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[PMID]:28460435
[Au] Autor:Li ZW; Zhu YR; Zhou XZ; Zhuo BB; Wang XD
[Ad] Endereço:The Center of Diagnosis and Treatment for Children's Bone Diseases, The Children's Hospital Affiliated to Soochow University, Suzhou, China.
[Ti] Título:microRNA-135b expression silences Ppm1e to provoke AMPK activation and inhibit osteoblastoma cell proliferation.
[So] Source:Oncotarget;8(16):26424-26433, 2017 Apr 18.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Forced-activation of AMP-activated protein kinase (AMPK) can possibly inhibit osteoblastoma cells. Here, we aim to provoke AMPK activation via microRNA silencing its phosphatase Ppm1e (protein phosphatase Mg2+/Mn2+-dependent 1e). We showed that microRNA-135b-5p ("miR-135b-5p"), the anti-Ppm1e microRNA, was significantly downregulated in human osteoblastoma tissues. It was correlated with Ppm1e upregulation and AMPKα1 de-phosphorylation. Forced-expression of miR-135b-5p in human osteoblastoma cells (MG-63 and U2OS lines) silenced Ppm1e, and induced a profound AMPKα1 phosphorylation (at Thr-172). Osteoblastoma cell proliferation was inhibited after miR-135b-5p expression. Intriguingly, Ppm1e shRNA knockdown similarly induced AMPKα1 phosphorylation, causing osteoblastoma cell proliferation. Reversely, AMPKα1 shRNA knockdown or dominant negative mutation almost abolished miR-135b-5p's actions in osteoblastoma cells. Further in vivo studies demonstrated that U2OS tumor growth in mice was dramatically inhibited after expressing miR-135b-5p or Ppm1e shRNA. Together, our results suggest that miR-135b-induced Ppm1e silence induces AMPK activation to inhibit osteoblastoma cell proliferation.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Neoplasias Ósseas/genética
Neoplasias Ósseas/metabolismo
Inativação Gênica
MicroRNAs/genética
Osteoblastoma/genética
Osteoblastoma/metabolismo
Proteína Fosfatase 2C/genética
[Mh] Termos MeSH secundário: Animais
Neoplasias Ósseas/patologia
Linhagem Celular Tumoral
Proliferação Celular
Modelos Animais de Doenças
Ativação Enzimática
Regulação Neoplásica da Expressão Gênica
Técnicas de Silenciamento de Genes
Seres Humanos
Camundongos
Mutação
Osteoblastoma/patologia
Fosforilação
RNA Interferente Pequeno/genética
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN135 microRNA, human); 0 (MicroRNAs); 0 (RNA, Small Interfering); EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 3.1.3.16 (PPM1E protein, human); EC 3.1.3.16 (Protein Phosphatase 2C)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15477


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Dedivitis, Rogerio Aparecido
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[PMID]:28468168
[Au] Autor:Salmen FS; Oliveira MR; Navarro CM; Dedivitis RA; Pereira Filho VA; Gabrielli MFR
[Ad] Endereço:*Araraquara Dental School, São Paulo State University (UNESP) †São Paulo School of Medicine, University of São Paulo (USP), Santos, Brazil.
[Ti] Título:Aggressive Osteoblastoma in the Maxilla: Unusual Lesion in the Craniofacial Skeleton.
[So] Source:J Craniofac Surg;28(3):794-797, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteoblastomas are benign bone tumors, which are unusual in the craniofacial skeleton, being most often observed in the axial skeleton and long bones. The most common site in the maxillofacial region is the mandible and the involvement of the maxilla and paranasal sinuses is extremely rare. Although it is a benign lesion, the aggressive variant raises concerns due to its huge local destructive potential and tendency to relapse. In this clinical case, an aggressive osteoblastoma is described in a 7-year-old patient. The lesion was large and fully involved the left maxilla, including the maxillary sinus and the nasal cavity. Recurrent volume increase was observed 2 months following enucleation of the lesion and en bloc resection of the maxillary segment was performed. Histological and immunohistochemical evaluation associated with clinical and imaging findings allowed to define the tumor as an aggressive variant of osteoblastoma and not osteosarcoma, despite the aggressive behavior. The patient recovered well and no relapses were observed after 12 months following maxillary resection.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Maxila/patologia
Neoplasias Maxilares/diagnóstico
Estadiamento de Neoplasias
Procedimentos Cirúrgicos Bucais/métodos
Osteoblastoma/diagnóstico
[Mh] Termos MeSH secundário: Neoplasias Ósseas/diagnóstico
Criança
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Maxila/cirurgia
Neoplasias Maxilares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003641


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[PMID]:28686147
[Au] Autor:Versteeg AL; Dea N; Boriani S; Varga PP; Luzzati A; Fehlings MG; Bilsky MH; Rhines LD; Reynolds JJ; Dekutoski MB; Gokaslan ZL; Germscheid NM; Fisher CG
[Ad] Endereço:Department of Orthopaedic Surgery, University Medical Center Utrecht, The Netherlands.
[Ti] Título:Surgical management of spinal osteoblastomas.
[So] Source:J Neurosurg Spine;27(3):321-327, 2017 Sep.
[Is] ISSN:1547-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE Osteoblastoma is a rare primary benign bone tumor with a predilection for the spinal column. Although of benign origin, osteoblastomas tend to behave more aggressively clinically than other benign tumors. Because of the low incidence of osteoblastomas, evidence-based treatment guidelines and high-quality research are lacking, which has resulted in inconsistent treatment. The goal of this study was to determine whether application of the Enneking classification in the management of spinal osteoblastomas influences local recurrence and survival time. METHODS A multicenter database of patients who underwent surgical intervention for spinal osteoblastoma was developed by the AOSpine Knowledge Forum Tumor. Patient data pertaining to demographics, diagnosis, treatment, cross-sectional survival, and local recurrence were collected. Patients in 2 cohorts, based on the Enneking classification of the tumor (Enneking appropriate [EA] and Enneking inappropriate [EI]), were analyzed. If the final pathology margin matched the Enneking-recommended surgical margin, the tumor was classified as EA; if not, it was classified as EI. RESULTS A total of 102 patients diagnosed with a spinal osteoblastoma were identified between November 1991 and June 2012. Twenty-nine patients were omitted from the analysis because of short follow-up time, incomplete survival data, or invalid staging, which left 73 patients for the final analysis. Thirteen (18%) patients suffered a local recurrence, and 6 (8%) patients died during the study period. Local recurrence was strongly associated with mortality (relative risk 9.2; p = 0.008). When adjusted for Enneking appropriateness, this result was not altered significantly. No significant differences were found between the EA and EI groups in regard to local recurrence and mortality. CONCLUSIONS In this evaluation of the largest multicenter cohort of spinal osteoblastomas, local recurrence was found to be strongly associated with mortality. Application of the Enneking classification as a treatment guide for preventing local recurrence was not validated.
[Mh] Termos MeSH primário: Osteoblastoma/cirurgia
Neoplasias da Coluna Vertebral/cirurgia
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Estudos Transversais
Bases de Dados Factuais
Feminino
Seguimentos
Seres Humanos
Estimativa de Kaplan-Meier
Masculino
Recidiva Local de Neoplasia
Osteoblastoma/classificação
Osteoblastoma/mortalidade
Estudos Prospectivos
Estudos Retrospectivos
Neoplasias da Coluna Vertebral/classificação
Neoplasias da Coluna Vertebral/mortalidade
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.3171/2017.1.SPINE16788


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[PMID]:28282544
[Au] Autor:Elsayed H; Puttaraju A; Cribb G; Cool P; Afifi H; Abdalla O
[Ad] Endereço:Trauma and Orthopedics, Tameside NHS Hospital, Ashton-Under-Lyne, UK. Electronic address: Hassanfarouk80@hotmail.com.
[Ti] Título:Osteobastoma of the Talus: A case report and review of the literature.
[So] Source:Foot (Edinb);30:59-62, 2017 Mar.
[Is] ISSN:1532-2963
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Osteoblastoma is benign bone forming tumour with rare malignant transformation. The common locations include spine, proximal humerus and hip. It rarely affects the talus. A case of osteoblastoma of the talus in a 33-years old healthy male who presented to the foot and ankle clinic in October 2015 complaining of pain of the right ankle for 12 months following football injury is discussed.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico por imagem
Osteoblastoma/diagnóstico por imagem
Tálus/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Artralgia/etiologia
Neoplasias Ósseas/patologia
Neoplasias Ósseas/cirurgia
Edema/etiologia
Seres Humanos
Masculino
Osteoblastoma/patologia
Osteoblastoma/cirurgia
Tálus/patologia
Tálus/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


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[PMID]:28210742
[Au] Autor:Subramanian M; Chou H; Chokkappan K; Peh WC
[Ad] Endereço:Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore.
[Ti] Título:Clinics in diagnostic imaging (174). L5 vertebral superior facet osteoblastoma (OB).
[So] Source:Singapore Med J;58(2):79-84, 2017 Feb.
[Is] ISSN:0037-5675
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:A 25-year-old man presented with chronic low back pain and occasional radiation to the right lower limb. Magnetic resonance imaging and computed tomography (CT) of the lumbar spine showed an osteolytic expansile lesion with a central sclerotic nidus in the right superior facet of the L5 vertebra and surrounding marrow oedema. The diagnosis of osteoblastoma was made based on imaging findings and confirmed after CT-guided biopsy. Radiofrequency ablation of the lesion was successfully performed. The patient tolerated the procedure well and showed symptomatic relief. The imaging features and management of osteoblastoma are discussed.
[Mh] Termos MeSH primário: Dor Crônica/diagnóstico por imagem
Dor Lombar/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Ablação por Cateter
Seres Humanos
Processamento de Imagem Assistida por Computador
Biópsia Guiada por Imagem
Vértebras Lombares/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Osteoblastoma/diagnóstico por imagem
Osteólise
Osteoma/diagnóstico por imagem
Ondas de Rádio
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.11622/smedj.2017007


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[PMID]:28142170
[Ti] Título:Knochentumoren: Metastase oder Enostose?.
[So] Source:Rofo;189(2):112-113, 2017 Feb.
[Is] ISSN:1438-9010
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/secundário
Exostose/diagnóstico por imagem
Tomografia Computadorizada Multidetectores/métodos
Intensificação de Imagem Radiográfica/métodos
Interpretação de Imagem Radiográfica Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Osteoblastoma/diagnóstico por imagem
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-122074


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[PMID]:27957634
[Au] Autor:Cobb MIH; Zomorodi AR; Hauck EF; Smith TP; Fernando Gonzalez L
[Ad] Endereço:Department of Neurosurgery, Duke University Hospitals, DUMC Box 3807, Durham, NC, 27701, USA. maryih.cobb@duke.edu.
[Ti] Título:Optimal pediatric dosing of anti-platelet agents for pipeline stent embolization -a case report and review of the literature.
[So] Source:Childs Nerv Syst;33(4):685-690, 2017 Apr.
[Is] ISSN:1433-0350
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Various strategies are emerging for dosing antiplatelet therapies in preparation for pipeline stent embolization in adults. Hyper-response is associated with hemorrhagic complications. Hypo-response is associated with thromboembolic events. Dosing of antiplatelet agents is highly variable, with little consensus among experts for adults-and even more so for children. To date, pipeline stents have been deployed in 11 pediatric patients, ages 4-15. A variety of clopidogrel and aspirin dosing regimens have been used, with response tested in only three patients, who were all therapeutic. Thrombotic events occurred in two patients, neither of whom were tested. CASE: We describe here the first case of a hemorrhagic complication in a hyper-responsive pediatric patient undergoing placement of a pipeline stent. DISCUSSION: As the use of endovascular therapies requiring dual anti-platelet agents becomes more established, there is an increasing need to develop titration protocols that minimizes the risk of thrombotic and hemorrhagic events.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Hemorragia Cerebral
Embolização Terapêutica/métodos
Osteoblastoma/cirurgia
Inibidores da Agregação de Plaquetas/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Aspirina/uso terapêutico
Neoplasias Ósseas/diagnóstico por imagem
Hemorragia Cerebral/tratamento farmacológico
Hemorragia Cerebral/etiologia
Hemorragia Cerebral/cirurgia
Feminino
Seres Humanos
Osteoblastoma/diagnóstico por imagem
Ticlopidina/análogos & derivados
Ticlopidina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Platelet Aggregation Inhibitors); A74586SNO7 (clopidogrel); OM90ZUW7M1 (Ticlopidine); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1007/s00381-016-3311-z


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[PMID]:27853880
[Au] Autor:Toescu SM; Alalade AF; Steele L; Bhargava D; Hunter R
[Ad] Endereço:Victor Horsley Department of Neurosurgery, National Hospital of Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK. s.m.toescu@gmail.com.
[Ti] Título:Frontal skull osteoblastoma with aneurysmal bone cyst-like changes associated with trauma during pregnancy: a case report.
[So] Source:Acta Neurochir (Wien);159(2):393-396, 2017 Feb.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:We report the case of a large osteoblastoma arising in the frontal bone of a 20-year-old female. The lesion was first noted after a fall, and grew steadily in size following further head injury during pregnancy. Initial plain radiography demonstrated an area of radiolucency, with subsequent cross-sectional imaging revealing the extent of the lesion. Following successful surgical resection, histological features were suggestive of an aggressive osteoblastoma with aneurysmal bone cyst-like changes. We consider the influence of pregnancy and trauma on osteoblastoma behavior.
[Mh] Termos MeSH primário: Cistos Ósseos Aneurismáticos/diagnóstico por imagem
Neoplasias Ósseas/diagnóstico por imagem
Osteoblastoma/diagnóstico por imagem
Complicações Neoplásicas na Gravidez/diagnóstico por imagem
[Mh] Termos MeSH secundário: Cistos Ósseos Aneurismáticos/etiologia
Cistos Ósseos Aneurismáticos/patologia
Neoplasias Ósseas/etiologia
Neoplasias Ósseas/patologia
Feminino
Osso Frontal/patologia
Seres Humanos
Osteoblastoma/etiologia
Osteoblastoma/patologia
Gravidez
Complicações Neoplásicas na Gravidez/etiologia
Complicações Neoplásicas na Gravidez/patologia
Radiografia
Ferimentos e Lesões/complicações
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-016-3024-9


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[PMID]:27834626
[Au] Autor:Peciu-Florianu I; Chittur Viswanathan G; Barges-Coll J; Castillo-Velázquez GA; Zambelli PY; Duff JM
[Ad] Endereço:Neurosurgical Service, Department of Clinical Neurosciences and.
[Ti] Título:Bilateral C-1 lateral mass reconstruction following radical resection of a giant osteoblastoma of the atlas: case report.
[So] Source:J Neurosurg Spine;26(3):307-312, 2017 Mar.
[Is] ISSN:1547-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteoblastoma is a rare, benign, osteoid-producing, and slow-growing primary bone tumor, typically arising in long bones or in the spine, with a slight male predominance. This report describes the surgical treatment of a giant C-1 (atlantal) osteoblastoma diagnosed in a young male patient with neurofibromatosis Type 1. The authors describe the clinical presentation, the surgical procedure for complete excision and stabilization, and results as of the 1-year follow-up. They detail a bilateral occipitoaxial spinal interarticular stabilization technique that they used after complete tumor excision. To the best of their knowledge, this is the first case of bilateral C-1 lateral mass reconstruction by this technique to be reported in the literature.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Atlas Cervical/cirurgia
Vértebras Cervicais/cirurgia
Osteoblastoma/cirurgia
[Mh] Termos MeSH secundário: Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/patologia
Criança
Seres Humanos
Masculino
Osteoblastoma/diagnóstico
Procedimentos Cirúrgicos Reconstrutivos/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161112
[St] Status:MEDLINE
[do] DOI:10.3171/2016.8.SPINE16319


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[PMID]:27756672
[Au] Autor:Czigléczki G; Nagy Z; Papp Z; Padányi C; Banczerowski P
[Ad] Endereço:National Institute of Clinical Neurosciences, Budapest, Hungary; Department of Neurosurgery, Semmelweis University, Budapest, Hungary. Electronic address: gczigleczki@gmail.com.
[Ti] Título:Management Strategy of Osteoblastomas Localized in the Occipitocervical Junction.
[So] Source:World Neurosurg;97:505-512, 2017 Jan.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this article was to analyze extracted patient data from the literature and highlight the best treatment options and survival outcomes for osteoblastomas in the occipitocervical region. METHODS: A systematic literature search method was used to select articles containing information about the demographic features, tumor location, treatment characteristics, adjuvant therapies, and follow-up time. RESULTS: From 25 articles, 31 cases of osteoblastoma in the occipitocervical junction were selected for analysis. Average patient age was 17 years (range, 5-57 years); there were 21 male (67%) and 10 female (33%) patients. All patients had cervical pain as the presenting symptom. Other symptoms included torticollis (0.13%) and sensory or motor neurologic deficits (0.16%). The average follow-up time was 41 months, and the local recurrence rate was 0.125%. Recommendations of each article are categorized and discussed in detail. CONCLUSIONS: Osteoblastoma is a rare entity in the occipitocervical region, so treatment experiences are limited and mostly based on case reports. To determine the best treatment for these lesions, osteoblastomas should be staged using the Enneking staging system; different methods may be recommended for different stages, and the feasibility of fusion depends on the remaining amount of bony structures and joints. Additional adjuvant therapies may be recommended only in special cases.
[Mh] Termos MeSH primário: Articulação Atlantoaxial/cirurgia
Cervicalgia/mortalidade
Osteoblastoma/mortalidade
Osteoblastoma/cirurgia
Doenças da Medula Espinal/mortalidade
Neoplasias da Coluna Vertebral/mortalidade
Neoplasias da Coluna Vertebral/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Causalidade
Vértebras Cervicais/cirurgia
Criança
Pré-Escolar
Comorbidade
Feminino
Seres Humanos
Masculino
Meia-Idade
Cervicalgia/prevenção & controle
Prevalência
Fatores de Risco
Doenças da Medula Espinal/prevenção & controle
Taxa de Sobrevida
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE



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