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[PMID]:29382014
[Au] Autor:Li BJ; Yang XD; Chen WX; Shi YH; Nie ZH; Wu J
[Ad] Endereço:Department of Gastroenterology.
[Ti] Título:Calcifying fibrous tumor of stomach: A case report.
[So] Source:Medicine (Baltimore);96(47):e8882, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Calcifying fibrous tumor (CFT) is a rare benign soft tissue mesenchymal neoplasm. Although the gastrointestinal (GI) tract is the most common predilection site of CFT, the clinicians, even including pathologist, generally consider it as GI stromal tumor (GIST) or other submucosal tumors such as schwannoma and leiomyoma. PATIENT CONCERNS: A 55-year-old man presented with complaints of epigastric discomfort and abdominal distention for more than 1 year. DIAGNOSES: On the basis of endoscopic and computed tomography examination, preliminary diagnosis was GIST. INTERVENTIONS: Endoscopic submucosal dissection (ESD) surgery was performed to remove the gastric mass. OUTCOMES: The histopathological examination revealed a gastric CFT. LESSONS: We present a case of gastric CFT, which was misdiagnosed as GIST based on endoscopic and radiologic findings.
[Mh] Termos MeSH primário: Calcinose/diagnóstico
Erros de Diagnóstico
Neoplasias de Tecido Fibroso/diagnóstico
Neoplasias Gástricas/diagnóstico
[Mh] Termos MeSH secundário: Calcinose/patologia
Diagnóstico Diferencial
Neoplasias Gastrointestinais/diagnóstico
Tumores do Estroma Gastrointestinal/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Neoplasias de Tecido Fibroso/patologia
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008882


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[PMID]:29072951
[Au] Autor:Lucas DR
[Ad] Endereço:From the Department of Pathology, University of Michigan/Michigan Medicine, Ann Arbor, Michigan.
[Ti] Título:Myxoinflammatory Fibroblastic Sarcoma: Review and Update.
[So] Source:Arch Pathol Lab Med;141(11):1503-1507, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myxoinflammatory fibroblastic sarcoma is a rare soft tissue tumor with most occurring in the distal extremities of adult patients. It has a high rate of local recurrence and a low rate of metastasis. Because it may appear benign on clinical examination, and because the microscopic features are generally underrecognized, it is often inadequately treated and misdiagnosed. In this review, based upon experience and that of the literature, the intent is to highlight salient clinicopathologic features, detail the broad microscopic spectrum including high-grade aggressive variants, review the molecular features, and discuss its relation to hemosiderotic fibrolipomatous tumor.
[Mh] Termos MeSH primário: Fibrossarcoma/diagnóstico
Mixossarcoma/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Emperipolese
Extremidades
Fibrossarcoma/imunologia
Fibrossarcoma/patologia
Fibrossarcoma/terapia
Hemossiderose/diagnóstico
Hemossiderose/imunologia
Hemossiderose/patologia
Seres Humanos
Lipoma/diagnóstico
Lipoma/imunologia
Lipoma/patologia
Mixossarcoma/imunologia
Mixossarcoma/patologia
Mixossarcoma/terapia
Recidiva Local de Neoplasia
Neoplasias de Tecido Fibroso/diagnóstico
Neoplasias de Tecido Fibroso/imunologia
Neoplasias de Tecido Fibroso/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0219-RA


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[PMID]:28376586
[Au] Autor:Yao JM; Zeng HY; Tan YS; Hou YY
[Ad] Endereço:Department of Pathology, Zhongshan Hospital of Fudan University, Shanghai 200032, China.
[Ti] Título:[Desmoplastic fibroblastoma: a clinicopathologic analysis of 7 cases].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(4):223-227, 2017 Apr 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinical features, immunohistochemical and differential diagnosis of desmoplastic fibroblastoma. The clinical data and pathology features of 7 cases of desmoplastic fibroblastoma were collected and immunohistochemical study were carried out in all cases with a review of the literatures. There were 2 males and 5 females, with age ranging from 31 to 71 years (average and mean age were 59 and 61 years, respectively). The tumors were located in extremities and abdomen (left toe and right toe, right foot back, left leg and right thigh, right forearm and left hepatic lobe). Clinically, the tumors presented as slow growing painless masses of long standing duration. Grossly, the tumors were well-circumscribed with firm, white to gray cut-off surface. Tumor size ranged from 1.2 to 4.0 cm in maximum diameter (average 3.0 cm). Microscopically, 2 cases were located in dermis, 4 cases were located in subcutaneous and 1 case was located in liver parenchyma. It was composed of spindle-shaped or stellate cells with a fibroblastic or myofibroblastic appearance, and sparsely scattered in densely fibrous or fibromyxoid background. There was small vascular component in tumor background. At high magnification, the tumor cells were medium size with abundant cytoplasm, and the nucleus were small and always with small nucleoli. In some cases, the tumor cells were slightly larger with enlarged nuclei, but without cellular atypical and mitosis. Immunohistochemical study showed that the tumor cells were strongly positive for vimentin, desmin, S-100 protein and CD34, but CKpan was negative. α-SMA showed focal positive in one case. Ki-67 index ranged from 1% to 2%. Four cases were followed-up (ranged from 11 to 21 months, average 16.5 months) and the patients had no recurrence after surgery. Desmoplastic firoblastoma is a rare soft benign tumor. The differential diagnosis includes other benign or low-grade fibroblastic/myofibroblastic lesions.
[Mh] Termos MeSH primário: Neoplasias de Tecido Fibroso/patologia
[Mh] Termos MeSH secundário: Actinas/análise
Adulto
Idoso
Antígenos CD34/análise
Nucléolo Celular/patologia
Núcleo Celular/patologia
Desmina/análise
Diagnóstico Diferencial
Feminino
Fibroblastos/química
Fibroblastos/patologia
Fibroma/química
Fibroma/patologia
Seres Humanos
Masculino
Meia-Idade
Miofibroblastos/química
Miofibroblastos/patologia
Proteínas de Neoplasias/análise
Neoplasias de Tecido Fibroso/química
Neoplasias de Tecido Fibroso/diagnóstico
Proteínas S100/análise
Carga Tumoral
Vimentina/análise
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (ACTA2 protein, human); 0 (Actins); 0 (Antigens, CD34); 0 (Desmin); 0 (Neoplasm Proteins); 0 (S100 Proteins); 0 (Vimentin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.04.002


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[PMID]:28153506
[Au] Autor:Pezhouh MK; Rezaei MK; Shabihkhani M; Ghosh A; Belchis D; Montgomery EA; Voltaggio L
[Ad] Endereço:Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD, 21231 USA. Electronic address: mkherad1@jhmi.edu.
[Ti] Título:Clinicopathologic study of calcifying fibrous tumor of the gastrointestinal tract: a case series.
[So] Source:Hum Pathol;62:199-205, 2017 Apr.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calcifying fibrous tumor (CFT) is a rare benign mesenchymal lesion known to arise at multiple body sites that may clinically mimic other more aggressive lesions in the gastrointestinal (GI) tract. In this study we describe the clinicopathologic findings of 28 GI tract CFTs. Tumors predominantly arose in middle-aged adults with a slight female predominance. The most commonly involved sites were small bowel and colon, followed by stomach and appendix. Tumors ranged from 0.3 to 9.3 cm (median 1.4 cm), and submucosa was the most commonly involved layer. All tumors were well circumscribed and unencapsulated. Microscopically, tumors were hypocellular and composed of spindle cells with abundant, haphazardly arranged hyalinized collagen. No necrosis and less than one mitosis per 10 HPF were identified in all cases. Calcification was present in most (81%) of the cases. All cases had lymphoplasmacytic inflammatory infiltrates either scattered throughout the lesion with occasional perivascular conglomeration or in the form of lymphoid aggregates. A lymphoplasmacytic cuff was usually present (81%). Immunostains showed variable CD34 immunoreactivity and variable numbers of IgG4-positive plasma cells. The lesional cells were negative for DOG-1, ALK-1, S100, C-kit, Sox10, Melan A, HMB45, desmin, CK7, and CK20, and showed cytoplasmic staining for ß-catenin. Follow-up information was available in 5 cases with no recurrences reported to date (mean follow-up, 3 years). CFT is a rare benign tumor that can occur in part of the GI tract and should be distinguished from other mesenchymal tumors due to its low risk of recurrence.
[Mh] Termos MeSH primário: Calcinose/patologia
Neoplasias Gastrointestinais/patologia
Neoplasias de Tecido Fibroso/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Biópsia
Calcinose/metabolismo
Calcinose/cirurgia
Diagnóstico Diferencial
Feminino
Neoplasias Gastrointestinais/química
Neoplasias Gastrointestinais/cirurgia
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Neoplasias de Tecido Fibroso/química
Neoplasias de Tecido Fibroso/cirurgia
Valor Preditivo dos Testes
Fatores de Tempo
Resultado do Tratamento
Carga Tumoral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


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[PMID]:26459706
[Au] Autor:Koch PF; Fierst T; Heuer AJ; Santi M; Heuer GG
[Ad] Endereço:Department of Neurosurgery, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, USA. Electronic address: paul.koch@uphs.upenn.edu.
[Ti] Título:Ruptured Infantile Myofibroma of the Head Presenting in a Neonate: Case Report and Review of the Literature.
[So] Source:World Neurosurg;98:884.e13-884.e18, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Infantile myofibroma/myofibromatosis (IM/M) is a myofibroblastic proliferative disorder often seen in infants and children. IM/M can result in congenital tumors of the head and neck and may occasionally present to the neurosurgeon. CASE DESCRIPTION: We report a case of a solitary ruptured myofibroma of the head in a newborn patient. The lesion was initially suggestive of encephalocele. We describe the presentation and management of this patient, including relevant imaging, histopathologic evaluation, and surgical technique. We subsequently review the literature of IM/M of the head and neck, highlighting the 3 forms of the condition, each requiring a distinct management strategy. CONCLUSIONS: Although this tumor rarely presents to the neurosurgeon, it may do so in the process of ruling out other more dangerous conditions. It is therefore important to consider this diagnosis in masses that occur in the head and neck of newborns.
[Mh] Termos MeSH primário: Miofibroma/cirurgia
Neoplasias de Tecido Fibroso/cirurgia
Procedimentos Neurocirúrgicos/métodos
Neoplasias Cutâneas/cirurgia
[Mh] Termos MeSH secundário: Angiografia por Tomografia Computadorizada
Feminino
Seres Humanos
Recém-Nascido
Imagem por Ressonância Magnética
Miofibroma/complicações
Miofibroma/diagnóstico por imagem
Miofibromatose/congênito
Miofibromatose/diagnóstico por imagem
Miofibromatose/etiologia
Miofibromatose/cirurgia
Neoplasias de Tecido Fibroso/complicações
Neoplasias de Tecido Fibroso/diagnóstico por imagem
Neoplasias Cutâneas/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151014
[St] Status:MEDLINE


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[PMID]:27821229
[Au] Autor:Ding H; Wang LL; Xu XL; Lao I QY; Yu L; Wang J
[Ad] Endereço:Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
[Ti] Título:[Clinicopathologic features of dermal nerve sheath myxoma and neurothekeoma: a comparative study].
[So] Source:Zhonghua Bing Li Xue Za Zhi;45(11):755-761, 2016 Nov 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the clinicopathologic characteristics and differential diagnosis of dermal nerve sheath myxoma (DNSM) and neurothekeoma (NTK). Clinical, pathological features and immunohistochemical profiles in 9 cases of DNSM and 8 cases of NTK were comparatively studied. The literature was reviewed. The involved site of 9 DNSMs included the hand/fingers ( =3), ear ( =2), face, back, abdominal wall and waist (1 case each). Two of 8 NTKs arose in the forearm ( =2), one each in the nose, lip, shoulder, supraclavicular region, leg and hand. The most common presentation was a painless cutaneous nodule or plaque which grew slowly. Grossly, DNSM was often gelatinous, whereas NTK appeared relatively solid. Microscopically, both tumors were located in the dermis and/or subcutis. DNSM was composed of well-defined multiple lobules separated by fibrous septa. NTK also exhibited lobular or multinodular architecture, but was relatively ill-defined. Besides, fascicular or whorl-like arrangement was present in 3 cases of NTK. The lobules in DNSM consisted of a paucicellular proliferation of spindled, stellate and epithelioid cells forming interconnecting cords within abundant myxoid matrix. Small syncytial-like aggregates were readily noted. The constituted neoplastic cells in NTK were composed of ovoid to round epithelioid or histiocytoid cells. Scattered multinucleated giant cells were present in 2 cases. Based on the amount of myxoid matrix, 8 NTKs were further classified into cellular (5 cases), mixed (2 cases) and myxoid (1 case). By immunohistochemistry, neoplastic cells in DNSM were diffusely positive for S-100 protein, CD68, glial fibrillary acidic protein and SOX10, whereas neoplastic cells in NTK consistently expressed CD10 and microphthalmia transcription factor, with negativity for S-100 protein and SOX10. One patient each with DNSM and NTK experienced local recurrence due to incomplete excision. Although DNSM and NTK share clinical and pathological features, they belong to different entities. Whereas the former is consistent with a peripheral nerve sheath tumor, the latter is more akin to fibrous histiocytic tumor. Familiarity with their cliniopathologic characteristics and distinctive immunophenotypes will help distinguishing these two entities, as well as in the differential diagnosis of cutaneous neoplasms with similar features.
[Mh] Termos MeSH primário: Mixoma/patologia
Neoplasias da Bainha Neural/patologia
Neurotecoma/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Parede Abdominal
Adulto
Diagnóstico Diferencial
Células Epitelioides/patologia
Feminino
Dedos
Células Gigantes/patologia
Proteína Glial Fibrilar Ácida/análise
Seres Humanos
Imuno-Histoquímica
Imunofenotipagem
Masculino
Fator de Transcrição Associado à Microftalmia/análise
Meia-Idade
Recidiva Local de Neoplasia
Neoplasias de Tecido Fibroso/química
Neoplasias de Tecido Fibroso/patologia
Neoplasias da Bainha Neural/química
Neurotecoma/química
Proteínas S100/análise
Neoplasias Cutâneas/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glial Fibrillary Acidic Protein); 0 (Microphthalmia-Associated Transcription Factor); 0 (S100 Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161109
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2016.11.003


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[PMID]:27432164
[Au] Autor:Li W; Molnar SL; Mott M; White E; De Las Casas LE
[Ad] Endereço:Department of Pathology, University of Toledo Medical Center, Toledo, Ohio.
[Ti] Título:Superficial CD34-positive fibroblastic tumor: Cytologic features, tissue correlation, ancillary studies, and differential diagnosis of a recently described soft tissue neoplasm.
[So] Source:Diagn Cytopathol;44(11):926-930, 2016 Nov.
[Is] ISSN:1097-0339
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Superficial CD34-positive fibroblastic tumor is a low-grade mesenchymal neoplasm of superficial soft tissues characterized by fascicles of spindle to epithelioid cells displaying nuclear pleomorphism and strong diffuse CD34 immunoreactivity. The intraoperative imprint cytology preparations (ICP) of a superficial CD34-positive fibroblastic tumor from a 50-year-old female are described. To the best of our knowledge, there is no report of the cytologic findings of superficial CD34-positive fibroblastic tumor in the English medical literature. The ICP, differential diagnosis, tissue correlation, and ancillary studies of this fascinating entity are discussed. Diagn. Cytopathol. 2016;44:926-930. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Antígenos CD34/metabolismo
Biomarcadores Tumorais/metabolismo
Neoplasias de Tecido Fibroso/patologia
Neoplasias de Tecidos Moles/patologia
[Mh] Termos MeSH secundário: Antígenos CD34/genética
Biomarcadores Tumorais/genética
Diagnóstico Diferencial
Feminino
Seres Humanos
Meia-Idade
Neoplasias de Tecido Fibroso/diagnóstico por imagem
Neoplasias de Tecido Fibroso/metabolismo
Neoplasias de Tecidos Moles/diagnóstico por imagem
Neoplasias de Tecidos Moles/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD34); 0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.1002/dc.23529


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[PMID]:27399243
[Au] Autor:Sargar KM; Sheybani EF; Shenoy A; Aranake-Chrisinger J; Khanna G
[Ad] Endereço:From the Mallinckrodt Institute of Radiology (K.M.S., E.F.S., G.K.) and Department of Pathology (A.S., J.A.C.), Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131-MIR, St Louis, MO 63110.
[Ti] Título:Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
[So] Source:Radiographics;36(4):1195-214, 2016 Jul-Aug.
[Is] ISSN:1527-1323
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), intermediate-locally aggressive (eg, lipofibromatosis, desmoid fibroma), intermediate-rarely metastasizing (eg, inflammatory myofibroblastic tumors, infantile fibrosarcoma, low-grade myofibroblastic sarcoma), and malignant (eg, fibromyxoid sarcoma, adult fibrosarcoma). Imaging has a key role in the evaluation of lesion origin, extent, and involvement with adjacent structures, and in the treatment management and postresection surveillance of these tumors. The imaging findings of these tumors are often nonspecific. However, certain imaging features, such as low or intermediate signal intensity on T2-weighted magnetic resonance images and extension along fascial planes, support the diagnosis of a fibroblastic or myofibroblastic tumor. In addition, certain tumors have characteristic imaging findings (eg, multiple subcutaneous or intramuscular lesions in infantile myofibromatosis, plaquelike growth pattern of Gardner fibroma, presence of adipose tissue in lipofibromatosis) or characteristic clinical manifestations (eg, great toe malformations in fibrodysplasia ossificans fibroma, neonatal torticollis in fibromatosis colli) that suggest the correct diagnosis. Knowledge of the syndrome associations of some of these tumors-for example, the association between familial adenomatous polyposis syndrome and both Gardner fibroma and desmoid fibromatosis, and that between nevoid basal cell carcinoma syndrome and cardiac fibroma-further facilitate a diagnosis. The recognition of key imaging findings can help guide treatment management and help avoid unnecessary intervention in cases of benign lesions such as myositis ossificans and fibromatosis colli. In this article, we describe the various types of fibroblastic and myofibroblastic tumors in children and the characteristic clinical manifestations, imaging features, and growth patterns of these neoplasms-all of which aid in the appropriate radiologic assessment and management of these lesions. (©)RSNA, 2016.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico por imagem
Diagnóstico por Imagem/métodos
Neoplasias de Tecido Fibroso/diagnóstico por imagem
Neoplasias de Tecidos Moles/diagnóstico por imagem
[Mh] Termos MeSH secundário: Neoplasias Ósseas/patologia
Criança
Diagnóstico Diferencial
Seres Humanos
Neoplasias de Tecido Fibroso/patologia
Prognóstico
Neoplasias de Tecidos Moles/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE
[do] DOI:10.1148/rg.2016150191


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[PMID]:27256046
[Au] Autor:Chen CY; Zhang HZ; Jiang ZM; Zhou J; Chen J; Liu L
[Ad] Endereço:Department of Pathology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
[Ti] Título:[Value of MDM2, CDK4 and SATB2 immunohistochemistry in histologic diagnosis of low-grade osteosarcoma].
[So] Source:Zhonghua Bing Li Xue Za Zhi;45(6):387-92, 2016 Jun 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the value of combined application of MDM2, CDK4 and SATB2 immunohistochemistry in pathological diagnosis of low-grade osteosarcoma. METHODS: Forty-seven cases of low grade osteosarcoma, including low grade central osteosarcoma (n=20) and parosteal osteosarcoma (n=27), were selected from Shanghai Jiaotong University Affiliated the Sixth People's Hospital. The clinical, radiography and histopathology were reviewed. The sensitivity and specificity of MDM2, CDK4 and SATB2 immunohistochemistry in the diagnosis of low-grade osteosarcoma were assessed along with an evaluation of their expressions in fibrous dysplasia, desmoplastic fibroma, low-grade fibrosarcoma and other fibrous tumors. RESULTS: Low-grade osteosarcoma had protracted clinical course, occurring mostly in elder adults and mainly involving long bones. Radiographic studies showed that low-grade central osteosarcoma had a mainly malignant lytic presentation, however about 5/18 of tumors overlapping with intermediate and benign bone diseases, while parosteal osteosarcoma was characterized by a densely sclerotic malignant appearance. Histologically, low-grade osteosarcomas were characterized by well-differentiated spindle tumor cells, various mature tumor bones and an aggressive growth pattern. The positive expression rates of MDM2 and CDK4 in low-grade osteosarcoma were 74.5% and 55.3%, respectively. Eighty-three percent of low-grade osteosarcoma expressed one or both markers. Low-grade osteosarcoma and fibrous dysplasia were both positive for SATB2, while desmoplastic fibroma, low-grade fibrosacoma and other fibrous tumors were negative for SATB2. CONCLUSIONS: Accurate diagnosis of low-grade osteosarcoma should be based on combination of clinical presentation, imaging and histopathology, with immunohistochemistry as a diagnostic adjunct. Positive immunostaining for CDK4 and/or MDM2 supports the diagnosis of low-grade osteosarcoma, but the negative one does not rule out such lesion. The negative expression of SATB2 is helpful to exclude fibrous tumors originating from bone with the exception of fibrous dysplasia.
[Mh] Termos MeSH primário: Neoplasias Ósseas/diagnóstico
Quinase 4 Dependente de Ciclina/metabolismo
Proteínas de Ligação à Região de Interação com a Matriz/metabolismo
Osteossarcoma/diagnóstico
Proteínas Proto-Oncogênicas c-mdm2/metabolismo
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/metabolismo
Osso e Ossos/patologia
Fibrossarcoma/diagnóstico
Fibrossarcoma/metabolismo
Seres Humanos
Imuno-Histoquímica
Neoplasias de Tecido Fibroso/diagnóstico
Neoplasias de Tecido Fibroso/metabolismo
Osteossarcoma/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Matrix Attachment Region Binding Proteins); 0 (SATB2 protein, human); 0 (Transcription Factors); EC 2.3.2.27 (MDM2 protein, human); EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2); EC 2.7.11.22 (CDK4 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160604
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2016.06.007


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[PMID]:27196478
[Au] Autor:Chorti A; Papavramidis TS; Michalopoulos A
[Ad] Endereço:From the 1st Propedeutic Department of Surgery, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.
[Ti] Título:Calcifying Fibrous Tumor: Review of 157 Patients Reported in International Literature.
[So] Source:Medicine (Baltimore);95(20):e3690, 2016 May.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Calcifying fibrous tumor (CFT) is a benign lesion characterized by its specific histological findings and is found as solitary or multiple lesions in several locations of the human body. The aim of the present systematic review is to give a detailed account of all reported cases of CFT in the literature and to analyze the available data, to completely characterize the entity from epidemiological, medical, and surgical aspects.A bibliographic research was performed from 1988 until 2015. A database with the patients' characteristics was made, including sex, age, location of the tumor, symptoms, symptoms duration, size of the tumor, diagnostic methods, treatment, metastasis, and follow-up.A total of 104 articles were identified, reporting 157 cases of CFT. Mean age of patients was 33.58 years and the ratio between men and women was 1:1.27. The most common locations of CFT were stomach (18%), small intestine (8.7%), pleura (9.9%), mesentery (5%), and peritoneum (6.8%). Mean diameter of the tumor was estimated 4.6 cm. The correlations proceeded showed that as age increases, size decreases (P = 0.001) and that the tumor is larger in females (P = 0.027). Kruskal-Wallis test showed that the larger tumors appear in the neck and adrenal gland (P = 0.001). The percentage of asymptomatic patients was 30.57%. Computed tomography and biopsy were the most common tests for the diagnosis of CFT. Open surgical procedure was performed in the majority of cases. The median hospitalization was 6.06 days and the mean follow-up period was 29.97 months. Recurrences were mentioned in 10 of 96 patients with available data. No deaths owing to CFT were mentioned in the literature.CFT should be included in the differential diagnosis of enlarging mass revealed by clinical or imaging examination either incidentally or after specific acute or chronic symptomatology.
[Mh] Termos MeSH primário: Calcinose/patologia
Neoplasias de Tecido Fibroso/diagnóstico
Neoplasias de Tecido Fibroso/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Calcinose/diagnóstico
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Neoplasias de Tecido Fibroso/cirurgia
Fatores Sexuais
Carga Tumoral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170221
[Lr] Data última revisão:
170221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160520
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000003690



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