Base de dados : MEDLINE
Pesquisa : C04.557.450.565.280 [Categoria DeCS]
Referências encontradas : 5925 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 593 ir para página                         

  1 / 5925 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28463156
[Au] Autor:Demizu Y; Jin D; Sulaiman NS; Nagano F; Terashima K; Tokumaru S; Akagi T; Fujii O; Daimon T; Sasaki R; Fuwa N; Okimoto T
[Ad] Endereço:Department of Radiology, Hyogo Ion Beam Medical Center, Tatsuno, Hyogo, Japan. Electronic address: y_demizu@nifty.com.
[Ti] Título:Particle Therapy Using Protons or Carbon Ions for Unresectable or Incompletely Resected Bone and Soft Tissue Sarcomas of the Pelvis.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):367-374, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To retrospectively analyze the treatment outcomes of particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas (BSTSs) of the pelvis. METHODS AND MATERIALS: From May 2005 to December 2014, 91 patients with nonmetastatic histologically proven unresectable or incompletely resected pelvic BSTSs underwent particle therapy with curative intent. The particle therapy used protons (52 patients) or carbon ions (39 patients). All patients received a dose of 70.4 Gy (relative biologic effectiveness) in 32 fractions (55 patients) or 16 fractions (36 patients). RESULTS: The median patient age was 67 years (range 18-87). The median planning target volume (PTV) was 455 cm (range 108-1984). The histologic type was chordoma in 53 patients, chondrosarcoma in 14, osteosarcoma in 10, malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma in 5, and other in 9 patients. Of the 91 patients, 82 had a primary tumor and 9 a recurrent tumor. The median follow-up period was 32 months (range 3-112). The 3-year rate of overall survival (OS), progression-free survival (PFS), and local control was 83%, 72%, and 92%, respectively. A Cox proportional hazards model revealed that chordoma histologic features and a PTV of ≤500 cm were significantly associated with better OS, and a primary tumor and PTV of ≤500 cm were significantly associated with better PFS. Ion type and number of fractions were not significantly associated with OS, PFS, or local control. Late grade ≥3 toxicities were observed in 23 patients. Compared with the 32-fraction protocol, the 16-fraction protocol was associated with significantly more frequent late grade ≥3 toxicities (18 of 36 vs 5 of 55; P<.001). CONCLUSIONS: Particle therapy using protons or carbon ions was effective for unresectable or incompletely resected pelvic BSTS, and the 32-fraction protocol was effective and relatively less toxic. Nevertheless, a longer follow-up period is needed to confirm these results.
[Mh] Termos MeSH primário: Neoplasias Ósseas/radioterapia
Radioterapia com Íons Pesados/métodos
Ossos Pélvicos
Terapia com Prótons/métodos
Sarcoma/radioterapia
[Mh] Termos MeSH secundário: Idoso
Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/mortalidade
Neoplasias Ósseas/cirurgia
Condrossarcoma/mortalidade
Condrossarcoma/radioterapia
Condrossarcoma/cirurgia
Cordoma/diagnóstico por imagem
Cordoma/mortalidade
Cordoma/radioterapia
Cordoma/cirurgia
Feminino
Radioterapia com Íons Pesados/estatística & dados numéricos
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Osteossarcoma/mortalidade
Osteossarcoma/radioterapia
Osteossarcoma/cirurgia
Ossos Pélvicos/diagnóstico por imagem
Modelos de Riscos Proporcionais
Terapia com Prótons/estatística & dados numéricos
Planejamento da Radioterapia Assistida por Computador/métodos
Eficiência Biológica Relativa
Estudos Retrospectivos
Sarcoma/diagnóstico por imagem
Sarcoma/mortalidade
Sarcoma/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  2 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29437070
[Au] Autor:Kim W; Lee JS; Chung HW
[Ad] Endereço:Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.
[Ti] Título:Outcomes after extensive manual curettage and limited burring for atypical cartilaginous tumour of long bone.
[So] Source:Bone Joint J;100-B(2):256-261, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Adjuvant treatment after intralesional curettage for atypical cartilaginous tumours (ACTs) of long bones is widely accepted for extending surgical margins. However, evaluating the isolated effect of adjuvant treatment is difficult, and it is unclear whether not using such adjuvants provides poor oncological outcomes. Hence, we analyzed whether intralesional curettage without cryosurgery or chemical adjuvants provides poor oncological outcomes in patients with an ACT. PATIENTS AND METHODS: A total of 24 patients (nine men, 15 women) (mean age 45 years; 18 to 62) were treated for ACTs of long bones and followed up for a median of 66 months (interquartile range 50 to 84). All patients were treated with extensive manual curettage and limited burring. Bone cement and grafts were used to fill bone defects in 16 and eight patients, respectively. No chemical adjuvants or cryosurgery were used. RESULTS: No local recurrence was detectable on plain radiographs and MRI or CT images. At the last follow-up, there were no distant metastases or disease-specific deaths. No procedure-related complications or postoperative fractures developed. CONCLUSION: Intralesional curettage without cryosurgery or chemical adjuvants may provide excellent oncological outcomes for patients with ACTs of long bones, without the risk of complications related to adjuvant use. Our investigation suggests thorough curettage alone is a reasonable treatment option for ACT. However, we acknowledge the limited size of our investigation warrants a multicentre collaborative study to confirm our findings. Cite this article: 2018;100-B:256-61.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Condrossarcoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ossos do Braço/diagnóstico por imagem
Ossos do Braço/patologia
Ossos do Braço/cirurgia
Biópsia
Cimentos para Ossos
Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/patologia
Transplante Ósseo
Condrossarcoma/diagnóstico por imagem
Condrossarcoma/patologia
Curetagem
Feminino
Seres Humanos
Ossos da Perna/diagnóstico por imagem
Ossos da Perna/patologia
Ossos da Perna/cirurgia
Masculino
Meia-Idade
Estudos Prospectivos
Instrumentos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Cements)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0707.R1


  3 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29381948
[Au] Autor:Qin Y; Zhang HB; Ke CS; Huang J; Wu B; Wan C; Yang CS; Yang KY
[Ad] Endereço:Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei.
[Ti] Título:Primary extraskeletal myxoid chondrosarcoma in cerebellum: A case report with literature review.
[So] Source:Medicine (Baltimore);96(47):e8684, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignant neoplasm of which intracranial EMC is the rarest. PATIENT CONCERNS: We present an unusual case report of a 41-year-old woman who was sent to the emergency department for a sudden headache and other symptoms related to increased intracranial pressure. INTERVENTIONS: Emergent CT revealed an occupying lesion in the left cerebellum with surrounding edema. A complete surgical excision of the lesion through a transcortical approach was performed. After the operation, this patient received adjuvant radiotherapy and temozolomide treatment. DIAGNOSES: Pathology diagnosis was an intracranial EMC. OUTCOMES: The patient survives with no tumor recurrence as of the last follow-up. Progression-free survival exceeded 20 months. LESSONS: We have reviewed the literature and here summarize the diagnosis and treatment options for intracranial EMC. Diagnosis and treatment options of this rare disease are discussed.
[Mh] Termos MeSH primário: Neoplasias Cerebelares
Cerebelo
Condrossarcoma
Dacarbazina/análogos & derivados
Neoplasias de Tecido Conjuntivo e de Tecidos Moles
Procedimentos Neurocirúrgicos/métodos
[Mh] Termos MeSH secundário: Adulto
Antineoplásicos Alquilantes/administração & dosagem
Neoplasias Cerebelares/complicações
Neoplasias Cerebelares/patologia
Neoplasias Cerebelares/fisiopatologia
Neoplasias Cerebelares/cirurgia
Cerebelo/diagnóstico por imagem
Cerebelo/cirurgia
Quimiorradioterapia Adjuvante/métodos
Condrossarcoma/complicações
Condrossarcoma/patologia
Condrossarcoma/fisiopatologia
Condrossarcoma/cirurgia
Dacarbazina/administração & dosagem
Feminino
Seres Humanos
Hipertensão Intracraniana/diagnóstico
Hipertensão Intracraniana/etiologia
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/complicações
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/patologia
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/fisiopatologia
Neoplasias de Tecido Conjuntivo e de Tecidos Moles/cirurgia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 7GR28W0FJI (Dacarbazine); YF1K15M17Y (temozolomide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008684


  4 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29230266
[Au] Autor:Naciri I; Hassam B
[Ad] Endereço:Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN SINA, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
[Ti] Título:[Shoulder tumor of startling appearance].
[Ti] Título:Une tumeur historique de l'épaule..
[So] Source:Pan Afr Med J;28:65, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Chondrosarcoma is a malignant tumor of bone of mesenchymal origin which usually occurs in people after age 40 at the level of the pelvis and the shoulder. We report the case of a 65-year old female patient, with no particular past medical history, with impaired general condition, hospitalized for exploration of a large tumor of the right shoulder, evolving over 3 years. Clinical examination showed giant, humpbacked, hard, adherent tumor measuring 44 × 32 cm along its longer axis, with inflammatory signs associated with signs of vasculo-nervous compression. Radiological evaluation showed expansive, epiphyseal, metaphyseal, diaphyseal, heterogeneou, multilobulated, poorly differentiated, calcified tumoral process with complete destruction of the glenohumeral joint that extensively invaded the soft tissues with loco-regional extension. Histological examination of a deep biopsy specimen was in favor of poorly differentiated chondrosarcoma. Staging evaluation objectified bilateral axillary lymphadenopathies and multiple metastatic subpleural and hepatic nodules. The patient died after 2 months. This study highlights the role of awareness campaigns for early diagnosis and management.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico
Condrossarcoma/diagnóstico
Ombro/patologia
[Mh] Termos MeSH secundário: Idoso
Biópsia
Neoplasias Ósseas/patologia
Condrossarcoma/patologia
Evolução Fatal
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.65.13541


  5 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29187480
[Au] Autor:Imai R; Kamada T; Araki N; WORKING GROUP FOR BONE and SOFT-TISSUE SARCOMAS
[Ad] Endereço:Hospital of the National Institute of Radiological Sciences, Quantum and Radiological Science and Technology, Chiba, Japan imai.reiko@qst.go.jp.
[Ti] Título:Clinical Efficacy of Carbon Ion Radiotherapy for Unresectable Chondrosarcomas.
[So] Source:Anticancer Res;37(12):6959-6964, 2017 12.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas. PATIENTS AND METHODS: A retrospective analysis of 75 tumors in 73 patients treated with carbon ion radiotherapy was performed. There were 26 spinal, 38 pelvic, and 11 other types of tumors. Seventy conventional and five dedifferentiated chondrosarcomas were treated in 69 and four patients, respectively. RESULTS: The median follow-up period was 49.4 (range=6.4-146.4) months. The 5-year local control, overall survival, and disease-free survival rates were 53%, 53%, and 34%, respectively. By multivariate analysis, tumor volume and histological grade were significantly related to overall and disease-free survival. Five patients required surgical intervention because of adverse events in the bones. CONCLUSION: Carbon ion radiotherapy might be a treatment option for unresectable chondrosarcoma.
[Mh] Termos MeSH primário: Neoplasias Ósseas/radioterapia
Condrossarcoma/radioterapia
Radioterapia com Íons Pesados/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Intervalo Livre de Doença
Feminino
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Estudos Retrospectivos
Resultado do Tratamento
Carga Tumoral/efeitos da radiação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  6 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28906396
[Au] Autor:Ye C; Luo Z; Zeng J; Dai M
[Ad] Endereço:aDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Jiangxi bDepartment of Orthopaedics, Shenzhen Hospital, Southern Medical University, Shenzhen City, China.
[Ti] Título:Chondrosarcoma of the patella: A case report.
[So] Source:Medicine (Baltimore);96(37):e8049, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Chondrosarcoma, characterized by the production of cartilage matrix, is a common bone tumor, accounting for 20% to 27% of all malignant bone tumors. It often occurs in the cartilage of the pelvis, femur, tibia, and humerus. However, chondrosarcoma of the patella is extremely rare. PATIENT CONCERNS: The present study describes a case of chondrosarcoma affecting the right patella in a 68-year-old woman. The chief complaints were painful swelling and limitation of motion of the right knee for about half a year. The pain was a kind of dull ache. The skin around the right knee was red and hot. Moreover, she had a claudication gait due to the symptoms. DIAGNOSES: Irregular lytic lesions with ill-defined margins in the patella were determined through computed tomography and magnetic resonance imaging. The diagnosis of primary grade II chondrosarcoma was finally confirmed on the basis of postoperative pathological examination. INTERVENTIONS: The patient underwent an open surgery named extensive resection of patellar tumor to remove the tumor tissue completely. OUTCOMES: The patient was discharged without any complications 1 week after the surgery. At the 3-month follow-up, the patient was completely free from pain during daily activities, and normal range of motion of the right knee was achieved. Her gait was normal. There was no evidence of recurrence. LESSONS: We believe that an extensive resection is suitable for treating chondrosarcoma to avoid as far as possible local recurrence. An awareness of the potential for chondrosarcoma to present in the patella is crucial for both orthopedic surgeons and radiologists when confronted with similar cases. Besides, as reports of chondrosarcoma of the patella are rare, this study adds a better understanding of this rare condition to the medical literature.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Condrossarcoma/cirurgia
Patela/cirurgia
[Mh] Termos MeSH secundário: Idoso
Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/patologia
Condrossarcoma/diagnóstico por imagem
Condrossarcoma/patologia
Feminino
Seres Humanos
Patela/diagnóstico por imagem
Patela/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008049


  7 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28872530
[Au] Autor:Shah AA; Paulino Pereira NR; Pedlow FX; Wain JC; Yoon SS; Hornicek FJ; Schwab JH
[Ad] Endereço:1Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 2Division of Thoracic Surgery, St. Elizabeth's Medical Center, Brighton, Massachusetts 3Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
[Ti] Título:Modified En Bloc Spondylectomy for Tumors of the Thoracic and Lumbar Spine: Surgical Technique and Outcomes.
[So] Source:J Bone Joint Surg Am;99(17):1476-1484, 2017 Sep 06.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Total en bloc spondylectomy (TES) for the treatment of spinal tumors decreases local recurrence and improves survival compared with intralesional resection. TES approaches vary in both the number of stages to complete the procedure and instruments with which osteotomies are performed. METHODS: We describe a 2-stage technique that employs the use of threadwire saws. We performed a retrospective review of cases of primary tumors and solitary metastases involving the thoracic or lumbar spine treated with use of our modified technique at our institution between 2010 and 2016, identifying eligible patients by searching for specific phrases in operative reports found in our oncologic database. Clinical notes, operative notes, imaging reports, and pathology reports were reviewed for all patients. RESULTS: Thirty-three patients underwent our modified technique, in which we pass a threadwire saw between the vertebral body and the thecal sac. The most common tumor type was chordoma (64%), and tumors were most commonly located in the lumbar spine (61%). There were no intraoperative injuries to the spinal cord or great vessels. One patient experienced a dural tear secondary to the passage of a saw. Seventeen (52%) of the patients had perioperative complications, with 1 death. Seven (22%) of the patients had complications occurring within 90 days after discharge, and 8 (25%) had complications occurring >90 days after discharge. Instrumentation failure was observed in 8 cases (25%). Negative margins were obtained in 94% of the cases. Local recurrence was observed in 2 cases (6%). The majority of patients had normal motor function at the time of the most recent follow-up. CONCLUSIONS: Our modified en bloc spondylectomy represents an effective technique for the resection of spinal tumors in selected patients, allowing for visualization of vessels anterior to the spine and the avoidance of spinal cord injury. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
[Mh] Termos MeSH primário: Condrossarcoma/cirurgia
Cordoma/cirurgia
Vértebras Lombares/cirurgia
Osteotomia/métodos
Neoplasias da Coluna Vertebral/cirurgia
Vértebras Torácicas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.17.00141


  8 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28853588
[Au] Autor:Yang P; Evans S; Bali N; Ramasamy A; Evans R; Stevenson J; Jeys L; Grimer R
[Ad] Endereço:Royal Orthopaedic Hospital NHS Foundation Trust , UK.
[Ti] Título:Malignant bone tumours of the foot.
[So] Source:Ann R Coll Surg Engl;99(7):568-572, 2017 Sep.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Introduction Malignant osseous foot tumours are uncommon. Their oncological outcomes have been poorly documented in the literature so far. The aim of this study was to establish the incidence and to evaluate the oncological outcomes of such patients. Methods Our large orthopaedic oncology database was used to review 70 malignant osseous foot tumour patients. Results The age at diagnosis of malignant osseous foot tumours demonstrated a bimodal distribution peaking in the second and eighth decades of life. Overall, 55 primary malignant bone tumours of the foot (79%) were identified. The median duration from onset of symptoms to diagnosis was 52 weeks (interquartile range [IQR]: 17-104). Eight primary tumours (15%) underwent an accidental excision (ie intralesional excision of a malignant bone tumour where some of the tumour has been left behind, also known as a 'whoops procedure') prior to referral to our unit. Forty-six patients (84%) underwent surgery overall and thirteen of these developed recurrence or metastases. Seven of eight patients with a previous accidental excision underwent amputation. Fifteen osseous metastatic foot lesions were identified. The median length of foot symptoms to diagnosis was 24 weeks (IQR: 20-36 weeks). The median time to death following diagnosis of osseous foot metastases was 20.1 months (IQR: 11.3-27.8 months). Conclusions A high index of suspicion and awareness of clinical features of malignant osseous foot tumours are both essential to avoid diagnostic delays. Amputation is associated with a respectable outcome for patients who have undergone previous accidental excisions.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico
Ossos do Pé
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Ósseas/mortalidade
Neoplasias Ósseas/cirurgia
Criança
Pré-Escolar
Condrossarcoma/diagnóstico
Condrossarcoma/mortalidade
Condrossarcoma/cirurgia
Feminino
Ossos do Pé/cirurgia
Seres Humanos
Lactente
Masculino
Meia-Idade
Osteossarcoma/diagnóstico
Osteossarcoma/mortalidade
Osteossarcoma/cirurgia
Estudos Retrospectivos
Sarcoma de Ewing/diagnóstico
Sarcoma de Ewing/mortalidade
Sarcoma de Ewing/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2017.0114


  9 / 5925 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28704566
[Au] Autor:Voissiere A; Jouberton E; Maubert E; Degoul F; Peyrode C; Chezal JM; Miot-Noirault É
[Ad] Endereço:Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, Clermont-Ferrand, France.
[Ti] Título:Development and characterization of a human three-dimensional chondrosarcoma culture for in vitro drug testing.
[So] Source:PLoS One;12(7):e0181340, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been suggested that chemoresistance of chondrosarcoma (CHS), the cartilage tumor, is caused by the phenotypic microenvironmental features of the tumor tissue, mainly the chondrogenic extracellular matrix (ECM), and hypoxia. We developed and characterized a multicellular tumor spheroid (MCTS) of human chondrosarcoma HEMC-SS cells to gain insight into tumor cell biology and drug response. At Day 7, HEMC-SS spheroids exhibited a homogeneous distribution of proliferative Ki-67 positive cells, whereas in larger spheroids (Day 14 and Day 20), proliferation was mainly localized in the periphery. In the core of larger spheroids, apoptotic cells were evidenced by TUNEL assay, and hypoxia by pimonidazole staining. Interestingly, VEGF excretion, evidenced by ELISA on culture media, was detectable from Day 14 spheroids, and increased as the spheroids grew in size. HEMC-SS spheroids synthesized a chondrogenic extracellular matrix rich in glycosaminoglycans and type-2 collagen. Finally, we investigated the sensitivity of Day 7 and Day 14 chondrosarcoma MCTS to hypoxia-activated prodrug TH-302 and doxorubicin compared with their 2D counterparts. As expected, TH-302 exhibited higher cytotoxic activity on larger hypoxic spheroids (Day 14) than on non-hypoxic spheroids (Day 7), with multicellular resistance index (MCRI) values of 7.7 and 9.1 respectively. For doxorubicin, the larger-sized spheroids exhibited higher drug resistance (MCRI of 5.0 for Day 7 and 18.3 for Day 14 spheroids), possibly due to impeded drug penetration into the deep layer of spheroids, evidenced by its auto-fluorescence property. We have developed a model of human chondrosarcoma MCTS that combines an ECM rich in glycosaminoglycans with a high hypoxic core associated with VEGF excretion. This model could offer a more predictive in vitro chondrosarcoma system for screening drugs targeting tumor cells and their microenvironment.
[Mh] Termos MeSH primário: Neoplasias Ósseas/patologia
Técnicas de Cultura de Células/métodos
Condrossarcoma/patologia
Ensaios de Seleção de Medicamentos Antitumorais/métodos
Esferoides Celulares/patologia
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Doxorrubicina/farmacologia
Seres Humanos
Nitroimidazóis/farmacologia
Mostardas de Fosforamida/farmacologia
Esferoides Celulares/efeitos dos fármacos
Tecidos Suporte/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Nitroimidazoles); 0 (Phosphoramide Mustards); 0 (TH 302); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181340


  10 / 5925 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28666625
[Au] Autor:Chen X; Yu LJ; Peng HM; Jiang C; Ye CH; Zhu SB; Qian WW
[Ad] Endereço:Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science China, 100730, Beijing, China. Electronic address: geteff@vip.qq.com.
[Ti] Título:Is intralesional resection suitable for central grade 1 chondrosarcoma: A systematic review and updated meta-analysis.
[So] Source:Eur J Surg Oncol;43(9):1718-1726, 2017 Sep.
[Is] ISSN:1532-2157
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The surgical choice for grade 1 chondrosarcoma has been debated for decades. Intralesional resection can minimize the damage caused by surgery and offer better functional outcome. However, controversy remains about whether it will result in higher rates of local recurrence and metastasis, fewer complications, and better functional outcome compared with resection with wide margin. This systematic review and updated meta-analysis therefore compared intralesional resection and resection with wide margin in terms of local recurrence, metastasis, complications, and functional outcome. METHODS: Medline, Embase, and the Cochrane Library were comprehensively searched in December 2016 to identify studies comparing intralesional resection and resection with wide margin for central grade 1 chondrosarcoma. Data of interest were extracted and analyzed using Review Manager 5.3. RESULTS: Ten studies involving 394 patients were included, with 214 patients who had intralesional resection and 180 patients who had resection with wide margin for grade 1 chondrosarcoma. Intralesional resection was associated with lower complication rates (P < 0.0001) and better Musculoskeletal Tumor Society score (MSTS). There were no significant differences in terms of overall local recurrence (P = 0.27), local recurrence based on adjuvant therapies (P = 0.22), local recurrence in studies that included lesions of the hand, foot, pelvis, and axial skeleton (P = 0.55), and metastasis (P = 0.74) between groups. CONCLUSION: Intralesional resection provides lower complications and better functional outcome with no significant increase in the risk of recurrence and metastasis. We think it is a suitable treatment for central grade 1 chondrosarcoma.
[Mh] Termos MeSH primário: Neoplasias Ósseas/patologia
Neoplasias Ósseas/cirurgia
Condrossarcoma/patologia
Condrossarcoma/cirurgia
Margens de Excisão
Recidiva Local de Neoplasia
[Mh] Termos MeSH secundário: Seres Humanos
Sistema Musculoesquelético/fisiopatologia
Gradação de Tumores
Metástase Neoplásica
Complicações Pós-Operatórias/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE



página 1 de 593 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde