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[PMID]:29310354
[Au] Autor:Chu Y; Guo Q; Wu D
[Ad] Endereço:Department of Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, P.R. China.
[Ti] Título:Mesenteric fibromatosis after resection for gastrointestinal stromal tumor of stomach: A case report.
[So] Source:Medicine (Baltimore);96(48):e8792, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Gastrointestinal stromal tumor and mesenteric fibromatosis are rare mesenchymal tumors. Coexistence of these two diseases is uncommon, with only a few anecdotal reports of individuals. PATIENT CONCERNS: Clinical data and treatment of a 43-year-old man with subsequent mesenteric fibromatosis from gastrointestinal stromal tumor are summarized. The Ethics Committee of The Second Affiliated Hospital, College of Medicine, Zhejiang University approved this study, and the patient provided written informed consent form. DIAGNOSES: The initial diagnosis of the recurrent mesenteric mass was recurrent gastrointestinal stromal tumor. INTERVENTIONS: The operation was performed as possible at the time when the mass was found after the first surgery. OUTCOMES: The diagnosis was revised as mesenteric fibromatosis according to the postoperative immunohistochemical staining. The postoperative condition was normal without adjuvant therapy and no recidivation has been found. LESSONS: The potential for the coexistence of gastrointestinal stromal tumor and mesenteric fibromatosis should always be considered.
[Mh] Termos MeSH primário: Fibromatose Abdominal/patologia
Tumores do Estroma Gastrointestinal/patologia
Neoplasias Primárias Múltiplas/patologia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico por Imagem
Fibromatose Abdominal/diagnóstico
Fibromatose Abdominal/cirurgia
Tumores do Estroma Gastrointestinal/cirurgia
Gastroscopia
Seres Humanos
Imuno-Histoquímica
Masculino
Neoplasias Primárias Múltiplas/diagnóstico
Neoplasias Primárias Múltiplas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008792


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[PMID]:28767596
[Au] Autor:Li J; Le H; Chai W; Zhou Y; Jin L; Liu T; Zhang K
[Ad] Endereço:aDepartment of General Surgery, The Second Hospital of Jilin University bDepartment of Gynecology and Obstetrics, The First Hospital of Jilin University cDepartment of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin, China.
[Ti] Título:Duodenum-derived fibromatosis that invaded the muscular layer of intestinal wall: A rare case report.
[So] Source:Medicine (Baltimore);96(31):e7684, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Intraabdominal fibromatosis is a rare benign tumor that often affects the mesentery or retroperitoneum, and can infiltrate adjacent organs. However, it is rare for fibromatosis to arise from the small intestinal wall. PATIENT CONCERNS: A 27-year-old female with a tangible abdominal tumor is described. DIAGNOSES: The computed tomography (CT) scan revealed a 7.5 cm, small intestine-associated tumor in the right abdomen. INTERVENTIONS: The patient received tumor resection and intestinal anastomosis. OUTCOMES: Further pathological examination confirmed the tumor as a duodenal fibromatosis that infiltrated the intestinal wall. To the best of our knowledge, this is the first report of a duodenum-derived fibromatosis that invaded the muscular layer of the intestine. LESSONS: Our study demonstrated that an unexplained abdominal mass should be noteworthy and properly treated.
[Mh] Termos MeSH primário: Neoplasias Duodenais/diagnóstico por imagem
Neoplasias Duodenais/patologia
Fibromatose Abdominal/diagnóstico por imagem
Fibromatose Abdominal/patologia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Neoplasias Duodenais/cirurgia
Feminino
Fibromatose Abdominal/cirurgia
Seres Humanos
Músculo Liso
Invasividade Neoplásica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007684


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[PMID]:28528910
[Au] Autor:Smith HG; Tzanis D; Messiou C; Benson C; van der Hage JA; Fiore M; Bonvalot S; Hayes AJ
[Ad] Endereço:The Sarcoma Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.
[Ti] Título:The management of soft tissue tumours of the abdominal wall.
[So] Source:Eur J Surg Oncol;43(9):1647-1655, 2017 Sep.
[Is] ISSN:1532-2157
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Soft tissue tumours of the abdominal wall account for approximately 10% of all soft tissue tumours. Tumours at this site comprise a heterogeneous group of pathologies with distinct clinical behaviours and responses to treatment. The management of these tumours has largely been extrapolated from studies of soft tissue tumours at other sites. This review aims to summarise the existing data relating to abdominal wall tumours and suggest principles for managing soft tissue tumours at this site. METHODS: Relevant articles were retrieved from a comprehensive literature search using the PubMed database. Key words included abdominal wall, soft tissue tumours, surgery, radiotherapy and chemotherapy. No restrictions on publication date were used. RESULTS: The most common pathologies presenting in the abdominal wall are desmoid tumours, soft-tissue sarcoma and dermatofibrosarcoma protuberans (DFSP). Desmoid tumours should be managed with an initial period of observation, with surgery reserved for progressive lesions. Surgery should be the primary treatment for soft-tissue sarcomas and DFSP, with radiotherapy reserved for large-high grade tumours and preferentially given pre-operatively. CONCLUSIONS: Abdominal wall tumours are rare and should be managed in centres with experience in the management of soft tissue tumours. Management should be tailored to the biological behaviour of specific pathologies.
[Mh] Termos MeSH primário: Parede Abdominal
Dermatofibrossarcoma/terapia
Fibromatose Abdominal/terapia
Sarcoma/terapia
Neoplasias de Tecidos Moles/terapia
[Mh] Termos MeSH secundário: Dermatofibrossarcoma/diagnóstico
Dermatofibrossarcoma/epidemiologia
Dermatofibrossarcoma/patologia
Fibromatose Abdominal/diagnóstico
Fibromatose Abdominal/epidemiologia
Fibromatose Abdominal/patologia
Seres Humanos
Estadiamento de Neoplasias
Procedimentos Cirúrgicos Reconstrutivos
Sarcoma/diagnóstico
Sarcoma/epidemiologia
Sarcoma/patologia
Neoplasias de Tecidos Moles/diagnóstico
Neoplasias de Tecidos Moles/epidemiologia
Neoplasias de Tecidos Moles/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


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[PMID]:28282712
[Au] Autor:Sadighi S; Ghaffari-Moghaddam M; Saffari M; Mohagheghi MA; Shirkoohi R
[Ad] Endereço:Department of Medical Oncology, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
[Ti] Título:A Patient With Desmoid Tumors and Familial FAP Having Frame Shift Mutation of the APC Gene.
[So] Source:Acta Med Iran;55(2):134-138, 2017 Feb.
[Is] ISSN:1735-9694
[Cp] País de publicação:Iran
[La] Idioma:eng
[Ab] Resumo:Desmoids tumors, characterized by monoclonal proliferation of myofibroblasts, could occur in 5-10% of patients with familial adenomatous polyposis (FAP) as an extra-colonic manifestation of the disease. FAP can develop when there is a germ-line mutation in the adenomatous polyposis coli gene. Although mild or attenuated FAP may follow mutations in 5΄ extreme of the gene, it is more likely that 3΄ extreme mutations haveamore severe manifestation of thedisease. A 28-year-old woman was admitted to the Cancer Institute of Iran with an abdominal painful mass. She had strong family history of FAP and underwent prophylactic total colectomy. Pre-operative CT scans revealed a large mass. Microscopic observation showed diffuse fibroblast cell infiltration of the adjacent tissue structures. Peripheral blood DNA extraction followed by adenomatous polyposis coli gene exon by exon sequencing was performed to investigate the mutation in adenomatous polyposis coli gene. Analysis of DNA sequencing demonstrated a mutation of 4 bpdeletions at codon 1309-1310 of the exon 16 of adenomatous polyposis coli gene sequence which was repeated in 3 members of the family. Some of them had desmoid tumor without classical FAP history. Even when there is no familial history of adenomatous polyposis, the adenomatous polyposis coli gene mutation should be investigated in cases of familial desmoids tumors for a suitable prevention. The 3΄ extreme of the adenomatous polyposis coli gene is still the best likely location in such families.
[Mh] Termos MeSH primário: Neoplasias Abdominais/genética
Polipose Adenomatosa do Colo/genética
Fibromatose Abdominal/genética
Mutação da Fase de Leitura
Genes APC
[Mh] Termos MeSH secundário: Adulto
Feminino
Predisposição Genética para Doença
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28199014
[Au] Autor:Janssen ML; van Broekhoven DL; Cates JM; Bramer WM; Nuyttens JJ; Gronchi A; Salas S; Bonvalot S; Grünhagen DJ; Verhoef C
[Ad] Endereço:Departments of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
[Ti] Título:Meta-analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid-type fibromatosis.
[So] Source:Br J Surg;104(4):347-357, 2017 Mar.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Extra-abdominal desmoid-type fibromatosis (DF) is a rare, locally aggressive neoplasm that is usually managed conservatively. When treatment is indicated, it typically involves surgical resection, possibly with adjuvant radiotherapy. The indications for postoperative radiotherapy and its effectiveness are unclear. The objective of this study was to estimate the effect of surgical resection margins and adjuvant radiotherapy on rates of recurrence of DF. METHODS: Literature published between 1999 and 2015 was extracted from MEDLINE, Embase, Cochrane Central Registry of Trials, Web of Science and Google Scholar. Recurrence rate was analysed by meta-analysis and compared between subgroups. RESULTS: Sixteen reports were included, consisting of a total of 1295 patients with DF. In patients treated by surgical resection alone, the risk of local recurrence was almost twofold higher for those with microscopically positive resection margins (risk ratio (RR) 1·78, 95 per cent c.i. 1·40 to 2·26). Adjuvant radiotherapy after surgery with negative margins had no detectable benefit on recurrence. In contrast, after incomplete surgical resection, adjuvant radiotherapy improved recurrence rates both in patients with primary tumours (RR 1·54, 1·05 to 2·27) and in those with recurrent DF (RR 1·60, 1·12 to 2·28). CONCLUSION: DF resected with microscopically positive margins has a higher risk of recurrence. Adjuvant radiotherapy appears to reduce the risk of recurrence after incomplete surgical resection, particularly in patients with recurrent tumours.
[Mh] Termos MeSH primário: Fibromatose Abdominal/cirurgia
[Mh] Termos MeSH secundário: Fibromatose Abdominal/radioterapia
Seres Humanos
Margens de Excisão
Recidiva Local de Neoplasia/etiologia
Radioterapia Adjuvante
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10477


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[PMID]:27538186
[Au] Autor:Hammer J; Léonard D; Chateau F; Abbes Orabi N; Ciccarelli O; Bachmann R; Remue C; Lengelé B; Kartheuser A
[Ad] Endereço:a Colorectal Surgery Unit, Department of Abdominal Surgery and Transplantation , Cliniques universitaires Saint-Luc , Brussels , Belgium.
[Ti] Título:Reconstruction of an abdominal wall defect with biologic mesh after resection of a desmoid tumor in a patient with a Gardner's syndrome.
[So] Source:Acta Chir Belg;117(1):55-60, 2017 Feb.
[Is] ISSN:0001-5458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Desmoid tumors are rare proliferative and invasive benign lesions. They can be sporadic, but in most instances, desmoid tumors develop in the context of Gardner's syndrome with principal localization in the abdominal cavity and abdominal wall. CASE-REPORT: We report the case of a 24-year-old female presenting Gardner's syndrome with a symptomatic abdominal wall desmoid tumor. Lack of response to medical treatment led to surgical management consisting in a complete resection and parietal reconstruction with a biologic mesh. Postoperative course was uneventful and there was no evidence of recurrence at 12 months of follow-up. DISCUSSION: Conventional treatment of abdominal wall desmoid tumors consists in a wide and radical resection. However, complete resection is not always feasible because of difficulty to differentiate the desmoid tumor from adjacent tissues. The surgical approach may require different techniques to repair the parietal defect including prosthetic material such as synthetic or biologic meshes. Biological mesh is an ideal alternative to synthetic graft, mainly in case of infection. CONCLUSION: We have encountered a case of a symptomatic growing desmoid tumor of the abdominal wall in a young patient with Gardner's syndrome, successfully treated by complete resection and reconstruction with a biologic mesh to correct the parietal defect.
[Mh] Termos MeSH primário: Parede Abdominal/cirurgia
Fibromatose Abdominal/cirurgia
Síndrome de Gardner/complicações
Telas Cirúrgicas
[Mh] Termos MeSH secundário: Feminino
Fibromatose Abdominal/complicações
Fibromatose Abdominal/patologia
Síndrome de Gardner/cirurgia
Seres Humanos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.1080/00015458.2016.1212499


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[PMID]:28133149
[Au] Autor:Nakai M; Tazawa T; Wajima N; Muroya T; Mikami K; Hakamada K
[Ad] Endereço:Dept. of Surgery, Hirosaki National Hospital.
[Ti] Título:[A Case of Mesenteric Fibromatosis after Robot-Assisted Total Gastrectomy for Gastric Cancer].
[So] Source:Gan To Kagaku Ryoho;43(12):1839-1841, 2016 Nov.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The patient underwent robot-assisted total gastrectomy for an early gastric cancer. Thirty-four months later, he was admitted to another hospital because of abdominal discomfort. Computed tomography scans showed a giant solid mass approximately 13 cm in diameter in the lower abdomen. We performed a resection of the tumor; operative findings showed a giant solid tumor, without adhesion, in the mesentery of the jejunum. The tumor did not involve other parts of the small intestine. The resected tumor had a smooth surface with an elastic hard consistency. Pathological examination revealed that the tumor was immunohistochemically positive for a-SMA and b-catenin and negative for S-100, CD34, and c-kit. The tumor was diagnosed as a mesenteric fibromatosis. The patient did not show any incidence of recurrence for five months after resection. Mesenteric fibromatosis is a very rare condition and has been reported in association with Gardner's syndrome, abdominal traumas such as surgery and injury, and with pregnancy. This report describes a case of mesenteric fibromatosis after robotassisted laparoscopic surgery.
[Mh] Termos MeSH primário: Fibromatose Abdominal
Mesentério/patologia
Neoplasias Peritoneais/patologia
Neoplasias Gástricas
[Mh] Termos MeSH secundário: Idoso
Fibromatose Abdominal/cirurgia
Gastrectomia
Seres Humanos
Masculino
Mesentério/cirurgia
Neoplasias Peritoneais/cirurgia
Procedimentos Cirúrgicos Robóticos
Neoplasias Gástricas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


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[PMID]:27647224
[Au] Autor:Mussi CE; Colombo P; Lo Russo C; Kasangian A; Cananzi F; Marrari A; Morenghi E; De Sanctis R; Quagliuolo V
[Ad] Endereço:Department of Surgical Oncology, Humanitas Clinical and Research Center, Milan - Italy.
[Ti] Título:Sporadic desmoid tumors of the abdominal wall: the results of surgery.
[So] Source:Tumori;102(6):582-587, 2016 Dec 01.
[Is] ISSN:2038-2529
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Before the wait-and-see policy became the standard approach in abdominal wall desmoid tumors, surgery was performed on a systematic basis. Surgery remains indicated for progressing tumors but its extent is debatable. The abdominal wall is a common site of origin of sporadic desmoids, usually associated with a favorable prognosis. We analyzed the results of surgery at this specific site. METHODS: Data from 33 patients affected by sporadic desmoid tumors of the abdominal wall (31 primary, 2 recurrent) consecutively treated at our cancer center between January 2000 and September 2013 were retrospectively studied. RESULTS: Twenty-nine patients underwent surgery upfront and 1 after progression during the initial wait-and-see period. Prosthetic reconstruction of the abdominal wall was required in 28 patients. The average hospital stay was 5 days. Three patients developed surgical complications. Local recurrence-free survival was 90% at 5 and 10 years. Three patients had an uneventful childbirth during the follow-up after surgery. CONCLUSIONS: Desmoid tumors of the abdominal wall have a favorable prognosis after surgical resection, which remains a safe and effective treatment. Wild-type tumors are common, whereas the incidence of S45F mutation in the beta-catenin gene is lower than in other anatomic sites. Upfront surgery may be considered in selected women who wish to bear a child.
[Mh] Termos MeSH primário: Fibromatose Abdominal/patologia
Fibromatose Abdominal/cirurgia
[Mh] Termos MeSH secundário: Adulto
Progressão da Doença
Feminino
Fibromatose Abdominal/genética
Fibromatose Abdominal/mortalidade
Seres Humanos
Masculino
Meia-Idade
Mutação
Recidiva Local de Neoplasia
Complicações Pós-Operatórias
Prognóstico
Modelos de Riscos Proporcionais
Resultado do Tratamento
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.5301/tj.5000552


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[PMID]:27624694
[Au] Autor:Nagata T; Demizu Y; Okumura T; Sekine S; Hashimoto N; Fuwa N; Okimoto T; Shimada Y
[Ad] Endereço:Department of Surgery and Science, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of To1yama, 2630 Sugitani, Toyama, 930-0194, Japan. naga0103@med.u-toyama.ac.jp.
[Ti] Título:Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report.
[So] Source:World J Surg Oncol;14(1):245, 2016 Sep 13.
[Is] ISSN:1477-7819
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Desmoid tumors, which are associated with familial adenomatous polyposis (FAP), tend to occur frequently in the abdominal wall and mesentery. Currently, there are no recognized treatments other than surgery, and frequent surgeries result in gastrointestinal obstructions and functional gastrointestinal disorders. CASE PRESENTATION: After surgery that was performed on a 39-year-old patient with FAP, we performed a second tumor excision which was the procedure used for frequently occurring mesenteric desmoid tumors. It was determined that the enlarged tumor would be difficult to operate on through an abdominal incision. Subsequently, the carbon ion radiotherapy of 50 Gy was then performed on the patient. Three years later, the tumor still remains reduced in size. In addition, we have not observed any negative effect on the digestive tract. CONCLUSIONS: This is the first instance that the carbon ion radiotherapy has been effective for the unresected desmoid tumor, and it is believed that this will become the one effective option for the treatment of desmoid tumors.
[Mh] Termos MeSH primário: Polipose Adenomatosa do Colo/cirurgia
Fibromatose Abdominal/radioterapia
Fibromatose Agressiva/radioterapia
Radioterapia com Íons Pesados
Recidiva Local de Neoplasia/radioterapia
Neoplasias Peritoneais/radioterapia
[Mh] Termos MeSH secundário: Parede Abdominal/patologia
Polipose Adenomatosa do Colo/patologia
Colectomia/efeitos adversos
Duodenostomia
Fibromatose Abdominal/diagnóstico por imagem
Fibromatose Abdominal/cirurgia
Fibromatose Agressiva/diagnóstico por imagem
Fibromatose Agressiva/cirurgia
Seres Humanos
Ileostomia/efeitos adversos
Jejunostomia
Masculino
Mesentério/patologia
Meia-Idade
Recidiva Local de Neoplasia/diagnóstico por imagem
Neoplasias Peritoneais/diagnóstico por imagem
Neoplasias Peritoneais/patologia
Aderências Teciduais/complicações
Aderências Teciduais/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1186/s12957-016-1000-8


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[PMID]:27124915
[Au] Autor:Zreik RT; Fritchie KJ
[Ad] Endereço:From the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
[Ti] Título:Morphologic Spectrum of Desmoid-Type Fibromatosis.
[So] Source:Am J Clin Pathol;145(3):332-40, 2016 Mar.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Desmoid-type fibromatosis is a locally aggressive neoplasm composed of long sweeping fascicles of bland fibroblasts/myofibroblasts. Tumors with classic features are easy to identify, but the morphologic spectrum of this entity spans beyond the conventional histologic pattern. Since sampling of an unrecognized histologic variant may lead to misdiagnosis, especially on small needle biopsy specimens, we sought to fully characterize the morphologic spectrum of this entity. METHODS: We examined 165 cases of desmoid-type fibromatosis and catalogued the morphologic patterns and percentage of those patterns identified in each case. Clinicopathologic variables, including age, sex, location, and recurrence, were analyzed and correlated with pattern frequency. RESULTS: Seven morphologic patterns were identified, including conventional, hyalinized/hypocellular, staghorn vessel, myxoid, keloidal, nodular fasciitis-like, and hypercellular. The mean number of patterns per case was two, but some cases harbored up to five patterns. The greatest morphologic variability was seen in the intra-abdominal lesions, with these tumors having a significantly higher percentage of the keloidal and staghorn patterns compared with extra-abdominal and abdominal wall sites. No significant correlation between patient outcome (recurrence) and presence of variant morphologic pattern was observed (P = .549). CONCLUSIONS: The morphologic spectrum of desmoid-type fibromatosis is deceptively broad, and awareness of the variety of histologic patterns is critical for accurate diagnosis.
[Mh] Termos MeSH primário: Fibromatose Abdominal/patologia
Fibromatose Agressiva/patologia
Neoplasias de Tecidos Moles/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Estudos de Coortes
Educação Médica Continuada
Feminino
Fibroblastos/patologia
Fibromatose Abdominal/classificação
Fibromatose Agressiva/classificação
Seres Humanos
Masculino
Meia-Idade
Miofibroblastos/patologia
Invasividade Neoplásica
Recidiva Local de Neoplasia/classificação
Recidiva Local de Neoplasia/diagnóstico
Recidiva Local de Neoplasia/patologia
Estudos Retrospectivos
Neoplasias de Tecidos Moles/classificação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqv094



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde