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  1 / 2129 MEDLINE  
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[PMID]:29310405
[Au] Autor:Mandato VD; Valli R; Mastrofilippo V; Bisagni A; Aguzzoli L; La Sala GB
[Ad] Endereço:Unit of Obstetrics and Gynecology.
[Ti] Título:Uterine inflammatory myofibroblastic tumor: more common than expected: Case report and review.
[So] Source:Medicine (Baltimore);96(48):e8974, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm composed of spindled to epithelioid cells with prominent myxoid stroma and inflammatory infiltrate. It has a low but definite malignant potential. However, its management has never been standardized. PATIENT CONCERNS AND DIAGNOSIS: We present the first case of uterine IMT laparoscopically treated. Moreover, we reviewed the English literature regarding uterine IMT published between 1987 and June 2017. A total of 72 cases of uterine IMT were included. Clinical and pathological characteristics, treatments and outcomes were recorded. INTERVENTIONS AND OUTCOMES: A total laparoscopic hysterectomy with opportunistic bilateral salpingectomy was performed. Patient is free of disease at 6 months of follow-up. LESSONS: Uterine IMT may be identified by anaplastic lymphoma kinase overexpression, its prognosis is usually good, complete excision seems to be effective to avoid relapse and mini invasive surgery seems to be effective and safe to treat uterine IMT. However, considering the age of women affected by disease, conservative management, or medical therapy could be taken in account to avoid surgical injuries and to preserve fertility.
[Mh] Termos MeSH primário: Neoplasias de Tecido Muscular/terapia
Neoplasias Uterinas/terapia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Laparoscopia
Neoplasias de Tecido Muscular/diagnóstico
Neoplasias de Tecido Muscular/epidemiologia
Neoplasias de Tecido Muscular/patologia
Neoplasias Uterinas/diagnóstico
Neoplasias Uterinas/epidemiologia
Neoplasias Uterinas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008974


  2 / 2129 MEDLINE  
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[PMID]:29245287
[Au] Autor:Shang J; Wang YY; Dang Y; Zhang XJ; Song Y; Ruan LT
[Ad] Endereço:aDepartment of Ultrasound MedicinebDepartment of Pathological Diagnosis, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
[Ti] Título:An inflammatory myofibroblastic tumor in the transplanted liver displaying quick wash-in and wash-out on contrast-enhanced ultrasound: A case report.
[So] Source:Medicine (Baltimore);96(49):e9024, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm, and its presence in a grafted liver is exceedingly rare. PATIENT CONCERNS: A 54-year-old woman was admitted to our hospital with a half-month history of intermittent melena. She had undergone deceased-donor liver transplantation (LT) for hepatitis B virus related liver cirrhosis without hepatocellular carcinoma 5 months previously. DIAGNOSIS: Laboratory examination showed impaired liver and renal functions and Epstein-Barr virus (EBV) infection, but tumor markers within normal ranges. Gastroscopy showed esophageal varices. Ultrasound and computed tomography angiography revealed an ill-defined and irregular solitary lesion in the porta hepatis, encasing both the portal vein and the hepatic artery. The lesion was characterized by arterial hyper-enhancement and hypo-enhancement in the remaining phases with contrast-enhanced ultrasound (CEUS). The lesion was finally confirmed as an IMT by ultrasound-guided biopsy. INTERVENTION: The patient received conservative treatment, including immunosuppression, endoscopic variceal ligation, antibiotics, steroids, and antiviral agents. OUTCOME: The patient's gastrointestinal bleeding was controlled, but the symptoms associated with portal hypertension worsened. Attempts to perform a transjugular intrahepatic portosystemic shunt were unsuccessful, and she unfortunately died soon after. LESSONS: A differential diagnosis of IMT should be considered in LT recipients presenting with EBV infection, normal tumor markers, and a de novo hepatic lesion with quick wash-in and wash-out on CEUS. Ultrasound is associated with the advantages of convenience and nonionizing radiation, and should thus be the priority approach for monitoring transplanted liver.
[Mh] Termos MeSH primário: Neoplasias Hepáticas/etiologia
Transplante de Fígado/efeitos adversos
Neoplasias de Tecido Muscular/etiologia
[Mh] Termos MeSH secundário: Feminino
Hemorragia Gastrointestinal/etiologia
Hemorragia Gastrointestinal/terapia
Seres Humanos
Neoplasias Hepáticas/complicações
Meia-Idade
Neoplasias de Tecido Muscular/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009024


  3 / 2129 MEDLINE  
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[PMID]:29245241
[Au] Autor:Sun Z; Wang H; Guo X; Jiang S; Jing C
[Ad] Endereço:aDepartment of Minimally Invasive Urology Center, Shandong Provincial Hospital affiliated to Shandong UniversitybThe Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
[Ti] Título:Inflammatory myofibroblastic tumor of kidney together with ipsilateral perinephric and periureteric fibrosis: A case report and literature review.
[So] Source:Medicine (Baltimore);96(49):e8807, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Both inflammatory myofibroblastic tumor (IMT) and retroperitoneal fibrosis are rare lesions, but kidney involvement is more rare. It is the first study about IMT of the kidney in a patient with perinephric and periureteric fibrosis and we hold that fibroblast proliferation may be an intermediate status in oncogenesis of IMT. But further investigation is necessary in order to better clarify the relationship between fibroblast proliferation and IMT. PATIENT CONCERNS: A 54-year-old female presented no positive signs except dull back pain after overwork. DIAGNOSES: On the basis of the urinary ultrasonography and computed tomography (CT) scan, we strongly suspected a renal cell carcinoma. INTERVENTIONS: Considering the little remaining function of the right kidney and the possibility of malignancy, we performed a laparoscopic right radical nephrectomy. OUTCOMES: According to the analysis of the postoperative paraffin section and immunohistochemistry assay, a final diagnosis of IMT and retroperitoneal fibrosis nodules was made. LESSONS: Both IMTs are rare lesions and its etiology and pathogeny are unclear. It is the first study about IMT of the kidney in a patient with perinephric and periureteric fibrosis. This report suggested that fibroblast proliferation may be an intermediate status in oncogenesis of IMT, but further investigation is necessary in order to better clarify the relationship between fibroblast proliferation and IMT. The preoperative diagnosis of renal IMT remains difficult. Preoperative fine-needle aspiration or percutaneous biopsy and intraoperative frozen section were applied to confirm the diagnosis to avoid unnecessary nephrectomy, especially in patients with renal insufficiency, bilateral masses, or a solitary kidney.
[Mh] Termos MeSH primário: Neoplasias Renais/complicações
Neoplasias de Tecido Muscular/complicações
Perinefrite/etiologia
Doenças Ureterais/etiologia
[Mh] Termos MeSH secundário: Feminino
Fibrose
Seres Humanos
Neoplasias Renais/cirurgia
Meia-Idade
Neoplasias de Tecido Muscular/cirurgia
Nefrectomia/métodos
Perinefrite/cirurgia
Doenças Ureterais/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008807


  4 / 2129 MEDLINE  
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[PMID]:29019904
[Au] Autor:Liang W; Lin S; Chen Z
[Ad] Endereço:aDepartment of Radiology bDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, College of Medicine, Zhejiang University.79# Qingchun Road, Hangzhou City, Zhejiang Province cDepartment of General Surgery, the First People's Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Taicang, Suzhou, China.
[Ti] Título:Imaging findings of inflammatory myofibroblastic tumor from the greater omentum: One case report.
[So] Source:Medicine (Baltimore);96(41):e8297, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Inflammatory myofibroblastic tumors (IMTs) are rare neoplastic lesions with benign tendency. Even more rare are IMTs from the greater omentum (GO-IMT). A GO-IMT is easily misdiagnosed as other malignant tumors before operation; thus, clinicians need to be familiar with its imaging findings. Here, we report the imaging findings of a GO-IMT patient presenting with a pelvic mass. PATIENT CONCERNS: Ultrasound of the IMT in the pelvic cavity showed a hypoechoic mass. A computed tomography (CT) scan showed a nearly circular soft tissue mass with a clear border and heterogeneous density, and the surrounding tissues were pushed and compressed. Contrast-enhanced CT showed severe persistent enhancement in the lesion edges and mural nodules, but not in the central necrosis. DIAGNOSES: Histopathology and immunohistochemistry confirmed that the mass was a GO-IMT. INTERVENTIONS: The tumor was resected after preoperative preparation. OUTCOMES: No recurrence or metastasis was found during a short-term follow-up. LESSONS: The GO-IMT is an inferior epigastric mass in the periphery of the bowel, and is usually well-demarcated without calcification or lymphadenopathy. Contrast-enhanced CT showed a heterogeneous hypervascular mass where the center necrosis, the edge of the tumor, and the mural nodules can be partially reinforced.
[Mh] Termos MeSH primário: Dissecação/métodos
Laparoscopia/métodos
Linfonodos
Neoplasias de Tecido Muscular
Omento/patologia
Neoplasias Peritoneais
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hiperplasia
Inflamação/etiologia
Excisão de Linfonodo/métodos
Linfonodos/patologia
Linfonodos/cirurgia
Neoplasias de Tecido Muscular/patologia
Neoplasias de Tecido Muscular/fisiopatologia
Neoplasias de Tecido Muscular/cirurgia
Neoplasias Peritoneais/patologia
Neoplasias Peritoneais/fisiopatologia
Neoplasias Peritoneais/cirurgia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008297


  5 / 2129 MEDLINE  
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[PMID]:28787259
[Au] Autor:Mossé YP; Voss SD; Lim MS; Rolland D; Minard CG; Fox E; Adamson P; Wilner K; Blaney SM; Weigel BJ
[Ad] Endereço:Yael P. Mossé, Megan S. Lim, Delphine Rolland, Elizabeth Fox, and Peter Adamson, University of Pennsylvania, Philadelphia, PA; Stephan D. Voss, Harvard Medical School, Boston, MA; Charles G. Minard and Susan M. Blaney, Baylor College of Medicine, Houston, TX; Keith Wilner, Pfizer Oncology, La Jolla,
[Ti] Título:Targeting ALK With Crizotinib in Pediatric Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumor: A Children's Oncology Group Study.
[So] Source:J Clin Oncol;35(28):3215-3221, 2017 Oct 01.
[Is] ISSN:1527-7755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose Fusions involving the ALK gene are the predominant genetic lesion underlying pediatric anaplastic large cell lymphomas (ALCL) and inflammatory myofibroblastic tumors (IMTs). We assessed the activity of the ALK inhibitor crizotinib in patients who had no known curative treatment options at diagnosis or with relapsed/recurrent disease. Methods In this study, 26 patients with relapsed/refractory ALK-positive ALCL and 14 patients with metastatic or inoperable ALK-positive IMT received crizotinib orally twice daily. Study objectives were measurement of efficacy and safety. Correlative studies evaluated the serial detection of NPM-ALK fusion transcripts in patients with ALCL. Results The overall response rates for patients with ALCL treated at doses of 165 (ALCL165) and 280 (ALCL280) mg/m were 83% and 90%, respectively. The overall response rate for patients with IMT (treated at 100, 165, and 280 mg/m /dose) was 86%. A complete response was observed in 83% (five of six) of ALCL165, 80% (16 of 20) of ALCL280, and 36% (five of 14) of patients with IMT. Partial response rates were 0% (none of six), 10% (two of 20), and 50% (seven of 14), respectively. The median duration of therapy was 2.79, 0.4, and 1.63 years, respectively, with 12 patients ceasing protocol therapy to proceed to transplantation. The most common drug-related adverse event was decrease in neutrophil count in 33% and 70% of the ALCL165 and ALCL280 groups, respectively, and in 43% of patients with IMT. Levels of NPM-ALK decreased during therapy in most patients with ALCL. Conclusion The robust and sustained clinical responses to crizotinib therapy in patients with relapsed ALCL and metastatic or unresectable IMT highlight the importance of the ALK pathway in these diseases.
[Mh] Termos MeSH primário: Linfoma Anaplásico de Células Grandes/tratamento farmacológico
Neoplasias de Tecido Muscular/tratamento farmacológico
Inibidores de Proteínas Quinases/administração & dosagem
Pirazóis/administração & dosagem
Piridinas/administração & dosagem
Receptores Proteína Tirosina Quinases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Linfoma Anaplásico de Células Grandes/enzimologia
Masculino
Terapia de Alvo Molecular
Recidiva Local de Neoplasia/tratamento farmacológico
Recidiva Local de Neoplasia/enzimologia
Neoplasias de Tecido Muscular/enzimologia
Inibidores de Proteínas Quinases/efeitos adversos
Pirazóis/efeitos adversos
Piridinas/efeitos adversos
Receptores Proteína Tirosina Quinases/metabolismo
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protein Kinase Inhibitors); 0 (Pyrazoles); 0 (Pyridines); 53AH36668S (crizotinib); EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (anaplastic lymphoma kinase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1200/JCO.2017.73.4830


  6 / 2129 MEDLINE  
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[PMID]:28756644
[Au] Autor:Takita J
[Ad] Endereço:Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
[Ti] Título:The role of anaplastic lymphoma kinase in pediatric cancers.
[So] Source:Cancer Sci;108(10):1913-1920, 2017 Oct.
[Is] ISSN:1349-7006
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The anaplastic lymphoma kinase (ALK) gene was initially identified as a fusion partner of the nucleophosmin gene in anaplastic large-cell lymphoma with t(2;5)(p23;q35) translocation, and then described with different genetic abnormalities in a number of tumors. Although ALK is known to be involved in the pathogenesis of neuroblastoma through activating mutations or gene amplification, its role in the pathogenesis of other pediatric cancers is still elusive. In addition to neuroblastoma, the high-grade amplification of ALK has been described in a subset of rhabdomyosarcoma cases. Normal ALK protein expression is restricted to the nervous systems of adult mammals, but the aberrant expression of ALK has been observed in a variety of pediatric cancers, including glioma and Ewing sarcoma. The discovery of oncogenic activation of ALK in neuroblastoma suggests that this cancer could be potentially treated with an ALK inhibitor, as could other cancers, such as non-small-cell lung cancer and anaplastic large-cell lymphoma. However, cellular responses to mutant ALK are complex when compared to rearranged ALK, and treatment remains a challenge. This review focuses on the biology of ALK in pediatric cancers and possible therapeutic strategies for ALK-associated tumors.
[Mh] Termos MeSH primário: Amplificação de Genes
Mutação
Receptores Proteína Tirosina Quinases/genética
Receptores Proteína Tirosina Quinases/metabolismo
[Mh] Termos MeSH secundário: Animais
Carcinoma Pulmonar de Células não Pequenas/genética
Criança
Ativação Enzimática
Predisposição Genética para Doença
Glioma/genética
Seres Humanos
Neoplasias Pulmonares/genética
Linfoma Anaplásico de Células Grandes/genética
Neoplasias/genética
Neoplasias de Tecido Muscular/genética
Neuroblastoma/genética
Sarcoma de Ewing/genética
Transdução de Sinais
Translocação Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (anaplastic lymphoma kinase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE
[do] DOI:10.1111/cas.13333


  7 / 2129 MEDLINE  
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[PMID]:28751104
[Au] Autor:Krings G; McIntire P; Shin SJ
[Ad] Endereço:Department of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA. Electronic address: gregor.krings@ucsf.edu.
[Ti] Título:Myofibroblastic, fibroblastic and myoid lesions of the breast.
[So] Source:Semin Diagn Pathol;34(5):427-437, 2017 Sep.
[Is] ISSN:0740-2570
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myofibroblastic, fibroblastic and/or myoid lesions are rare in the breast but comprise the majority of mammary mesenchymal spindle cell lesions. Whereas most have similar features to their counterparts at extramammary sites, pseudoangiomatous stromal hyperplasia is considered a breast-specific myofibroblastic proliferation on the same spectrum as myofibroblastoma. Other lesions with myofibroblastic/fibroblastic differentiation include fibromatosis and nodular fasciitis, as well as more aggressive tumors such as the rarely reported myofibrosarcoma, inflammatory myofibroblastic tumor and fibrosarcoma. Lesions with myoid differentiation include benign leiomyoma, myoid hamartoma and leiomyomatous myofibroblastoma, but primary leiomyosarcoma and rhabdomyosarcoma may also rarely arise in the breast. Furthermore, fibroepithelial lesions and metaplastic carcinomas can demonstrate myoid metaplasia. Diagnosis can be challenging, particularly on core biopsy, but benign lesions with or without recurrence potential must be distinguished from more aggressive tumors, especially metaplastic carcinoma and phyllodes tumors. This article will review lesions with myofibroblastic, fibroblastic and myoid differentiation in the breast, with special emphasis on differential diagnosis.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Fibroblastos/patologia
Fibroma/patologia
Miofibroblastos/patologia
Neoplasias de Tecido Muscular/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biópsia
Neoplasias da Mama/química
Diferenciação Celular
Diagnóstico Diferencial
Feminino
Fibroblastos/química
Fibroma/química
Seres Humanos
Imuno-Histoquímica
Miofibroblastos/química
Neoplasias de Tecido Muscular/química
Valor Preditivo dos Testes
Prognóstico
Sarcoma/química
Sarcoma/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE


  8 / 2129 MEDLINE  
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[PMID]:28683506
[Au] Autor:Hammel A; Schönnagel BP; Herrmann J
[Ad] Endereço:Department for Diagnostic and Interventional Radiology, UKE Hamburg, Germany.
[Ti] Título:Inflammatorischer myofibroblastischer Tumor: ungewöhnliche Differenzialdiagnose einer Lobärpneumonie im Röntgenthorax..
[So] Source:Rofo;189(8):767-768, 2017 Aug.
[Is] ISSN:1438-9010
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Neoplasias Pulmonares/complicações
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias de Tecido Muscular/complicações
Neoplasias de Tecido Muscular/diagnóstico por imagem
Pneumonia/diagnóstico por imagem
Pneumonia/etiologia
[Mh] Termos MeSH secundário: Criança
Diagnóstico Diferencial
Feminino
Seres Humanos
Radiografia Torácica/métodos
Doenças Raras/diagnóstico por imagem
Doenças Raras/etiologia
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-108690


  9 / 2129 MEDLINE  
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[PMID]:28550673
[Au] Autor:Wang FH; Liang JH; Zeng JH; Tang J; Wang H; Liu W
[Ad] Endereço:Department of Thoracic Surgery, Guangzhou Women and Children's Medical Central, Guangzhou 510120, China.
[Ti] Título:[Clinical characteristics, diagnosis and treatment of pulmonary inflammatory myofibroblastic tumor in children].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(4):299-302, 2017 Apr 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the clinical characteristics, diagnosis and treatment of pulmonary inflammatory myofibroblastic tumor in children. The clinical data of 13 patients with pulmonary inflammatory myofibroblastic tumor between October 2009 and October 2015 were retrospectively analyzed, including 9 boys and 4 girls aged 1 to 12 years 4 months (mean 4 years 9 months). Seven patients underwent total tumor resection, 4 had lobectomy, 1 had partial tumor resection and 1 had biopsy. The follow-up time ranged from 2 months to 6 years and 2 months. Among the 13 patients, 9 were cured. Two patients lived with tumor. One of them had tumor which shrinked gradually and the other had stable disease. One patient with multiple lesions encountered recurrence after 3 operations and developed suspicious hepatic metastasis. One died during the operation because of airway mismanagement. Pulmonary inflammatory myofibroblastic tumor in children has rather good prognosis while a few cases have the potential of recurrence and canceration. Surgery is the primary therapeutic approach. Close post-operative follow up is necessary.
[Mh] Termos MeSH primário: Neoplasias Pulmonares
Neoplasias de Tecido Muscular
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/patologia
Neoplasias Pulmonares/cirurgia
Masculino
Neoplasias de Tecido Muscular/mortalidade
Neoplasias de Tecido Muscular/patologia
Neoplasias de Tecido Muscular/cirurgia
Estudos Retrospectivos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170528
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.04.013


  10 / 2129 MEDLINE  
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[PMID]:28250406
[Au] Autor:Mansour-Ghanaei F; Gharibpoor A; Joukar F; Mavaddati S; Askari K; Askari SA; Gharibpoor F
[Ad] Endereço:Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
[Ti] Título:Inflammatory Myofibroblastic Tumors in a Case with Hypogastric Discomfort.
[So] Source:Am J Case Rep;18:217-221, 2017 Mar 02.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Inflammatory myofibroblastic tumors (IMTs) are scarce tumors with discrete immunohistochemical and molecular attributes which are not related to a particular location. There are different reports about the intrinsic nature of these tumors as benign to possibly malignant. CASE REPORT Here we report the case of a 68-year-old man referred to the Internal Medicine Department of Razi Hospital in Rasht (a city in the north of Iran) due to right lower quadrant (RLQ) discomfort with no specific symptoms. Colonoscopy revealed a mass-like lesion. Polymorphonuclear cells (PMNCs) admixed by some eosinophils were demonstrated histopathologically. Immunohistochemical evaluation was positive for vimentin, CD34, smooth muscle actin, and ALK, and negative for CD117 and desmin. The tumor was successfully removed by surgery with no chemotherapy. No recurrence was reported. CONCLUSIONS We have performed surgical excision of the mass with no chemotherapy and no recurrence. Although recurrence is reported to be low, we recommend long-term follow-up after surgery.
[Mh] Termos MeSH primário: Neoplasias do Ceco/diagnóstico
Neoplasias do Ceco/cirurgia
Neoplasias de Tecido Muscular/diagnóstico
Neoplasias de Tecido Muscular/cirurgia
[Mh] Termos MeSH secundário: Idoso
Neoplasias do Ceco/complicações
Seres Humanos
Irã (Geográfico)
Masculino
Neoplasias de Tecido Muscular/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE



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