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[PMID]:29505520
[Au] Autor:Liu H; Tao M; Ding H; Zhang P
[Ad] Endereço:Department of Ultrasonography.
[Ti] Título:Ultrasonographic manifestations of a rare granular cell tumor of the accessory breast: A case report.
[So] Source:Medicine (Baltimore);97(1):e9462, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The ultrasound manifestations of granular cell tumor (GCT) is a consequence of the histopathological characteristic of the tumor and can be distinguished from breast cancer. PATIENT CONCERNS: A GCT is a rare, benign, hyperplasia-based lesion. Approximately 1% to 2% of GCTs are malignant. About 5% to15% of the cases occur in the breast, and it is relatively rare in the axillary accessory breast. There are no effective preventive measures for GCTs, early detection combined with a thorough and wide complete resection of the tumor remains the best treatment for a favorable outcome. DIAGNOSES: A 45-year-old female patient with an axillary mass of more than 3 months duration was examined through physical examination, color Doppler ultrasound and postoperative pathology. INTERVENTIONS: A provisional diagnosis of left axillary lymph node enlargement was made and necessary investigations were advised. OUTCOMES: A differential diagnosis of accessory breast in the left arm pit, possibly malignant, or a solid mass in the left arm pit secondary to chronic inflammation. Postoperative pathology: GCT of axillary accessory breast, with tumor-free margins. Immunohistochemical staining showed strong S-100 positivity, CD68 positivity, and negative periodic acid-Schiff staining. LESSONS: The ultrasound examination can detect GCT mass in the breast/accessory breast and is not easy to misdiagnosis.
[Mh] Termos MeSH primário: Axila/diagnóstico por imagem
Neoplasias da Mama/diagnóstico por imagem
Tumor de Células Granulares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Axila/patologia
Neoplasias da Mama/patologia
Feminino
Tumor de Células Granulares/patologia
Seres Humanos
Meia-Idade
Ultrassonografia Doppler em Cores
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009462


  2 / 1246 MEDLINE  
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[PMID]:29095317
[Au] Autor:Jia X; Chen C; Chen L; Yu C; Kondo T
[Ad] Endereço:aDepartment of Hand Surgery, Huashan Hospital, Fudan University bKey Laboratory of Hand Reconstruction, Ministry of Health cShanghai Key Laboratory of Peripheral Nerve and Microsurgery dDepartment of Gynecology and Obstetrics, Putuo District Center Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China eDivision of Rare Cancer Research, National Cancer Center Research Institute, Tokyo, Japan.
[Ti] Título:Large malignant granular cell tumor with suprascapular nerve and brachial plexus invasion: A case report and literature review.
[So] Source:Medicine (Baltimore);96(44):e8531, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Malignant granular cell tumor is a kind of rare and highly aggressive malignant tumor that commonly occurs in lower extremity, trunk, and peritoneal cavity. Huge malignant granular cell tumor (MGCT) with suprascapular nerve and brachial plexus invasion was extremely rare. PATIENT CONCERNS: We present a special case of a 48-year-old orthopedist who suffered from MGCT. The orthopedist had regarded that he suffered from scapulohumeral periarthritis. DIAGNOSES: The disease was noticed until a painless mass on his right neck was discovered 9 months later. MRI result confirmed a large occupying in axillary fossa, supraclavicular and infraclavicular region. INTERVENTIONS: During the operation, a tumor measuring 22 × 13 × 6 cm with suprascapular nerve and brachial plexus invasion was identified. The tumor was fractional resected carefully to maintain the integrity of nerves and vessels. Lymph nodes were simultaneously resected. OUTCOMES: The motor function and sensation of the upper extremity were same to that of preoperation. The postoperative histological diagnosis was MGCT. At a 12-month follow-up, there was no recurrence of the tumor showed by MRI. LESSONS: This study presents a rare case of large MGCT with suprascapular nerve and brachial plexus invasion that was successfully managed by surgery.
[Mh] Termos MeSH primário: Neoplasias Ósseas/patologia
Plexo Braquial/patologia
Tumor de Células Granulares/patologia
Escápula/patologia
[Mh] Termos MeSH secundário: Neoplasias Ósseas/cirurgia
Plexo Braquial/cirurgia
Tumor de Células Granulares/cirurgia
Seres Humanos
Masculino
Meia-Idade
Invasividade Neoplásica
Procedimentos Neurocirúrgicos/métodos
Escápula/inervação
Escápula/cirurgia
Ombro/inervação
Ombro/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008531


  3 / 1246 MEDLINE  
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[PMID]:28898987
[Au] Autor:Stemm M; Suster D; Wakely PE; Suster S
[Ad] Endereço:Department of Pathology, Medical College of Wisconsin, Milwaukee.
[Ti] Título:Typical and Atypical Granular Cell Tumors of Soft Tissue: A Clinicopathologic Study of 50 Patients.
[So] Source:Am J Clin Pathol;148(2):161-166, 2017 Aug 01.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: Granular cell tumors are rare neoplasms of neural origin. Despite the mesenchymal nature of these tumors, they rarely occur in the soft tissue, and as a result, this subset is not well characterized. We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. Methods: All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings. Results: The most common location was the upper extremity. The mean age was 38.6 years, and the mean size of the tumor was 2.1 cm. An infiltrative growth pattern was seen in 58.8% of cases, and positive margins were found in 68.2%. Eleven (21.6%) cases showed evidence of cytologic atypia and fulfilled the criteria for a diagnosis of atypical giant cell tumor. Two of 11 patients with long-term follow-up experienced local recurrence. Conclusions: Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts.
[Mh] Termos MeSH primário: Tumor de Células Granulares/patologia
Neoplasias de Tecidos Moles/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Biomarcadores Tumorais/análise
Criança
Pré-Escolar
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqx058


  4 / 1246 MEDLINE  
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[PMID]:28647116
[Au] Autor:Charu V; Cimino-Mathews A
[Ad] Endereço:Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
[Ti] Título:Peripheral nerve sheath tumors of the breast.
[So] Source:Semin Diagn Pathol;34(5):420-426, 2017 Sep.
[Is] ISSN:0740-2570
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Benign and malignant peripheral nerve sheath tumors can involve the breast, presenting as masses in the dermis, deep breast parenchyma or axillary soft tissue. Although the histologic features are frequently characteristic, diagnosis can be challenging on core needle biopsy, and the differential diagnosis includes a variety of other benign and malignant spindle cell lesions of the breast. Here, we review the key clinical and pathological features of breast schwannoma, neurofibroma, granular cell tumor, and malignant peripheral nerve sheath tumor.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Tumor de Células Granulares/patologia
Neurilemoma/patologia
Neurofibroma/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biópsia
Neoplasias da Mama/química
Diagnóstico Diferencial
Feminino
Tumor de Células Granulares/química
Seres Humanos
Imuno-Histoquímica
Neurilemoma/química
Neurofibroma/química
Valor Preditivo dos Testes
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


  5 / 1246 MEDLINE  
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[PMID]:28593688
[Au] Autor:Goto K
[Ad] Endereço:Department of Pathology and Cytology, Karolinska University Hospital, Huddinge, Sweden.
[Ti] Título:Similarity between non-neural granular cell tumors and granular cell fibrous papules.
[So] Source:J Cutan Pathol;44(8):726, 2017 08.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Angiofibroma
Tumor de Células Granulares
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Cutâneas
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12974


  6 / 1246 MEDLINE  
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[PMID]:28480946
[Au] Autor:Schriber M; Schmitt AM; Suter VGA
[Ad] Endereço:Klinik für Oralchirurgie und Stomatologie, Zahnmedizinische Kliniken der Universität Bern, Bern, Switzerland.
[Ti] Título:Granularzelltumor der Zunge..
[So] Source:Swiss Dent J;127(4):312-313, 2017.
[Is] ISSN:2296-6498
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Mh] Termos MeSH primário: Tumor de Células Granulares/diagnóstico
Neoplasias da Língua/diagnóstico
Neoplasias da Língua/cirurgia
[Mh] Termos MeSH secundário: Tumor de Células Granulares/patologia
Tumor de Células Granulares/cirurgia
Seres Humanos
Prognóstico
Língua/patologia
Língua/cirurgia
Neoplasias da Língua/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


  7 / 1246 MEDLINE  
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[PMID]:28296675
[Au] Autor:Riffle ME; Polydorides AD; Niakan J; Chehade M
[Ad] Endereço:Department of *Pediatrics, Mount Sinai Center for Eosinophilic Disorders, Jaffe Food Allergy Institute †Pathology, Icahn School of Medicine at Mount Sinai, New York, NY.
[Ti] Título:Eosinophilic Esophagitis and Esophageal Granular Cell Tumor: An Unexpected Association.
[So] Source:Am J Surg Pathol;41(5):616-621, 2017 May.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Esophageal granular cell tumors (GCTs) are rare. Eosinophilic esophagitis (EoE) is an immune-mediated disease characterized by esophageal eosinophilia despite proton pump inhibitor (PPI) therapy. Given that GCTs occur at sites of scarring and inflammation, we sought to determine the prevalence of EoE in patients with esophageal GCTs. Our center's pathology database was searched for GCT specimens from 1995 to 2014. Slides were blindly rereviewed. GCTs were scored for atypical cytological features. Presence and number of eosinophils in the tumor and the surrounding esophageal epithelium and any EoE features were recorded. Medical records were reviewed. From >30,000 esophageal cases, 23 esophageal GCTs were identified, with 18 available for review (16 adult, 2 pediatric). Median patient age was 38.7 years. Four adults had esophageal intraepithelial eosinophilia (peak 38 to 68 eosinophils/high power field [HPF]); 2 confirmed to have EoE, 1 with PPI-responsive esophageal eosinophilia, and 1 had not received PPI therapy. Both pediatric cases had confirmed EoE (peak 24 and 34 eosinophils/HPF). In total, 12/18 GCTs had intratumoral eosinophilia (peak 1 to 16 eosinophils/HPF). All 6 cases with esophageal eosinophilia had intratumoral eosinophilia. Two GCTs displayed atypical cytologic features. Esophageal eosinophilia was present in 25% of adult and 100% of pediatric GCTs, the majority confirmed to have EoE. Overall, 67% of cases had intratumoral eosinophilia and 2 had atypical features. On the basis of these findings, we propose evaluating surrounding tissue for eosinophilia when esophageal GCT is diagnosed, and adding GCT as a potential complication of untreated EoE. Research for an immunologic link between EoE and esophageal GCTs is needed.
[Mh] Termos MeSH primário: Esofagite Eosinofílica/complicações
Eosinófilos/patologia
Neoplasias Esofágicas/complicações
Tumor de Células Granulares/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Biomarcadores Tumorais/análise
Biópsia
Bases de Dados Factuais
Esofagite Eosinofílica/tratamento farmacológico
Esofagite Eosinofílica/patologia
Neoplasias Esofágicas/química
Neoplasias Esofágicas/patologia
Esofagoscopia
Feminino
Tumor de Células Granulares/química
Tumor de Células Granulares/patologia
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Cidade de Nova Iorque
Inibidores da Bomba de Prótons/uso terapêutico
Estudos Retrospectivos
Proteínas S100/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Proton Pump Inhibitors); 0 (S100 Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000832


  8 / 1246 MEDLINE  
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[PMID]:28256763
[Au] Autor:Cardis MA; Ni J; Bhawan J
[Ad] Endereço:MedStar Washington Hospital Center/MedStar Georgetown University Hospital, Washington, District of Columbia, USA.
[Ti] Título:Granular cell differentiation: A review of the published work.
[So] Source:J Dermatol;44(3):251-258, 2017 Mar.
[Is] ISSN:1346-8138
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features.
[Mh] Termos MeSH primário: Diferenciação Celular
Tumor de Células Granulares/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias/patologia
Neoplasias/fisiopatologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1111/1346-8138.13758


  9 / 1246 MEDLINE  
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[PMID]:28218065
[Au] Autor:Korsaga-Some N; Sizaret D; Machet L
[Ad] Endereço:Department of Dermatology, CHRU, Tours, France.
[Ti] Título:Residents' corner. sQuiz your knowledge: A solitary asymptomatic nodule on the arm.
[So] Source:Eur J Dermatol;27(1):108-109, 2017 Feb 01.
[Is] ISSN:1952-4013
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Tumor de Células Granulares/diagnóstico
Tumor de Células Granulares/patologia
Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/patologia
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.1684/ejd.2017.2968


  10 / 1246 MEDLINE  
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[PMID]:28062976
[Au] Autor:Kim HK; Lee K; Han KN; Eo JS; Kim S; Choi YH
[Ad] Endereço:Departments of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, Korea University College of Medicine, 97 Guro-donggil, Guro-gu, 152-703, Seoul, South Korea. kimhyunkoo@korea.ac.kr.
[Ti] Título:The predictive accuracy of sentinel nodes mapping in the setting of pulmonary metastasectomy.
[So] Source:Clin Exp Metastasis;34(2):125-131, 2017 Feb.
[Is] ISSN:1573-7276
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This is the first study to evaluate the feasibility of mediastinal lymph node dissection (MLND) based on sentinel lymph node (SLN) status during pulmonary metastasectomy. A total of 22 patients (16 men, 6 women; age 63.3 ± 7.01 years) who were candidates for metastasectomy through segmentectomy or lobectomy with MLND owing to cancers metastatic to the lung were enrolled in this study. Radiotracer was administered at the peritumoral region before surgery or soon after initiating surgery. During the operation, the radioactivity of the lymph nodes (ex vivo) was counted with a handheld gamma probe after MLND. Lobectomy was performed in 17 patients, and segmentectomy, in 5 patients. The number of dissected lymph nodes per patient was 14.4 ± 8.69 (range, 5-36). In all patients, the SLN could be detected, and the number of SLNs identified was 2.0 ± 1.15 (range, 1-5) per patient. Lymph node metastasis was identified in 3 of the 22 patients (13.6%), and none of the 3 patients with N1 or N2 disease had false-negative SLNs. SLN identification might be an indicator of whether or not MLND should be performed during pulmonary metastasectomy. However, further large-volume and multi-institutional studies are needed.
[Mh] Termos MeSH primário: Carcinoma/secundário
Neoplasias Pulmonares/secundário
Metástase Linfática/diagnóstico por imagem
Pneumonectomia
Biópsia de Linfonodo Sentinela/métodos
Linfonodo Sentinela/patologia
[Mh] Termos MeSH secundário: Idoso
Biópsia por Agulha
Carcinoma/diagnóstico por imagem
Carcinoma/cirurgia
Intervalo Livre de Doença
Estudos de Viabilidade
Feminino
Tumor de Células Granulares/diagnóstico por imagem
Tumor de Células Granulares/secundário
Tumor de Células Granulares/cirurgia
Seres Humanos
Estimativa de Kaplan-Meier
Neoplasias Pulmonares/cirurgia
Excisão de Linfonodo
Masculino
Mediastino/diagnóstico por imagem
Meia-Idade
Pneumonectomia/métodos
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Valor Preditivo dos Testes
Cintilografia/instrumentação
Compostos Radiofarmacêuticos
Sarcoma/diagnóstico por imagem
Sarcoma/secundário
Sarcoma/cirurgia
Sensibilidade e Especificidade
Biópsia de Linfonodo Sentinela/instrumentação
Tecnécio
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 7440-26-8 (Technetium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170108
[St] Status:MEDLINE
[do] DOI:10.1007/s10585-016-9834-6



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