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[PMID]: 29390446 [Au] Autor: Corrias G; Escalon JG; Tang L; Monti S; Saba L; Mannelli L [Ad] Endereço: Department of Radiology, Memorial Sloan Kettering Cancer Center, York Avenue, New York, NY, USA. [Ti] Título: Hepatic angiosarcomatous transformation of a mediastinal germinal cell tumor: A care case report. [So] Source: Medicine (Baltimore);96(51):e9152, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Mediastinal nonseminomatous germ cell tumor (NSGCT) is an uncommon entity. Metastatic hepatic sarcomatous transformation is rare. PATIENT CONCERNS: We report a 24-year-old man with no previous related medical history presented with chest pain and left arm numbness. DIAGNOSES: The x-ray showed an anterior mediastinal mass. The chest computed tomography (CT) confirmed the presence of a mildly enhancing mass in the same location, without invasion of any vascular structure. A CT-guided biopsy was performed, revealing a primary mediastinal nonseminomatous germ cell tumor (NSGCT), yolk sac histology, with areas of somatic transformation to malignant nerve sheath tumor. After surgery patient was followed-up with imaging. Two years later a CT scan showed a new hepatic hyper vascular lesion, confirmed by a subsequent magnetic resonance imaging (MRI) and positron emission tomography (PET) scan. A CT-guided biopsy revealed a hepatic metastatic transformation to angiosarcoma of the primitive NSGCT. INTERVENTIONS: The patient went on to received palliative chemotherapy. OUTCOMES: The patient is being followed-up regularly at the outpatient department. LESSONS: Because of the potential of metastatic sarcoma arising from germ cell tumors, these patients should undergo periodical follow-up, with periodical scans. PET\CT scan might have a role in the follow-up of these patients. [Mh] Termos MeSH primário: Transformação Celular Neoplásica Hemangiossarcoma/patologia Neoplasias Hepáticas/patologia Neoplasias do Mediastino/patologia Neoplasias Embrionárias de Células Germinativas/patologia [Mh] Termos MeSH secundário: Diagnóstico por Imagem Hemangiossarcoma/diagnóstico por imagem Seres Humanos Neoplasias Hepáticas/diagnóstico por imagem Masculino Neoplasias do Mediastino/diagnóstico por imagem Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem Adulto Jovem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009152

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[PMID]: 29183799 [Au] Autor: Xing JS; Bai ZM [Ad] Endereço: Department of Urinary Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital(Haikou People's Hospital), Haikou 570208, PR China. [Ti] Título: Is testicular dysgenesis syndrome a genetic, endocrine, or environmental disease, or an unexplained reproductive disorder? [So] Source: Life Sci;194:120-129, 2018 Feb 01. [Is] ISSN: 1879-0631 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Progressive increases in the incidence of male reproductive disorders inclusive of hypospadias, cryptorchidism, poor semen quality, and testicular germ cell cancer (TGCC) have been observed in recent times. The central hypothesis of this study asserted that these disorders may all collectively signify testicular dysgenesis syndrome (TDS). This review aimed to provide evidence verifying the reality of TDS based on four key aspects: environmental endocrine-disrupting chemicals (EDCs), genetic factors, intrauterine growth disorders and lifestyle factors. Although TDS might result from genetic polymorphisms or aberration, recent evidence has highlighted links indicating the conditions associations to both environmental and lifestyle factors due to the rapid temporal changes in the clinical symptoms observed over recent decades. Based on our review of genetic and environmental factors, a key observation of our study suggested that there is an urgent need to prioritize research in reproductive physiology and pathophysiology, particularly in highly industrialized countries facing decreasing populations. At present, current research has yet to elucidate the mechanisms of TDS, in addition to the lack of genuine consideration of a variety of potentially key factors and TDS mechanisms. In conclusion, our study revealed that environmental exposures owing to modern lifestyles are primary factors involved in the associated trends of the syndrome, which are capable of affecting the adult endocrine system via direct means or through epigenetic mechanisms. [Mh] Termos MeSH primário: Disgenesia Gonadal/etiologia Infertilidade Masculina/etiologia Doenças Testiculares/etiologia Testículo/patologia [Mh] Termos MeSH secundário: Animais Disruptores Endócrinos/efeitos adversos Retardo do Crescimento Fetal/genética Retardo do Crescimento Fetal/patologia Disgenesia Gonadal/genética Disgenesia Gonadal/patologia Seres Humanos Infertilidade Masculina/genética Infertilidade Masculina/patologia Estilo de Vida Masculino Neoplasias Embrionárias de Células Germinativas/etiologia Neoplasias Embrionárias de Células Germinativas/genética Neoplasias Embrionárias de Células Germinativas/patologia Polimorfismo Genético Doenças Testiculares/genética Doenças Testiculares/patologia Neoplasias Testiculares/etiologia Neoplasias Testiculares/genética Neoplasias Testiculares/patologia Testículo/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Endocrine Disruptors) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171130 [St] Status: MEDLINE

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[PMID]: 28463397 [Au] Autor: Murray MJ; Bailey S; Heinemann K; Mann J; Göbel UK; Saran F; Hale JP; Calaminus G; Nicholson JC [Ad] Endereço: Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, United Kingdom. [Ti] Título: Treatment and outcomes of UK and German patients with relapsed intracranial germ cell tumors following uniform first-line therapy. [So] Source: Int J Cancer;141(3):621-635, 2017 08 01. [Is] ISSN: 1097-0215 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We aimed to retrospectively assess treatments/outcomes, including the value of high-dose-chemotherapy and autologous-stem-cell-rescue (HDC + AuSCR) and re-irradiation, in a large, European patient-cohort with relapsed intracranial germ-cell-tumors (GCTs) receiving uniform first-line therapy, including radiotherapy as standard-of-care. Fifty-eight UK/German patients (48 male/10 female) with relapsed intracranial-GCTs [13 germinoma/45 non-germinomatous GCT (NGGCT)] treated 1996-2010 as per the SIOP-CNS-GCT-96 protocol were evaluated. For germinoma, six patients relapsed with germinoma and five with NGGCT (one palliative, one teratoma patient excluded). Five-year overall-survival (OS) for the whole-group (n = 11) was 55%. Four of six germinoma relapses and two of five relapsing with NGGCT were salvaged; patients were salvaged with either standard-dose-chemotherapy (SDC) and re-irradiation or HDC + AuSCR with/without re-irradiation. Of 45 relapsed NGGCT patients, 13 were excluded (three non-protocol adherence, five teratoma, five palliation). Five-year OS for the remaining 32 relapsed malignant NGGCT patients treated with curative intent was 9% (95%CI: 2-26%). By treatment received, 5-year OS for the 10 patients receiving SDC and 22 patients treated with intention for HDC + AuSCR was 0% (0-0%) and 14% (3-36%), respectively. The three relapsed NGGCT survivors had raised HCG markers alone; two received additional irradiation. Patients with relapsed germinoma had better 5-year OS than those with relapsed NGGCT (55 vs. 9%; p = 0.007). Patients with relapsed germinoma were salvaged both with SDC and re-irradiation or HDC + AuSCR with/without re-irradiation; both represent valid treatment options. Outcomes for malignant relapse following initial diagnosis of NGGCT were exceptionally poor; the few survivors received thiotepa-based HDC + AuSCR, which is a treatment option at first malignant relapse for such patients, with further surgery/irradiation where feasible. [Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Neoplasias Encefálicas/terapia Germinoma/terapia Recidiva Local de Neoplasia/terapia Neoplasias Embrionárias de Células Germinativas/terapia [Mh] Termos MeSH secundário: Adolescente Adulto Neoplasias Encefálicas/patologia Criança Pré-Escolar Terapia Combinada Feminino Seguimentos Alemanha Germinoma/patologia Seres Humanos Lactente Masculino Recidiva Local de Neoplasia/patologia Estadiamento de Neoplasias Neoplasias Embrionárias de Células Germinativas/patologia Prognóstico Estudos Retrospectivos Taxa de Sobrevida Reino Unido Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180208 [Lr] Data última revisão: 180208 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.1002/ijc.30755

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[PMID]: 29248013 [Au] Autor: Ghalleb M; Bouzaiene H; Slim S; Hadiji A; Hechiche M; Ben Hassouna J; Rahal K [Ad] Endereço: Surgical Oncology Department, Salah Azaiez Institute of Cancer, Tunis, Tunisia. [Ti] Título: Fertility-sparing surgery in advanced stage malignant ovarian germ cell tumor: a case report. [So] Source: J Med Case Rep;11(1):350, 2017 Dec 17. [Is] ISSN: 1752-1947 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Malignant ovarian germ cell tumor is a rare type of disease, which generally has a good prognosis due to the high chemosensitivity of this type of tumor. Fertility preservation is an important issue because malignant ovarian germ cell tumor commonly affects young women. Although conservation is the standard for early stage, it becomes more debatable as the disease progresses to more advanced stages. AIM: Report the case of a patient with an International Federation of Gynecology and Obstetrics Stage IIIc malignant ovarian germ cell tumor, who had conservative surgery and chemotherapy with a good fertility outcome. CASE PRESENTATION: A 23-year-old North African woman with a left malignant ovarian germ cell tumor stage IIIc was treated by left adnexectomy and omentectomy followed by chemotherapy. A 15-year follow-up showed no signs of relapse, and she completed three full-term natural pregnancies. CONCLUSIONS: Malignant ovarian germ cell tumor is a rare ovarian tumor with a good prognosis. It is usually associated with a good fertility outcome in early stages. However, due to the rarity of the disease in advanced stages, the fertility outcome for this group of patients is not clear. This lack of data surrounding advanced stages points to the need for a meta-analysis of all published cases. [Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Preservação da Fertilidade/métodos Neoplasias Embrionárias de Células Germinativas/cirurgia Neoplasias Ovarianas/cirurgia Ovariectomia/métodos Neoplasias Peritoneais/cirurgia [Mh] Termos MeSH secundário: Bleomicina/uso terapêutico Quimioterapia Adjuvante Cisplatino/uso terapêutico Etoposídeo/uso terapêutico Feminino Seres Humanos Estadiamento de Neoplasias Neoplasias Embrionárias de Células Germinativas/patologia Omento/cirurgia Neoplasias Ovarianas/patologia Neoplasias Peritoneais/secundário Adulto Jovem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 11056-06-7 (Bleomycin); 6PLQ3CP4P3 (Etoposide); Q20Q21Q62J (Cisplatin) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180130 [Lr] Data última revisão: 180130 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171218 [St] Status: MEDLINE [do] DOI: 10.1186/s13256-017-1516-8

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[PMID]: 28471449 [Au] Autor: Özata DM; Li X; Lee L; Liu J; Warsito D; Hajeri P; Hultman I; Fotouhi O; Marklund S; Ährlund-Richter L; Juhlin CC; Larsson C; Lui WO [Ad] Endereço: Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. [Ti] Título: Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. [So] Source: Cell Death Dis;8(5):e2759, 2017 May 04. [Is] ISSN: 2041-4889 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Deregulation of microRNAs (miRNAs) contributes to the development and progression of many cancer types; however, their functions in the pathogenesis of testicular germ cell tumor (TGCT) remain unclear. Here, we determined miRNA expression profiles of TGCTs and normal testes using small RNA sequencing, and identified several deregulated miRNAs in TGCTs, including the miR-506~514 cluster. In functional studies in vitro we demonstrated that miR-514a-3p induced apoptosis through direct regulation of the paternally expressed gene 3 (PEG3), and ectopically expressed PEG3 could rescue the apoptotic effect of miR-514a-3p overexpression. Silencing of PEG3 or miR-514a-3p overexpression reduced nuclear accumulation of p50 and NF-κB reporter activity. Furthermore, PEG3 was co-immunoprecipitated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in TGCT cell lysates. We propose a model of PEG3-mediated activation of NF-κB in TGCT. Loss of miR-514a-3p expression in TGCT increases PEG3 expression that recruits TRAF2 and activates the NF-kappa B pathway, which protects germ cells from apoptosis. Importantly, we observed strong expression of PEG3 and nuclear p50 in the majority of TGCTs (83% and 78%, respectively). In conclusion, our study describes a novel function for miR-514a-3p in TGCT and highlights an unrecognized mechanism of PEG3 regulation and NF-κB activation in TGCT. [Mh] Termos MeSH primário: Fatores de Transcrição Kruppel-Like/metabolismo MicroRNAs/metabolismo NF-kappa B/metabolismo Neoplasias Embrionárias de Células Germinativas/patologia Neoplasias Testiculares/patologia [Mh] Termos MeSH secundário: Antagomirs/metabolismo Apoptose Sequência de Bases Linhagem Celular Tumoral Metilação de DNA Seres Humanos Imunoprecipitação Fatores de Transcrição Kruppel-Like/antagonistas & inibidores Fatores de Transcrição Kruppel-Like/genética Masculino MicroRNAs/antagonistas & inibidores MicroRNAs/genética Subunidade p50 de NF-kappa B/metabolismo Neoplasias Embrionárias de Células Germinativas/metabolismo Poli(ADP-Ribose) Polimerases/metabolismo Regiões Promotoras Genéticas Interferência de RNA Alinhamento de Sequência Transdução de Sinais Fator 2 Associado a Receptor de TNF/metabolismo Neoplasias Testiculares/metabolismo Transcriptoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antagomirs); 0 (Kruppel-Like Transcription Factors); 0 (MicroRNAs); 0 (NF-kappa B); 0 (NF-kappa B p50 Subunit); 0 (PEG3 protein, human); 0 (TNF Receptor-Associated Factor 2); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180129 [Lr] Data última revisão: 180129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1038/cddis.2016.464

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[PMID]: 29245261 [Au] Autor: Qin J; Wang P; Jing T; Kong D; Xia D; Wang S [Ad] Endereço: Department of Urology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. [Ti] Título: Extraperitoneal robot-assisted laparoscopic retroperitoneal lymph node dissection for early-stage testicular nonseminomatous germ cell tumors: A case report and literature review. [So] Source: Medicine (Baltimore);96(49):e8938, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Typically robot-assisted laparoscopic retroperitoneal lymph node dissection (R-RPLND) has been performed via a transperitoneal approach. Herein we report the first case of a novel R-RPLND using an extraperitoneal approach. PATIENT CONCERNS: A 38-year-old man presented with an enlarging right scrotal mass. DIAGNOSES: Scrotal ultrasonography demonstrated a 5.5-cm solid mass of the right testis. The patient underwent right radical inguinal orchiectomy. Pathologic examination demonstrated a mixed germ cell tumor, predominately embryonal carcinoma with yolk sac tumor. INTERVENTIONS: Extraperitoneal R-PRLND was performed 3 weeks after the radical orchiectomy. OUTCOME: The final pathologic examination showed a count of 19 lymph nodes, all of them negative. Normal antegrade ejaculation returned within 4 weeks postoperatively. No retroperitoneal recurrence or elevation of tumor marker levels were seen via surveillance imaging. LESSONS: Our study shows that extraperitoneal R-RPLND is a safe and feasible procedure using an extraperitoneal approach that provides minimal invasion and rapid recovery of patients. [Mh] Termos MeSH primário: Laparoscopia/métodos Excisão de Linfonodo/métodos Neoplasias Embrionárias de Células Germinativas/patologia Neoplasias Embrionárias de Células Germinativas/cirurgia Procedimentos Cirúrgicos Robóticos Neoplasias Testiculares/patologia Neoplasias Testiculares/cirurgia [Mh] Termos MeSH secundário: Adulto Seres Humanos Masculino Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem Neoplasias Testiculares/diagnóstico por imagem Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171225 [Lr] Data última revisão: 171225 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 171217 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008938

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[PMID]: 28893722 [Au] Autor: Le Cornet C; Fervers B; Pukkala E; Tynes T; Feychting M; Hansen J; Togawa K; Nordby KC; Oksbjerg Dalton S; Uuksulainen S; Wiebert P; Woldbæk T; Skakkebæk NE; Olsson A; Schüz J [Ad] Endereço: Section of Environment and Radiation, International Agency for Research on Cancer (IARC) , Lyon, France. [Ti] Título: Parental Occupational Exposure to Organic Solvents and Testicular Germ Cell Tumors in their Offspring: NORD-TEST Study. [So] Source: Environ Health Perspect;125(6):067023, 2017 06 30. [Is] ISSN: 1552-9924 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development . OBJECTIVES: We aimed to assess the association between maternal and paternal occupational exposures to organic solvents during the prenatal period and TGCT risk in their offspring. METHODS: This registry-based case control study included TGCT cases aged 14­49 y ( =8,112) diagnosed from 1978 to 2012 in Finland, Norway, and Sweden. Controls ( =26,264) were randomly selected from the central population registries and were individually matched to cases on year and country of birth. Occupational histories of parents prior to the child's birth were extracted from the national censuses. Job codes were converted into solvent exposure using the Nordic job-Nordic Occupational Cancer Study Job-Exposure Matrix. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Overall, no association was found between prenatal maternal exposure to solvents and TGCT risk. In subset analyses using only mothers for whom occupational information was available in the year of or in the year prior to the child's birth, there was an association with maternal exposure to aromatic hydrocarbon solvents (ARHC) (OR=1.53; CI: 1.08, 2.17), driven by exposure to toluene (OR=1.67; CI: 1.02, 2.73). No association was seen for any paternal occupational exposure to solvents with the exception of exposure to perchloroethylene in Finland (OR=2.42; CI: 1.32, 4.41). CONCLUSIONS: This study suggests a modest increase in TGCT risk associated with maternal prenatal exposure to ARHC. https://doi.org/10.1289/EHP864. [Mh] Termos MeSH primário: Neoplasias Embrionárias de Células Germinativas/epidemiologia Exposição Ocupacional/estatística & dados numéricos Exposição Paterna/estatística & dados numéricos Efeitos Tardios da Exposição Pré-Natal/epidemiologia Solventes Neoplasias Testiculares/epidemiologia [Mh] Termos MeSH secundário: Adolescente Adulto Estudos de Casos e Controles Feminino Finlândia/epidemiologia Seres Humanos Masculino Exposição Materna Meia-Idade Noruega/epidemiologia Razão de Chances Gravidez Suécia/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Solvents) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171102 [Lr] Data última revisão: 171102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170913 [St] Status: MEDLINE [do] DOI: 10.1289/EHP864

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[PMID]: 28892064 [Au] Autor: Neumann JE; Wefers AK; Lambo S; Bianchi E; Bockstaller M; Dorostkar MM; Meister V; Schindler P; Korshunov A; von Hoff K; Nowak J; Warmuth-Metz M; Schneider MR; Renner-Müller I; Merk DJ; Shakarami M; Sharma T; Chavez L; Glass R; Chan JA; Taketo MM; Neumann P; Kool M; Schüller U [Ad] Endereço: Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany. [Ti] Título: A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors. [So] Source: Nat Med;23(10):1191-1202, 2017 Oct. [Is] ISSN: 1546-170X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Embryonal tumors with multilayered rosettes (ETMRs) have recently been described as a new entity of rare pediatric brain tumors with a fatal outcome. We show here that ETMRs are characterized by a parallel activation of Shh and Wnt signaling. Co-activation of these pathways in mouse neural precursors is sufficient to induce ETMR-like tumors in vivo that resemble their human counterparts on the basis of histology and global gene-expression analyses, and that point to apical radial glia cells as the possible tumor cell of origin. Overexpression of LIN28A, which is a hallmark of human ETMRs, augments Sonic-hedgehog (Shh) and Wnt signaling in these precursor cells through the downregulation of let7-miRNA, and LIN28A/let7a interaction with the Shh pathway was detected at the level of Gli mRNA. Finally, human ETMR cells that were transplanted into immunocompromised host mice were responsive to the SHH inhibitor arsenic trioxide (ATO). Our work provides a novel mouse model in which to study this tumor type, demonstrates the driving role of Wnt and Shh activation in the growth of ETMRs and proposes downstream inhibition of Shh signaling as a therapeutic option for patients with ETMRs. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Arsenicais/farmacologia Neoplasias Encefálicas/genética Proteínas Hedgehog/genética Neoplasias Embrionárias de Células Germinativas/genética Óxidos/farmacologia Via de Sinalização Wnt/genética [Mh] Termos MeSH secundário: Animais Western Blotting Neoplasias Encefálicas/metabolismo Linhagem Celular Tumoral Modelos Animais de Doenças Regulação para Baixo Perfilação da Expressão Gênica Proteínas Hedgehog/antagonistas & inibidores Seres Humanos Imuno-Histoquímica Camundongos Camundongos Transgênicos MicroRNAs/genética Neoplasias Embrionárias de Células Germinativas/metabolismo Proteínas de Ligação a RNA/genética Reação em Cadeia da Polimerase Via Transcriptase Reversa Transdução de Sinais Ensaios Antitumorais Modelo de Xenoenxerto Proteína GLI1 em Dedos de Zinco/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Arsenicals); 0 (Gli protein, mouse); 0 (Hedgehog Proteins); 0 (Lin-28 protein, mouse); 0 (MicroRNAs); 0 (Oxides); 0 (RNA-Binding Proteins); 0 (Shh protein, mouse); 0 (Zinc Finger Protein GLI1); 0 (mirnlet7 microRNA, mouse); S7V92P67HO (arsenic trioxide) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170912 [St] Status: MEDLINE [do] DOI: 10.1038/nm.4402

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[PMID]: 28866371 [Au] Autor: De La Pena H; Sharma A; Glicksman C; Joseph J; Subesinghe M; Traill Z; Verrill C; Sullivan M; Redgwell J; Bataillard E; Pintus E; Dallas N; Gogbashian A; Tuthill M; Protheroe A; Hall M [Ad] Endereço: Department of Oncology, Oxford University Hospitals NHS Foundation Trust, UK. [Ti] Título: No longer any role for routine follow-up chest x-rays in men with stage I germ cell cancer. [So] Source: Eur J Cancer;84:354-359, 2017 Oct. [Is] ISSN: 1879-0852 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Following radical orchidectomy for testicular cancer, most patients undergo protocolled surveillance to detect tumour recurrences rather than receive adjuvant chemotherapy. Current United Kingdom national and most international guidelines recommend that patients require a chest x-ray (CXR) and serum tumour markers at each follow-up visit as well as regular CT scans; there is however, variation among cancer centres with follow-up protocols. Seminomas often do not cause tumour marker elevation; therefore, CT scans are the main diagnostic tool for detecting relapse. For non-seminomatous tumours, serum beta-HCG (HCG) and AFP levels are a very sensitive harbinger of relapse, but this only occurs in 50% of patients [1], and therefore, imaging remains as important. CXRs are meant to aid in the detection of lung recurrences and before the introduction of modern cross-sectional imaging in the early 1980s, CXRs would have been the only method of identifying lung metastasis. We examined the Thames Valley and Mount Vernon Cancer Centre databases to evaluate the role of CXRs in the 21st century for the follow-up of men with stage I testicular cancer between 2003 and 2015 to assess its value in diagnosing relapsed germ cell tumours. From a total of 1447 patients, we identified 159 relapses. All relapses were detected either by rising tumour markers or planned follow-up CT scans. Not a single relapse was identified on CXR. We conclude that with timely and appropriate modern cross-sectional imaging and tumour marker assays, the CXR no longer has any value in the routine surveillance of stage I testicular cancer and should be removed from follow-up guidelines and clinical practice. Omitting routine CXR from follow-up schedules will reduce anxiety as well as time that patients spend at hospitals and result in significant cost savings. [Mh] Termos MeSH primário: Neoplasias Pulmonares/diagnóstico por imagem Neoplasias Pulmonares/secundário Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem Neoplasias Embrionárias de Células Germinativas/secundário Radiografia Torácica Neoplasias Testiculares/diagnóstico por imagem Neoplasias Testiculares/secundário Procedimentos Desnecessários [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Biomarcadores Tumorais/sangue Criança Redução de Custos Análise Custo-Benefício Bases de Dados Factuais Inglaterra Custos de Cuidados de Saúde Seres Humanos Neoplasias Pulmonares/economia Masculino Meia-Idade Estadiamento de Neoplasias Neoplasias Embrionárias de Células Germinativas/economia Neoplasias Embrionárias de Células Germinativas/cirurgia Orquiectomia Valor Preditivo dos Testes Dose de Radiação Exposição à Radiação/efeitos adversos Exposição à Radiação/prevenção & controle Radiografia Torácica/efeitos adversos Radiografia Torácica/economia Neoplasias Testiculares/economia Neoplasias Testiculares/cirurgia Tomografia Computadorizada por Raios X Resultado do Tratamento Procedimentos Desnecessários/efeitos adversos Procedimentos Desnecessários/economia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY [Nm] Nome de substância: 0 (Biomarkers, Tumor) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170904 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 28822326 [Au] Autor: Zong X; Pole JD; Grundy PE; Mahmud SM; Parker L; Hung RJ [Ad] Endereço: Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, M5T 3L9, Canada. [Ti] Título: Second malignant neoplasms after childhood non-central nervous system embryonal tumours in North America: A population-based study. [So] Source: Eur J Cancer;84:173-183, 2017 Oct. [Is] ISSN: 1879-0852 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Few studies in North America have quantified the risks of second malignant neoplasms (SMNs) among survivors of childhood non-central nervous system (non-CNS) embryonal tumours due to their rarity. We aimed to investigate these risks by combining population-based data from the United States of America and Canada. METHODS: We evaluated patients with childhood non-CNS embryonal tumours reported to the Surveillance Epidemiology and End Results program and eight Canadian cancer registries from 1969 to 2010. Standardised incidence ratio (SIR) and cumulative incidence of SMNs were calculated. Subgroup analyses were conducted by the type of first primary cancer, age at first primary diagnosis and follow-up duration. FINDINGS: Of the 13,107 survivors, 190 SMNs were reported over 134,548 person-years of follow-up. The SIR for all SMNs combined was 6.4 (95% confidence interval [CI]: 5.5-7.4). Most site-specific SIRs were significantly increased, ranging from 36 (95% CI: 26-49) for bone and joint cancer to 3.1 (95% CI: 1.5-5.2) for brain tumour. The risk for second malignancies declined as the time elapsed from the first primary diagnosis and was less prominent for patients first diagnosed at age 1-4 years. Notably, rhabdomyosarcoma survivors had a higher risk for SMNs than those with other first primaries. The overall cumulative incidence of SMNs was 1.0% at 10 years, increasing to 2.2% at 20 years and 4.1% at 30 years. INTERPRETATION: Survivors with childhood non-CNS embryonal tumours faced an increased risk for SMNs compared to the general population. The risk variations observed in different patient categories may help target prevention strategies in high-risk subgroups. [Mh] Termos MeSH primário: Neoplasias Embrionárias de Células Germinativas/epidemiologia Segunda Neoplasia Primária/epidemiologia Sobreviventes [Mh] Termos MeSH secundário: Adolescente Adulto Idade de Início Criança Pré-Escolar Seres Humanos Incidência Lactente Neoplasias Embrionárias de Células Germinativas/patologia Segunda Neoplasia Primária/patologia América do Norte/epidemiologia Medição de Risco Fatores de Risco Programa de SEER Fatores de Tempo [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170820 [St] Status: MEDLINE

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