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[PMID]:29072946
[Au] Autor:Stanoszek LM; Wang GY; Harms PW
[Ad] Endereço:From the Departments of Pathology (Drs Stanoszek, Wang, and Harms) and Dermatology (Dr Harms), University of Michigan Medical School, Ann Arbor. Drs Stanoszek and Wang contributed equally.
[Ti] Título:Histologic Mimics of Basal Cell Carcinoma.
[So] Source:Arch Pathol Lab Med;141(11):1490-1502, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Basal cell carcinoma (BCC) is the most common human malignant neoplasm and is a frequently encountered diagnosis in dermatopathology. Although BCC may be locally destructive, it rarely metastasizes. Many diagnostic entities display morphologic and immunophenotypic overlap with BCC, including nonneoplastic processes, such as follicular induction over dermatofibroma; benign follicular tumors, such as trichoblastoma, trichoepithelioma, or basaloid follicular hamartoma; and malignant tumors, such as sebaceous carcinoma or Merkel cell carcinoma. Thus, misdiagnosis has significant potential to result in overtreatment or undertreatment. OBJECTIVE: - To review key features distinguishing BCC from histologic mimics, including current evidence regarding immunohistochemical markers useful for that distinction. DATA SOURCES: - Review of pertinent literature on BCC immunohistochemistry and differential diagnosis. CONCLUSIONS: - In most cases, BCC can be reliably diagnosed by histopathologic features. Immunohistochemistry may provide useful ancillary data in certain cases. Awareness of potential mimics is critical to avoid misdiagnosis and resulting inappropriate management.
[Mh] Termos MeSH primário: Carcinoma Basocelular/diagnóstico
Neoplasias Cutâneas/diagnóstico
Pele/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Sebáceo/diagnóstico
Adenocarcinoma Sebáceo/imunologia
Adenocarcinoma Sebáceo/metabolismo
Adenocarcinoma Sebáceo/patologia
Biomarcadores Tumorais/metabolismo
Carcinoma Basocelular/imunologia
Carcinoma Basocelular/metabolismo
Carcinoma Basocelular/patologia
Diagnóstico Diferencial
Hamartoma/diagnóstico
Hamartoma/imunologia
Hamartoma/metabolismo
Hamartoma/patologia
Histiocitoma Fibroso Benigno/diagnóstico
Histiocitoma Fibroso Benigno/imunologia
Histiocitoma Fibroso Benigno/metabolismo
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
Imuno-Histoquímica/tendências
Imunofenotipagem/tendências
Pele/imunologia
Pele/metabolismo
Neoplasias Cutâneas/imunologia
Neoplasias Cutâneas/metabolismo
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0222-RA


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[PMID]:28932344
[Au] Autor:Kissou A; Hassam B
[Ad] Endereço:Service de Dermatologie, Centre Hospitalier Universitaire Ibn Sina, Rabat, Maroc.
[Ti] Título:[A pink nodule on the face].
[Ti] Título:Un nodule rose du visage..
[So] Source:Pan Afr Med J;27:205, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:We report the case of a 32-year old female patient, with no notable medical history, requiring dermatology consultation for evaluation of a nodule on her right cheek which had evolved over the past 10 years. Clinical examination showed a reddish dermal-based nodule with a smooth surface. The lesion measured 1cm in diameter and was located at the level of the right cheek (A). There was no adenopathy and the remainder of the clinical examination was normal. The patient underwent skin biopsy which showed tumor proliferation composed of fusiform cells with poorly limited eosinophilic cytoplasm and lightly atypical elongated nuclei without mitosis and with mononuclear inflammatory cell infiltrate at the level of the dermis. The epidermis was thinner. Anti-CD68 antibody was positive, while anti-CD34 antibody, PS100 and anti-AML were negative. The diagnosis of benign cellular histiocytofibroma was retained. The patient underwent total resection with a healthy resection margin of 5mm. The patient had a median 2-year follow-up with no recurrences identified. Benign histiocytofibroma mainly occurs in middle-aged women. It more often appears as an erythematous nodular, bluish, brownish or achromique dermal-based little painful but sometimes embarrassing lesion characterized by firm consistency and commonly located at the level of the lower limbs. Racial histiocytofibroma is rarely reported in the literature. Differential diagnosis includes Darier-Ferrand dermatofibrosarcoma, leiomyoma, Kaposi nodule and solitary fibrous tumor of the skin. Histologically, benign cellular histiocytofibroma is composed of pure intradermal disordered proliferation of fusiform cells arranged in bundles or in eddies and circumscribed by lymphocytic inflammatory reaction with presence of foamy histiocytes. The lesion is often highly vascularized with possibile hemorrhagic foci and especially, with angiogenesis images. In a minority of cases, especially in the case of huge histiocytofibromas, the epidermis is thinner and may even ulcerate. The immunohistochemistry shows the expression of CD68 and F XIIIa + positive cells while a lack of CD34, PS100 and Anti-AML expression. It is characterized by a chronic, benign evolution with possible spontaneous regression. The treatment is based on surgical resection.
[Mh] Termos MeSH primário: Neoplasias Faciais/diagnóstico
Histiocitoma Fibroso Benigno/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia
Neoplasias Faciais/patologia
Feminino
Seguimentos
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.205.13273


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[PMID]:28551623
[Au] Autor:Fujimura T; Kakizaki A; Sato Y; Tanita K; Furudate S; Aiba S
[Ad] Endereço:Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan tfujimura1@mac.com.
[Ti] Título:The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans.
[So] Source:Anticancer Res;37(6):2867-2873, 2017 06.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Dermatofibrosarcoma protuberance (DFSP) is a fibrohistiocytic tumor of intermediate malignancy characterized by slow infiltrative growth and a high tendency to recur locally. Periostin is involved in modulating cell function and inducing the production of proinflammatory cytokines, chemokines, and matrix metalloproteinases (MMPs) from tumor-associated macrophages (TAMs) to promote fibrosis and tumor growth. This study aimed to examine the cancer stroma of DFSP, focusing on TAMs-related proteins and MMPs. PATIENTS AND METHODS: Using immunohistochemical staining and DNA microarray database, we evaluated periostin, CD163, CD206, MMP1 and MMP12 in 10 cases of DFSP and dermatofibroma. RESULTS: Dense deposits of periostin as well as a substantial number of CD163 TAMs were detected at the peripheral areas of DFSP. Moreover, MMP1 and MMP12, that were selected by using a DNA microarray database of monocyte-derived macrophages, were observed in the TAMs-detected area. CONCLUSION: Increased levels of MMP1 and MMP12 on TAMs in the peripheral areas of DFSP might contribute to local invasion.
[Mh] Termos MeSH primário: Moléculas de Adesão Celular/metabolismo
Dermatofibrossarcoma/metabolismo
Macrófagos/metabolismo
Metaloproteinase 12 da Matriz/metabolismo
Metaloproteinase 1 da Matriz/metabolismo
Neoplasias Cutâneas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos CD/metabolismo
Antígenos de Diferenciação Mielomonocítica/metabolismo
Pré-Escolar
Dermatofibrossarcoma/genética
Feminino
Regulação Neoplásica da Expressão Gênica
Histiocitoma Fibroso Benigno/genética
Histiocitoma Fibroso Benigno/metabolismo
Seres Humanos
Lectinas Tipo C/metabolismo
Masculino
Lectinas de Ligação a Manose/metabolismo
Metaloproteinase 1 da Matriz/genética
Metaloproteinase 12 da Matriz/genética
Meia-Idade
Análise de Sequência com Séries de Oligonucleotídeos
Receptores de Superfície Celular/metabolismo
Neoplasias Cutâneas/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, Differentiation, Myelomonocytic); 0 (CD163 antigen); 0 (Cell Adhesion Molecules); 0 (Lectins, C-Type); 0 (Mannose-Binding Lectins); 0 (POSTN protein, human); 0 (Receptors, Cell Surface); 0 (mannose receptor); EC 3.4.24.65 (MMP12 protein, human); EC 3.4.24.65 (Matrix Metalloproteinase 12); EC 3.4.24.7 (MMP1 protein, human); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28252420
[Au] Autor:Lysenko N; Sharmazanova Y; Voronzhev I; Sorochan A; Kolomiychenko Y
[Ad] Endereço:Kharkov Medical Academy of Postgraduate Education, Department of Radiology and Paediatric Radiology, Department of Radiologic Diagnostics, Ukraine.
[Ti] Título:METAPHYSEAL CORTICAL DEFECT AND TUMOR-LIKE PROCESSES OF LONG BONES (A LITERATURE REVIEW AND OWN OBSERVATIONS).
[So] Source:Georgian Med News;(262):4-14, 2017 Jan.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:Metaphyseal cortical defect (metaphyseal fibrous defect, cortical fibrous defect) of the long bones is a quite common variant of the bone structure's pathologic changes. The cortical defects and similar to their tumor-like processes (non-ossifying fibroma, benign fibrous histiocytoma etc.) are characterized by particular qualities of the clinical symptoms and radiologic signs. The aim of this article is to analyze a known literature data about cortical fibrous defects of long bones and similar to their tumor-like processes and present results of our own observations. We have observed 52 patients with different variants of bone lesions (metaphyseal cortical defect as the variant of pathological bone restructuring, local form of fibrous dysplasia, giant cell tumor, solitary done cyst, benign fibrous histiocytoma, non-ossifying fibroma). Complex clinical and radiologic differential diagnosis is based on a thorough study of the history findings, the degree of pain intensity and radiologic signs of pathological processes (location, sizes, number of destruction nodes as well as dynamics of changing). Revealed features along with histological verification undoubtedly influence on choice of medical tactics.
[Mh] Termos MeSH primário: Doenças Ósseas/diagnóstico
Osso e Ossos/patologia
[Mh] Termos MeSH secundário: Doenças Ósseas/diagnóstico por imagem
Doenças Ósseas/patologia
Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/patologia
Osso e Ossos/diagnóstico por imagem
Diagnóstico Diferencial
Fibroma/diagnóstico
Fibroma/diagnóstico por imagem
Fibroma/patologia
Displasia Fibrosa Óssea/diagnóstico
Displasia Fibrosa Óssea/diagnóstico por imagem
Displasia Fibrosa Óssea/patologia
Histiocitoma Fibroso Benigno/diagnóstico
Histiocitoma Fibroso Benigno/diagnóstico por imagem
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE


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[PMID]:28240656
[Au] Autor:Aydin F; Akçal A; Ünal B; Sezgin Göksu S; Güngör F
[Ad] Endereço:From the Departments of *Nuclear Medicine, †Plastic, Reconstructive and Aesthetic Surgery, ‡Pathology, and §Medical Oncology, Akdeniz University, Antalya; and ∥Department of Nuclear Medicine, Emsey Hospital, Istanbul, Turkey.
[Ti] Título:68Ga-PSMA Uptake by Dermatofibroma in a Patient With Prostate Cancer.
[So] Source:Clin Nucl Med;42(5):358-360, 2017 May.
[Is] ISSN:1536-0229
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Prostate-specific membrane antigen (PSMA) is a typ. 2 transmembrane protein that is highly expressed in prostate cancer cells. Ga-PSMA PET/CT imaging is a modality used to determine the extent of prostate cancer. Various other neoplasias may also express PSMA, which appears as Ga-PSMA uptake in PET/CT imaging. A 71-year-old man with prostate cancer underwent Ga-PSMA PET/CT imaging for restaging after having an elevated prostate-specific antigen level. Subcutaneous lesions showing focal PSMA uptake were detected, one of which was excised. The histopathologic diagnosis was dermatofibroma.
[Mh] Termos MeSH primário: Histiocitoma Fibroso Benigno/diagnóstico por imagem
Compostos Organometálicos
Neoplasias da Próstata/diagnóstico por imagem
Compostos Radiofarmacêuticos
[Mh] Termos MeSH secundário: Idoso
Histiocitoma Fibroso Benigno/complicações
Seres Humanos
Masculino
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Neoplasias da Próstata/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 ((68Ga)Glu-urea-Lys(Ahx)-HBED-CC); 0 (Organometallic Compounds); 0 (Radiopharmaceuticals)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1097/RLU.0000000000001591


  6 / 5562 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28225965
[Au] Autor:Campagnolo OA; Morais CF; Ughini MO; Aoki CM; Menegazzo M
[Ad] Endereço:Dermatology Departament of Centro Universitário da Fundação Assis Gurgacz (FAG) - Cascavel (PR), Brazil.
[Ti] Título:Dermatomyofibroma.
[So] Source:An Bras Dermatol;92(1):101-103, 2017 Jan-Feb.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:We report a case of dermatomyofibroma that, to our knowledge, is the second case reported in Brazil. About 100 cases have been reported worldwide. Dermatomyofibroma represents a rare, benign mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation, with prolonged evolution and little or no symptoms. It most commonly occurs in young women and male children. Dermatomyofibroma can be easily confused with other clinical entities, which could lead to unnecessary treatments. Therefore, it is important that dermatologists and pediatricians suspect and start to consider this hypothesis in their diagnostic exercises.
[Mh] Termos MeSH primário: Histiocitoma Fibroso Benigno/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais
Feminino
Seres Humanos
Imuno-Histoquímica
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


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[PMID]:28221323
[Au] Autor:Saikaly SK; Khachemoune A
[Ad] Endereço:Sami Kameel Saikaly is a student in the University of Central Florida's College of Medicine. Amor Khachemoune is on the dermatology faculty at SUNY Downstate and practices at the Veterans Affairs Medical Center, both in Brooklyn, N.Y. The authors have disclosed no potential conflicts of interest, financial or otherwise.
[Ti] Título:A man with a large nodule on his lower leg.
[So] Source:JAAPA;30(3):55-56, 2017 Mar.
[Is] ISSN:1547-1896
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatofibrossarcoma/diagnóstico
Cisto Epidérmico/diagnóstico
Histiocitoma Fibroso Benigno/diagnóstico
Melanoma Amelanótico/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Perna (Membro)
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1097/01.JAA.0000512246.96989.53


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[PMID]:28134725
[Au] Autor:Abdaljaleel MY; North JP
[Ad] Endereço:Departments of *Dermatology, and †Pathology, University of California San Francisco, San Francisco, CA.
[Ti] Título:Sclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
[So] Source:Am J Dermatopathol;39(2):83-88, 2017 Feb.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low-to-intermediate grade sarcoma with several histologic variants, including pigmented (Bednar tumor), sclerosing, myxoid, atrophic, and DFSP with fibrosarcomatous changes. Two patterns of sclerosis in DFSP can be observed, a sclerotic fibroma-like pattern and a morphea/lichen sclerosus-like pattern. Partial biopsies of sclerosing DFSPs with the sclerotic fibroma pattern can be misdiagnosed as sclerotic fibroma or other benign sclerosing tumors (eg, perineurioma, dermatofibroma). DFSPs from our tissue archives were screened for tumors with a sclerosing pattern, and then studied with epithelial membrane antigen (EMA), CD34, and elastic tissue staining to investigate whether such stains can differentiate sclerosing DFSP from sclerotic fibroma. Ten cases of sclerotic fibroma were similarly studied. Two of the 27 DFSPs were predominantly sclerosing and 5 additional DFSPs had a mixed histopathologic pattern including a sclerosing component. Immunohistochemically, all DFSPs with sclerosing (predominant or mixed) pattern were positive for CD34, and 5/7 were at least focally positive for EMA. Elastic tissue staining was reduced or absent in the sclerotic areas. All cases of sclerotic fibroma were either positive or focally positive for CD34, whereas EMA was focally positive in 5/10. Elastic tissue staining ranged from reduced to totally absent in the sclerotic fibromas. In conclusion, the similar histopathologic and immunophenotypic characteristics in sclerotic fibroma and sclerosing DFSP found in this analysis highlight the importance of obtaining clinical information and potentially additional excision for partial biopsies showing a sclerotic fibroma-like pattern.
[Mh] Termos MeSH primário: Dermatofibrossarcoma/diagnóstico
Histiocitoma Fibroso Benigno/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores Tumorais/análise
Criança
Dermatofibrossarcoma/patologia
Diagnóstico Diferencial
Feminino
Histiocitoma Fibroso Benigno/patologia
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000584


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[PMID]:28106946
[Au] Autor:Guarneri C; Cannavò SP; Lentini M; Vaccaro M
[Ad] Endereço:Department of Clinical Experimental Medicine, Section of Dermatology, University of Messina, Italy.
[Ti] Título:Unexpected amelanotic melanoma simulators.
[So] Source:J Dtsch Dermatol Ges;15(2):205-207, 2017 Feb.
[Is] ISSN:1610-0387
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Erros de Diagnóstico/prevenção & controle
Histiocitoma Fibroso Benigno/patologia
Melanoma/patologia
Neoplasias Fibroepiteliais/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Idoso
Dermoscopia/métodos
Diagnóstico Diferencial
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; LETTER; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1111/ddg.13030


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[PMID]:28087033
[Au] Autor:Piccolo V; Russo T; Danielsson M; Russo D; Lòpez Muñoz AM; Mascolo M; Argenziano G
[Ad] Endereço:Dermatology Unit, Second University of Naples, Naples, Italy. Electronic address: piccolo.vincenzo@gmail.com.
[Ti] Título:Keratoacanthoma-like dermatofibroma: A dermoscopic challenge.
[So] Source:J Am Acad Dermatol;76(2S1):S57-S59, 2017 Feb.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermoscopia
Histiocitoma Fibroso Benigno/patologia
Ceratoacantoma/patologia
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Dorso
Diagnóstico Diferencial
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE



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