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[PMID]:29187512
[Au] Autor:Apellaniz-Ruiz M; de Kock L; Sabbaghian N; Guaraldi F; Ghizzoni L; Beccuti G; Foulkes WD
[Ad] Endereço:Lady Davis InstituteSegal Cancer Centre, Jewish General Hospital, Montréal, Québec, Canada.
[Ti] Título:Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame deletion.
[So] Source:Eur J Endocrinol;178(2):K11-K19, 2018 Feb.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Familial multinodular goiter (MNG), with or without ovarian Sertoli-Leydig cell tumor (SLCT), has been linked to DICER1 syndrome. We aimed to search for the presence of a germline mutation in a large family with a remarkable history of MNG and SLCT, and to further explore the relevance of the identified mutation. DESIGN AND METHODS: Sanger sequencing, Fluidigm Access Array and multiplex ligation-dependent probe amplification (MLPA) techniques were used to screen for mutations in germline DNA from 16 family members. Where available, tumor DNA was also studied. mRNA and protein extracted from carriers' lymphocytes were used to characterize the expression of the mutant DICER1. RESULTS: Nine of 16 tested individuals carried a germline, in-frame deletion (c.4207-41_5364+1034del), which resulted in the loss of exons 23 and 24 from the cDNA. The mutant transcript does not undergo nonsense-mediated decay and the protein is devoid of specific metal ion-binding amino acids (p.E1705 and p.D1709) in the RNase IIIb domain. In addition, characteristic somatic 'second hit' mutations in this region were found on the other allele in tumors. CONCLUSIONS: Patients with DICER1 syndrome usually present a combination of a typically truncating germline mutation and a tumor-specific hotspot missense mutation within the sequence encoding the RNase IIIb domain. The in-frame deletion found in this family suggests that the germline absence of p.E1705 and p.D1709, which are crucial for RNase IIIb activity, may be enough to permit DICER1 syndrome to occur.
[Mh] Termos MeSH primário: RNA Helicases DEAD-box/genética
Bócio Nodular/genética
Ribonuclease III/genética
Tumor de Células de Sertoli-Leydig/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Neoplasias da Mama/genética
DNA/análise
DNA/sangue
Feminino
Fibroadenoma/genética
Predisposição Genética para Doença
Mutação em Linhagem Germinativa/genética
Bócio Nodular/cirurgia
Seres Humanos
Linfócitos/química
Masculino
Neoplasias Ovarianas/genética
Neoplasias Ovarianas/cirurgia
Linhagem
RNA Mensageiro Estocado/sangue
Análise de Sequência de DNA
Deleção de Sequência
Tumor de Células de Sertoli-Leydig/cirurgia
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger, Stored); 9007-49-2 (DNA); EC 3.1.26.3 (DICER1 protein, human); EC 3.1.26.3 (Ribonuclease III); EC 3.6.4.13 (DEAD-box RNA Helicases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0904


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[PMID]:29187920
[Au] Autor:Kane Gueye SM; Gueye M; Coulibaly MT; Mahtouk D; Moreau JC
[Ad] Endereço:Unité de Sénologie du Centre Hospitalier Universitaire Aristide Le Dantec de Dakar, Sénégal.
[Ti] Título:[Benign tumors of the breast in the department of senology at the University Hospital Aristide Le Dantec, Dakar (Senegal)].
[Ti] Título:Tumeurs bénignes du sein à l'unité de sénologie du Centre Hospitalier Universitaire Aristide Le Dantec de Dakar (Sénégal)..
[So] Source:Pan Afr Med J;27:251, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Introduction: This study aimed to identify the epidemiological, clinical and therapeutic features of benign tumors of the breast treated in the department of senology at the university hospital Aristide Le Dantec, Dakar. Methods: We conducted a cross-sectional, descriptive and analytical study of 220 patients treated in the Department of Senology at the University Hospital Aristide Le Dantec, Dakar over the period from 1 January 2008 to 31 December 2013. Results: 220 patients out of 984 consultants had benign tumor of the breast (22.5%). Benign tumors of the breast accounted for 58.2% of tumor pathologies. The average age was 24 years. The age group 11-30 years was the most represented (70%). The quasi-totality of patients were women of childbearing age (95%), 58.6% were nulliparous women. The main reason for consultation was a breast mass in 94.5% of cases. The left side was most often affected (49.5%), especially the upper outer quadrant (41.6%). 145 patients (65.9% of cases) underwent ultrasound. Cytologic examination showed conjunctival epithelial hyperplasia in almost all cases (96.1%). 44 women underwent histologic examination, which confirmed the histologic nature of the lesions. Fibroadenoma and fibrocystic changes were the most retained diagnoses, accounting for 86.3% and 5.9% respectively. 28 patients (12.7%) underwent lumpectomy, all tumor types were taken together. The majority of patients had follow-up appointments within 3 months, with favorable outcome. Conclusion: Benign tumors are very frequent in senology consultations. The recommended diagnostic approach combines the clinico-radio-cytological triad and, in case of doubt or discrepancy, biopsy or surgical resection are essential. Surgery is not always the treatment of choice. This is based on the nature of the tumor.
[Mh] Termos MeSH primário: Doenças Mamárias/diagnóstico
Neoplasias da Mama/diagnóstico
Fibroadenoma/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Doenças Mamárias/patologia
Doenças Mamárias/cirurgia
Neoplasias da Mama/patologia
Neoplasias da Mama/cirurgia
Criança
Estudos Transversais
Feminino
Fibroadenoma/patologia
Fibroadenoma/cirurgia
Seguimentos
Hospitais Universitários
Seres Humanos
Hiperplasia
Mastectomia Segmentar/métodos
Meia-Idade
Senegal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.251.12262


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[PMID]:28688536
[Au] Autor:Krings G; Bean GR; Chen YY
[Ad] Endereço:Department of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA. Electronic address: gregor.krings@ucsf.edu.
[Ti] Título:Fibroepithelial lesions; The WHO spectrum.
[So] Source:Semin Diagn Pathol;34(5):438-452, 2017 Sep.
[Is] ISSN:0740-2570
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fibroepithelial lesions of the breast comprise a morphologically and biologically heterogeneous group of biphasic tumors with epithelial and stromal components that demonstrate widely variable clinical behavior. Fibroadenomas are common benign tumors with a number of histologic variants, most of which pose no diagnostic challenge. Cellular and juvenile fibroadenomas can have overlapping features with phyllodes tumors and should be recognized. Phyllodes tumors constitute a spectrum of lesions with varying clinical behavior and are graded as benign, borderline or malignant based on a set of histologic features according to recommendations by the World Health Organization (WHO). Recent developments have significantly expanded our understanding of the pathogenesis of fibroepithelial lesions, highlighting fibroadenomas as true neoplasms and underscoring a commonality with phyllodes tumors in the form of recurrent MED12 exon 2 mutations. In addition, sequencing studies have elucidated pathways associated with phyllodes tumor progression. Accurate diagnosis and grading of phyllodes tumors are important for patient management and prognosis, as grade broadly correlates with increasing local recurrence risk, and essentially only malignant tumors metastasize. However, classification of fibroepithelial lesions in many cases remains challenging on both core biopsy and excision specimens. A commonly encountered problem at the benign end of the spectrum is the distinction of benign phyllodes tumor from cellular fibroadenoma, which is largely due to the subjective nature of histologic features used in diagnosis and histologic overlap between lesions. Grading is further complicated by the requirement to integrate multiple subjective and ill-defined parameters. On the opposite end of the histologic spectrum, malignant phyllodes tumors must be distinguished from more common metaplastic carcinomas and from primary or metastatic sarcomas, which can be especially difficult in core biopsies. Immunohistochemistry can be useful in the differential diagnosis but should be interpreted with attention to caveats. This review provides an overview and update on the spectrum of fibroepithelial lesions, with special emphasis on common problems and practical issues in diagnosis.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Neoplasias Fibroepiteliais/patologia
Tumor Filoide/patologia
Organização Mundial da Saúde
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Neoplasias da Mama/química
Neoplasias da Mama/genética
Diagnóstico Diferencial
Feminino
Fibroadenoma/química
Fibroadenoma/genética
Fibroadenoma/patologia
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Técnicas de Diagnóstico Molecular
Gradação de Tumores
Neoplasias Fibroepiteliais/química
Neoplasias Fibroepiteliais/genética
Fenótipo
Tumor Filoide/química
Tumor Filoide/genética
Valor Preditivo dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


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[PMID]:28376591
[Au] Autor:He YN; Zhang SC; Zhang HM
[Ad] Endereço:JOINN Laboratories, Beijing 100176, China.
[Ti] Título:[Pathologic changes of spontaneous tumors in Sprague-Dawley and Wistar rats].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(4):249-254, 2017 Apr 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the spontaneous neoplastic lesions and their incidences in Sprague-Dawley (SD) and Wistar rats, and to accumulate background data for carcinogenicity studies. One hundred and eighty SD rats and 240 Wistar rats (4-week old) , half in each sex, were used in this study. The rats were housed routinely under specific pathogen-free environment and euthanized after 104 weeks. Histopathological examination was undertaken for all animals including deaths and scheduled euthanasia. The types and incidences of spontaneous tumors were gathered statistically. Total 411 rats (176 SD rats and 235 Wistar rats) were examined in this study. The total tumor incidence of the 411 rats was 57.7%(237/411). The total tumor incidence in SD rats was 55.7%(98/176), benign tumor incidence was 48.9%(86/176) and malignant tumor incidence was 15.9%(28/176). The total tumor incidence in Wistar rats was 59.1%(139/235), benign tumor incidence was 51.5%(121/235) and malignant tumor incidence was 14.5%(34/235). The main benign tumors were pituitary adenoma (23.3% in SD rats, 12.3% in Wistar rats), breast fibroadenoma (21.3% in SD rats, 12.9% in Wistar rats) and breast adenoma (16.9% in SD rats, 9.5% in Wistar rats) in females; testis Leydig cell tumor (0 in SD rats, 14.3% in Wistar rats) in males. The main malignant tumors were breast carcinoma (10.1% in SD rats, 3.4% in Wistar rats) and uterine leiomyosarcoma (0 in SD rats, 2.6% in Wistar rats) in females; squamous cell carcinoma of skin (2.3% in SD rats, 0.9% in Wistar rats); subcutaneous fibrosarcoma (1.1% in SD rats, 2.1% in Wistar rats); brain malignant glioma (1.1% in SD rats, 1.7% in Wistar rats). In the study, a high incidence of spontaneous tumors is reported in both SD and Wistar rats housed for 2 years. The incidence of benign tumors is higher than that of malignant rumors. The benign tumors mainly are pituitary adenoma, breast fibroadenoma and breast adenoma in females, and testis Leydig cell tumor in males. The malignant tumors mainly are breast carcinoma and some soft tissue sarcomas. The results of the study enrich the data of spontaneous tumor in SD and Wisar rats and provide background data for carcinogenicity studies for new drugs.
[Mh] Termos MeSH primário: Neoplasias/patologia
Ratos Sprague-Dawley
Ratos Wistar
[Mh] Termos MeSH secundário: Adenoma/patologia
Animais
Neoplasias Encefálicas/patologia
Carcinoma de Células Escamosas/patologia
Feminino
Fibroadenoma/patologia
Glioma/patologia
Leiomiossarcoma/patologia
Tumor de Células de Leydig/patologia
Masculino
Neoplasias Mamárias Animais/patologia
Neoplasias Hipofisárias/patologia
Ratos
Neoplasias Cutâneas/patologia
Especificidade da Espécie
Neoplasias Testiculares/patologia
Neoplasias Uterinas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.04.007


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[PMID]:28301375
[Au] Autor:Gkali C; Giannos A; Primetis E; Chalazonitis A; Anastasiadi T; Feida E; Sotiropoulou M; Dimitrakakis C; Antoniou A
[Ad] Endereço:*Department of Radiology, and †Breast Unit, 1st Department of Obstetrics and Gynecology, Athens University Medical School, Alexandra Hospital; ‡Department of Radiology, Aretaieion Hospital, University of Athens Medical School; and §Pathology Department, Alexandra Hospital, Athens, Greece.
[Ti] Título:Giant Juvenile Fibroadenoma in a 12-Year-Old Girl: Ultrasonography, Elastography, Clinical, and Pathology Findings of This Rare Type of Fibroadenoma.
[So] Source:Ultrasound Q;33(1):51-54, 2017 Mar.
[Is] ISSN:1536-0253
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 12-year-old girl was referred to our radiology department with a rapidly enlarging mass in the right breast. Fine-needle aspiration cytology was suggestive of fibroadenoma. Total excision of the mass was done, and diagnosis was confirmed by histopathology.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem
Fibroadenoma/diagnóstico por imagem
Ultrassonografia
[Mh] Termos MeSH secundário: Mama/diagnóstico por imagem
Mama/patologia
Mama/cirurgia
Neoplasias da Mama/patologia
Neoplasias da Mama/cirurgia
Criança
Feminino
Fibroadenoma/patologia
Fibroadenoma/cirurgia
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1097/RUQ.0000000000000283


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[PMID]:28299887
[Au] Autor:Ross DS; Giri DD; Akram MM; Catalano JP; Olcese C; Van Zee KJ; Brogi E
[Ad] Endereço:Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
[Ti] Título:Fibroepithelial Lesions in the Breast of Adolescent Females: A Clinicopathological Study of 54 Cases.
[So] Source:Breast J;23(2):182-192, 2017 Mar.
[Is] ISSN:1524-4741
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fibroepithelial lesions (FELs) are the most frequent breast tumors in adolescent females. The pubertal hormonal surge could impact the growth and microscopic appearance of FELs in this age group. In this study, we evaluate the morphology and clinical behavior of FELs in adolescents. We searched the 1992-2012 pathology data base for FELs in females 18 years old or younger (F ≤18 years). Seven FELs from 1975 to 1983 were also included. Three pathologists reviewed all available material. Patient (pt) characteristics and follow-up information were obtained from electronic medical records. Forty-eight F ≤18 years had 54 FELs with available slides. Thirty (67%) pts were Caucasian, 12 (27%) African-American, two (4%) Hispanic, one (2%) Asian; three were of unknown race/ethnicity. Median age at diagnosis was 16 years. Median age at menarche was 12 years; most (96%) FELs occurred after menarche (median interval 48 months). All patients underwent lumpectomy; one required subsequent mastectomy. The FELs were 34 fibroadenomas (FAs) (11 usual, 23 juvenile), and 20 phyllodes tumors (PTs) (16 benign, one borderline and three malignant). Eight (35%) juvenile FAs showed slight intratumoral heterogeneity. The mean mitotic rate was 1.3 mitoses/10 high-power fields (HPFs) (range, 0-6) in usual FAs, 1.8/10 HPFs in juvenile FAs, 3.1/10 HPFs in benign PTs, 10/10 HPFs in the borderline PT and 17/10 HPFs in malignant PTs. The mean follow-up for 29 pts with 33 FELs was 44 months. Two (10%) PTs recurred locally (a benign PT at 18 months, and a borderline PT at 11 months). Both recurrent PTs had microscopic margins <1 mm. Mitotic activity in FAs from adolescents can be substantial and this finding should be interpreted cautiously. Awareness of the morphologic features of FELs in adolescents is important to avoid overdiagnosis of PTs, which can lead to additional unnecessary and potentially disfiguring surgery.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
[Mh] Termos MeSH secundário: Adolescente
Neoplasias da Mama/cirurgia
Feminino
Fibroadenoma/patologia
Fibroadenoma/cirurgia
Seguimentos
Seres Humanos
Margens de Excisão
Menarca
Recidiva Local de Neoplasia/patologia
Tumor Filoide/patologia
Tumor Filoide/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1111/tbj.12706


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[PMID]:28295007
[Au] Autor:Konstantinova AM; Belousova IE; Kacerovska D; Michal M; Shelekhova KV; Kazakov DV
[Ad] Endereço:Pathology Department, Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care, Saint Petersburg, Russia; Pathology Department, Medical Faculty, Saint Petersburg State University, Saint Petersburg, Russia; Department of Pathology, Saint Petersburg Sociomedical In
[Ti] Título:[Anogenital mammary-like glands and related lesions. Part 1. Benign tumors and tumor-like disorders].
[Ti] Título:Anogenital'nye mammaropodobnye zhelezy i svyazannye s nimi zabolevaniya. Chast' 1. Dobrokachestvennye opukholi i opukholepodobnye protsessy anogenital'nykh zhelez..
[So] Source:Arkh Patol;79(1):43-51, 2017.
[Is] ISSN:0004-1955
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Anogenital mammary-like glands represent a normal anatomic constituent of the anogenital area and may give rise to many benign and malignant tumors that morphologically mimic similar breast diseases. The literature review is complemented by a description of 286 cases of benign tumors and tumor-like processes in the mammary-like glands. The paper presents the clinical and morphological characteristics of papillary hidradenoma, fibroadenoma, benign phyllodes tumor, lactating adenoma, sclerosing adenosis, pseudoangiomatous stromal hyperplasia, etc.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Neoplasias da Mama/patologia
Mama/patologia
Neoplasias/patologia
[Mh] Termos MeSH secundário: Acrospiroma/diagnóstico
Adenoma/diagnóstico
Adenoma/patologia
Neoplasias da Mama/classificação
Neoplasias da Mama/diagnóstico
Feminino
Fibroadenoma/diagnóstico
Fibroadenoma/patologia
Seres Humanos
Lactação/fisiologia
Neoplasias/classificação
Neoplasias/diagnóstico
Tumor Filoide/diagnóstico
Tumor Filoide/patologia
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.17116/patol201779143-51


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[PMID]:28267555
[Au] Autor:Mus RD; Borelli C; Bult P; Weiland E; Karssemeijer N; Barentsz JO; Gubern-Mérida A; Platel B; Mann RM
[Ad] Endereço:Department of Radiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA Nijmegen, The Netherlands. Electronic address: aroel.mus@radboudumc.nl.
[Ti] Título:Time to enhancement derived from ultrafast breast MRI as a novel parameter to discriminate benign from malignant breast lesions.
[So] Source:Eur J Radiol;89:90-96, 2017 Apr.
[Is] ISSN:1872-7727
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To investigate time to enhancement (TTE) as novel dynamic parameter for lesion classification in breast magnetic resonance imaging (MRI). METHODS: In this retrospective study, 157 women with 195 enhancing abnormalities (99 malignant and 96 benign) were included. All patients underwent a bi-temporal MRI protocol that included ultrafast time-resolved angiography with stochastic trajectory (TWIST) acquisitions (1.0×0.9×2.5mm, temporal resolution 4.32s), during the inflow of contrast agent. TTE derived from TWIST series and relative enhancement versus time curve type derived from volumetric interpolated breath-hold examination (VIBE) series were assessed and combined with basic morphological information to differentiate benign from malignant lesions. Receiver operating characteristic analysis and kappa statistics were applied. RESULTS: TTE had a significantly better discriminative ability than curve type (p<0.001 and p=0.026 for reader 1 and 2, respectively). Including morphology, sensitivity of TWIST and VIBE assessment was equivalent (p=0.549 and p=0.344, respectively). Specificity and diagnostic accuracy were significantly higher for TWIST than for VIBE assessment (p<0.001). Inter-reader agreement in differentiating malignant from benign lesions was almost perfect for TWIST evaluation (κ=0.86) and substantial for conventional assessment (κ=0.75). CONCLUSIONS: TTE derived from ultrafast TWIST acquisitions is a valuable parameter that allows robust differentiation between malignant and benign breast lesions with high accuracy.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Carcinoma Ductal de Mama/patologia
Meios de Contraste
Fibroadenoma/patologia
[Mh] Termos MeSH secundário: Mama/patologia
Suspensão da Respiração
Diagnóstico Diferencial
Detecção Precoce de Câncer
Feminino
Seres Humanos
Angiografia por Ressonância Magnética/métodos
Imagem por Ressonância Magnética/métodos
Meia-Idade
Variações Dependentes do Observador
Curva ROC
Estudos Retrospectivos
Sensibilidade e Especificidade
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28267544
[Au] Autor:Marcon M; Frauenfelder T; Becker AS; Dedes KJ; Boss A
[Ad] Endereço:Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: magda.marcon@usz.ch.
[Ti] Título:First ultrasound diagnosis of BI-RADS 3 lesions in young patients: Can 6-months follow-up be sufficient to assess stability?
[So] Source:Eur J Radiol;89:226-233, 2017 Apr.
[Is] ISSN:1872-7727
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the outcome of repeated short-term follow-up with ultrasound in no high-risk young patients with a BI-RADS3 lesion at first examination. METHODS: In this IRB-approved study 492 women, aged 18-34 years (mean±standard deviation, 28±4.5years) with first breast ultrasound examination in 2012-2014 were retrospectively evaluated. Inclusion criteria were: at least one BI-RADS3 lesion and (a) biopsy/surgical excision or (b) follow-up of at least 18 months (including a 6-month follow-up). BI-RADS category assigned during follow-up and pathologic findings in cases undergoing biopsy/surgical excision were collected. At the 6- and 18-month follow-up the recommended biopsy rates (RBR) and the corresponding positive predictive value (PPV) were calculated. RESULTS: In 97 patients, 151 BI-RADS3 lesions were identified. Biopsy/surgical excision was initially performed in 25/151 (16.5%) lesions. After 6-month, category was downgraded to BI-RADS1/2 in 23/126 (15.3%) and upgraded to BI-RADS4 in 9/126 lesions (7.1%). Pathological diagnosis of these lesions was fibroadenoma in 5 and benign phyllodes tumor in 4 cases (RBR 7%, PPV 44.4%). After 18-month one lesion was classified BI-RADS4 and pathological diagnosis was fibroadenoma (RBR 1.1%, PPV 0%). CONCLUSIONS: Our preliminary data show that follow-up imaging performed after 18 months from a first BI-RADS3 diagnosis does not affect clinical treatment and 6-month follow-up may be sufficient to assess the stability of probably benign lesions.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem
Fibroadenoma/diagnóstico por imagem
Tumor Filoide/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biópsia
Neoplasias da Mama/patologia
Feminino
Seguimentos
Seres Humanos
Tumor Filoide/patologia
Exame Físico
Estudos Retrospectivos
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28250098
[Au] Autor:Wijesinghe P; Sampson DD; Kennedy BF
[Ad] Endereço:Optical+Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, 35 Stirling Highway, Perth, Western Australia 6009, Australia philip.wijesinghe@gmail.com.
[Ti] Título:Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor.
[So] Source:J R Soc Interface;14(128), 2017 Mar.
[Is] ISSN:1742-5662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:High-resolution tactile imaging, superior to the sense of touch, has potential for future biomedical applications such as robotic surgery. In this paper, we propose a tactile imaging method, termed computational optical palpation, based on measuring the change in thickness of a thin, compliant layer with optical coherence tomography and calculating tactile stress using finite-element analysis. We demonstrate our method on test targets and on freshly excised human breast fibroadenoma, demonstrating a resolution of up to 15-25 µm and a field of view of up to 7 mm. Our method is open source and readily adaptable to other imaging modalities, such as ultrasonography and confocal microscopy.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem
Fibroadenoma/diagnóstico por imagem
Modelos Teóricos
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Feminino
Análise de Elementos Finitos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE



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