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Pesquisa : C04.557.450.565.575.610 [Categoria DeCS]
Referências encontradas : 1301 [refinar]
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  1 / 1301 MEDLINE  
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[PMID]:29252754
[Au] Autor:Kim CH; Kekatpure AL; Kashikar A; Chang JS; Jeong MY; Yoon PW
[Ad] Endereço:Departments of Orthopedic Surgery (C.-H.K., A.L.K., J.S.C., M.Y.J., and P.W.Y.) and Pathology (A.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
[Ti] Título:Arthroscopic Excision of a Solitary Acetabular Osteochondroma in an Adult: A Case Report.
[So] Source:JBJS Case Connect;6(4):e101, 2016 Oct-Dec.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: A 43-year-old woman presented with localized pain of the right hip 2 months after a trivial trauma. Physical examination revealed a positive Patrick (FABER [Flexion, Abduction, and External Rotation]) test. Radiographs showed a radiopaque lesion at the acetabular fossa, and magnetic resonance imaging revealed a mass with adjacent bone marrow edema. Arthroscopic excision of the lesion was performed; histopathologic examination demonstrated that it was an osteochondroma. CONCLUSION: A solitary intra-articular osteochondroma is a possible cause of localized hip pain. Hip arthroscopy can be a good diagnostic and therapeutic option.
[Mh] Termos MeSH primário: Acetábulo/cirurgia
Artroscopia/métodos
Neoplasias Ósseas/cirurgia
Osteocondroma/cirurgia
[Mh] Termos MeSH secundário: Acetábulo/diagnóstico por imagem
Adulto
Neoplasias Ósseas/diagnóstico por imagem
Feminino
Seres Humanos
Osteocondroma/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00101


  2 / 1301 MEDLINE  
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[PMID]:28577786
[Au] Autor:Chao J; Pao A
[Ad] Endereço:Peachtree Orthopaedic Clinic, 5505 Peachtree Dunwoody Road, Suite 600, Atlanta, GA 30342, USA. Electronic address: jchao@pocatlanta.com.
[Ti] Título:Restorative Tissue Transplantation Options for Osteochondral Lesions of the Talus: A Review.
[So] Source:Orthop Clin North Am;48(3):371-383, 2017 Jul.
[Is] ISSN:1558-1373
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Symptomatic osteochondral lesions of the talus remain a challenging problem due to inability for cartilage lesions to heal. Numerous treatment options exist, including nonoperative management, marrow stimulating techniques, and autograft-allograft. Arthroscopic marrow stimulation forms fibrocartilage that has been shown to be biomechanically weaker than hyaline cartilage. Restorative tissue transplantation options are being used more for larger and cystic lesions. Newer biologics and particulated juvenile cartilage are currently under investigation for possible clinical efficacy. This article provides an evidenced-based summary of available literature on the use of biologics for treatment of osteochondral lesions of the talus.
[Mh] Termos MeSH primário: Terapia Biológica/métodos
Cartilagem Articular
Osteocondroma
Tálus
Transplante de Tecidos/métodos
[Mh] Termos MeSH secundário: Cartilagem Articular/patologia
Cartilagem Articular/cirurgia
Seres Humanos
Osteocondroma/patologia
Osteocondroma/fisiopatologia
Osteocondroma/cirurgia
Tálus/patologia
Tálus/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


  3 / 1301 MEDLINE  
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[PMID]:28566052
[Au] Autor:Akinyemi OA; Mabry LM; Dardenelle SI
[Ti] Título:Buttock Pain and Sciatica Caused by a Femoral Osteochondroma.
[So] Source:J Orthop Sports Phys Ther;47(6):442, 2017 Jun.
[Is] ISSN:1938-1344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 26-year-old woman was referred to physical therapy with lower back pain extending into the right buttock. Palpation of the right buttock revealed a firm, immobile mass of considerable size, which the patient identified as her locus of symptoms. Due to the noted palpable mass, her pain, her inability to sit normally, and the longevity of symptoms, the physical therapist ordered radiographs, which identified multiple osteochondromas. J Orthop Sports Phys Ther 2017;47(6):442. doi:10.2519/jospt.2017.6877.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico por imagem
Nádegas/diagnóstico por imagem
Fêmur/diagnóstico por imagem
Osteocondroma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Dor Musculoesquelética/etiologia
Osteocondroma/diagnóstico
Ciática/diagnóstico
Ciática/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.2519/jospt.2017.6877


  4 / 1301 MEDLINE  
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[PMID]:28531939
[Au] Autor:Vahedi P; Rymarczuk G; Gillick JL; Prasad SK; Lotfinia I
[Ad] Endereço:Department of Neurological Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Department of Neurosurgery, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address: payman.vahedi@gmail.com.
[Ti] Título:Letter to the Editor: Intraspinal Cervical Osteochondroma.
[So] Source:World Neurosurg;101:805-810, 2017 05.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteocondroma
Compressão da Medula Espinal
[Mh] Termos MeSH secundário: Neoplasias Ósseas
Vértebras Cervicais
Seres Humanos
Neoplasias da Coluna Vertebral
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


  5 / 1301 MEDLINE  
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[PMID]:28445472
[Au] Autor:Sinha S; Mundy C; Bechtold T; Sgariglia F; Ibrahim MM; Billings PC; Carroll K; Koyama E; Jones KB; Pacifici M
[Ad] Endereço:Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
[Ti] Título:Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
[So] Source:PLoS Genet;13(4):e1006742, 2017 Apr.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. HME is characterized by formation of cartilaginous outgrowths-called osteochondromas- next to the growth plates of many axial and appendicular skeletal elements. Surprisingly, it is not known whether such tumors also form in endochondral elements of the craniofacial skeleton. Here, we carried out a retrospective analysis of cervical spine MRI and CT scans from 50 consecutive HME patients that included cranial skeletal images. Interestingly, nearly half of the patients displayed moderate defects or osteochondroma-like outgrowths in the cranial base and specifically in the clivus. In good correlation, osteochondromas developed in the cranial base of mutant Ext1f/f;Col2-CreER or Ext1f/f;Aggrecan-CreER mouse models of HME along the synchondrosis growth plates. Osteochondroma formation was preceded by phenotypic alteration of cells at the chondro-perichondrial boundary and was accompanied by ectopic expression of major cartilage matrix genes -collagen 2 and collagen X- within the growing ectopic masses. Because chondrogenesis requires bone morphogenetic protein (BMP) signaling, we asked whether osteochondroma formation could be blocked by a BMP signaling antagonist. Systemic administration with LDN-193189 effectively inhibited osteochondroma growth in conditional Ext1-mutant mice. In vitro studies with mouse embryo chondrogenic cells clarified the mechanisms of LDN-193189 action that turned out to include decreases in canonical BMP signaling pSMAD1/5/8 effectors but interestingly, concurrent increases in such anti-chondrogenic mechanisms as pERK1/2 and Chordin, Fgf9 and Fgf18 expression. Our study is the first to reveal that the cranial base can be affected in patients with HME and that osteochondroma formation is amenable to therapeutic drug intervention.
[Mh] Termos MeSH primário: Exostose Múltipla Hereditária/genética
N-Acetilglucosaminiltransferases/genética
Osteocondroma/genética
Proteína Smad1/genética
[Mh] Termos MeSH secundário: Animais
Proteínas Morfogenéticas Ósseas/genética
Proteínas Morfogenéticas Ósseas/metabolismo
Medula Cervical/metabolismo
Medula Cervical/patologia
Condrogênese/genética
Modelos Animais de Doenças
Desenvolvimento Embrionário/genética
Exostose Múltipla Hereditária/diagnóstico por imagem
Exostose Múltipla Hereditária/tratamento farmacológico
Exostose Múltipla Hereditária/patologia
Lâmina de Crescimento/metabolismo
Lâmina de Crescimento/patologia
Heparitina Sulfato/biossíntese
Seres Humanos
Imagem por Ressonância Magnética
Camundongos
Camundongos Knockout
Mutação
Osteocondroma/diagnóstico por imagem
Osteocondroma/patologia
Pirazóis/administração & dosagem
Pirimidinas/administração & dosagem
Tomografia Computadorizada de Emissão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Proteins); 0 (LDN 193189); 0 (Pyrazoles); 0 (Pyrimidines); 0 (Smad1 Protein); 0 (Smad1 protein, mouse); 9050-30-0 (Heparitin Sulfate); EC 2.4.1.- (N-Acetylglucosaminyltransferases); EC 2.4.1.224 (exostosin-1); EC 2.4.1.224 (exostosin-2)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006742


  6 / 1301 MEDLINE  
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[PMID]:28377548
[Au] Autor:Aldashash F; Elraie M
[Ad] Endereço:Dr. Fahad Aldashash, King Saud St. 40501, Riyadh 11551, Saudi Arabia, f.a.dashash@gmail.com, ORCID: http://orcid. org/0000-0002-6190-0788.
[Ti] Título:Solitary osteochondroma of the proximal femur causing sciatic nerve compression.
[So] Source:Ann Saudi Med;37(2):166-169, 2017 Mar-Apr.
[Is] ISSN:0975-4466
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:Osteochondromas (OC) are the most common benign tumors of the bones. They are most frequently found near the knee joint and are typically asymptomatic. The presence of OC near the hip joint is rare. In addition, OC is an extremely uncommon cause of sciatica. We present a rare case of OC of the proximal femur. The patient presented with left hip pain and manifestations of sciatic nerve compression. Surgical excision was performed. The diagnosis was confirmed postoperatively by histopathology. SIMILAR CASES PUBLISHED: 1.
[Mh] Termos MeSH primário: Neoplasias Ósseas/complicações
Neoplasias Femorais/complicações
Síndromes de Compressão Nervosa/etiologia
Osteocondroma/complicações
[Mh] Termos MeSH secundário: Adulto
Neoplasias Ósseas/patologia
Neoplasias Ósseas/cirurgia
Feminino
Neoplasias Femorais/patologia
Neoplasias Femorais/cirurgia
Articulação do Quadril/patologia
Seres Humanos
Osteocondroma/patologia
Osteocondroma/cirurgia
Dor/etiologia
Nervo Isquiático/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.5144/0256-4947.2017.166


  7 / 1301 MEDLINE  
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[PMID]:28328842
[Au] Autor:Zhang Y; Wen L; Zhang J; Yan G; Zhou Y; Huang B
[Ad] Endereço:Department of Orthopedics, Xinqiao Hospital, The Third Military Medical University, Chongqing, China.
[Ti] Título:Three-dimensional printing and computer navigation assisted hemipelvectomy for en bloc resection of osteochondroma: A case report.
[So] Source:Medicine (Baltimore);96(12):e6414, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Three-dimensional (3D) printed templates can be designed to match an individual's anatomy, allowing surgeons to refine preoperative planning. In addition, the use of computer navigation (NAV) is gaining popularity to improve surgical accuracy in the resection of pelvic tumors. However, its use in combination with 3D printing to assist complex pelvic tumor resection has not been reported. PATIENT CONCERNS: A 36-year-old man presented with left-sided pelvic pain and a fast-growing mass. He also complained of a 3-month history of radiating pain and numbness in the lower left extremity. DIAGNOSES: A biopsy revealed an osteochondroma with malignant potential. This osteochondroma arises from the ilium and involves the sacrum and lower lumbar vertebrae. INTERVENTIONS: Here, we describe a novel combined application of 3D printing and intraoperative NAV systems to guide hemipelvectomy for en-bloc resection of the osteochondroma. The 3D printed template is analyzed during surgical planning and guides the initial intraoperative bone work to improve surgical accuracy and efficiency, while a computer NAV system provides real-time imaging during the tumor removal to achieve adequate resection margins and minimize the likelihood of injury to adjacent critical structures. OUTCOMES: The tumor mass and the invaded spinal structures were removed en bloc. LESSONS: The combined application of 3D printing and computer NAV may be useful for tumor targeting and safe osteotomies in pelvic tumor surgery.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Hemipelvectomia/métodos
Osteocondroma/cirurgia
Impressão Tridimensional/instrumentação
Cirurgia Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Adulto
Hemipelvectomia/instrumentação
Seres Humanos
Masculino
Cirurgia Assistida por Computador/instrumentação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006414


  8 / 1301 MEDLINE  
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[PMID]:28296944
[Au] Autor:Kierdorf U; Miller KV; Flohr S; Gomez S; Kierdorf H
[Ad] Endereço:Department of Biology, University of Hildesheim, Hildesheim, Germany.
[Ti] Título:Multiple osteochondromas of the antlers and cranium in a free-ranging white-tailed deer (Odocoileus virginianus).
[So] Source:PLoS One;12(3):e0173775, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This paper reports a case of multiple osteochondromas affecting the antlers and the left zygomatic bone of a free-ranging adult white-tailed buck (Odocoileus virginianus) from Georgia, USA. Along with a few postcranial bones, the antlered cranium of the individual was found in a severely weathered condition and devoid of any soft tissue. The antlers exhibited five pedunculated exostoses that were composed of cancellous bone and, in their peripheral portions, also mineralized cartilage. The largest of the exostoses, located on the right antler, had a maximum circumference of 55 cm. The exostosis arising from the zygomatic bone was broad-based and much smaller than the exophytic outgrowths on the antlers. Diagnosis of the exostoses as osteochondromas was based on their overall morphology, the normal bone structure in their stalk regions, and the continuity of their spongiosa and cortex with the respective components of the parent bones. Antleromas, i.e., pathological outgrowths developing on antlers as a result of insufficient androgen production, were excluded in the differential diagnosis, based on (1) the apparent maturity and, except for the tumors, normal shape of the antlers and (2) the fact that exostosis formation had also affected the zygomatic bone. Previously only a single case of solitary osteochondroma of an antler has been described in the scientific literature. The case presented here is the first report of multiple osteochondromas in a deer. As antlers are regularly collected as trophies, and huge numbers of them are critically inspected each year, the fact that thus far only two cases of antler osteochondromas have been reported suggests that these tumors are very rare.
[Mh] Termos MeSH primário: Chifres de Veado/patologia
Neoplasias Ósseas/veterinária
Osteocondroma/veterinária
Crânio/patologia
[Mh] Termos MeSH secundário: Animais
Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/patologia
Cervos
Osteocondroma/diagnóstico
Osteocondroma/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173775


  9 / 1301 MEDLINE  
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[PMID]:28275813
[Au] Autor:Sampath AJ; Miller DC; Mesfin FB; Crim JR
[Ad] Endereço:University of Missouri School of Medicine, Columbia, MO, USA.
[Ti] Título:Osteochondroma mimicking meningioma: case report and literature update.
[So] Source:Skeletal Radiol;46(6):825-829, 2017 Jun.
[Is] ISSN:1432-2161
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We report a case of an osteochondroma in a 47-year-old woman presenting with a 2-month history of thoracic back pain that radiated down her left arm. Based on imaging features, the osteochondroma was initially thought to represent a calcified meningioma. The unusual features of the case include the location of the tumor, patient age, the erosion of the vertebra, and the confusing neuroradiological features. We review reported cases in which a solitary costal osteochondroma impinges on the neural foramina or central spinal canal and we discuss reasons for the misdiagnosis in our case.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico por imagem
Meningioma
Osteocondroma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Dor nas Costas/etiologia
Neoplasias Ósseas/complicações
Neoplasias Ósseas/cirurgia
Diagnóstico Diferencial
Feminino
Seres Humanos
Vértebras Lombares/diagnóstico por imagem
Vértebras Lombares/cirurgia
Imagem por Ressonância Magnética
Meia-Idade
Osteocondroma/complicações
Osteocondroma/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1007/s00256-017-2608-7


  10 / 1301 MEDLINE  
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[PMID]:28110943
[Au] Autor:Ji H; Li J; Shao J; He D; Liu Y; Fei W; Luo E
[Ad] Endereço:West China Hospital of Stomatology, State Key Laboratory of Oral Disease, Sichuan University, Chengdu, P. R. China.
[Ti] Título:Histopathologic comparison of condylar hyperplasia and condylar osteochondroma by using different staining methods.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;123(3):320-329, 2017 Mar.
[Is] ISSN:2212-4411
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objectives of this study were to investigate the application and differential diagnostic value of safranin O staining, safranin-fast green staining, and Runt-related transcription factor 2 (Runx2) immunohistochemistry with regard to condylar hyperplasia and condylar osteochondroma. STUDY DESIGN: Histopathologic presence was evaluated by using hematoxylin and eosin staining, safranin O staining, safranin-fast green staining, and immunohistochemistry of Runx2 in postoperative specimens of normal condyle (control), condylar hyperplasia, and condylar osteochondroma. RESULTS: Safranin O staining clearly highlighted the tissue structure of the condylar cartilage, especially the hypertrophic layer. The safranin-fast green method showed a contrast in staining between cartilage and subchondral cancellous bone in the condyle specimens. Both methods were better than hematoxylin and eosin staining for morphologically distinguishing condylar hyperplasia and condylar osteochondroma. The expression of Runx2 in condylar hyperplasia was significantly greater than that in condylar osteochondroma. CONCLUSIONS: This study indicated that safranin O staining and safranin-fast green staining are effective staining methods to differentiate between condylar hyperplasia and condylar osteochondroma. Immunohistochemistry findings suggested that Runx2 is valuable in the differential diagnosis of these two diseases.
[Mh] Termos MeSH primário: Neoplasias Ósseas/patologia
Côndilo Mandibular/patologia
Osteocondroma/patologia
Coloração e Rotulagem/métodos
[Mh] Termos MeSH secundário: Adulto
Neoplasias Ósseas/diagnóstico por imagem
Subunidades alfa de Fatores de Ligação ao Core
Feminino
Seres Humanos
Hiperplasia/diagnóstico por imagem
Hiperplasia/patologia
Imuno-Histoquímica
Masculino
Côndilo Mandibular/diagnóstico por imagem
Osteocondroma/diagnóstico por imagem
Fenazinas
Radiografia Panorâmica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Core Binding Factor alpha Subunits); 0 (Phenazines); XTX0YXU2HV (safranine T)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE



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