Base de dados : MEDLINE
Pesquisa : C04.557.450.565.835 [Categoria DeCS]
Referências encontradas : 2693 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 270 ir para página                         

  1 / 2693 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29201311
[Au] Autor:Savvidou OD; Chloros GD; Koutsouradis P; Megaloikonomos PD; Skarpidi E; Papagelopoulos PJ
[Ad] Endereço:The First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Medical School, ATTIKON University Hospital, Athens, Greece.
[Ti] Título:Synovial Sarcoma Complicating Total Knee Arthroplasty.
[So] Source:Clin Orthop Surg;9(4):547-552, 2017 Dec.
[Is] ISSN:2005-4408
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Synovial sarcoma is a relatively common periarticular soft tissue malignancy, occurring mostly in the extremities of younger patients. Occasionally, diversity in its clinical features may lead to misdiagnosis and inappropriate management. The authors report herein a unique case of a patient who underwent a primary total knee arthroplasty to treat osteoarthritis. During the operation, a mass was discovered but was attributed to synovitis. Biopsy revealed a rare intra-articular synovial sarcoma. The patient underwent reoperation with wide excision and endoprosthesis placement and is disease-free at the 8-year follow-up.
[Mh] Termos MeSH primário: Artroplastia do Joelho
Sarcoma Sinovial/cirurgia
Neoplasias de Tecidos Moles/cirurgia
[Mh] Termos MeSH secundário: Idoso
Artroplastia do Joelho/instrumentação
Feminino
Seres Humanos
Achados Incidentais
Osteoartrite/complicações
Osteoartrite/cirurgia
Reoperação
Sarcoma Sinovial/complicações
Sarcoma Sinovial/patologia
Neoplasias de Tecidos Moles/complicações
Neoplasias de Tecidos Moles/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.4055/cios.2017.9.4.547


  2 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29191657
[Au] Autor:Shiozawa K; Shuting J; Yoshioka Y; Ochiya T; Kondo T
[Ad] Endereço:Division of Rare Cancer Research, National Cancer Center Research Institute, Tokyo, Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. Electronic address: kshiozaw@ncc.go.jp.
[Ti] Título:Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma.
[So] Source:Biochem Biophys Res Commun;495(1):1322-1327, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The development of drug resistance in tumor cells leads to relapse and distant metastasis. Secreted microRNAs (miRNAs) enclosed in extracellular vesicles (EVs) can act as intercellular messengers. The objective of our study was to elucidate the role of secreted miRNAs to better understand the regulatory network underlying pazopanib-resistance in synovial sarcoma cells. We performed a comprehensive analysis of secreted miRNA abundance in pazopanib treated/untreated synovial sarcoma cells from four different cell lines (SYO-1, HS-SYII, 1273/99, and YaFuSS) using microarray technology, and discovered miR-761 in EVs as a potential biomarker of pazopanib-resistance in synovial sarcoma. Furthermore, we showed that miR-761 putatively targeted three proteins, thyroid hormone receptor interactor 6 (TRIP6), lamin A/C (LMNA), and NAD-dependent protein deacetylase sirtuin-3 (SIRT3). Knockdown of any of these proteins was shown in previous studies to confer increased resistance to chemotherapeutic agents. Our findings provide new insight into the potential role of miR-761, an EV-secreted miRNA from synovial sarcoma cells, making it a potential candidate for use in sarcoma therapy in the future.
[Mh] Termos MeSH primário: Resistência a Medicamentos Antineoplásicos
Vesículas Extracelulares/metabolismo
MicroRNAs/metabolismo
Pirimidinas/administração & dosagem
Sarcoma Sinovial/tratamento farmacológico
Sarcoma Sinovial/metabolismo
Sulfonamidas/administração & dosagem
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Antineoplásicos/administração & dosagem
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Seres Humanos
Proteínas com Domínio LIM/metabolismo
Lamina Tipo A/metabolismo
Sarcoma Sinovial/patologia
Sirtuína 3/metabolismo
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Antineoplastic Agents); 0 (LIM Domain Proteins); 0 (LMNA protein, human); 0 (Lamin Type A); 0 (MicroRNAs); 0 (Pyrimidines); 0 (Sulfonamides); 0 (TRIP6 protein, human); 0 (Transcription Factors); 0 (microRNA761 microRNA, human); 7RN5DR86CK (pazopanib); EC 3.5.1.- (SIRT3 protein, human); EC 3.5.1.- (Sirtuin 3)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  3 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29245254
[Au] Autor:So IT; Cho KB; Lee JY; Kim SJ; Jung HI; Choi JH; Lee YJ; Lee HJ; Park KS; Ryu SW; Kang YN
[Ad] Endereço:aDepartment of Internal MedicinebDepartment of SurgerycDepartment of Pathology, Keimyung University School of Medicine, Daegu, Korea.
[Ti] Título:A primary gastric synovial sarcoma: A case report and literature review.
[So] Source:Medicine (Baltimore);96(49):e8904, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: When a gastric spindle cell tumor is observed, the possibility of synovial carcinoma, besides common mesenchymal tumor, should also be considered. PRESENTING CONCERNS OF THE PATIENT: The patient is a 51-year-old American woman who underwent medical check-up at a general hospital. Upper endoscopy showed a 2-cm sized mass covered with intact mucosa, and a central depression located on the posterior wall of the mid body. Biopsy of the mass showed focal atypical cells proliferation in mucosa on hematoxylin & eosin (H&E) staining. Endoscopic ultrasound showed a 17-mm homogenously hypoechoic mass within the submucosal layer. INTERVENTIONS: After diagnostic endoscopic submucosal dissection was performed, H&E and immunohistochemical staining showed synovial sarcoma (SS). To confirm the diagnosis, reverse transcriptase-polymerase chain reaction was performed, revealing a chimeric transcript of the SYT-SSX1 fusion gene. The diagnosis of primary gastric SS was confirmed because no evidence of possible primary lesions or metastatic lesions was observed. Therefore, the patient underwent distal gastrectomy. OUTCOMES: After surgery, the surgical specimen demonstrated no residual tumor cells. The patient received no adjuvant therapy, and there has been no evidence of local recurrence or distant metastasis for 2 months after the operation. LESSONS: When gastric subepithelial tumor is suspicious, we should also consider gastric SS.
[Mh] Termos MeSH primário: Sarcoma Sinovial/diagnóstico
Sarcoma Sinovial/cirurgia
Neoplasias Gástricas/diagnóstico
Neoplasias Gástricas/cirurgia
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Endossonografia
Feminino
Gastrectomia
Gastroscopia
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Reação em Cadeia da Polimerase
Sarcoma Sinovial/patologia
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008904


  4 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29255556
[Au] Autor:Margad O; Boukhris J; Azriouil O; Daoudi M; Mortaji A; Koulali K
[Ad] Endereço:Service de Traumatologie Orthopédie de l'Hôpital Militaire Avicenne, Marrakech, Maroc.
[Ti] Título:[Villonodular synovitis of the knee: about 20 cases].
[Ti] Título:Les synovites villonodulaires du genou: à propos de 20 cas..
[So] Source:Pan Afr Med J;28:86, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Pigmented villonodular synovitis (PVNS) is a rare benign proliferation of synovial joints, serous bursa, tendinous sheaths of unknown etiopathogeny. We here report 20 cases of PVNS of the knee recorded at the Avicenne Military Hospital, Marrakech over a period of 9 years, from January 2000 to December 2009. This study aimed to identify the specific features of this lesion and to examine its anatomoclinic and prognostic aspects. Annual incidence was 2.2 cases per year: 15 men and 5 women. The average age was 32.5 years. It occurred in the right-hand in 55%, 18 patients had monoarticular presentation of the disease while 1 patient had biarticular presentation of the disease. 80% of cases had pain and swelling, palpable mass was detected in 1 case, meniscal syndrome in 1 case, monoseptic arthritis in 3 cases while popliteal cyst in 2 cases. 14 cases (70%) had diffuse involvement, 6 cases had localized involvement. MRI was evocative in 3 patients out of 5; 2 patients underwent diagnostic arthroscopy. Diagnosis was based on anatomo-pathological examination. Treatment was based on subtotal synovectomy in 15 cases and on tumor excision in patients with localized involvement. 2 cases with osteocartilaginous destruction underwent arthroplasty. Patients' evolution was marked by 2 diffuse recurrences after a mean follow-up of 3-7 years. 3 patients had stiffness associated with quadriceps atrophy, therefore arthrolysis was performed. One case of histologically confirmed PVNS had proved to be a monophasic synovial sarcoma invading the bone 5 months after total synovectomy. Hence, the indication for amputation.
[Mh] Termos MeSH primário: Articulação do Joelho/patologia
Sinovectomia/métodos
Sinovite Pigmentada Vilonodular/patologia
[Mh] Termos MeSH secundário: Adulto
Artroscopia/métodos
Feminino
Seguimentos
Seres Humanos
Articulação do Joelho/cirurgia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Dor/etiologia
Prognóstico
Estudos Retrospectivos
Sarcoma Sinovial/diagnóstico
Sarcoma Sinovial/cirurgia
Sinovite Pigmentada Vilonodular/diagnóstico
Sinovite Pigmentada Vilonodular/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.86.9507


  5 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29206019
[Au] Autor:Matkovic E; Schwalbe M; Matkowskyj KA
[Ti] Título:Pathologic Features of Miscellaneous Foregut Malignancies.
[So] Source:Cancer Treat Res;168:45-58, 2016.
[Is] ISSN:0927-3042
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In addition to tumors arising from the primary mucosal epithelium, the foregut is host to a variety of non-epithelial precursor cells which may give rise to neoplasms of neuroendocrine, mesenchymal, and hematolymphoid lineages. Many of these lesions also occur outside of the gastrointestinal tract, such as the extranodal lymphomas and many of the sarcomas, and in many cases share the features of their non-alimentary counterparts. This heterogeneous collection of malignancies features a wide spectrum of clinical presentations, morphologic and histopathologic features, genetic underpinnings, and treatment considerations. Although encountered less frequently than primary carcinomas, it is important to correctly recognize and classify these lesions to effectively manage and prognosticate the patients in which they occur. In this chapter, we focus on the clinical, morphologic, and genetic features of the primary esophageal and gastric neoplasms of neuroendocrine, mesenchymal, and lymphoid origin.
[Mh] Termos MeSH primário: Neoplasias Esofágicas/patologia
Neoplasias Gástricas/patologia
[Mh] Termos MeSH secundário: Tumores do Estroma Gastrointestinal/patologia
Seres Humanos
Tumores Neuroendócrinos/patologia
Sarcoma Sinovial/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  6 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29173366
[Au] Autor:Agrawal A; Bajaj N; Maroules M
[Ad] Endereço:Internal Medicine, Saint Joseph's Regional Medical Center, Paterson, New Jersey. Electronic address: Astha22agrawal@gmail.com.
[Ti] Título:Synovial Sarcoma With Intracranial Metastasis as the Site of Reoccurrence.
[So] Source:Am J Med Sci;354(5):523-526, 2017 Nov.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Neoplasias Encefálicas
Recidiva Local de Neoplasia
Sarcoma Sinovial
[Mh] Termos MeSH secundário: Adulto
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/secundário
Neoplasias Encefálicas/cirurgia
Seres Humanos
Masculino
Metástase Neoplásica
Recidiva Local de Neoplasia/diagnóstico por imagem
Recidiva Local de Neoplasia/cirurgia
Sarcoma Sinovial/diagnóstico por imagem
Sarcoma Sinovial/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171206
[Lr] Data última revisão:
171206
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  7 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28829837
[Au] Autor:Qi Y; Wang N; He Y; Zhang J; Zou H; Zhang W; Gu W; Huang Y; Lian X; Hu J; Zhao J; Cui X; Pang L; Li F
[Ad] Endereço:Department of Pathology and the Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
[Ti] Título:Transforming growth factor-ß1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells.
[So] Source:PLoS One;12(8):e0182680, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The epithelial-to-mesenchymal transition (EMT) and the reverse process (the mesenchymal-to-epithelial transition [MET]) have been shown to be associated with tumor cell invasion and metastasis in different carcinomas. The EMT and MET have recently been shown to play a key role in the pathogenic processes of sarcomas, which are completely different from those of carcinomas. However, the definitive roles of the EMT in the tumorigenesis of synovial sarcomas remain unknown. Here, we explored whether transforming growth factor (TGF)-ß signaling, an important oncogenic event in synovial sarcoma, modulates tumor cell characteristics related to the EMT, such as cell adhesion, migration, invasion, and proliferation. Interestingly, we found that TGF-ß1 induced tumor cell activation, resulting in a tendency to aggregate and biphasic-like features. TGF-ß1 also caused downregulation of E-cadherin and subsequent upregulation of N-cadherin, Snail, and Slug, which are responsible for EMT-like phenomena and increased cell motility and invasion. To further investigate the roles of TGF-ß1 in the EMT, we established a SW982 cell line with stable TGF-ß1 inhibition viaSB431542.These cells exhibited significantly decreased motility, migration, and proliferation (P = 0.001). Taken together, our data demonstrated that alterations in the TGF-ß1/Smad signaling pathway could regulate the expression of EMT-related factors and the EMT process, resulting in changes in tumor cell invasion, migration, and proliferation in synovial sarcoma cells. These results may provide a important insights into therapeutic interventions and contribute to the present understanding of tumor progression in patients.
[Mh] Termos MeSH primário: Transição Epitelial-Mesenquimal
Sarcoma Sinovial/patologia
Fator de Crescimento Transformador beta1/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Invasividade Neoplásica
Metástase Neoplásica
Sarcoma Sinovial/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Transforming Growth Factor beta1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182680


  8 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28682557
[Au] Autor:Qingying C; Youmei Z; Shuai F; Changbin Z; Ming L
[Ad] Endereço:Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital of Kunming Medical University, Kunming 650000, China.
[Ti] Título:[Primary pharynx synovial sarcoma: a case report].
[So] Source:Hua Xi Kou Qiang Yi Xue Za Zhi;35(2):221-222, 2017 Apr 01.
[Is] ISSN:1000-1182
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A case of primary pharynx synovial sarcoma was reported in this paper. A 15-year-old male patient experienced painless pharyngeal swelling that gradually proliferated for 1 month. Special examination showed an 8 cm × 4 cm × 3 cm tumor located in the left pharynx and the supratonsillar crypt. Imaging tests revealed an irregular mass on the left side of the oropharynx and an unclear boundary. Immunohistochemical examination yielded the following results: epithelial membrane antigen (+), cytokeratin (CK)19 (+), CD7(+), vimentin (+), CK10(-), E-cadherin (+), B-cell lymphoma-2 (-), CD2 (-), CD10 (-), CD138 (+), CD99 (+), leukocyte common antigen (+), and Ki-67 (20%+). This condition was pathologically diagnosed as primary pharynx synovial sarcoma.
[Mh] Termos MeSH primário: Faringe
Sarcoma Sinovial
[Mh] Termos MeSH secundário: Adolescente
Caderinas
Seres Humanos
Masculino
Vimentina
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CDH1 protein, human); 0 (Cadherins); 0 (Vimentin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.7518/hxkq.2017.02.021


  9 / 2693 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28660813
[Au] Autor:Alcalá Serrano FJ; Hernández Hernández JR; Montenegro Dámaso T; López-Tomassetti Fernández E
[Ad] Endereço:General Surgery Department, Hospital Universitario Insular de Gran Canaria , Las Palmas , Spain.
[Ti] Título:Monophasic synovial sarcoma of the greater omentum: case report and review of literature.
[So] Source:Ann R Coll Surg Engl;99(6):e172-e173, 2017 Jul.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Synovial sarcoma is a malignant spindle cell neoplasm normally arising from tissues around joints, bursa and tendon sheaths. Several reports involving the gastrointestinal tract, mainly the oesophagus and stomach, have been documented; however, the omentum remains an extremely unusual location. Monophasic type is composed exclusively of spindle cells arranged in fascicles. Establishing the correct diagnosis of these tumours could be challenging because of the similarities with gastrointestinal stromal tumours and other mesenchymal tumours with similar histology.
[Mh] Termos MeSH primário: Omento
Neoplasias Peritoneais
Sarcoma Sinovial
[Mh] Termos MeSH secundário: Seres Humanos
Imuno-Histoquímica
Omento/diagnóstico por imagem
Omento/patologia
Omento/cirurgia
Neoplasias Peritoneais/diagnóstico por imagem
Neoplasias Peritoneais/patologia
Neoplasias Peritoneais/cirurgia
Radiografia Abdominal
Sarcoma Sinovial/diagnóstico por imagem
Sarcoma Sinovial/patologia
Sarcoma Sinovial/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2017.0076


  10 / 2693 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28634201
[Au] Autor:Fleuren EDG; Vlenterie M; van der Graaf WTA; Hillebrandt-Roeffen MHS; Blackburn J; Ma X; Chan H; Magias MC; van Erp A; van Houdt L; Cebeci SAS; van de Ven A; Flucke UE; Heyer EE; Thomas DM; Lord CJ; Marini KD; Vaghjiani V; Mercer TR; Cain JE; Wu J; Versleijen-Jonkers YMH; Daly RJ
[Ad] Endereço:Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom. Emmy.Fleuren@icr.ac.uk roger.daly@monash.edu.
[Ti] Título:Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes.
[So] Source:Cancer Res;77(16):4279-4292, 2017 Aug 15.
[Is] ISSN:1538-7445
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite intensive multimodal treatment of sarcomas, a heterogeneous group of malignant tumors arising from connective tissue, survival remains poor. Candidate-based targeted treatments have demonstrated limited clinical success, urging an unbiased and comprehensive analysis of oncogenic signaling networks to reveal therapeutic targets and personalized treatment strategies. Here we applied mass spectrometry-based phosphoproteomic profiling to the largest and most heterogeneous set of sarcoma cell lines characterized to date and identified novel tyrosine phosphorylation patterns, enhanced tyrosine kinases in specific subtypes, and potential driver kinases. ALK was identified as a novel driver in the Aska-SS synovial sarcoma (SS) cell line via expression of an ALK variant with a large extracellular domain deletion (ALK ). Functional ALK dependency was confirmed and with selective inhibitors. Importantly, ALK immunopositivity was detected in 6 of 43 (14%) of SS patient specimens, one of which exhibited an ALK rearrangement. High PDGFRα phosphorylation also characterized SS cell lines, which was accompanied by enhanced MET activation in Yamato-SS cells. Although Yamato-SS cells were sensitive to crizotinib (ALK/MET-inhibitor) but not pazopanib (VEGFR/PDGFR-inhibitor) monotherapy , synergistic effects were observed upon drug combination. , both drugs were individually effective, with pazopanib efficacy likely attributable to reduced angiogenesis. MET or PDGFRα expression was detected in 58% and 84% of SS patients, respectively, with coexpression in 56%. Consequently, our integrated approach has led to the identification of ALK and MET as promising therapeutic targets in SS. .
[Mh] Termos MeSH primário: Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-met/metabolismo
Receptores Proteína Tirosina Quinases/metabolismo
Sarcoma Sinovial/tratamento farmacológico
Sarcoma Sinovial/enzimologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Estudos de Coortes
Feminino
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Terapia de Alvo Molecular
Fosforilação
Proteômica
Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-met/genética
Pirazóis/farmacologia
Piridinas/farmacologia
Pirimidinas/farmacologia
Receptores Proteína Tirosina Quinases/antagonistas & inibidores
Receptores Proteína Tirosina Quinases/genética
Receptor alfa de Fator de Crescimento Derivado de Plaquetas/biossíntese
Sarcoma Sinovial/genética
Transdução de Sinais
Sulfonamidas/farmacologia
Sulfonas/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0 (Pyrazoles); 0 (Pyridines); 0 (Pyrimidines); 0 (Sulfonamides); 0 (Sulfones); 53AH36668S (crizotinib); 7RN5DR86CK (pazopanib); EC 2.7.10.1 (MET protein, human); EC 2.7.10.1 (Proto-Oncogene Proteins c-met); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (Receptor, Platelet-Derived Growth Factor alpha); EC 2.7.10.1 (anaplastic lymphoma kinase); K418KG2GET (ceritinib)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.1158/0008-5472.CAN-16-2550



página 1 de 270 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde