Base de dados : MEDLINE
Pesquisa : C04.557.450.692 [Categoria DeCS]
Referências encontradas : 317 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 32 ir para página                         

  1 / 317 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29245304
[Au] Autor:Han X; Sun MY; Liu JH; Zhang XY; Wang MY; Fan R; Qamar S
[Ad] Endereço:aThe First Affiliated Hospital of Dalian Medical University, Dalian, LiaoningbCancer Hospital of Peking University, BeijingcThe Chinese University of Hong Kong, Shatin, Hong Kong, China.
[Ti] Título:Computed tomography imaging features of hepatic perivascular epithelioid cell tumor: A case report and literature review.
[So] Source:Medicine (Baltimore);96(49):e9046, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Perivascular epithelioid cell tumor (PEComa) is a rare tumor which is most frequently found in uterus. The tumor arising from liver is extremely uncommon. PATIENT CONCERNS: A 36-year-old female with abdominal distention, cramps, and low-grade fever for over 15 days. The patient had a history of gastric adenocarcinoma with ovarian, celiac lymph nodes, and retroperitoneal lymph nodes metastases. DIAGNOSES: Computed tomography (CT) imaging demonstrated an ill-defined heterogeneous hypo-dense mass in segment 8 (S8) of the liver. Contrast-enhanced CT imaging showed marked enhancement in arterial phase, mild-to-moderate enhancement in portal and equilibrium phases. Tumor-feeding artery was demonstrated from the right hepatic artery by the three-dimensional reconstruction images. Biopsy was performed, and a diagnosis of PEComa was rendered. INTERVENTIONS: No intervention for this tumor before liver biopsy. LESSONS: We present a rare case of hepatic PEComa. The information we provided is useful for summarizing the CT features of this kind of tumors. It should be included in differential diagnoses from common hypervascular neoplasms of liver. The final diagnosis is established on histopathological and immunohistochemical studies that are the "gold standard."
[Mh] Termos MeSH primário: Meios de Contraste
Neoplasias Hepáticas/diagnóstico por imagem
Neoplasias de Células Epitelioides Perivasculares/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Fígado/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009046


  2 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28562565
[Au] Autor:Zhang S; Chen F; Huang X; Jiang Q; Zhao Y; Chen Y; Zhang J; Ma J; Yuan W; Xu Q; Zhao J; Wang C
[Ad] Endereço:aDepartment of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing bDepartment of Oncology, Bozhou People's Hospital, Bozhou cDepartment of Abdominal Surgery, Cancer Hospital of Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen Cancer Hospital, Shenzhen dState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing eDepartment of Medical Oncology, Affiliated Hospital of Qinghai University, Xining, China.
[Ti] Título:Perivascular epithelial cell tumor (PEComa) of the pancreas: A case report and review of literature.
[So] Source:Medicine (Baltimore);96(22):e7050, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Perivascular epithelial cell tumors (PEComas) of the pancreas are rare mesenchymal tumors and, to our knowledge, only 20 cases have been reported to date. PATIENT CONCERNS: We report a 43-year-old female who presented with upper abdominal pain for 1 year. She underwent an exploratory laparotomy at a local hospital, which failed to resect the tumor. Five months later, she came to the Chinese National Cancer Center for surgery. Preoperative imaging revealed an 11.5-cm-sized mass located in the head of the pancreas. At the microscopic level, the tumor was composed of epithelioid and spindle cells possessing clear to focally granular eosinophilic cytoplasm, which grew in a nested and alveolar pattern around blood vessels. The tumor cells showed immunoreactivity for human melanoma black 45 (HMB-45), but did not express epithelial or endocrine markers. DIAGNOSES: Pancreatic PEComa. INTERVENTIONS: Pancreaticoduodenectomy, partial hepatectomy, and vascular replacement were performed. After the surgery, the patient received 4 cycles of chemotherapy. OUTCOMES: The patient is free of recurrence and metastasis 1.5 years after surgical resection. LESSONS: PEComa should be recognized as a preoperative differential diagnosis of pancreatic tumors. For treatment, removal of the tumor should be attempted, and in the case of tumors with malignant tendencies, the addition of chemotherapy should be considered.
[Mh] Termos MeSH primário: Neoplasias Pancreáticas/diagnóstico
Neoplasias de Células Epitelioides Perivasculares/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Seres Humanos
Pâncreas/diagnóstico por imagem
Pâncreas/efeitos dos fármacos
Pâncreas/patologia
Pâncreas/cirurgia
Neoplasias Pancreáticas/tratamento farmacológico
Neoplasias Pancreáticas/cirurgia
Neoplasias de Células Epitelioides Perivasculares/tratamento farmacológico
Neoplasias de Células Epitelioides Perivasculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007050


  3 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28562547
[Au] Autor:Guan H; Zou Y; Lv Y; Wang C
[Ad] Endereço:Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, West City Area, Beijing, China.
[Ti] Título:Hepatic perivascular epithelioid cell tumor treated by transarterial embolization plus radiofrequency ablation: A case report and literature review.
[So] Source:Medicine (Baltimore);96(22):e6969, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Perivascular epithelioid cell tumors (PEComas) are extremely rare mesenchymal entities with potentially malignant properties; the liver cases are not encountered frequently. Owing to themalignant potential, these tumors are treated by surgical methods to ensure total resection. In the present report, a case of liver PEComa treated by embolization combined with radiofrequency ablation (RFA) has been described. CASE SUMMARY: A 40-year-old female was admitted for the detection of a liver mass during an annual physical examination. The patient did not have any liver disease background, enhanced computed tomography (CT), and magnetic resonance revealed a huge mass in the right lobe. Pathology gave the diagnosis of PEComa, for disagreement of open surgery, a combination of transarterial embolization (TAE) and RFA were applied for treatment and the outcomes were acceptable, the patient was under follow-up to observe the long-term effect. CONCLUSION: Interventional procedures such as TAE and RFA are feasible and effective for such lesions and may serve as an alternate when resection is not indicated. Prospective studies are warranted to verify the long-term outcomes.
[Mh] Termos MeSH primário: Ablação por Cateter
Embolização Terapêutica
Neoplasias Hepáticas/terapia
Neoplasias de Células Epitelioides Perivasculares/terapia
[Mh] Termos MeSH secundário: Adulto
Terapia Combinada
Feminino
Seres Humanos
Fígado/diagnóstico por imagem
Fígado/patologia
Neoplasias Hepáticas/diagnóstico por imagem
Neoplasias Hepáticas/patologia
Neoplasias de Células Epitelioides Perivasculares/diagnóstico por imagem
Neoplasias de Células Epitelioides Perivasculares/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006969


  4 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28547987
[Au] Autor:Danilewicz M; Strzelczyk JM; Wagrowska-Danilewicz M
[Ti] Título:Perirenal perivascular epithelioid cell tumor (PEComa) coexisting with other malignancies: a case report.
[So] Source:Pol J Pathol;68(1):92-95, 2017.
[Is] ISSN:1233-9687
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Perivascular epithelioid cell tumor (PEComa) is a very rare lesion and is described by the World Health Organization (WHO) as a mesenchymal tumor composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. In this report we describe PEComa with perirenal manifestation, which is exceedingly rare and to our best knowledge up to now worldwide only three cases have been described. Despite the reports that most PEComas are benign, this tumor met criteria for malignancy and coexisted with mucinous gallbladder cancer and nonresectable pancreatic head tumor. We concluded that despite the rarity of perirenal PEComas, in cases with an unusual epithelioid histological pattern the diagnosis of PEComa should also be taken into consideration on the basis of the immunohistochemical study.
[Mh] Termos MeSH primário: Adenocarcinoma Mucinoso/patologia
Neoplasias da Vesícula Biliar/patologia
Neoplasias Primárias Múltiplas/patologia
Neoplasias de Células Epitelioides Perivasculares/patologia
Neoplasias Retroperitoneais/patologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Feminino
Seres Humanos
Imuno-Histoquímica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170527
[St] Status:MEDLINE


  5 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28288506
[Au] Autor:Son HJ; Kang DW; Kim JH; Han HY; Lee MK
[Ad] Endereço:Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
[Ti] Título:Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures.
[So] Source:Clin Mol Hepatol;23(1):80-86, 2017 Mar.
[Is] ISSN:2287-285X
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Hepatic perivascular epithelioid cell tumors (PEComas) are very rare. We report a primary hepatic PEComa with a review of the literature. A 56-year-old women presented with a nodular mass detected during the management of chronic renal failure and chronic hepatitis C. Diagnostic imaging studies suggested a nodular hepatocellular carcinoma in segment 5 of the liver. The patient underwent partial hepatectomy. A brown-colored expansile mass measuring 3.2×3.0 cm was relatively demarcated from the surrounding liver parenchyma. The tumor was mainly composed of epithelioid cells that were arranged in a trabecular growth pattern. Adipose tissue and thick-walled blood vessels were minimally identified. A small amount of extramedullary hematopoiesis was observed in the sinusoidal spaces between tumor cells. Tumor cells were diffusely immunoreactive for human melanoma black 45 (HMB45) and Melan A, focally immunoreactive for smooth muscle actin, but not for hepatocyte specific antigen (HSA).
[Mh] Termos MeSH primário: Neoplasias Hepáticas/diagnóstico
Neoplasias de Células Epitelioides Perivasculares/diagnóstico
[Mh] Termos MeSH secundário: Actinas/metabolismo
Anticorpos Antivirais/sangue
Feminino
Hepatite C Crônica/complicações
Seres Humanos
Neoplasias Hepáticas/complicações
Neoplasias Hepáticas/patologia
Antígeno MART-1/metabolismo
Antígenos Específicos de Melanoma/metabolismo
Microscopia de Fluorescência
Neoplasias de Células Epitelioides Perivasculares/complicações
Neoplasias de Células Epitelioides Perivasculares/patologia
Tomografia Computadorizada por Raios X
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (ACTA2 protein, human); 0 (Actins); 0 (Antibodies, Viral); 0 (HMB-45 protein, human); 0 (MART-1 Antigen); 0 (MLANA protein, human); 0 (Melanoma-Specific Antigens)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.3350/cmh.2016.0034


  6 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28270196
[Au] Autor:Kwon BS; Suh DS; Lee NK; Song YJ; Choi KU; Kim KH
[Ad] Endereço:Department of Obstetrics and Gynecology, Pusan National University School of Medicine, 179, Gudeok-Ro, Seo-Gu, Busan, 49241, South Korea.
[Ti] Título:Two cases of perivascular epithelioid cell tumor of the uterus: clinical, radiological and pathological diagnostic challenge.
[So] Source:Eur J Med Res;22(1):7, 2017 Mar 07.
[Is] ISSN:2047-783X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Perivascular epithelioid cell tumor (PEComa) is a rare subtype of mesenchymal origin tumor composed of epithelioid cells which exhibits immunohistochemical co-expressions of melanocytic markers and smooth muscle markers. CASE PRESENTATION: In the first case, malignant uterine PEComa with vaginal and multiple lung metastasis was misdiagnosed preoperatively as uterine leiomyosarcoma despite a preoperative punch biopsy and immunohistochemical analysis of the metastatic vaginal mass. In the second case, synchronous uterine PEComa showing benign histology with lymph node involvement was incidentally detected after a staging operation for ovarian cancer. Definitive diagnosis of uterine PEComa was achieved only after hysterectomy despite preoperative assessment with pelvic magnetic resonance imaging and punch biopsy of metastatic lesion. CONCLUSION: The authors report two rare cases of uterine PEComa diagnosed postoperatively based on the morphologic and immunohistochemical features.
[Mh] Termos MeSH primário: Neoplasias de Células Epitelioides Perivasculares/diagnóstico por imagem
Neoplasias Uterinas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Seres Humanos
Meia-Idade
Neoplasias de Células Epitelioides Perivasculares/patologia
Neoplasias Uterinas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s40001-017-0248-y


  7 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28246920
[Au] Autor:O'Malley ME; Chawla TP; Lavelle LP; Cleary S; Fischer S
[Ad] Endereço:Joint Department of Medical Imaging, Princess Margaret Hospital, University of Toronto, 3-961, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. martin.o'malley@uhn.ca.
[Ti] Título:Primary perivascular epithelioid cell tumors of the liver: CT/MRI findings and clinical outcomes.
[So] Source:Abdom Radiol (NY);42(6):1705-1712, 2017 Jun.
[Is] ISSN:2366-0058
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of our study was to describe the CT and MRI features of primary PEComas of the liver and to document the associated clinical outcomes. METHODS: Retrospective study included 20 patients with primary hepatic perivascular epithelioid cell tumors (PEComa) with pathology and clinical outcomes for correlation. RESULTS: Study group included 20 patients: 16 women, 4 men; mean age 53 (range 35-77) years. Initial pathology diagnoses were classic angiomyolipoma (AML) (n = 11), epithelioid AML (n = 7), and PEComa not otherwise specified (n = 2). Mean tumor size was 5.1 (range 1.3-15.0) cm. CT/MRI features included well-defined margins 20/20 (100%), arterial enhancement 18/19 (95%), subcapsular location 17/20 (85%), heterogeneous 16/20 (80%), dysmorphic vessels 14/20 (70%), fat 13/20 (65%), hemorrhage 4/20 (20%), cystic components 4/20 (20%), and calcification 1/20 (5%). At the time of discovery, 18 patients were asymptomatic and their tumors were incidentally detected on imaging, and 2 patients were symptomatic. Ultimately, 18 tumors were benign and 2 developed metastases. CONCLUSIONS: On CT/MRI, most primary hepatic PEComas were well-defined, arterial enhancing, subcapsular, heterogeneous masses that often had dysmorphic vessels and contained fat. Most tumors were benign but complications included local symptoms, bleeding, and malignant change.
[Mh] Termos MeSH primário: Neoplasias Hepáticas/diagnóstico por imagem
Imagem por Ressonância Magnética
Neoplasias de Células Epitelioides Perivasculares/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Idoso
Meios de Contraste
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Achados Incidentais
Neoplasias Hepáticas/patologia
Masculino
Meia-Idade
Neoplasias de Células Epitelioides Perivasculares/patologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1007/s00261-017-1074-y


  8 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28234575
[Au] Autor:Acosta AM; Adley BP
[Ti] Título:Predicting the Behavior of Perivascular Epithelioid Cell Tumors of the Uterine Corpus.
[So] Source:Arch Pathol Lab Med;141(3):463-469, 2017 Mar.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perivascular epithelioid cell tumors (PEComas) are rare neoplasms that share phenotypic features with angiomyolipomas, clear cell sugar tumors, and lymphangioleiomyomatosis. They presumably represent the neoplastic counterpart of a yet-unidentified perivascular epithelioid cell that expresses smooth muscle and melanocytic immunomarkers. The uterus is the second most common site of origin for perivascular epithelioid cell tumors, after the retroperitoneum. Although most uterine perivascular epithelioid cell tumors are clinically benign and can be cured by a complete surgical excision, there is a subset characterized by both local and distant dissemination. Unfortunately, no single histopathologic or immunohistochemical parameter can accurately predict the clinical behavior of these tumors, which is why the 2012 World Health Organization classification of tumors of the female reproductive organs suggests the use of several criteria to predict the risk of aggressive clinical behavior. Here we review those perivascular epithelioid cell tumors of the uterine corpus with aggressive clinical behavior reported in the literature, and we discuss their most relevant clinical and histopathologic features.
[Mh] Termos MeSH primário: Neoplasias de Células Epitelioides Perivasculares/patologia
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0092-RS


  9 / 317 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28009610
[Au] Autor:Schoolmeester JK; Carlson J; Keeney GL; Fritchie KJ; Oliva E; Young RH; Nucci MR
[Ad] Endereço:*Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN †Department of Pathology, Karolinska Institutet and University Hospital, Stockholm, Sweden ‡Department of Pathology, Massachusetts General Hospital §Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA.
[Ti] Título:Alveolar Soft Part Sarcoma of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases With Emphasis on its Distinction From Morphologic Mimics.
[So] Source:Am J Surg Pathol;41(5):622-632, 2017 May.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alveolar soft part sarcoma (ASPS) is a morphologically distinctive neoplasm of unknown differentiation that bears a characteristic gene fusion involving ASPSCR1 and TFE3. ASPS can occur in the female genital tract, but is rare. Eleven cases with an initial diagnosis of ASPS at female genital tract sites were evaluated for their morphologic features and immunoprofile using a panel of antibodies (TFE3, HMB45, melan-A, smooth muscle actin, desmin, and h-Caldesmon). In addition, the presence of TFE3 rearrangement and subsequent ASPSCR1-TFE3 fusion were determined by fluorescence in situ hybridization. Ten tumors retained their classification as ASPS based on their morphologic appearance, immunohistochemical profile, and demonstration of ASPSCR1-TFE3 fusion. The remaining case was reclassified as conventional-type PEComa due to its pattern of HMB45, melan-A, and desmin positivity as well as absence of TFE3 rearrangement. Sites of the 10 ASPS were uterine corpus (3), cervix (2), uterus not further specified (2), vagina (2), and vulva (1). The age of the patients ranged from 15 to 68 years (mean 34 y, median 32 y). The tumors demonstrated a spectrum of morphologic features, but all had a consistent immunophenotype of strong TFE3 nuclear expression and lack of muscle (smooth muscle actin, desmin, h-Caldesmon) and melanocytic (melan-A, HMB45) markers, except focal positivity for HMB45 in 1. Follow-up was available for 4 patients ranging from 1 to 35 months (mean 15 mo, median 25 mo) and they were alive and had no evidence of recurrence or metastasis at last follow-up. Distinguishing ASPS from its morphologic mimics, particularly PEComa, is important due to increasingly efficacious targeted agents such as MET-selective and VEGF signaling inhibitors in the former and mTOR inhibition therapy in the latter.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Neoplasias dos Genitais Femininos/diagnóstico
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Técnicas de Diagnóstico Molecular
Neoplasias de Células Epitelioides Perivasculares/diagnóstico
Sarcoma Alveolar de Partes Moles/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/análise
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética
Biópsia
Boston
Diagnóstico Diferencial
Feminino
Fusão Gênica
Rearranjo Gênico
Neoplasias dos Genitais Femininos/química
Neoplasias dos Genitais Femininos/genética
Neoplasias dos Genitais Femininos/patologia
Seres Humanos
Meia-Idade
Proteínas de Fusão Oncogênicas/genética
Neoplasias de Células Epitelioides Perivasculares/química
Neoplasias de Células Epitelioides Perivasculares/genética
Neoplasias de Células Epitelioides Perivasculares/patologia
Valor Preditivo dos Testes
Prognóstico
Sarcoma Alveolar de Partes Moles/química
Sarcoma Alveolar de Partes Moles/genética
Sarcoma Alveolar de Partes Moles/patologia
Suécia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (ASPSCR1 protein, human); 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Biomarkers, Tumor); 0 (Oncogene Proteins, Fusion); 0 (TFE3 protein, human)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000796


  10 / 317 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28009605
[Au] Autor:McGregor SM; Alikhan MB; John RA; Kotler H; Bridge JA; Mujacic I; Kadri S; Segal J; Krausz T
[Ad] Endereço:*Department of Pathology, University of Chicago Medicine §Chicago Otolaryngology Associates, Chicago ‡Dermatopathology, Midwest Diagnostic Pathology, Park Ridge, IL †Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI ∥Department of Pathology/Microbiology, Pediatrics, and Orthopaedic Surgery, 983135 Nebraska Medical Center, University of Nebraska, Omaha, NE.
[Ti] Título:Melanotic PEComa of the Sinonasal Mucosa With NONO-TFE3 Fusion: An Elusive Mimic of Sinonasal Melanoma.
[So] Source:Am J Surg Pathol;41(5):717-722, 2017 May.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perivascular epithelioid cell neoplasms (PEComas) are a family of mesenchymal tumors with features of both smooth muscle and melanocytic differentiation, with or without true melanin pigment. The highly variable morphology of PEComas results in a broad differential diagnosis that is also dependent on anatomic site. A subset demonstrates rearrangements involving the TFE3 (Xp11) locus, which can be used in diagnostically difficult cases. Here we describe a case of a melanotic PEComa with NONO-TFE3 fusion occurring in the sinonasal mucosa, as demonstrated by both next-generation sequencing and molecular cytogenetic studies. This case is the first of its kind in the literature and only the second documented PEComa harboring a NONO-TFE3 rearrangement. In light of unequivocal molecular ancillary studies, this case illustrates that PEComa must enter the differential for pigmented lesions of the sinonasal mucosa, where malignant melanoma would be much more likely to occur.
[Mh] Termos MeSH primário: Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Fusão Gênica
Melaninas/análise
Melanoma/genética
Mucosa Nasal/química
Neoplasias Nasais/genética
Proteínas Associadas à Matriz Nuclear/genética
Fatores de Transcrição de Octâmero/genética
Neoplasias de Células Epitelioides Perivasculares/genética
Proteínas de Ligação a RNA/genética
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Feminino
Seres Humanos
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Melanoma/química
Melanoma/patologia
Meia-Idade
Mucosa Nasal/patologia
Neoplasias Nasais/química
Neoplasias Nasais/patologia
Neoplasias de Células Epitelioides Perivasculares/química
Neoplasias de Células Epitelioides Perivasculares/patologia
Valor Preditivo dos Testes
Análise de Sequência de DNA
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Biomarkers, Tumor); 0 (Melanins); 0 (NONO protein, human); 0 (Nuclear Matrix-Associated Proteins); 0 (Octamer Transcription Factors); 0 (RNA-Binding Proteins); 0 (TFE3 protein, human)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000778



página 1 de 32 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde