative course was uneventful. Anatomo-pathological examination confirmed the diagnosis of lipoma of the deep lobe of the parotid gland.
[Mh] Termos MeSH primário: Lipoma/diagnóstico
Glândula Parótida/patologia
Neoplasias Parotídeas/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lipoma/patologia
Lipoma/cirurgia
Imagem por Ressonância Magnética/métodos
Meia-Idade
Glândula Parótida/diagnóstico por imagem
Glândula Parótida/cirurgia
Neoplasias Parotídeas/patologia
Neoplasias Parotídeas/cirurgia
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.47.13000


  8 / 10142 MEDLINE  
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[PMID]:29072951
[Au] Autor:Lucas DR
[Ad] Endereço:From the Department of Pathology, University of Michigan/Michigan Medicine, Ann Arbor, Michigan.
[Ti] Título:Myxoinflammatory Fibroblastic Sarcoma: Review and Update.
[So] Source:Arch Pathol Lab Med;141(11):1503-1507, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myxoinflammatory fibroblastic sarcoma is a rare soft tissue tumor with most occurring in the distal extremities of adult patients. It has a high rate of local recurrence and a low rate of metastasis. Because it may appear benign on clinical examination, and because the microscopic features are generally underrecognized, it is often inadequately treated and misdiagnosed. In this review, based upon experience and that of the literature, the intent is to highlight salient clinicopathologic features, detail the broad microscopic spectrum including high-grade aggressive variants, review the molecular features, and discuss its relation to hemosiderotic fibrolipomatous tumor.
[Mh] Termos MeSH primário: Fibrossarcoma/diagnóstico
Mixossarcoma/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Emperipolese
Extremidades
Fibrossarcoma/imunologia
Fibrossarcoma/patologia
Fibrossarcoma/terapia
Hemossiderose/diagnóstico
Hemossiderose/imunologia
Hemossiderose/patologia
Seres Humanos
Lipoma/diagnóstico
Lipoma/imunologia
Lipoma/patologia
Mixossarcoma/imunologia
Mixossarcoma/patologia
Mixossarcoma/terapia
Recidiva Local de Neoplasia
Neoplasias de Tecido Fibroso/diagnóstico
Neoplasias de Tecido Fibroso/imunologia
Neoplasias de Tecido Fibroso/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0219-RA


  9 / 10142 MEDLINE  
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[PMID]:29068974
[Au] Autor:Ioanidis KE; MacNeil SD; Tay KY; Wehrli B
[Ad] Endereço:aDepartment of Otolaryngology-Head and Neck Surgery bDepartment of Medical Imaging cDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
[Ti] Título:An atypical lipomatous tumor mimicking a giant fibrovascular polyp of the hypopharynx: A case report.
[So] Source:Medicine (Baltimore);96(43):e6927, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Giant fibrovascular polyps (GFVPs) found in the hypopharynx are exceedingly rare. These are benign tumors which are identified by CT or MRI and usually treated based on symptoms. Even more rarely, pathology may identify one of these masses as an atypical lipomatous tumor (ALT). This paper will present a case of an ALT of the hypopharynx that was originally classified as a GFVP, highlighting the difficulty in distinguishing between them and the importance of making the correct diagnosis. PATIENT CONCERNS: An 84-year-old man presented to the emergency department with a 6-month history of a pedunculated hypopharyngeal growth, dysphagia, and intermittent dyspnea. DIAGNOSES: The mass was characterized as a GFVP by barium swallow and MRI. INTERVENTIONS: The hypopharyngeal mass was resected for obstructive symptoms and to confirm the diagnosis. Final pathology found the mass to be more consistent with an atypical lipomatous tumor (ALT). OUTCOMES: The patient's dysphagia and dyspnea resolved. He was free of recurrence at 22 months postoperative. LESSONS: Both GFVPs and ALTs are very rarely found in the hypopharynx but can be easily misclassified as one another. Imaging is useful to initially characterize the mass, but to definitively differentiate between them, pathological analysis is necessary. Although they are rare, it is important to consider both possibilities on the differential for hypopharyngeal masses. Further, accurate analysis is essential to distinguish between them because their definitive management and follow-up is different.
[Mh] Termos MeSH primário: Neoplasias Hipofaríngeas/patologia
Lipoma/patologia
Pólipos/patologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Transtornos de Deglutição/etiologia
Diagnóstico Diferencial
Dispneia/etiologia
Seres Humanos
Neoplasias Hipofaríngeas/classificação
Neoplasias Hipofaríngeas/complicações
Neoplasias Hipofaríngeas/cirurgia
Lipoma/classificação
Lipoma/complicações
Lipoma/cirurgia
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006927


  10 / 10142 MEDLINE  
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[PMID]:29049236
[Au] Autor:Hu Z; Yue Z; Tang Y; Zhu Y
[Ad] Endereço:aDepartment of Orthopedics, Xiaoshan Traditional Chinese Medical Hospital bThe Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, P.R. China.
[Ti] Título:Lipoma of the middle finger: A case report and review of literature.
[So] Source:Medicine (Baltimore);96(42):e8309, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Lipomas originated from fingers are rare and the dissection is necessary when the lipomas limit the finger movement or cause pain. PATIENT CONCERNS: A 57-year-old male was admitted to our department due to a painless swelling on the volar side of the middle finger of the right hand. The flexion movement of the distal interphalangeal joint was limited. DIAGNOSES: Imaging studies and open biopsy confirmed that it was a finger lipoma. INTERVENTIONS: An excisional biopsy was performed. OUTCOMES: The patient recovered completely after two weeks. LESSONS: Based on this case and literature we reviewed, ultrasound and MRI should be used to diagnose the finger lipoma and excision was the main treatment option.
[Mh] Termos MeSH primário: Dedos
Lipoma/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Lipoma/diagnóstico por imagem
Lipoma/cirurgia
Masculino
Meia-Idade
Amplitude de Movimento Articular
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008309



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