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  1 / 2046 MEDLINE  
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[PMID]:27889201
[Au] Autor:Giuliano A; Dos Santos Horta R; Constantino-Casas F; Hoather T; Dobson J
[Ad] Endereço:University of Cambridge, Department of Veterinary Medicine, Madingley Road, Cambridge, UK. Electronic address: ag847@cam.ac.uk.
[Ti] Título:Expression of Fibroblast Activating Protein and Correlation with Histological Grade, Mitotic Index and Ki67 Expression in Canine Mast Cell Tumours.
[So] Source:J Comp Pathol;156(1):14-20, 2017 Jan.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Fibroblast activating protein (FAP) is a membrane serine protease expressed by activated fibroblasts, particularly tumour associated fibroblasts (TAFs). FAP expression has not been reported in canine mast cell tumours (MCTs). The objective of this study was to evaluate the expression of FAP in TAFs and its correlation with histological grade, mitotic index and Ki67 expression in canine MCTs. FAP expression was evaluated by immunohistochemistry (IHC) in 30 canine MCTs. Twenty-eight (90%) of the MCTs expressed FAP in the stroma, 16 cases showed low to intermediate FAP score and 14 cases had a high FAP score. FAP was correlated positively with both Patnaik (P = 0.007) and Kiupel (P = 0.008) grading systems, mitotic index (P = 0.0008) and Ki67 expression (P = 0.009). High stromal FAP expression could be a potential negative prognostic factor in canine MCTs.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Fibroblastos/patologia
Gelatinases/biossíntese
Sarcoma de Mastócitos/veterinária
Mastocitoma/veterinária
Proteínas de Membrana/biossíntese
Serina Endopeptidases/biossíntese
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/metabolismo
Cães
Imuno-Histoquímica
Antígeno Ki-67/biossíntese
Índice Mitótico
Gradação de Tumores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ki-67 Antigen); 0 (Membrane Proteins); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.- (fibroblast activation protein alpha); EC 3.4.24.- (Gelatinases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE


  2 / 2046 MEDLINE  
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[PMID]:27034386
[Au] Autor:Camus MS; Priest HL; Koehler JW; Driskell EA; Rakich PM; Ilha MR; Krimer PM
[Ad] Endereço:Department of Pathology, University of Georgia, Athens, GA, USA mscamus@uga.edu.
[Ti] Título:Cytologic Criteria for Mast Cell Tumor Grading in Dogs With Evaluation of Clinical Outcome.
[So] Source:Vet Pathol;53(6):1117-1123, 2016 Nov.
[Is] ISSN:1544-2217
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 2-tiered histologic grading scheme for canine cutaneous mast cell tumors (MCTs) is based on morphologic characteristics of neoplastic cells, including karyomegaly, multinucleation, nuclear pleomorphism, and mitotic figures. Aspirates from MCTs may provide the same information more quickly, inexpensively, and less invasively. This study used these criteria to develop a cytologic grading scheme for canine MCTs to predict outcome. Three anatomic pathologists graded histologic samples from 152 canine MCTs. Three clinical pathologists evaluated aspirates from these masses using similar criteria. A cytologic grading scheme was created based on correlation with histologic grade and evaluated with a kappa statistic. Survival was evaluated with Kaplan-Meier survival curves. Cox proportional hazards regression was used to estimate hazard ratios for tumor grades and individual grading components. Simple logistic regression tested for relationships between risk factors and mortality. The cytologic grading scheme that best correlated with histology (kappa = 0.725 ± 0.085) classified a tumor as high grade if it was poorly granulated or had at least 2 of 4 findings: mitotic figures, binucleated or multinucleated cells, nuclear pleomorphism, or >50% anisokaryosis. The cytologic grading scheme had 88% sensitivity and 94% specificity relative to histologic grading. Dogs with histologic and cytologic high grade MCTs were 39 times and 25 times more likely to die within the 2-year follow-up period, respectively, than dogs with low grade MCTs. High tumor grade was associated with increased probability of additional tumors or tumor regrowth. This study concluded that cytologic grade is a useful predictor for treatment planning and prognostication.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Sarcoma de Mastócitos/veterinária
Neoplasias Cutâneas/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/diagnóstico
Doenças do Cão/mortalidade
Cães
Feminino
Masculino
Sarcoma de Mastócitos/diagnóstico
Sarcoma de Mastócitos/mortalidade
Sarcoma de Mastócitos/patologia
Gradação de Tumores/veterinária
Prognóstico
Pele/citologia
Pele/patologia
Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/mortalidade
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


  3 / 2046 MEDLINE  
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[PMID]:26525106
[Au] Autor:Azaña JM; Torrelo A; Matito A
[Ad] Endereço:Servicio de Dermatología, Complejo Hospitalario Universitario, Albacete, España. Electronic address: jmazana8@gmail.com.
[Ti] Título:Update on Mastocytosis (Part 2): Categories, Prognosis, and Treatment.
[So] Source:Actas Dermosifiliogr;107(1):15-22, 2016 Jan-Feb.
[Is] ISSN:1578-2190
[Cp] País de publicação:Spain
[La] Idioma:eng; spa
[Ab] Resumo:Mastocytosis is a term used to describe a heterogeneous group of disorders characterized by clonal proliferation of mast cells in different organs. The organ most often affected is the skin. The World Health Organization classifies cutaneous mastocytosis into mastocytoma, maculopapular cutaneous mastocytosis, and diffuse mastocytosis. The systemic variants in this classification are as follows: indolent systemic mastocytosis (SM), aggressive SM, SM with an associated clonal hematological non-mast cell lineage disease, mast cell leukemia, mast cell sarcoma, and extracutaneous mastocytoma. The two latest systemic variants are rare. Although the course of disease is unpredictable in children, lesions generally resolve by early adulthood. In adults, however, the disease tends to persist. The goal of treatment should be to control clinical manifestations caused by the release of mast cell mediators and, in more aggressive forms of the disease, to reduce mast cell burden.
[Mh] Termos MeSH primário: Mastócitos/patologia
Mastocitose/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Leucemia de Mastócitos/diagnóstico
Sarcoma de Mastócitos/diagnóstico
Mastocitose/classificação
Mastocitose/terapia
Mastocitose Cutânea/diagnóstico
Mastocitose Sistêmica/diagnóstico
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151104
[St] Status:MEDLINE


  4 / 2046 MEDLINE  
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[PMID]:26122231
[Au] Autor:Oikonomidis IL; Tsouloufi TK; Brellou GD; Soubasis N; Ververidis C; Vlemmas I; Kritsepi-Konstantinou M
[Ad] Endereço:Diagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Greece.
[Ti] Título:Α case of multiple bilateral testicular capsule mast cell tumours in a dog.
[So] Source:J Biol Regul Homeost Agents;29(2):417-21, 2015 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:A 5-year-old intact male German Shepherd dog was referred with a diagnosis of leishmaniasis. Several testicular masses were palpated during the physical examination, while the diagnostic screening yielded no remarkable findings. Fine needle aspiration cytology of the masses revealed the presence of intermediately differentiated mast cell tumours. Scrotal ablation and orchiectomy were performed as a definitive treatment option. The pathological examination of the surgical specimens confirmed the diagnosis of grade II mast cell tumours and showed that they were all confined to the testicular capsule. At 7 months post-admission, the dog exhibited neither postsurgical complications nor metastatic foci and was, therefore, given a favourable prognosis. Despite their exceptionally rare occurrence, mast cell tumours should be considered for the differential diagnosis of testicular tumours.
[Mh] Termos MeSH primário: Doenças do Cão/diagnóstico
Sarcoma de Mastócitos/veterinária
Neoplasias Primárias Múltiplas/veterinária
Neoplasias Testiculares/veterinária
[Mh] Termos MeSH secundário: Animais
Biópsia por Agulha Fina
Doenças do Cão/patologia
Doenças do Cão/cirurgia
Cães
Achados Incidentais
Leishmaniose/complicações
Leishmaniose/veterinária
Masculino
Sarcoma de Mastócitos/diagnóstico
Sarcoma de Mastócitos/patologia
Sarcoma de Mastócitos/cirurgia
Neoplasias Primárias Múltiplas/diagnóstico
Neoplasias Primárias Múltiplas/patologia
Neoplasias Primárias Múltiplas/cirurgia
Orquiectomia
Escroto/cirurgia
Neoplasias Testiculares/diagnóstico
Neoplasias Testiculares/patologia
Neoplasias Testiculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1508
[Cu] Atualização por classe:161005
[Lr] Data última revisão:
161005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE


  5 / 2046 MEDLINE  
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[PMID]:23721492
[Au] Autor:Lejeune A; Skorupski K; Frazier S; Vanhaezebrouck I; Rebhun RB; Reilly CM; Rodriguez CO
[Ad] Endereço:Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA.
[Ti] Título:Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012).
[So] Source:Vet Comp Oncol;13(3):267-80, 2015 Sep.
[Is] ISSN:1476-5829
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This retrospective case series evaluates the outcome of 21 dogs with grade II stage 2 mast cell tumour (MCT) treated with adequate local therapy and adjuvant systemic chemotherapy (prednisone, vinblastine and CCNU). The median survival for all dogs was 1359 days (range, 188-2340). Median disease-free interval was 2120 days (149-2325 days). Dogs treated with surgery and chemotherapy had shorter survival (median, 1103 days; 188-2010 days) than those that underwent surgery, radiation therapy and chemotherapy as part of their treatment (median, 2056 days; 300-2340 days). Two patients had local recurrence in the radiation field and four patients had de novo MCT. Distant metastasis was not observed in any dogs. The results of this study suggest that, in the presence of loco-regional lymph node metastasis in grade II MCT, the use of prednisone, vinblastine and CCNU after adequate local-regional therapy can provide a median survival in excess of 40 months.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Doenças do Cão/tratamento farmacológico
Lomustina/uso terapêutico
Sarcoma de Mastócitos/veterinária
Prednisona/uso terapêutico
Vimblastina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Alquilantes/farmacologia
Antineoplásicos Alquilantes/uso terapêutico
Antineoplásicos Hormonais/farmacologia
Antineoplásicos Hormonais/uso terapêutico
Antineoplásicos Fitogênicos/farmacologia
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia
California
Intervalo Livre de Doença
Doenças do Cão/patologia
Cães
Feminino
Lomustina/farmacologia
Linfonodos/patologia
Masculino
Sarcoma de Mastócitos/tratamento farmacológico
Sarcoma de Mastócitos/patologia
Estadiamento de Neoplasias
Prednisona/farmacologia
Estudos Retrospectivos
Vimblastina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 0 (Antineoplastic Agents, Hormonal); 0 (Antineoplastic Agents, Phytogenic); 5V9KLZ54CY (Vinblastine); 7BRF0Z81KG (Lomustine); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130601
[St] Status:MEDLINE
[do] DOI:10.1111/vco.12042


  6 / 2046 MEDLINE  
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[PMID]:23654224
[Au] Autor:Gentilini F; Mantovani V; Turba ME
[Ad] Endereço:Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
[Ti] Título:The use of COLD-PCR, DHPLC and GeneScanning for the highly sensitive detection of c-KIT somatic mutations in canine mast cell tumours.
[So] Source:Vet Comp Oncol;13(3):218-28, 2015 Sep.
[Is] ISSN:1476-5829
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The conventional polymerase chain reaction (PCR)/sequencing methods may be poorly suited for the detection of somatic mutations in canine mast cell tumour (MCT) samples owing to limited sensitivity. This study was aimed at establishing novel and more sensitive methods, assessing their limit of detection and comparing their sensitivity with conventional methods.Two different 'driver' somatic mutations of c-KIT, together with the wild-type counterparts, were cloned in plasmids to prepare standard samples with known concentrations of mutated alleles in a background of wild-type alleles; the plasmids standards were assayed using either conventional or novel, highly sensitive technique. Conventional PCR/sequencing showed a sensitivity of 50-20%. Conversely, all the novel methods obtained higher sensitivities allowed reaching as low as 2.5-1.2% of the mutated DNA.The study demonstrates that early conventional methods could likely have underestimated the prevalence of KIT mutations of MCTs, therefore affecting the assessment of their relevance in prognosis and tyrosine kinase inhibitor (TKI) treatment effectiveness.
[Mh] Termos MeSH primário: Doenças do Cão/diagnóstico
Doenças do Cão/genética
Sarcoma de Mastócitos/veterinária
Reação em Cadeia da Polimerase/veterinária
Proteínas Proto-Oncogênicas c-kit/genética
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/veterinária
Bases de Dados Genéticas
Cães
Sarcoma de Mastócitos/diagnóstico
Sarcoma de Mastócitos/genética
Mutação
Plasmídeos
Reação em Cadeia da Polimerase/métodos
Polimorfismo Genético
Prognóstico
Proteínas Proto-Oncogênicas c-kit/análise
Sensibilidade e Especificidade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150821
[Lr] Data última revisão:
150821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130510
[St] Status:MEDLINE
[do] DOI:10.1111/vco.12039


  7 / 2046 MEDLINE  
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[PMID]:25172053
[Au] Autor:Weishaar KM; Thamm DH; Worley DR; Kamstock DA
[Ad] Endereço:Flint Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA.
[Ti] Título:Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis.
[So] Source:J Comp Pathol;151(4):329-38, 2014 Nov.
[Is] ISSN:1532-3129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lymph node metastasis in dogs with mast cell tumour has been reported as a negative prognostic indicator; however, no standardized histological criteria exist to define metastatic disease. The primary aim of this study was to determine whether different histological patterns of node-associated mast cells correlate with clinical outcome in dogs with mast cell tumour. A secondary goal was to propose a criteria-defined classification system for histological evaluation of lymph node metastasis. The Colorado State University Diagnostic Medicine Center database was searched for cases of canine mast cell tumours with reported lymph node metastasis or evidence of node-associated mast cells. Additional cases were obtained from a clinical trial involving sentinel lymph node mapping and node extirpation in dogs with mast cell neoplasia. Forty-one cases were identified for inclusion in the study. Demographic data, treatment and clinical outcome were collected for each case. Lymph nodes were classified according to a novel classification system (HN0-HN3) based on the number of, distribution of, and architectural disruption by, nodal mast cells. The findings of this study indicate that characterization of nodal mast cells as proposed by this novel classification system correlates with, and is prognostic for, clinical outcome in dogs with mast cell tumours.
[Mh] Termos MeSH primário: Metástase Linfática/patologia
Sarcoma de Mastócitos/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/classificação
Doenças do Cão/patologia
Cães
Feminino
Masculino
Sarcoma de Mastócitos/classificação
Sarcoma de Mastócitos/patologia
Biópsia de Linfonodo Sentinela
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141201
[Lr] Data última revisão:
141201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140831
[St] Status:MEDLINE


  8 / 2046 MEDLINE  
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[PMID]:24745684
[Au] Autor:Weiler CR; Butterfield J
[Ad] Endereço:Program of Excellence in Mast Cell and Eosinophil Disorders, Division of Allergic Disease, Department of Internal Medicine, W-15 Mayo Building, 200 First Street Southwest, Rochester, MN 55905, USA.
[Ti] Título:Mast cell sarcoma: clinical management.
[So] Source:Immunol Allergy Clin North Am;34(2):423-32, 2014 May.
[Is] ISSN:1557-8607
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mast cell sarcoma is a disorder that results in abnormal mast cells as identified by morphology, special stains, and in some publications, c-kit mutation analysis. It affects animal species such as canines more commonly than humans. In humans it is a very rare condition, with variable clinical presentation. There is no standard therapy for the disorder. It can affect any age group. It is occasionally associated with systemic mastocytosis and/or urticaria pigmentosa. The prognosis of mast cell sarcoma in published literature is very poor in humans.
[Mh] Termos MeSH primário: Sarcoma de Mastócitos/tratamento farmacológico
Sarcoma de Mastócitos/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Animais
Osso e Ossos/efeitos dos fármacos
Osso e Ossos/metabolismo
Osso e Ossos/patologia
Osso e Ossos/cirurgia
Criança
Colo/efeitos dos fármacos
Colo/metabolismo
Colo/patologia
Colo/cirurgia
Progressão da Doença
Cães
Feminino
Seres Humanos
Laringe/efeitos dos fármacos
Laringe/metabolismo
Laringe/patologia
Laringe/cirurgia
Masculino
Mastócitos/efeitos dos fármacos
Mastócitos/metabolismo
Mastócitos/patologia
Sarcoma de Mastócitos/metabolismo
Sarcoma de Mastócitos/patologia
Prognóstico
Inibidores de Proteínas Quinases/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140421
[Lr] Data última revisão:
140421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140422
[St] Status:MEDLINE


  9 / 2046 MEDLINE  
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[PMID]:24659731
[Au] Autor:Schwab TM; Popovitch C; DeBiasio J; Goldschmidt M
[Ad] Endereço:Department of Surgery, Metropolitan Veterinary Associates, Norristown, PA; and Department of Pathology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA (M.G.).
[Ti] Título:Clinical outcome for MCTs of canine pinnae treated with surgical excision (2004-2008).
[So] Source:J Am Anim Hosp Assoc;50(3):187-91, 2014 May-Jun.
[Is] ISSN:1547-3317
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Canine mast cell tumors (MCTs) are the most common cutaneous neoplasm in the dog. It has been suggested that MCT in certain locations may behave in a more biologically aggressive fashion than MCTs located in others; however, no published data are available for MCTs of canine pinnae treated with surgical excision. A retrospective study of 28 animals with surgical excision of MCTs of pinnae was completed with a medical record review and follow-up questionnaire to the operating veterinarian. The effect of tumor grade, clean or dirty excision, cartilage penetration, and mitotic index (MI) on local recurrence and survival time (ST) was evaluated. There was local recurrence in one dog with a grade 2 MCT and in seven of eight dogs with grade 3 MCTs. The median ST of animals with grade 1 and 2 MCTs was not reached, whereas the median ST of animals with grade 3 MCTs was 10 mo. There was no statistical association between histologically clean and dirty margins and either local recurrence or ST. A prolonged disease free interval without local recurrence may be achieved with local excision of grade 1 and 2 MCTs. Animals with grade 3 MCTs had a uniformly poor outcome with short times to local recurrence and death.
[Mh] Termos MeSH primário: Doenças do Cão/cirurgia
Pavilhão Auricular
Sarcoma de Mastócitos/veterinária
Recidiva Local de Neoplasia/veterinária
Neoplasias Cutâneas/veterinária
[Mh] Termos MeSH secundário: Animais
Intervalo Livre de Doença
Doenças do Cão/mortalidade
Doenças do Cão/patologia
Cães
Sarcoma de Mastócitos/cirurgia
Recidiva Local de Neoplasia/cirurgia
Estadiamento de Neoplasias/veterinária
Estudos Retrospectivos
Neoplasias Cutâneas/cirurgia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1505
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140325
[St] Status:MEDLINE
[do] DOI:10.5326/JAAHA-MS-6039


  10 / 2046 MEDLINE  
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[PMID]:24446400
[Au] Autor:Baginski H; Davis G; Bastian RP
[Ad] Endereço:Surgery Department, Red Bank Veterinary Hospital, Tinton Falls, NJ.
[Ti] Título:The prognostic value of lymph node metastasis with grade 2 MCTs in dogs: 55 cases (2001-2010).
[So] Source:J Am Anim Hosp Assoc;50(2):89-95, 2014 Mar-Apr.
[Is] ISSN:1547-3317
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study evaluates a series of dogs diagnosed with grade 2 cutaneous mast cell tumors (MCTs) with concurrent lymph node (LN) metastasis. All dogs had surgical excision of the primary tumor. The presence of metastasis was confirmed with either histopathology (n = 35) or cytology (n = 20). There was no significant difference in survival times (STs) between dogs with and without LN metastasis. Median survival time (MST) was not reached at 65.9 mo. LN palpation was a poor predictor of metastasis (sensitivity, .71; specificity, .54). Tumor location was the only prognostic factor for survival in this series of dogs. ST was greater for dogs that had removal of their metastatic LN. This study suggests that in dogs with grade 2 MCTs, outcome may not be affected by the presence of LN metastasis; however, removal of the metastatic LN may prolong survival.
[Mh] Termos MeSH primário: Doenças do Cão/cirurgia
Sarcoma de Mastócitos/veterinária
Neoplasias Cutâneas/veterinária
[Mh] Termos MeSH secundário: Animais
Intervalo Livre de Doença
Doenças do Cão/mortalidade
Doenças do Cão/patologia
Cães
Metástase Linfática
Sarcoma de Mastócitos/secundário
Sarcoma de Mastócitos/cirurgia
Gradação de Tumores
Prognóstico
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140304
[Lr] Data última revisão:
140304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140122
[St] Status:MEDLINE
[do] DOI:10.5326/JAAHA-MS-5997



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