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[PMID]:29390446
[Au] Autor:Corrias G; Escalon JG; Tang L; Monti S; Saba L; Mannelli L
[Ad] Endereço:Department of Radiology, Memorial Sloan Kettering Cancer Center, York Avenue, New York, NY, USA.
[Ti] Título:Hepatic angiosarcomatous transformation of a mediastinal germinal cell tumor: A care case report.
[So] Source:Medicine (Baltimore);96(51):e9152, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare. PATIENT CONCERNS: We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness. DIAGNOSES: The x-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure. A CT-guided biopsy was performed, revealing a primary mediastinal nonseminomatous germ cell tumor (NSGCT), yolk sac histology, with areas of somatic transformation to malignant nerve sheath tumor. After surgery patient was followed-up with imaging. Two years later a CT scan showed a new hepatic hyper vascular lesion, confirmed by a subsequent magnetic resonance imaging (MRI) and positron emission tomography (PET) scan. A CT-guided biopsy revealed a hepatic metastatic transformation to angiosarcoma of the primitive NSGCT. INTERVENTIONS: The patient went on to received palliative chemotherapy. OUTCOMES: The patient is being followed-up regularly at the outpatient department. LESSONS: Because of the potential of metastatic sarcoma arising from germ cell tumors, these patients should undergo periodical follow-up, with periodical scans. PET\CT scan might have a role in the follow-up of these patients.
[Mh] Termos MeSH primário: Transformação Celular Neoplásica
Hemangiossarcoma/patologia
Neoplasias Hepáticas/patologia
Neoplasias do Mediastino/patologia
Neoplasias Embrionárias de Células Germinativas/patologia
[Mh] Termos MeSH secundário: Diagnóstico por Imagem
Hemangiossarcoma/diagnóstico por imagem
Seres Humanos
Neoplasias Hepáticas/diagnóstico por imagem
Masculino
Neoplasias do Mediastino/diagnóstico por imagem
Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009152


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[PMID]:29384853
[Au] Autor:Chen X; Li H; Wang F; Liu H
[Ad] Endereço:Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China.
[Ti] Título:Early detection and integral resection are keys to extend survival in patients suffered from primary angiosarcoma of the spleen: A care-compliant case report and literature review.
[So] Source:Medicine (Baltimore);97(5):e9718, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary angiosarcoma of the spleen (PAS) is a very rare malignant neoplasm that originates from endothelial cells of the splenic blood vessels. Without typical clinical presentations and specific radiological features, PAS is very difficult to be early identified and 1-year mortality is extremely high. Late detection and spleen rupture are considered as the most important risk factors for early metastasis. PATIENT CONCERNS: Without any obvious symptom, a 35-year-old woman was admitted with splenic neoplasm that was accidentally discovered through a routine physical examination. DIAGNOSES: The patient was first diagnosed as lymphoma by laboratory tests and imaging studies, but changed to PAS by histological examinations after the surgery. INTERVENTIONS: After careful preoperational assessment, a laparoscopic-assisted splenectomy was scrutinously performed and the entire spleen was removed without any rupture. OUTCOMES: The postoperative followed-up was uneventful until 3 years later, when she sought medical attention due to persisting back pain. Bone metastasis was consequently identified and the symptom was quickly alleviated after radiation therapy. However, intra-abdominal metastases leading to intestinal obstruction occurred 4.5 years after surgery. Following short palliative treatment, the patient passed away 4 years and 9 months after the operation due to multiple organ failure. LESSONS: PAS is an uncommon and aggressive splenic disease. Once suspected, PAS require prompt and precise surgical procedures to remove the tumor origin. Laparoscopic-assisted splenectomy was technically feasible and therapeutically harmless for PAS treatment compared with open surgery as long as the spleen was removed intact. However, more evaluation of this option will be needed due to limited experience by now. Early discovery, precautious plan, meticulous operation, close follow-up, and comprehensive treatment may significantly prolong the living period of this fatal disease.
[Mh] Termos MeSH primário: Hemangiossarcoma/diagnóstico
Hemangiossarcoma/cirurgia
Neoplasias Esplênicas/diagnóstico
Neoplasias Esplênicas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Diagnóstico Precoce
Evolução Fatal
Feminino
Hemangiossarcoma/patologia
Hemangiossarcoma/radioterapia
Seres Humanos
Achados Incidentais
Linfoma/diagnóstico
Neoplasias Esplênicas/patologia
Neoplasias Esplênicas/radioterapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009718


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[PMID]:29390474
[Au] Autor:Liu B; Sun W; Wang K
[Ad] Endereço:Department of Parenteral and Enteral Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
[Ti] Título:A successful insertion of PICC in patient with cardiac angiosarcoma and neoplasty of right atrium and pacemaker: A case report.
[So] Source:Medicine (Baltimore);96(51):e9225, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Primary cardiac angiosarcoma is a rare tumor and the common treatment is surgical resection followed by chemotherapy. Peripherally inserted central venous catheters (PICCs) are widely used in cancer patients and ultrasound-guided PICC insertion could improve success rate especially in patient with abnormal anatomy structure. Reports about PICCs being placed in patient who had suffered from the cardiac angiosarcoma and neoplasty of right atrium with an ipsilateral cardiac permanent pacemaker are rarely.After patient's informed consent, we present a case of the successful insertion of PICC into a patient with the ipsilateral cardiac disease with a pacemaker placement, which has not been previously reported. CONCLUSIONS: This report highlights PICC could be used in patient with cardiac disease with a pacemaker placement for chemotherapy.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Cateterismo Periférico/métodos
Cateteres Venosos Centrais
Neoplasias Cardíacas/terapia
Hemangiossarcoma/terapia
Marca-Passo Artificial
[Mh] Termos MeSH secundário: Terapia Combinada
Feminino
Seguimentos
Átrios do Coração/efeitos dos fármacos
Neoplasias Cardíacas/diagnóstico
Hemangiossarcoma/diagnóstico
Seres Humanos
Infusões Intralesionais
Meia-Idade
Doenças Raras
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009225


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[PMID]:29176321
[Au] Autor:Li R; Ouyang ZY; Xiao JB; He J; Zhou YW; Zhang GY; Li Q; Gu H; Leng AM; Liu T
[Ad] Endereço:Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha, China.
[Ti] Título:Clinical Characteristics and Prognostic Factors of Small Intestine Angiosarcoma: a Retrospective Clinical Analysis of 66 Cases.
[So] Source:Cell Physiol Biochem;44(2):817-827, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. METHODS: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data. RESULTS: There were 66 patients diagnosed with small intestine angiosarcoma. The onset age ranged from 24-92 years old. There were 24 patients diagnosed before the year 2000, and 42 patients were diagnosed after 2000. The data indicated that 49 cases were diagnosed as primary disease, and the remaining 15 cases were secondary disease. The main clinical symptoms were nonspecific and included gastrointestinal (GI) bleeding and abdominal pain. Additionally, we found multi-center foci were one of the characteristics of this disease. Radiation-induced small intestine angiosarcoma (RSIA) is a special type of disease with a similar prognosis. This type was more frequent in females and decreased after the year 2000. We also found that GI bleeding was less common in RSIA cases. The log-rank test results revealed that old-age, poor differentiation, and GI bleeding were associated with worse prognosis. Surgical treatment showed a trend toward a prolonged survival time. However, the result was not statistically significant. Our results show treatment with adjuvant therapy improved prognosis. The multivariate Cox analysis demonstrated adjuvant therapy was an independent indicator of a favorable outcome in small intestine angiosarcoma patients. CONCLUSION: Pay attention to the unexplained gastrointestinal bleeding could lead to a faster diagnosis and control of small intestine angiosarcoma. Furthermore, treatments including adjuvant therapy can effectively improve the prognosis.
[Mh] Termos MeSH primário: Hemangiossarcoma/diagnóstico
Neoplasias Intestinais/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Quimioterapia Adjuvante
Bases de Dados Factuais
Feminino
Hemorragia Gastrointestinal
Hemangiossarcoma/mortalidade
Hemangiossarcoma/terapia
Seres Humanos
Neoplasias Intestinais/mortalidade
Neoplasias Intestinais/terapia
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Prognóstico
Modelos de Riscos Proporcionais
Estudos Retrospectivos
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1159/000485345


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[PMID]:29249796
[Au] Autor:Farran Y; Padilla O; Chambers K; Philipovskiy A; Nahleh Z
[Ad] Endereço:Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA.
[Ti] Título:Atypical Presentation of Radiation-Associated Breast Angiosarcoma: A Case Report and Review of Literature.
[So] Source:Am J Case Rep;18:1347-1350, 2017 Dec 18.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Radiation-associated breast angiosarcoma is a rare clinical entity that is thought to be increasing in incidence. CASE REPORT Here we present the case of a 67-year-old female with a history of left breast invasive ductal carcinoma who received breast conserving surgery and radiation therapy eight years ago. She then presented with a painless mild skin discoloration of the left breast that had been present for over one year. Mammograms and ultrasounds were normal. A punch biopsy and a subsequent excisional biopsy revealed the diagnosis of angiosarcoma. The patient was treated with mastectomy and had no subsequent recurrences. CONCLUSIONS The long-term clinical surveillance for all patients who receive breast conservation surgery is recommended and a high degree of suspicion should be exercised in view of potential atypical presentations of this disease.
[Mh] Termos MeSH primário: Neoplasias da Mama/etiologia
Hemangiossarcoma/etiologia
Neoplasias Induzidas por Radiação
Transtornos da Pigmentação/etiologia
Radioterapia Adjuvante/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Neoplasias da Mama/patologia
Neoplasias da Mama/radioterapia
Carcinoma Ductal de Mama/radioterapia
Feminino
Hemangiossarcoma/patologia
Seres Humanos
Transtornos da Pigmentação/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29190660
[Au] Autor:Wang G; Wu M; Maloneyhuss MA; Wojcik J; Durham AC; Mason NJ; Roth DB
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
[Ti] Título:Actionable mutations in canine hemangiosarcoma.
[So] Source:PLoS One;12(11):e0188667, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Angiosarcomas (AS) are rare in humans, but they are a deadly subtype of soft tissue sarcoma. Discovery sequencing in AS, especially the visceral form, is hampered by the rarity of cases. Most diagnostic material exists as archival formalin fixed, paraffin embedded tissue which serves as a poor source of high quality DNA for genome-wide sequencing. We approached this problem through comparative genomics. We hypothesized that exome sequencing a histologically similar tumor, hemangiosarcoma (HSA), that occurs in approximately 50,000 dogs per year, may lead to the identification of potential oncogenic drivers and druggable targets that could also occur in angiosarcoma. METHODS: Splenic hemangiosarcomas are common in dogs, which allowed us to collect a cohort of archived matched tumor and normal tissue samples suitable for whole exome sequencing. Mapping of the reads to the latest canine reference genome (Canfam3) demonstrated that >99% of the targeted exomal regions were covered, with >80% at 20X coverage and >90% at 10X coverage. RESULTS AND CONCLUSIONS: Sequence analysis of 20 samples identified somatic mutations in PIK3CA, TP53, PTEN, and PLCG1, all of which correspond to well-known tumor drivers in human cancer, in more than half of the cases. In one case, we identified a mutation in PLCG1 identical to a mutation observed previously in this gene in human visceral AS. Activating PIK3CA mutations present novel therapeutic targets, and clinical trials of targeted inhibitors are underway in human cancers. Our results lay a foundation for similar clinical trials in canine HSA, enabling a precision medicine approach to this disease.
[Mh] Termos MeSH primário: Doenças do Cão/genética
Hemangiossarcoma/veterinária
Mutação
[Mh] Termos MeSH secundário: Animais
Cães
Hemangiossarcoma/genética
Proteína Supressora de Tumor p53/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188667


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[PMID]:29245237
[Au] Autor:Gao L; Xu W; Li T; Luo H; Gai S; Xing R; Chen G; Chen Y
[Ad] Endereço:aDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, HangzhoubDepartment of Neurosurgery, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, YiwucDepartment of Pathology, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
[Ti] Título:A rare case of angiosarcoma with skull masses and erythropenia and thrombocytopenia: A case report and review of literature.
[So] Source:Medicine (Baltimore);96(49):e8787, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary splenic angiosarcoma (PSA) is a rare, fatal neoplasm originating from sinusoidal vascular endothelial cells, and usually metastasizes and almost always has a poor prognosis. Surgical excision is the main treatment of this highly malignant disease. PATIENT CONCERNS: We reported a special case of a 68-year-old female who had a 6-month history of scalp masses. DIAGNOSIS: The patient was found to have 2 skull masses on computed tomography (CT). Laboratory findings revealed erythropenia and thrombocytopenia. Enhanced abdomen magnetic resonance imaging (MRI) showed multiple masses in liver and spleen. The pathological result of the skull masses was revealed to be metastatic angiosarcoma. INTERVENTIONS: The patient underwent surgical excision of skull masses, and no subsequent radiotherapy or chemotherapy was done. OUTCOMES: The patient died due to dyscrasia at August 12, 2015, with a survival of nearly 1 month. LESSONS: We highlight the importance for clinicians to be aware of this rare neoplasm, and to consider it in the differential diagnosis when encountering a skull mass. Early confirmation and treatment may improve the prognosis.
[Mh] Termos MeSH primário: Anemia/etiologia
Hemangiossarcoma/secundário
Neoplasias Cranianas/secundário
Neoplasias Esplênicas/patologia
Trombocitopenia/etiologia
[Mh] Termos MeSH secundário: Idoso
Anemia/sangue
Contagem de Eritrócitos
Eritrócitos
Evolução Fatal
Feminino
Hemangiossarcoma/sangue
Seres Humanos
Neoplasias Hepáticas/sangue
Neoplasias Hepáticas/secundário
Neoplasias Cranianas/sangue
Neoplasias Esplênicas/complicações
Trombocitopenia/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008787


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[PMID]:27776729
[Au] Autor:Dyer K; Varga-Szemes A; Spruill L; Costello P; Schoepf UJ; Suranyi P
[Ad] Endereço:Department of Radiology, Radiological Science and Medicine, Medical University of South Carolina, Charleston, SC.
[Ti] Título:Right Atrial Angiosarcoma Diagnosed by Cardiac Magnetic Resonance Imaging.
[So] Source:Am J Med Sci;352(4):435-437, 2016 Oct.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Átrios do Coração/diagnóstico por imagem
Neoplasias Cardíacas/diagnóstico por imagem
Hemangiossarcoma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Átrios do Coração/patologia
Neoplasias Cardíacas/patologia
Hemangiossarcoma/patologia
Hematemese
Hemoptise
Seres Humanos
Imagem por Ressonância Magnética
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29049172
[Au] Autor:Zhang R; Li L; Li X; Chu Y; Wu J; Gao Y
[Ad] Endereço:aDepartment of Oncology bDepartment of Thoracic Surgery cDepartment of Pathology, the 306th Hospital of PLA, Beijing, China.
[Ti] Título:Primary cardiac angiosarcoma: A case report.
[So] Source:Medicine (Baltimore);96(42):e7352, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Primary cardiac angiosarcoma is rare, but it is the most aggressive type of cardiac malignant tumor. When disease is confirmed it is often late in its stage resulting in a poor prognosis. CASE PRESENTATION: We reported a 52-year-old woman who complained of dyspnea for 2 months and dry cough for 10 days. Computed tomography (CT), F-fluorodeoxyglucose (F-FDG), positron emission tomography-computed tomography (PET-CT), and transthoracic echocardiography showed a space-occupying lesion 7 cm × 5 cm × 5 cm in the right atrium. Malignant cells can be seen in pericardial fluid by pericardiocentesis in local hospital, but not be diagnosed definitely. We conducted CT-guided biopsy of the tumor and observed the necrotic tissues. An exploratory thoracotomy was performed and histological examination confirmed angiosarcoma. Unable to be surgical excision due to infiltrating widely, the patients received chemotherapy with docetaxel for 2 cycles and the disease was progressive. Antiangiogenesis-targeted therapy was combined with chemotherapy for 3 months. Unfortunately, the tumor was still in progress. She died of respiratory failure, survived for 10 months. CONCLUSION: It is difficult to diagnose the primary cardiac angiosarcoma in early stage. Chemotherapy and target therapy are very limited in this case. Surgery remains the preferred treatment for patients with primary cardiac angiosarcoma. More efforts should be carried out on the effective diagnosis and multimodality treatment for this malignant disease.
[Mh] Termos MeSH primário: Neoplasias Cardíacas/diagnóstico por imagem
Hemangiossarcoma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Tosse/etiologia
Dispneia/etiologia
Ecocardiografia/métodos
Evolução Fatal
Feminino
Fluordesoxiglucose F18
Átrios do Coração/patologia
Neoplasias Cardíacas/complicações
Neoplasias Cardíacas/patologia
Hemangiossarcoma/complicações
Hemangiossarcoma/patologia
Seres Humanos
Meia-Idade
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007352


  10 / 6149 MEDLINE  
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[PMID]:28918185
[Au] Autor:Huis In 't Veld EA; Grünhagen DJ; Verhoef C; Smith HG; van Akkooi ACJ; Jones R; van Coevorden F; Hayes AJ; van Houdt WJ
[Ad] Endereço:Sarcoma Unit, Department of Surgery, Royal Marsden Hospital, London, United Kingdom; Department of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
[Ti] Título:Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study.
[So] Source:Eur J Cancer;85:114-121, 2017 Nov.
[Is] ISSN:1879-0852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Angiosarcomas are rare and aggressive soft-tissue sarcomas. The only potential curative treatment is complete surgical excision. This study reports the outcome of isolated limb perfusion (ILP) with high-dose melphalan and tumour necrosis factor α for locally advanced angiosarcoma. MATERIAL AND METHODS: All patients who underwent an ILP for angiosarcomas between 1991 and 2016 in three tertiary referral centres were identified from prospectively maintained databases. RESULTS: A total of 39 patients were included, with a median follow-up of 18 months (interquartile range 6.1-60.8). Of these patients, 23 (58.9%) patients had a complete response (CR) after ILP, 10 (25.6%) had a partial response, 4 (10.3%) had stable disease and 2 (5.1%) patients had progressive disease immediately after ILP. A total of 22 patients developed local progression (56.4%), whereas nine (23.1%) developed distant metastases. The patients with CR had a significantly prolonged median local progression-free survival (PFS) (15.4 versus 7.3 months, p = 0.015) when compared with non-CR patients, and a trend towards better median overall survival (81.2 versus 14.5 months, p = 0.054). Six patients underwent multiple ILPs, whereby the CR rate of the first, second and third ILPs were 60%, 80% and 67%, respectively. Thirteen (33.3%) patients needed further surgical intervention, consisting of resection in eight patients (20.5%) and amputation in five patients (12.8%). CONCLUSION: ILP is an effective treatment option for patients with locally advanced angiosarcoma in the extremities, resulting in a high number of CRs, a high limb salvage rate and prolonged local PFS.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Quimioterapia do Câncer por Perfusão Regional/métodos
Extremidades/irrigação sanguínea
Hemangiossarcoma/irrigação sanguínea
Hemangiossarcoma/terapia
Melfalan/administração & dosagem
Neoplasias de Tecidos Moles/irrigação sanguínea
Neoplasias de Tecidos Moles/terapia
Fator de Necrose Tumoral alfa/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Amputação
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Quimioterapia do Câncer por Perfusão Regional/efeitos adversos
Quimioterapia do Câncer por Perfusão Regional/mortalidade
Bases de Dados Factuais
Progressão da Doença
Intervalo Livre de Doença
Extremidades/patologia
Feminino
Hemangiossarcoma/mortalidade
Hemangiossarcoma/secundário
Seres Humanos
Estimativa de Kaplan-Meier
Salvamento de Membro
Londres
Masculino
Melfalan/efeitos adversos
Meia-Idade
Países Baixos
Modelos de Riscos Proporcionais
Fluxo Sanguíneo Regional
Retratamento
Estudos Retrospectivos
Fatores de Risco
Neoplasias de Tecidos Moles/mortalidade
Neoplasias de Tecidos Moles/patologia
Fatores de Tempo
Resultado do Tratamento
Fator de Necrose Tumoral alfa/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha); Q41OR9510P (Melphalan)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE



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