Base de dados : MEDLINE
Pesquisa : C04.557.450.795.650 [Categoria DeCS]
Referências encontradas : 1544 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 155 ir para página                         

  1 / 1544 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29245318
[Au] Autor:Wang Q; Su J; Lei Y
[Ad] Endereço:aDepartment of Breast Surgery, Peking University International HospitalbDepartment of Pathology, Peking University Health Science CentercDepartment of General Surgery, Peking University Third Hospital, Beijing, China.
[Ti] Título:Recurrent malignant phyllodes tumor of the breast: A case report.
[So] Source:Medicine (Baltimore);96(49):e9069, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Phyllodes tumor is a rare fibro epithelial neoplasm of the breast. They resemble fibroadenomas clinically and can be mistakenly ignored sometimes. PATIENT CONCERNS: We report the case of a young woman with her first presentation to hospital due to a hypoglycemia and she underwent 2 excised fibroadenomas in the same breast before diagnosed of malignant phyllodes tumor. She was complaining about 2 masses presented in her right breast 4 months after mastectomy. DIAGNOSES: Recurrent phyllodes tumor of the breast. INTERVENTIONS: We conducted an immediate autologous myocutaneous flap transplantation after a wide-excision. Postoperative radiotherapy was recommended. OUTCOMES: She was in good general condition without tumor relapses during 8 months of follow-up. LESSONS: Recurrent fibroadenomas in the same breast, especially those of large size with rapid growth rate, suggesting a high transformation possibility from fibroadenoma to phyllodes tumor. We recommend an extended tumor resection and immediate or delayed reconstruction of the breast for the recurrent phyllodes tumor with separately multiple relapses.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Neoplasias da Mama/cirurgia
Recidiva Local de Neoplasia/patologia
Recidiva Local de Neoplasia/cirurgia
Tumor Filoide/patologia
Tumor Filoide/cirurgia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Mastectomia
Retalhos Cirúrgicos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009069


  2 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
[PMID]:29189868
[Au] Autor:Nieto-Coronel T; Salazar-Campos JE; León DC; Díaz-Molina R; Vázquez-Romo R; Bargalló-Rocha E
[Ad] Endereço:Servicio de Tumores Mamarios, Instituto Nacional de Cancerología, Ciudad de México, México.
[Ti] Título:[Breast osteosarcoma originating in a phyllodes tumor. Report of one case].
[Ti] Título:Tumor Phyllodes con transformación a osteosarcoma..
[So] Source:Rev Med Chil;145(8):1076-1082, 2017 Aug.
[Is] ISSN:0717-6163
[Cp] País de publicação:Chile
[La] Idioma:spa
[Ab] Resumo:Phyllodes tumors account for less than 1% of tumors of the mammary gland, have both epithelial and stromal components and are classified as benign, borderline and malignant. The malignant tumors are highly heterogeneous: they can differentiate to liposarcomas, fibrosarcomas, rhabdomyosarcomas, chondrosarcomas or osteosarcomas. The differentiation to osteosarcoma is extremely rare, constitutes 1.3% of cases and is very aggressive. The standard treatment of these tumors is surgical. The role of radiotherapy and chemotherapy is not clear. However, in patients in whom wide surgical margins are not achieved, adjuvant radiotherapy can be of help. We report a 63 years old female with a right breast osteosarcoma with an osteoclastic component, originating in a phyllodes tumor. The tumor was excised surgically and afterwards she was treated with 10 sessions of 50 Gy of radiotherapy in 25 fractions. She has remained free of disease for the last 10 months.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Neoplasias Primárias Múltiplas/patologia
Osteossarcoma/patologia
Tumor Filoide/patologia
[Mh] Termos MeSH secundário: Biópsia
Neoplasias da Mama/radioterapia
Neoplasias da Mama/cirurgia
Feminino
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Neoplasias Primárias Múltiplas/radioterapia
Neoplasias Primárias Múltiplas/cirurgia
Osteossarcoma/radioterapia
Osteossarcoma/cirurgia
Tumor Filoide/radioterapia
Tumor Filoide/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  3 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28688536
[Au] Autor:Krings G; Bean GR; Chen YY
[Ad] Endereço:Department of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA. Electronic address: gregor.krings@ucsf.edu.
[Ti] Título:Fibroepithelial lesions; The WHO spectrum.
[So] Source:Semin Diagn Pathol;34(5):438-452, 2017 Sep.
[Is] ISSN:0740-2570
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fibroepithelial lesions of the breast comprise a morphologically and biologically heterogeneous group of biphasic tumors with epithelial and stromal components that demonstrate widely variable clinical behavior. Fibroadenomas are common benign tumors with a number of histologic variants, most of which pose no diagnostic challenge. Cellular and juvenile fibroadenomas can have overlapping features with phyllodes tumors and should be recognized. Phyllodes tumors constitute a spectrum of lesions with varying clinical behavior and are graded as benign, borderline or malignant based on a set of histologic features according to recommendations by the World Health Organization (WHO). Recent developments have significantly expanded our understanding of the pathogenesis of fibroepithelial lesions, highlighting fibroadenomas as true neoplasms and underscoring a commonality with phyllodes tumors in the form of recurrent MED12 exon 2 mutations. In addition, sequencing studies have elucidated pathways associated with phyllodes tumor progression. Accurate diagnosis and grading of phyllodes tumors are important for patient management and prognosis, as grade broadly correlates with increasing local recurrence risk, and essentially only malignant tumors metastasize. However, classification of fibroepithelial lesions in many cases remains challenging on both core biopsy and excision specimens. A commonly encountered problem at the benign end of the spectrum is the distinction of benign phyllodes tumor from cellular fibroadenoma, which is largely due to the subjective nature of histologic features used in diagnosis and histologic overlap between lesions. Grading is further complicated by the requirement to integrate multiple subjective and ill-defined parameters. On the opposite end of the histologic spectrum, malignant phyllodes tumors must be distinguished from more common metaplastic carcinomas and from primary or metastatic sarcomas, which can be especially difficult in core biopsies. Immunohistochemistry can be useful in the differential diagnosis but should be interpreted with attention to caveats. This review provides an overview and update on the spectrum of fibroepithelial lesions, with special emphasis on common problems and practical issues in diagnosis.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Neoplasias Fibroepiteliais/patologia
Tumor Filoide/patologia
Organização Mundial da Saúde
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Neoplasias da Mama/química
Neoplasias da Mama/genética
Diagnóstico Diferencial
Feminino
Fibroadenoma/química
Fibroadenoma/genética
Fibroadenoma/patologia
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Técnicas de Diagnóstico Molecular
Gradação de Tumores
Neoplasias Fibroepiteliais/química
Neoplasias Fibroepiteliais/genética
Fenótipo
Tumor Filoide/química
Tumor Filoide/genética
Valor Preditivo dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


  4 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28512246
[Au] Autor:Nie Y; Chen J; Huang D; Yao Y; Chen J; Ding L; Zeng J; Su S; Chao X; Su F; Yao H; Hu H; Song E
[Ad] Endereço:Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P.R. China.
[Ti] Título:Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation.
[So] Source:Cancer Res;77(13):3605-3618, 2017 Jul 01.
[Is] ISSN:1538-7445
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Myofibroblast differentiation plays an important role in the malignant progression of phyllodes tumor, a fast-growing neoplasm derived from periductal stromal cells of the breast. Macrophages are frequently found in close proximity with myofibroblasts, but it is uncertain whether they are involved in the myofibroblast differentiation during phyllodes tumor progression. Here we show that increased density of tumor-associated macrophage (TAM) correlates with malignant progression of phyllodes tumor. We found that TAMs stimulated myofibroblast differentiation and promoted the proliferation and invasion of phyllodes tumor cells. Furthermore, we found that levels of the chemokine CCL18 in TAM was an independent prognostic factor of phyllodes tumor. Mechanistic investigations showed that CCL18 promoted expression of α-smooth muscle actin, a hallmark of myofibroblast, along with the proliferation and invasion of phyllodes tumor cells, and that CCL18-driven myofibroblast differentiation was mediated by an NF-κB/miR-21/PTEN/AKT signaling axis. In murine xenograft models of human phyllodes tumor, CCL18 accelerated tumor growth, induced myofibroblast differentiation, and promoted metastasis. Taken together, our findings indicated that TAM drives myofibroblast differentiation and malignant progression of phyllodes tumor through a CCL18-driven signaling cascade amenable to antibody disruption. .
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Macrófagos/patologia
Miofibroblastos/patologia
Tumor Filoide/patologia
[Mh] Termos MeSH secundário: Animais
Neoplasias da Mama/genética
Neoplasias da Mama/imunologia
Diferenciação Celular/imunologia
Linhagem Celular Tumoral
Progressão da Doença
Feminino
Xenoenxertos
Seres Humanos
Macrófagos/imunologia
Macrófagos/metabolismo
Camundongos
Camundongos Nus
Miofibroblastos/imunologia
Miofibroblastos/metabolismo
Tumor Filoide/imunologia
Tumor Filoide/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE
[do] DOI:10.1158/0008-5472.CAN-16-2709


  5 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28299887
[Au] Autor:Ross DS; Giri DD; Akram MM; Catalano JP; Olcese C; Van Zee KJ; Brogi E
[Ad] Endereço:Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
[Ti] Título:Fibroepithelial Lesions in the Breast of Adolescent Females: A Clinicopathological Study of 54 Cases.
[So] Source:Breast J;23(2):182-192, 2017 Mar.
[Is] ISSN:1524-4741
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fibroepithelial lesions (FELs) are the most frequent breast tumors in adolescent females. The pubertal hormonal surge could impact the growth and microscopic appearance of FELs in this age group. In this study, we evaluate the morphology and clinical behavior of FELs in adolescents. We searched the 1992-2012 pathology data base for FELs in females 18 years old or younger (F ≤18 years). Seven FELs from 1975 to 1983 were also included. Three pathologists reviewed all available material. Patient (pt) characteristics and follow-up information were obtained from electronic medical records. Forty-eight F ≤18 years had 54 FELs with available slides. Thirty (67%) pts were Caucasian, 12 (27%) African-American, two (4%) Hispanic, one (2%) Asian; three were of unknown race/ethnicity. Median age at diagnosis was 16 years. Median age at menarche was 12 years; most (96%) FELs occurred after menarche (median interval 48 months). All patients underwent lumpectomy; one required subsequent mastectomy. The FELs were 34 fibroadenomas (FAs) (11 usual, 23 juvenile), and 20 phyllodes tumors (PTs) (16 benign, one borderline and three malignant). Eight (35%) juvenile FAs showed slight intratumoral heterogeneity. The mean mitotic rate was 1.3 mitoses/10 high-power fields (HPFs) (range, 0-6) in usual FAs, 1.8/10 HPFs in juvenile FAs, 3.1/10 HPFs in benign PTs, 10/10 HPFs in the borderline PT and 17/10 HPFs in malignant PTs. The mean follow-up for 29 pts with 33 FELs was 44 months. Two (10%) PTs recurred locally (a benign PT at 18 months, and a borderline PT at 11 months). Both recurrent PTs had microscopic margins <1 mm. Mitotic activity in FAs from adolescents can be substantial and this finding should be interpreted cautiously. Awareness of the morphologic features of FELs in adolescents is important to avoid overdiagnosis of PTs, which can lead to additional unnecessary and potentially disfiguring surgery.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
[Mh] Termos MeSH secundário: Adolescente
Neoplasias da Mama/cirurgia
Feminino
Fibroadenoma/patologia
Fibroadenoma/cirurgia
Seguimentos
Seres Humanos
Margens de Excisão
Menarca
Recidiva Local de Neoplasia/patologia
Tumor Filoide/patologia
Tumor Filoide/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1111/tbj.12706


  6 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28295007
[Au] Autor:Konstantinova AM; Belousova IE; Kacerovska D; Michal M; Shelekhova KV; Kazakov DV
[Ad] Endereço:Pathology Department, Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care, Saint Petersburg, Russia; Pathology Department, Medical Faculty, Saint Petersburg State University, Saint Petersburg, Russia; Department of Pathology, Saint Petersburg Sociomedical In
[Ti] Título:[Anogenital mammary-like glands and related lesions. Part 1. Benign tumors and tumor-like disorders].
[Ti] Título:Anogenital'nye mammaropodobnye zhelezy i svyazannye s nimi zabolevaniya. Chast' 1. Dobrokachestvennye opukholi i opukholepodobnye protsessy anogenital'nykh zhelez..
[So] Source:Arkh Patol;79(1):43-51, 2017.
[Is] ISSN:0004-1955
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Anogenital mammary-like glands represent a normal anatomic constituent of the anogenital area and may give rise to many benign and malignant tumors that morphologically mimic similar breast diseases. The literature review is complemented by a description of 286 cases of benign tumors and tumor-like processes in the mammary-like glands. The paper presents the clinical and morphological characteristics of papillary hidradenoma, fibroadenoma, benign phyllodes tumor, lactating adenoma, sclerosing adenosis, pseudoangiomatous stromal hyperplasia, etc.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Neoplasias da Mama/patologia
Mama/patologia
Neoplasias/patologia
[Mh] Termos MeSH secundário: Acrospiroma/diagnóstico
Adenoma/diagnóstico
Adenoma/patologia
Neoplasias da Mama/classificação
Neoplasias da Mama/diagnóstico
Feminino
Fibroadenoma/diagnóstico
Fibroadenoma/patologia
Seres Humanos
Lactação/fisiologia
Neoplasias/classificação
Neoplasias/diagnóstico
Tumor Filoide/diagnóstico
Tumor Filoide/patologia
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.17116/patol201779143-51


  7 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28267544
[Au] Autor:Marcon M; Frauenfelder T; Becker AS; Dedes KJ; Boss A
[Ad] Endereço:Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland. Electronic address: magda.marcon@usz.ch.
[Ti] Título:First ultrasound diagnosis of BI-RADS 3 lesions in young patients: Can 6-months follow-up be sufficient to assess stability?
[So] Source:Eur J Radiol;89:226-233, 2017 Apr.
[Is] ISSN:1872-7727
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the outcome of repeated short-term follow-up with ultrasound in no high-risk young patients with a BI-RADS3 lesion at first examination. METHODS: In this IRB-approved study 492 women, aged 18-34 years (mean±standard deviation, 28±4.5years) with first breast ultrasound examination in 2012-2014 were retrospectively evaluated. Inclusion criteria were: at least one BI-RADS3 lesion and (a) biopsy/surgical excision or (b) follow-up of at least 18 months (including a 6-month follow-up). BI-RADS category assigned during follow-up and pathologic findings in cases undergoing biopsy/surgical excision were collected. At the 6- and 18-month follow-up the recommended biopsy rates (RBR) and the corresponding positive predictive value (PPV) were calculated. RESULTS: In 97 patients, 151 BI-RADS3 lesions were identified. Biopsy/surgical excision was initially performed in 25/151 (16.5%) lesions. After 6-month, category was downgraded to BI-RADS1/2 in 23/126 (15.3%) and upgraded to BI-RADS4 in 9/126 lesions (7.1%). Pathological diagnosis of these lesions was fibroadenoma in 5 and benign phyllodes tumor in 4 cases (RBR 7%, PPV 44.4%). After 18-month one lesion was classified BI-RADS4 and pathological diagnosis was fibroadenoma (RBR 1.1%, PPV 0%). CONCLUSIONS: Our preliminary data show that follow-up imaging performed after 18 months from a first BI-RADS3 diagnosis does not affect clinical treatment and 6-month follow-up may be sufficient to assess the stability of probably benign lesions.
[Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem
Fibroadenoma/diagnóstico por imagem
Tumor Filoide/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Biópsia
Neoplasias da Mama/patologia
Feminino
Seguimentos
Seres Humanos
Tumor Filoide/patologia
Exame Físico
Estudos Retrospectivos
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


  8 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28223032
[Au] Autor:El Amine Elhadj O; Nasri M; Thabet S; Ben Hassouna J; Goucha A; Rahal K; Elmay A; Gamoudi A
[Ad] Endereço:Service d'immuno-histocytologie, institut Salah-Azaiez, boulevard 9-avril, 1006 Bab-Saadoun, Tunis, Tunisie. Electronic address: olfaelamine@yahoo.fr.
[Ti] Título:[Primary breast sarcomas: About 30 cases treated at Salah-Azaiez institute in Tunisia].
[Ti] Título:Sarcomes mammaires primitifs : à propos de 30 cas traités à l'institut Salah-Azaiez de Tunis..
[So] Source:Cancer Radiother;21(1):45-50, 2017 Feb.
[Is] ISSN:1769-6658
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:PURPOSE: To identify retrospectively prognostic factors of primary breast sarcoma and review its treatment modalities. MATERIALS AND METHODS: This is a descriptive study on 30 cases of primary breast sarcoma. We carried out a univariate and multivariate analysis correlating clinical, pathological and therapeutic parameters with disease-free survival and overall survival. RESULTS: The mean age was 46.8 years. The mean tumour size was 10cm. The 30 cases were 18 phyllodes sarcomas, eight angiosarcomas, three liposarcomas and a case of granulocytic sarcoma. Sixteen patients had adjuvant radiotherapy and only seven patients received adjuvant chemotherapy. The median follow-up was 64 months. Overall survival rates at 3 and 5 years were 49.1% and 33.7%. Disease-free survival rates at 3 and 5 years were 22.8% and 15.2% respectively. The analytical study of the following parameters: tumour size and presence or absence of node or distant metastases, showed no correlation with overall survival nor with disease-free survival. Furthermore, adjuvant radiotherapy did not improve overall survival (P=0.298; hazard ratio [HR]=1 [0.982-1.04]) nor disease-free survival (P=0.61; HR=0.942 [0.862-1.029]). By univariate analyses, we identified a correlation between overall survival, surgical margins (>1cm) (P=0005; HR=3.4 [1.217-9.919]) and tumour necrosis (P=0.028; HR=0.099 [0.014-0.682]). We did not find any independent prognostic factor by multivariate analysis. CONCLUSION: The prognosis of primary breast sarcoma seems to depend essentially on optimal surgical excision (margin over 1cm). The only potential histological parameter correlated with the prognosis is the presence of tumour necrosis. The histological subtype should not be considered as a prognostic marker for overall or disease-free survival in patients with primary breast sarcoma.
[Mh] Termos MeSH primário: Neoplasias da Mama/epidemiologia
Sarcoma/epidemiologia
[Mh] Termos MeSH secundário: Academias e Institutos
Adolescente
Adulto
Idoso
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias da Mama/diagnóstico por imagem
Neoplasias da Mama/terapia
Terapia Combinada
Progressão da Doença
Intervalo Livre de Doença
Feminino
Hemangiossarcoma/epidemiologia
Hemangiossarcoma/terapia
Seres Humanos
Lipossarcoma/epidemiologia
Lipossarcoma/terapia
Mastectomia/métodos
Meia-Idade
Recidiva Local de Neoplasia
Tumor Filoide/epidemiologia
Tumor Filoide/terapia
Prognóstico
Radioterapia Adjuvante
Estudos Retrospectivos
Sarcoma/diagnóstico por imagem
Sarcoma/terapia
Sarcoma Mieloide/epidemiologia
Sarcoma Mieloide/terapia
Resultado do Tratamento
Tunísia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170223
[St] Status:MEDLINE


  9 / 1544 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28103951
[Au] Autor:Sera T; Kashiwagi S; Takashima T; Asano Y; Goto W; Iimori N; Noda S; Onoda N; Ohsawa M; Hirakawa K; Ohira M
[Ad] Endereço:Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.
[Ti] Título:Multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis: a case report.
[So] Source:BMC Res Notes;10(1):55, 2017 Jan 19.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tonsillar metastasis is very rare and accounts for only 0.8% of tonsillar tumors. And phyllodes tumor of the breast with tonsillar metastasis is very rare. CASE PRESENTATION: A 57-year-old Japanese woman received surgery (partial mastectomy) of malignant phyllodes tumor. Seven months after initial surgery, pharyngeal pain, swelling, and a feeling of dyspnea developed, and tumor was found in the left palatine tonsil. Computed tomography for further evaluation showed a tonsillar lesion with contrast enhancement, and tonsillar metastasis was suspected. The metastatic lung tumors had not progressed. Laryngoscopic biopsy showed a tonsillar metastasis from the malignant phyllodes tumor. Despite the diagnosis of malignant phyllodes tumor with tonsillar and pulmonary metastases, the patient refused further treatment and died about 1 month later. CONCLUSIONS: A patient with a malignant phyllodes tumor of the breast and tonsillar metastasis was reported, along with a discussion of the relevant literature of this very rare pattern of metastasis.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Tumor Filoide/patologia
Neoplasias Tonsilares/secundário
[Mh] Termos MeSH secundário: Mama/patologia
Neoplasias da Mama/diagnóstico por imagem
Evolução Fatal
Feminino
Seres Humanos
Japão
Metástase Linfática
Meia-Idade
Metástase Neoplásica
Tumor Filoide/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Neoplasias Tonsilares/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2375-5


  10 / 1544 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28072970
[Au] Autor:Jia C; Mei F; Liu JY; Zhao HM; Lei YT; Su J; Huang SS; Zheng J; You JF
[Ad] Endereço:Department of Pathology, Peking University Health Science Center, Third Hospital of Peking University, Beijing 100191, China.
[Ti] Título:[Histologic classification and prognosis factors in phyllodes tumors of breast].
[So] Source:Zhonghua Bing Li Xue Za Zhi;46(1):14-19, 2017 Jan 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To study the relationship between morphological characteristics, grading, diagnosis and prognosis in phyllodes tumors (PT) of the breast. A retrospective study was carried out on 83 PTs diagnosed between 1999 and 2003 that were classified semi-quantitatively according to the WHO recommendation. Follow-up data was available for some cases, and Cox regression analysis was used to evaluate factors affecting metastasis and recurrence. All cases were classified into the benign (57.8%), borderline (28.9%) and malignant (13.3%). The overall recurrence rate for the 72 cases with follow-up data was 20.8% (15/72), and was 17.5% (7/40) in benign, 22.7% (5/22) in borderline and 3/10 in malignant PT, respectively, with no significant difference ( >0.05). The median interval between the initial diagnosis and the first recurrence was 24 months. Lung or bone metastases occurred in 1/22 borderline and 3/10 malignant PT patients 5 years post-surgery. The mitotic count and the degree of stromal cell atypia were significantly correlated with recurrence ( =0.001 and =0.006). Multivariate analysis showed that severe stromal cell atypia was an independent predictor of recurrence-free survival in PT [ =6.40 (95% =1.378 to 29.732), =0.018]. Each parameter in the histological grading of PT may have different prognostic value, and markedly increased mitotic count and were predictive of relapse.
[Mh] Termos MeSH primário: Neoplasias da Mama/patologia
Recidiva Local de Neoplasia
Tumor Filoide/patologia
[Mh] Termos MeSH secundário: Neoplasias Ósseas/secundário
Feminino
Seres Humanos
Neoplasias Pulmonares/secundário
Análise Multivariada
Gradação de Tumores
Prognóstico
Análise de Regressão
Estudos Retrospectivos
Células Estromais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2017.01.004



página 1 de 155 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde