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[PMID]:28440018
[Au] Autor:Santiago T; Clay MR; Azzato E; Newman S; Fernandez-Pineda I; Nichols KE; Zhang J; Downing JR; Davidoff A; Brennan RC; Ellison DW
[Ad] Endereço:Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.
[Ti] Título:Clear cell sarcoma of kidney involving a horseshoe kidney and harboring EGFR internal tandem duplication.
[So] Source:Pediatr Blood Cancer;64(11), 2017 Nov.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Clear cell sarcoma of kidney (CCSK) is a rare renal malignancy, previously unreported in horseshoe kidney (HSK). B-cell lymphoma 6 corepressor (BCOR) gene internal tandem duplication (ITD) was identified as a recurrent somatic alteration in approximately 85% of CCSKs. This and the YWHAE-NUTM2B/E fusion, the second most common recurrent molecular alteration in CCSK (10%), are considered to be mutually exclusive. However, there is a subset of CCSKs that do not harbor either the BCOR-ITD or YWHAE-NUTM2 translocation and lack known molecular alterations. Herein, we report the first case of CCSK arising in HSK and harboring epidermal growth factor receptor ITD.
[Mh] Termos MeSH primário: Rim Fundido/patologia
Neoplasias Renais/patologia
Receptor do Fator de Crescimento Epidérmico/genética
Sarcoma de Células Claras/patologia
[Mh] Termos MeSH secundário: Rim Fundido/genética
Rim Fundido/radioterapia
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Lactente
Neoplasias Renais/genética
Neoplasias Renais/radioterapia
Masculino
Prognóstico
Sarcoma de Células Claras/genética
Sarcoma de Células Claras/radioterapia
Sequências de Repetição em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26602


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[PMID]:28241093
[Au] Autor:Miwa S; Nishida H; Tanzawa Y; Takeuchi A; Hayashi K; Yamamoto N; Mizukoshi E; Nakamoto Y; Kaneko S; Tsuchiya H
[Ad] Endereço:Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
[Ti] Título:Phase 1/2 study of immunotherapy with dendritic cells pulsed with autologous tumor lysate in patients with refractory bone and soft tissue sarcoma.
[So] Source:Cancer;123(9):1576-1584, 2017 May 01.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There are limited options for the curative treatment of refractory bone and soft tissue sarcomas. The purpose of this phase 1/2 study was to assess the immunological and clinical effects of dendritic cells (DCs) pulsed with autologous tumor lysate (TL) in patients with advanced bone and soft tissue sarcomas. METHODS: Thirty-seven patients with metastatic or recurrent sarcomas were enrolled in this study. Peripheral blood mononuclear cells obtained from the patients were suspended in media containing interleukin 4 (IL-4) and granulocyte-macrophage colony-stimulating factor. Subsequently, these cells were treated with TL, tumor necrosis factor α, and OK-432. The DCs were injected into the inguinal or axillary region. One treatment course comprised 6 weekly DC injections. The toxicity, clinical response (tumor volume, serum interferon-γ [IFN-γ], and serum IL-12), and oncological outcomes were observed. RESULTS: In total, 47 courses of DC therapy were performed in 37 patients. No severe adverse events or deaths associated with the DC injections were observed in the study patients. Increased serum IFN-γ and IL-12 levels were observed 1 month after the DC injection. Among the 37 patients, 35 patients were assessed for clinical responses: 28 patients showed tumor progression, 6 patients had stable disease, and 1 patient showed a partial response 8 weeks after the DC injection. The 3-year overall and progression-free survival rates of the patients were 42.3% and 2.9%, respectively. CONCLUSIONS: Although DC therapy appears safe and resulted in an immunological response in patients with refractory sarcoma, it resulted in an improvement of the clinical outcome in only a small number of patients. Cancer 2017;123:1576-1584. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Neoplasias Ósseas/terapia
Células Dendríticas
Imunoterapia/métodos
Leucócitos Mononucleares
Sarcoma/terapia
Neoplasias de Tecidos Moles/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Antineoplásicos
Neoplasias Ósseas/sangue
Criança
Condrossarcoma/sangue
Condrossarcoma/terapia
Intervalo Livre de Doença
Feminino
Fator Estimulador de Colônias de Granulócitos e Macrófagos
Histiocitoma Fibroso Maligno/sangue
Histiocitoma Fibroso Maligno/terapia
Seres Humanos
Interferon gama/sangue
Interleucina-12/sangue
Interleucina-4
Leiomiossarcoma/sangue
Leiomiossarcoma/terapia
Masculino
Meia-Idade
Osteossarcoma/sangue
Osteossarcoma/terapia
Picibanil
Sarcoma/sangue
Sarcoma de Células Claras/sangue
Sarcoma de Células Claras/terapia
Sarcoma Sinovial/sangue
Sarcoma Sinovial/terapia
Neoplasias de Tecidos Moles/sangue
Resultado do Tratamento
Fator de Necrose Tumoral alfa
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Tumor Necrosis Factor-alpha); 187348-17-0 (Interleukin-12); 207137-56-2 (Interleukin-4); 39325-01-4 (Picibanil); 82115-62-6 (Interferon-gamma); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE
[do] DOI:10.1002/cncr.30606


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[PMID]:28195107
[Au] Autor:Deshpande RB
[Ad] Endereço:Department of Lab Medicine, P. D. Hinduja Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
[Ti] Título:Concurrent occurrence of neuroblastoma and clear cell sarcoma of kidney in an infant: Is it a random event?
[So] Source:Indian J Pathol Microbiol;60(1):115-116, 2017 Jan-Mar.
[Is] ISSN:0974-5130
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Neuroblastoma
Sarcoma de Células Claras
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
Rim
Neoplasias Renais
Sarcoma
Tumor de Wilms
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.4103/IJPM.IJPM_663_16


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[PMID]:28195106
[Au] Autor:Doshi PR; Karandikar MN; Swami RC; Singh HA; Nimbargi RC
[Ad] Endereço:Department of Pathology, Bharati Vidyapeeth University Medical College, Pune, Maharashtra, India.
[Ti] Título:Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature.
[So] Source:Indian J Pathol Microbiol;60(1):111-114, 2017 Jan-Mar.
[Is] ISSN:0974-5130
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Occurrence of two distinct synchronous primary tumors is a rare event in children as well as in adults. Here, we report an extremely rare case of an infant found to have two synchronous Tumours namely clear cell sarcoma of kidney(CCSK) and differentiating neuroblastoma of preaortic region. To our knowledge, this may be the first case of synchronous CCSK and differentiating neuroblastoma being reported.
[Mh] Termos MeSH primário: Neoplasias Renais/diagnóstico
Neoplasias Renais/patologia
Rim/patologia
Neuroblastoma/complicações
Neuroblastoma/diagnóstico
Sarcoma de Células Claras/complicações
Sarcoma de Células Claras/diagnóstico
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Histocitoquímica
Seres Humanos
Imuno-Histoquímica
Lactente
Masculino
Microscopia
Neuroblastoma/patologia
Sarcoma de Células Claras/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.4103/0377-4929.200047


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[PMID]:28195103
[Au] Autor:Kodiatte TA; George SV; Chacko RT; Ramakrishna B
[Ad] Endereço:Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
[Ti] Título:Malignant melanocytic neoplasm of pancreas with liver metastasis: Is it malignant melanoma or clear cell sarcoma?
[So] Source:Indian J Pathol Microbiol;60(1):102-104, 2017 Jan-Mar.
[Is] ISSN:0974-5130
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Malignant melanocytic neoplasm, usually seen in soft tissues, is rare in a visceral location and presents as a diagnostic dilemma. We present a case of pancreatic malignant melanocytic neoplasm with liver metastasis. A 58-year-old man presented with left upper abdominal swelling and loss of appetite. Imaging revealed a large mass arising from the pancreatic tail, and this was diagnosed as malignant neoplasm with melanocytic differentiation on biopsy with the possible differentials of malignant melanoma, clear cell sarcoma (CCS), and perivascular epithelioid cell neoplasm. The patient underwent distal pancreatectomy and splenectomy for the same. Follow-up imaging 6 months later showed a metastatic liver lesion, for which he also underwent a liver resection. BRAF mutational analysis was found to be negative. Both CCS and malignant melanoma have similar morphological features and melanocytic differentiation, but each harbors a distinct genetic background. Differentiation of both has diagnostic and therapeutic implications.
[Mh] Termos MeSH primário: Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/secundário
Melanoma/diagnóstico
Melanoma/patologia
Neoplasias Pancreáticas/complicações
Neoplasias Pancreáticas/diagnóstico
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biópsia
Histocitoquímica
Seres Humanos
Imuno-Histoquímica
Neoplasias Hepáticas/cirurgia
Antígeno MART-1/análise
Masculino
Antígenos Específicos de Melanoma/análise
Microscopia
Meia-Idade
Metástase Neoplásica/patologia
Pancreatectomia
Neoplasias Pancreáticas/patologia
Neoplasias Pancreáticas/cirurgia
Radiografia Abdominal
Proteínas S100/análise
Sarcoma de Células Claras/diagnóstico
Sarcoma de Células Claras/patologia
Esplenectomia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (HMB-45 protein, human); 0 (MART-1 Antigen); 0 (Melanoma-Specific Antigens); 0 (S100 Proteins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.4103/0377-4929.200054


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[PMID]:28086809
[Au] Autor:Jin L; Sui Y; Zhu H; Chen Z; Liu S
[Ad] Endereço:Department of Pathology, Provincial Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, 350001, Fujian Province, People's Republic of China.
[Ti] Título:Primary mediastinal clear cell sarcoma: a case report and review of the literature.
[So] Source:Diagn Pathol;12(1):5, 2017 Jan 13.
[Is] ISSN:1746-1596
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and rarely presents in the mediastinum. CASE PRESENTATION: We present a case of primary mediastinal CCS in a 57-year-old man. Computer tomography (CT) revealed a 12 × 12 × 7.5 cm mass in the anterior mediastinum. Microscopically, the tumour mainly consisted of epithelioid cells with oval vesicular nuclei and eosinophilic cytoplasm. Immunohistochemically, the tumour was positive for human melanoma black 45 (HMB-45) and vimentin but negative for S-100 and Melan-A. Fluorescence in situ hybridisation (FISH) showed a translocation involving the EWSR1 gene region. CONCLUSION: This report will illustrate that the mediastinum is a potential site for primary CCS and FISH plays an important role in making a conclusive diagnosis.
[Mh] Termos MeSH primário: Neoplasias do Mediastino/patologia
Sarcoma de Células Claras/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE
[do] DOI:10.1186/s13000-016-0594-z


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[PMID]:27719746
[Au] Autor:Guraya SS; Prayson RA
[Ti] Título:Brain metastasis from gastrointestinal clear cell sarcoma.
[So] Source:Clin Neuropathol;36 (2017)(1):41-45, 2017 Jan/Feb.
[Is] ISSN:0722-5091
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Clear cell sarcoma (CCS) of the gastrointestinal tract presents a diagnostic challenge to the pathologist due to its morphological and immunohistochemical similarity to melanoma. It usually metastasizes to regional lymph nodes, liver, and lungs. Herein, we report the first known metastasis of a gastrointestinal CCS to the central nervous system. Cytogenetic testing showed the t(12,22) translocation corresponding to the presence of the EWS/ATF1 hybrid consistent with CCS. The literature that compares melanoma to CCS is reviewed in the context of this rare presentation to differentiate between the two diseases.
.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/secundário
Neoplasias do Colo/patologia
Sarcoma de Células Claras/secundário
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Evolução Fatal
Seres Humanos
Imuno-Histoquímica
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27814905
[Au] Autor:Hassani J; Porubsky C; Berman C; Zager J; Messina J; Henderson-Jackson E
[Ad] Endereço:Department of Cutaneous Oncology, Sarcoma, H. Lee Moffitt Cancer Center, Tampa, FL, United States.
[Ti] Título:Intraperitoneal Rosai-Dorfman disease associated with clear cell sarcoma: first case report.
[So] Source:Pathology;48(7):742-744, 2016 Dec.
[Is] ISSN:1465-3931
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Histiocitose Sinusal/complicações
Histiocitose Sinusal/diagnóstico
Sarcoma de Células Claras/complicações
Sarcoma de Células Claras/diagnóstico
Neoplasias de Tecidos Moles/complicações
Neoplasias de Tecidos Moles/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Peritônio/patologia
Punho/patologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


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[PMID]:27452744
[Au] Autor:Zhang X; Hu C; Cai L
[Ad] Endereço:Department of VIP Ward, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79th, Qingchun Road, Hangzhou 310003, Zhejiang, China. Electronic address: zhangxian821030@163.com.
[Ti] Título:A giant clear cell sarcoma on right scapular: A case report.
[So] Source:Acta Orthop Traumatol Turc;50(4):473-6, 2016 Aug.
[Is] ISSN:1017-995X
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Clear-cell sarcoma is a rare and malignant soft tissue tumor most commonly located at the distal end of extremities and rarely at the trunk. Data on the clinical features of the tumor is limited, complicating the analysis of prognosis and establishment of treatment protocols. In our study, we present a case diagnosed with clear-cell sarcoma in his right scapula and treated with tumor resection and chemotherapy, combination of dacarbazine, pharmorubicin and cisplatin. The patient died due to multiple organ failure eight months after operation. Early diagnosis, attentive care, and extended surgical resection combined with adjuvant therapy is of essence in treatment of clear-cell sarcoma.
[Mh] Termos MeSH primário: Sarcoma de Células Claras/diagnóstico por imagem
Sarcoma de Células Claras/patologia
Neoplasias de Tecidos Moles/diagnóstico por imagem
Neoplasias de Tecidos Moles/patologia
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica
Cisplatino/uso terapêutico
Dacarbazina/uso terapêutico
Epirubicina/uso terapêutico
Evolução Fatal
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Sarcoma de Células Claras/tratamento farmacológico
Sarcoma de Células Claras/cirurgia
Neoplasias de Tecidos Moles/tratamento farmacológico
Neoplasias de Tecidos Moles/cirurgia
Tomografia Computadorizada de Emissão
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
3Z8479ZZ5X (Epirubicin); 7GR28W0FJI (Dacarbazine); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


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[PMID]:27264732
[Au] Autor:Feasel PC; Cheah AL; Fritchie K; Winn B; Piliang M; Billings SD
[Ad] Endereço:Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.
[Ti] Título:Primary clear cell sarcoma of the head and neck: a case series with review of the literature.
[So] Source:J Cutan Pathol;43(10):838-46, 2016 Oct.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clear cell sarcoma typically arises in deep soft tissues of the foot/ankle. Primary head and neck clear cell sarcoma is rare. We report three molecularly confirmed primary head and neck clear cell sarcoma and review the literature. METHODS: Head and neck clear cell sarcoma with no primary elsewhere were retrieved from archival/consultation files. English language literature review of all reported head and neck clear cell sarcoma was performed. RESULTS: Three cases were identified. The tumors, all in men, presented on the scalp of a 33-year-old, face of a 20-year-old and tongue of a 44-year-old. Tumors ranged from 0.6 to 1.4 cm. All had typical features of clear cell sarcoma, including nests of tumor cells divided by fibrous septae. One had multinucleated wreath-like giant cells. One had a focal junctional component. Immunohistochemistry was positive for S100 (three out of three), HMB45 (three out of three) and Melan-A (two out of three). All had EWSR1 rearrangements by fluorescence in situ hybridization. Follow up available for one patient revealed no evidence of disease after wide excision and radiation. Seven additional reported cases were identified and tabulated. CONCLUSION: Head and neck clear cell sarcoma is rare but should be considered in the differential diagnosis of nested tumors with fibrous septae. Molecular analysis should be considered for definitive diagnosis regardless of location.
[Mh] Termos MeSH primário: Neoplasias Faciais/patologia
Sarcoma de Células Claras/patologia
Neoplasias Cutâneas/patologia
Neoplasias da Língua/patologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160607
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12755



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