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Pesquisa : C04.557.450.565.590.595.150 [Categoria DeCS]
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[PMID]:29187928
[Au] Autor:Ajani MA; Salami A; Awolude OA; Oluwasola AO
[Ad] Endereço:Department of Histopathology, Babcock University, Ilishan-Remo, Ogun state, Nigeria.
[Ti] Título:Hormone-receptor expression status of epithelial ovarian cancer in Ibadan, South-western Nigeria.
[So] Source:Pan Afr Med J;27:259, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: Epidemiological evidence strongly suggests that steroid hormones are implicated in the pathogenesis of ovarian cancer. Estrogen receptor (ER) and Progesterone receptor (PR) are prognostic indicators for a number of epithelial tumors and may play the same role in ovarian cancers. This study aims to evaluate the expression of ER and PR in epithelial ovarian cancer (EOC) in an African population and compare it with other prognostic factors such as age, International Federation of Gynaecology and Obstetrics (FIGO) stage, grade and histological subtype. Methods: Ninety cases of histologically confirmed EOC were reviewed. Immunohistochemistry was used to assess their ER and PR expression status and was then compared with other demographic variables using statistical methods, with level of significance set at p < 0.05. Results: 30.2% and 8.3% of serous and mucinous carcinomas respectively were ER positive while 41.2% and 22.5% of both tumour types were PR positive. One of the two endometrioid carcinomas showed PR expression but neither were positive for ER. The only case of Brenner tumour in the series was ER positive but negative for PR. There was a significant association between ER and the histological subtypes (p = 0.042) while no significant association was found between PR expression and histological subtypes (p = 0.650). No significant association was found between hormone receptor status, age and stage of the EOC. Conclusion: The study showed a lower ER expression in serous carcinoma compared to large cohorts from developed countries. Future translational studies could be used to determine response of EOC to endocrine therapy.
[Mh] Termos MeSH primário: Neoplasias Epiteliais e Glandulares/epidemiologia
Neoplasias Ovarianas/epidemiologia
Receptores Estrogênicos/genética
Receptores de Progesterona/genética
[Mh] Termos MeSH secundário: Adenocarcinoma Mucinoso/epidemiologia
Adenocarcinoma Mucinoso/genética
Adenocarcinoma Mucinoso/patologia
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Tumor de Brenner/epidemiologia
Tumor de Brenner/genética
Tumor de Brenner/patologia
Feminino
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Neoplasias Epiteliais e Glandulares/genética
Neoplasias Epiteliais e Glandulares/patologia
Nigéria/epidemiologia
Neoplasias Ovarianas/genética
Neoplasias Ovarianas/patologia
Prognóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Estrogen); 0 (Receptors, Progesterone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.259.11883


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[PMID]:28984773
[Au] Autor:Jeon H; Ryu A; Seo HG; Jang SH
[Ad] Endereço:Department of Obstetrics and Gynecology, Department of Pathology, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
[Ti] Título:Ovarian torsion of mixed epithelial tumor misdiagnosed as a malignancy in postmenopausal woman: A case report.
[So] Source:Medicine (Baltimore);96(40):e8207, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Adnexal torsion is 1 of the most common emergency gynecological disease. It is more often diagnosed in reproductive age, but rarely in postmenopausal women. The clinical symptoms of adnexal torsion are nonspecific in postmenopausal women. Epithelial ovarian tumors are common in adults, and the risk of malignancy increases with age, especially after menopause. So, it is difficult to diagnose adnexal torsion precisely compared with reproductive women, and most cases of adnexal torsion with postmenopausal women are diagnosed as a malignancy preoperatively. We report a case of ovarian torsion with mixed epithelial tumor misdiagnosed as a malignancy in postmenopausal woman. PATIENT CONCERNS: A 65-year-old woman presented lower left abdominal pain, and there was slight abdominal distension, but no tenderness or rebound tenderness on abdominal palpation. DIAGNOSES: Radiologic assessments showed a huge multiseptated cystic mass with solid portion in the left ovary, and malignancy was suspected. The test for serum tumor markers revealed normal levels of cancer antigen 125 (CA-125). INTERVENTIONS: The patient underwent a laparotomy and there was torsion of the left ovary. We conducted frozen biopsy of left ovary for confirming malignancy before performing staging surgery. OUTCOMES: The result of a frozen section biopsy confirmed a borderline Brenner tumor associated with a benign mucinous tumor. Subsequently, total hysterectomy and right salpingo-oophorectomy were performed. The operation was completed without addition procedures LESSONS:: Ovarian torsion is benign in most cases and malignancy is rare. Although very rare, ovarian torsion can occur in postmenopausal women, and it should be taken into consideration that the possibility of malignancy is low in postmenopausal women with normal CA-125 levels. Instead of performing staging surgery, it appears to be appropriate to carry out surgery based on the result of intraoperative frozen section biopsy so that we were able to avoid unnecessary surgical procedures.
[Mh] Termos MeSH primário: Tumor de Brenner/diagnóstico
Erros de Diagnóstico
Neoplasias Ovarianas/diagnóstico
Ovário/anormalidades
Anormalidade Torcional/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Tumor de Brenner/patologia
Tumor de Brenner/cirurgia
Antígeno Ca-125/análise
Feminino
Secções Congeladas
Seres Humanos
Neoplasias Ovarianas/patologia
Neoplasias Ovarianas/cirurgia
Ovariectomia/métodos
Ovário/patologia
Ovário/cirurgia
Pós-Menopausa
Anormalidade Torcional/patologia
Anormalidade Torcional/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CA-125 Antigen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008207


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[PMID]:28351362
[Au] Autor:Hwang CS; Lee CH; Lee SJ; Kim YG; Kim A; Park DY; Kang HJ; Shin DH
[Ad] Endereço:Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
[Ti] Título:A peculiar case report of extraovarian Brenner tumor arising in the omentum.
[So] Source:World J Surg Oncol;15(1):72, 2017 Mar 28.
[Is] ISSN:1477-7819
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Brenner tumors almost always develop in the ovary. Exceptionally, extraovarian Brenner tumors have been reported in the lower abdomen or pelvic organs. Here, we introduce a peculiar case of an extraovarian Brenner tumor arising in the omentum. CASE PRESENTATION: A 43-year-old woman presented with a palpable abdominal mass. Computed tomography (CT) scan revealed a 9.0-cm solid mass in the omentum. The tumor was not associated with pelvic structures, including the ovaries. It was excised under the clinical impression of an extragastrointestinal stromal tumor or neurogenic tumor. Grossly, the mass was a well-circumscribed solid tumor, with yellow-tan cut surface and minute cystic spaces. Microscopically, the tumor showed well-defined epithelial nests with variable cystic changes embedded in an abundant fibrous stroma. The cells within the nests were reminiscent of benign urothelial cells in that they had oval, frequently grooved nuclei. The epithelial cells focally showed a gradual transition into the surrounding stromal cells with short spindled features. The urothelium-like cells were positive for pancytokeratin, WT-1, p63, CK7, uroplakin-III, and GATA-3 but were negative for CD34, CD10, CK20, c-KIT, DOG-1, PAX-8, and calretinin. Morphological and immunohistochemical features of the tumor were the same as an ovarian Brenner tumor, and so it was diagnosed as an extraovarian Brenner tumor. CONCLUSIONS: Although the location of the tumor was very unusual, we could diagnose the tumor as an extraovarian Brenner tumor on the basis of the histologic and immunohistochemical findings. This is the first case of extraovarian Brenner tumor arising in the omentum near the stomach ever reported in the English literature.
[Mh] Termos MeSH primário: Tumor de Brenner/patologia
Omento/patologia
Neoplasias Ovarianas/patologia
Células Estromais/patologia
[Mh] Termos MeSH secundário: Adulto
Tumor de Brenner/cirurgia
Feminino
Seres Humanos
Omento/cirurgia
Neoplasias Ovarianas/cirurgia
Prognóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1186/s12957-017-1135-2


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[PMID]:28238418
[Au] Autor:Karpathiou G; Venet M; Mobarki M; Forest F; Chauleur C; Peoc'h M
[Ad] Endereço:Department of Pathology, North Hospital, University Hospital of St-Etienne, France. Electronic address: gakarpath@yahoo.gr.
[Ti] Título:FOXA1 is expressed in ovarian mucinous neoplasms.
[So] Source:Pathology;49(3):271-276, 2017 Apr.
[Is] ISSN:1465-3931
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:FOXA1 is a transcription factor essential for the binding and action of other transcription factors on the chromatin. It is the major regulator of endoderm differentiation. It has important roles in breast, prostate and endometrial cancer. It has never been studied in ovarian tumours. The aim of this study was to investigate its expression in ovarian epithelial neoplasms. A total of 195 primary ovarian epithelial borderline or malignant tumours were immunohistochemically studied for the expression of FOXA1. Nineteen percent of the tumours strongly and diffusely expressed FOXA1. Of these, 75.7% belong to the mucinous category (p < 0.0001). Seventy-five per cent of mucinous borderline tumours and 46.7% of mucinous carcinomas overexpressed FOXA1. Brenner tumours also expressed FOXA1. FOXA1 was rarely expressed in serous (6/115) and endometrioid tumours (1/11). Clear cell tumours were completely negative (0/16). Of normal structures, ciliated tubal cells, Walthard nests and transitional metaplasias of the tubal-mesothelial junction, all strongly expressed FOXA1. In conclusion, FOXA1 is found in ovarian mucinous and Brenner tumours.
[Mh] Termos MeSH primário: Adenocarcinoma Mucinoso/patologia
Epitélio/patologia
Fator 3-alfa Nuclear de Hepatócito/metabolismo
Neoplasias Ovarianas/patologia
[Mh] Termos MeSH secundário: Adenocarcinoma Mucinoso/diagnóstico
Adenocarcinoma Mucinoso/metabolismo
Biomarcadores Tumorais/metabolismo
Tumor de Brenner/diagnóstico
Tumor de Brenner/metabolismo
Feminino
Seres Humanos
Metaplasia
Neoplasias Ovarianas/diagnóstico
Neoplasias Ovarianas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (FOXA1 protein, human); 0 (Hepatocyte Nuclear Factor 3-alpha)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE


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[PMID]:28231585
[Au] Autor:Minato J; Tokunaga H; Okamoto S; Shibuya Y; Niikura H; Yaegashi N
[Ad] Endereço:Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
[Ti] Título:Is Imprint Cytology Useful to Diagnose Malignancy for Brenner Tumors? A Case Series at a Single Institute.
[So] Source:Acta Cytol;61(2):153-159, 2017.
[Is] ISSN:1938-2650
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to investigate cytological features of Brenner tumors according to tumor grade using imprint cytology. CASE: Between 2004 and 2015, intraoperative imprint cytology was performed on 8 patients with Brenner tumors suspected to be malignant neoplasmas on gross examination because of their large size and solid part. These consisted of 1 benign, 3 borderline, and 4 malignant tumors. In patients with benign and borderline tumors, naked nucleus-like stromal cells and tumor cells in a sheet-like arrangement were observed against a clear background. The nuclei were round to oval-shaped with finely granular chromatin patterns and small nucleoli. Papillary cell clusters and high nucleus-to-cytoplasm ratios were only observed in 1 borderline case. In cases with malignancy, the background was necrotic. The tumor cells occurred in large papillary clusters. The nuclei showed a high degree of nuclear atypia. Nuclear grooves were present in 6 of our 8 cases and they were scant in the malignant cases. CONCLUSION: Imprint cytology of Brenner tumors provided no characteristic findings to enable a definitive distinction of benign versus borderline tumors, but it enabled discrimination between malignant and other tumors. Imprint cytology can facilitate intraoperative diagnosis and aid in selecting the appropriate surgical procedure.
[Mh] Termos MeSH primário: Tumor de Brenner/diagnóstico
Núcleo Celular/patologia
Citodiagnóstico/métodos
Neoplasias Ovarianas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Tumor de Brenner/patologia
Nucléolo Celular/patologia
Forma do Núcleo Celular
Tamanho do Núcleo Celular
Feminino
Seres Humanos
Japão
Meia-Idade
Gradação de Tumores
Neoplasias Ovarianas/patologia
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Estudos Retrospectivos
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170530
[Lr] Data última revisão:
170530
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1159/000455997


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[PMID]:27833989
[Au] Autor:Albu DF; Albu CC; Goganau AM; Albu SD; Mogoanta L; Edu A; DiTescu D; Vaduva CC
[Ad] Endereço:Department of Genetics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; crenguta.albu@yahoo.com.
[Ti] Título:Borderline Brenner tumors associated with ovarian cyst - case presentation.
[So] Source:Rom J Morphol Embryol;57(2 Suppl):893-898, 2016.
[Is] ISSN:1220-0522
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:Borderline Brenner tumors represent quite a rare entity of ovarian tumors (about 2%) that develop from the surface ovarian epithelium. They are formed from papillary structures made of fibrovascular conjunctive axes covered by a transition epithelium, similar to the urinary bladder epithelium. According to the WHO classification, Brenner tumors present the following forms: benign, borderline and malignant. The benign ones are the most frequent, representing about 95%, the borderline represent about 5%, and the malignant ones less than 1%. We present the case of a 64-year patient who was diagnosed with right ovary cyst. The histopathological examination highlighted the presence of a borderline Brenner tumor at the same time with the cystic lesion, on the same ovary. The surgical treatment led to a complete cure of the patient, so that the yearly ultrasound reexamination did not trace the presence of any tumoral relapse.
[Mh] Termos MeSH primário: Tumor de Brenner/complicações
Cistos Ovarianos/complicações
[Mh] Termos MeSH secundário: Tumor de Brenner/patologia
Feminino
Seres Humanos
Meia-Idade
Proteínas de Neoplasias/metabolismo
Cistos Ovarianos/patologia
Células Estromais/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neoplasm Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161112
[St] Status:MEDLINE


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[PMID]:27751433
[Au] Autor:Lee WM; Choi JS; Bae J; Jung US; Kang BK
[Ad] Endereço:Division of Gynecologic Oncology and Gynecologic Minimally Invasive Surgery, Department of Obstetrics and Gynecology, Hanyang University College of Medicine, Seoul, South Korea.
[Ti] Título:Laparoscopic treatment of Castleman's disease in a patient with a history of malignant Brenner tumor.
[So] Source:Taiwan J Obstet Gynecol;55(5):754-756, 2016 Oct.
[Is] ISSN:1875-6263
[Cp] País de publicação:China (Republic : 1949- )
[La] Idioma:eng
[Mh] Termos MeSH primário: Tumor de Brenner/complicações
Doença de Castleman/cirurgia
Histerectomia/métodos
Laparoscopia/métodos
Neoplasias Ovarianas/complicações
[Mh] Termos MeSH secundário: Biópsia
Tumor de Brenner/diagnóstico
Doença de Castleman/complicações
Doença de Castleman/diagnóstico
Feminino
Seres Humanos
Meia-Idade
Neoplasias Ovarianas/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27299795
[Au] Autor:Khani F; Diolombi ML; Khattar P; Huang W; Fallon JT; Epstein JI; Zhong M
[Ad] Endereço:*Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD †The Department of Pathology, Westchester Medical Center/New York Medical College, Valhalla, NY.
[Ti] Título:Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma.
[So] Source:Am J Surg Pathol;40(9):1291-5, 2016 Sep.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brenner tumors are uncommon ovarian neoplasms, which have morphologic and immunophenotypical features of transitional cell (urothelial) differentiation. The origin of Brenner tumors is perplexing, but they are believed to arise from transitional cell metaplasia occurring within the ovary and/or fallopian tube, although it is controversial whether this metaplasia is truly along transitional cell lines. Recently, TERT promoter mutations have been identified in urothelial carcinoma (UC) with high frequency (approximately 70%), and the current literature suggests a potential diagnostic and/or prognostic role of these mutations in UC. Molecular evidence supporting that Brenner tumors represent neoplasms exhibiting transitional cell differentiation is scant. To explore this further, we investigated a series of 19 Brenner tumors of the ovary (15 benign and 4 malignant) for the presence of TERT promoter mutations after genomic DNA extraction from formalin-fixed paraffin-embedded tissue blocks and standard polymerase chain reaction sequencing. TERT promoter mutations were not identified in any of the cases (0/19). The absence of TERT promoter mutations in Brenner tumors suggests that despite the morphologic and some immunophenotypical resemblance to non-neoplastic and neoplastic transitional epithelium, Brenner tumors may exhibit a molecularly distinct pathogenesis. The findings also may portend diagnostic utility in rare cases wherein it is difficult to distinguish a primary malignant Brenner tumor of the ovary from metastatic UC.
[Mh] Termos MeSH primário: Tumor de Brenner/genética
Mutação
Neoplasias Ovarianas/genética
Telomerase/genética
Neoplasias Urológicas/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma de Células de Transição/genética
Feminino
Seres Humanos
Meia-Idade
Reação em Cadeia da Polimerase
Regiões Promotoras Genéticas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.49 (TERT protein, human); EC 2.7.7.49 (Telomerase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000680


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[PMID]:27172761
[Au] Autor:Tsikouras P; Galazios G; Romanidis K; Pinidis P; Liberis A; Giatromanolaki A; Sivridis E
[Ti] Título:Brenner tumour of the ovary--an incidental histological finding.
[So] Source:Eur J Gynaecol Oncol;37(2):267-9, 2016.
[Is] ISSN:0392-2936
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Brenner tumours of the ovary are uncommon neoplasms and mostly benign. There is general agreement that Brenner tumors are derived from the surface epithelium of the ovary or the pelvic mesothelium through transitional cell metaplasia. It is essential to categorise these tumours as benign, borderline or malignant type as the biologic behaviour and choice of surgery differs in all of the three categories. The authors report a case of Brenner tumour that had only a single area with a beginning indistinct stroma vessel invasion. However the presence of characteristic epithelial nests, fibromatous stroma, and marked cytological metaplasia without atypia provided important clues to the correct diagnosis--proof of a benign tumour.
[Mh] Termos MeSH primário: Tumor de Brenner/patologia
Neoplasias Ovarianas/patologia
[Mh] Termos MeSH secundário: Tumor de Brenner/cirurgia
Feminino
Seres Humanos
Achados Incidentais
Meia-Idade
Neoplasias Ovarianas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160513
[Lr] Data última revisão:
160513
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE


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[PMID]:27130406
[Au] Autor:Nasioudis D; Sisti G; Holcomb K; Kanninen T; Witkin SS
[Ad] Endereço:Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
[Ti] Título:Malignant Brenner tumors of the ovary; a population-based analysis.
[So] Source:Gynecol Oncol;142(1):44-49, 2016 07.
[Is] ISSN:1095-6859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Malignant Brenner Tumor (MBT) is a tumor with an extremely low incidence that morphologically resembles to urothelium. Given the paucity of evidence on the epidemiology and prognosis of MBT, the aim of this retrospective population-based study was to elucidate the demographic and clinico-pathological characteristics of patients with ovarian MBT. METHODS: A cohort of patients diagnosed between 1988 and 2012 was drawn from the National Cancer Institute Surveillance and Epidemiology End Results database. For surgically treated patients, Observed and Disease Specific Survival were calculated following generation of Kaplan-Meier curves. Comparisons were made using the log-rank test. RESULTS: A total of 207 patients were identified. Median patient age was 65years and the majority presented with unilateral, high grade tumors with a median size of 10cm. Stage I, II, III and IV disease was noted for 55.4%, 14.4%, 18%, and 12.2% of patients respectively. Only 5.1% had positive lymph nodes for metastatic disease. Five-year disease-specific survival (DSS) of patients with tumors confined to the ovary was 94.5% compared to 51.3% for those with extra-ovarian spread (p<0.001). Lymphadenectomy was not associated with an improved DSS (p=0.2). CONCLUSIONS: MBTs are typically unilateral high grade tumors localized to the ovary. Regional lymphatic spread is uncommon and lymphadenectomy does not confer any improvement on survival. Patients with tumors confined to the ovary have an excellent prognosis while extra-ovarian spread is associated with a poor outcome.
[Mh] Termos MeSH primário: Tumor de Brenner/epidemiologia
Neoplasias Ovarianas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Tumor de Brenner/mortalidade
Tumor de Brenner/cirurgia
Estudos de Coortes
Feminino
Seres Humanos
Meia-Idade
Neoplasias Ovarianas/mortalidade
Neoplasias Ovarianas/cirurgia
Sistema de Registros
Programa de SEER
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE



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