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[PMID]:28662725
[Au] Autor:Alagrafi FS; Alawad AO; Abutaha NM; Nasr FA; Alhazzaa OA; Alharbi SN; Alkhrayef MN; Hammad M; Alhamdan ZA; Alenazi AD; Wadaan MA
[Ad] Endereço:National Center for StemCell Technology (NCSCT), Life Sciences and Environment Research Institute (LSERI), King Abdulaziz City for Science and Technology (KACST), Riyadh, 11442, Saudi Arabia.
[Ti] Título:In vitro induction of human embryonal carcinoma differentiation by a crude extract of Rhazya stricta.
[So] Source:BMC Complement Altern Med;17(1):342, 2017 Jun 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rhazya stricta Decne. is a medicinal plant that is widespread in Saudi Arabia and desert areas of the Arabian Peninsula. Its extract contains alkaloids, tannins, and flavonoids that are involved in different biological activities. The study aim was to evaluate the effects of Rhazya stricta plant extracts on the proliferation and differentiation of NTERA-2 (NT2) pluripotent embryonal carcinoma cells. METHODS: Soxhlet extraction was carried out using different solvents to extract stems, leaves and fruit parts of this plant. Cytotoxicity was evaluated by an MTS cell viability assay. The ability of the plant extract to induce cell differentiation was examined phenotypically using an inverted light microscope. The expression of pluripotency markers was investigated by reverse transcriptase polymerase chain reaction (RT-PCR) and immunocytochemistry. Phytochemical screening of chloroform stem extracts was carried out and a chromatographic fingerprint was generated using gas chromatography - mass spectrometry (GC-MS). RESULTS: Chloroform stem extract induced differentiation of NT2 cells at 5 µg/ml, and the differentiated cells exhibited neurite formation. Following induction of differentiation, there was significant down-regulation of the pluripotency marker genes Oct4 and Sox2. In addition, the surface antigen pluripotency marker, TRA-1-60, was strongly down-regulated. Phytochemical analysis of the extract showed the presence of alkaloids and saponins. The chromatogram revealed the presence of fifteen compounds with different retention times. CONCLUSION: Our results demonstrate for the first time that chloroform stem extract of R. stricta can induce neuronal differentiation of stem cells at an early stage and may contain potential therapeutic agent that can be used in neurodegenerative diseases.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apocynaceae/química
Carcinoma Embrionário/fisiopatologia
Diferenciação Celular/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação
Carcinoma Embrionário/tratamento farmacológico
Carcinoma Embrionário/genética
Carcinoma Embrionário/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Fator 3 de Transcrição de Octâmero/genética
Fator 3 de Transcrição de Octâmero/metabolismo
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Fatores de Transcrição SOXB1/genética
Fatores de Transcrição SOXB1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Octamer Transcription Factor-3); 0 (POU5F1 protein, human); 0 (Plant Extracts); 0 (SOX2 protein, human); 0 (SOXB1 Transcription Factors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1852-7


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[PMID]:28512062
[Au] Autor:Wang X; Zhang X; Wang G; Wang L; Lin Y; Sun F
[Ad] Endereço:Department of Cell and Developmental Biology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
[Ti] Título:Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells.
[So] Source:Gene;626:344-353, 2017 Aug 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Previous studies have reported the miR-513b is located on the X chromosome and is preferentially expressed in testis. However, the underlying mechanisms of miR-513b involved in spermatogenesis remains unknown. In this study, we found that hsa-miR-513b-5p was highly expressed in the testes of infertile males with maturation arrest compared with normal controls. Overexpression of hsa-miR-513b-5p suppressed testicular embryonal carcinoma (NT2) cell proliferation and induced apoptosis in vitro, whereas silencing of hsa-miR-513b-5p reversed these effects. In addition, we found that interferon regulatory transcription factor 2 (IRF2) was a direct and functional target of hsa-miR-513b-5p. Silencing of endogenous IRF2 enhanced hsa-miR-513b-5p-mediated effects on cell proliferation in NT2 cells, whereas overexpression of IRF2 reversed these effects. Moreover, immunoblotting showed that overexpression of hsa-miR-513b-5p or silencing of endogenous IRF2 could promote the expression of P53. Moreover, overexpression of hsa-miR-513b-5p in the absence of p53 could also induce cell apoptosis. Together, our results suggest that hsa-miR-513b-5p suppresses NT2 cell proliferation and promotes P53 protein expression by targeting IRF2, and abnormal testicular hsa-miR-513b-5p expression may contribute to maturation arrest.
[Mh] Termos MeSH primário: Carcinoma Embrionário/genética
Proliferação Celular
Fator Regulador 2 de Interferon/genética
MicroRNAs/genética
Neoplasias Testiculares/genética
Proteína Supressora de Tumor p53/genética
[Mh] Termos MeSH secundário: Apoptose
Carcinoma Embrionário/metabolismo
Carcinoma Embrionário/patologia
Linhagem Celular Tumoral
Regulação Neoplásica da Expressão Gênica
Células HEK293
Seres Humanos
Fator Regulador 2 de Interferon/metabolismo
Masculino
Processamento de RNA
Neoplasias Testiculares/metabolismo
Neoplasias Testiculares/patologia
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IRF2 protein, human); 0 (Interferon Regulatory Factor-2); 0 (MIRN513 microRNA, human); 0 (MicroRNAs); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


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[PMID]:28216981
[Au] Autor:Barbieux J; Memeo R; De Blasi V; Suciu S; Faucher V; Averous G; Roy C; Marescaux J; Mutter D; Pessaux P
[Ad] Endereço:Julien Barbieux, Riccardo Memeo, Vito De Blasi, Jacques Marescaux, Didier Mutter, Patrick Pessaux, Hepato-Biliary and Pancreatic Surgical Unit, IRCAD-IHU, University of Strasbourg, Place de l'Hôpital, 67091 Strasbourg, France.
[Ti] Título:Real case of primitive embryonal duodenal carcinoma in a young man.
[So] Source:World J Gastroenterol;23(4):730-734, 2017 Jan 28.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report here the case of a young man suffering from a rare germ cell tumour. The patient was a 25-year-old man who was referred to our centre for asthenia, stinging epigastric pain, and an iron deficiency anaemia. Gastroscopy revealed a circumferential vegetating lesion on the second portion of the duodenum. The lesion was indurated at the third portion of the duodenum, responsible for a tight stenosis. A computerized tomography-scan of the chest, abdomen and pelvis, and a pancreatic MRI showed a circumferential lesion with a bi-ductal dilatation ( ., of the common bile duct and Wirsung's duct) without metastatic localisation. The patient underwent a pancreaticoduodenectomy with lymph node dissection including all cellular adipose tissues of the hepatic pedicle from the hepatic common artery and of the retroportal lamina. Histological findings were suggestive of a duodenal embryonal carcinoma with pancreatic infiltration. This is the second published case highlighting the duodenal primitive localisation of an embryonal carcinoma with pancreatic infiltration.
[Mh] Termos MeSH primário: Carcinoma Embrionário/diagnóstico
Neoplasias Duodenais/diagnóstico
Duodeno/patologia
Neoplasias Embrionárias de Células Germinativas/diagnóstico
Neoplasias Pancreáticas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Anemia/complicações
Carcinoma Embrionário/patologia
Carcinoma Embrionário/cirurgia
Ducto Colédoco/cirurgia
Neoplasias Duodenais/patologia
Neoplasias Duodenais/cirurgia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Neoplasias Embrionárias de Células Germinativas/cirurgia
Ductos Pancreáticos/cirurgia
Neoplasias Pancreáticas/secundário
Neoplasias Pancreáticas/cirurgia
Pancreaticoduodenectomia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i4.730


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[PMID]:28322096
[Au] Autor:Oz Atalay F; Aytac Vuruskan B; Vuruskan H
[Ad] Endereço:1 Department of Surgical Pathology, Uludag University, Bursa, Turkey.
[Ti] Título:CDX2 immunostaining in primary and metastatic germ cell tumours of the testis.
[So] Source:J Int Med Res;44(6):1323-1330, 2016 Dec.
[Is] ISSN:1473-2300
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective To evaluate the immunohistochemical staining pattern of caudal type homeobox 2 (CDX2) protein in germ cell tumours (GCTs) of the testis. Methods This study reassessed archival tissue samples collected from patients diagnosed with primary and metastatic testicular GCTs for CDX2 immunoreactivity using standard immunohistochemical techniques. Positive nuclear immunostaining was evaluated with regard to both the staining intensity and the extent of the staining. Results Tissue sections from primary and metastatic testicular GCTs ( n = 104), germ cell neoplasia in situ (GCNis) ( n = 5) and benign testicles ( n = 15) were analysed. The GCNis and benign testicular tissues showed no immunoreactivity for CDX2. Strong and diffuse staining of CDX2 was demonstrated only in the mature colonic epithelium of teratomas in both primary and metastatic GCTs. CDX2 positivity in other tumours (one pure yolk sac tumour, one yolk sac component of a mixed GCT and one pure seminoma) was infrequent, and was only weak and focal. Conclusions CDX2 immunostaining should be interpreted based on both the staining intensity and the extent of staining so as not to cause misdiagnosis. Teratomas with colonic-type epithelium should be considered in the differential diagnosis if a metastatic tumour with an unknown primary shows prominent CDX2 immunostaining.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Fator de Transcrição CDX2/genética
Carcinoma Embrionário/diagnóstico
Neoplasias Embrionárias de Células Germinativas/diagnóstico
Seminoma/diagnóstico
Teratoma/diagnóstico
Neoplasias Testiculares/diagnóstico
Testículo/metabolismo
[Mh] Termos MeSH secundário: Adulto
Carcinoma Embrionário/genética
Carcinoma Embrionário/patologia
Diagnóstico Diferencial
Expressão Gênica
Seres Humanos
Imuno-Histoquímica
Masculino
Neoplasias Embrionárias de Células Germinativas/genética
Neoplasias Embrionárias de Células Germinativas/patologia
Estudos Retrospectivos
Seminoma/genética
Seminoma/patologia
Coloração e Rotulagem/métodos
Teratoma/genética
Teratoma/patologia
Neoplasias Testiculares/genética
Neoplasias Testiculares/patologia
Testículo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CDX2 Transcription Factor); 0 (CDX2 protein, human)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1177/0300060516665472


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[PMID]:28132046
[Au] Autor:Potapov S; Sidorenko R; Galata D; Stratiy N; Gargin V
[Ad] Endereço:Kharkiv National Medical University, Ukraine.
[Ti] Título:PECULIARITIES OF CATENIN ACTIVITY IN THE EMBRYONAL TESTICULAR CARCINOMA.
[So] Source:Georgian Med News;(261):68-73, 2016 Dec.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:The aim of the research was to study immunohistochemical peculiarities of catenin activity in the embryonal testicular carcinoma. Material is presented by 39 cases of embryonal testicular carcinoma for the period from 1993 to 2013. Macroscopic and histological investigation has been performed according to the WHO classification (2004). Immunohistochemical examination with monoclonal antibodies to Ki-67, ß-catenin and E-cadherin were performed. Embryonal carcinoma is presented 12.38% of all testicular germ cell tumors in our observations with median age of patients 30.85±1.16 years. Embryonic cancer of testis has been characterized histologicaly with combination of different areas of the structure: solid, forming a diffuse field, and acinar, tubular and papillary structures with different developed connective tissue background. Tumor cells are characterized by well-defined cytoplasm, polymorphic hyperchromatic nuclei with distinct nucleoli. Embryonic cancer is characterized pronounced reducing of membranous ß-catenin expression (that is usual localization of that protein) with uneven level of expression from weak till strong. Simultaneously nuclear positive immunoreactivity has been appeared in embryonic cancer in isolate and grouped cells of tumor. Correlation between Ki-67 and ß-catenin expression is 0.562, between E-cadherin and ß-catenin is 0.737. It was concluded that immunohistochemical catenin activity must be interpreted accurately in case of embryonal carcinoma of the testis as there is no clear evidence on prognostic importance of neoplastic behavior as it is in some other tumors.
[Mh] Termos MeSH primário: Carcinoma Embrionário/metabolismo
Neoplasias Testiculares/metabolismo
beta Catenina/metabolismo
[Mh] Termos MeSH secundário: Adulto
Caderinas/metabolismo
Carcinoma Embrionário/patologia
Seres Humanos
Antígeno Ki-67/metabolismo
Masculino
Neoplasias Testiculares/patologia
Carga Tumoral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cadherins); 0 (Ki-67 Antigen); 0 (beta Catenin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170130
[St] Status:MEDLINE


  6 / 1050 MEDLINE  
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[PMID]:27813385
[Au] Autor:Ucer O; Nese N; Muezzinoglu T
[Ad] Endereço:Department of Urology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.
[Ti] Título:Pure Yolk sac presenting with inferior vena cava thrombus extending from bilateral external iliac veins to hepatic vein.
[So] Source:Int Braz J Urol;42(6):1244-1247, 2016 Nov-Dec.
[Is] ISSN:1677-6119
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Vena cava thrombus is an extremely rare complication of testicular tumors. We report on an unusual case of testicular tumor presenting with inferior vena cava thrombus extending from the left spermatic and bilateral external iliac veins to the hepatic vein. CASE REPORT: A-35-year old man presented with a 6-month history of left scrotal mass and a 1-day history of bilateral lower extremity edema. Computed tomography (CT) revealed the presence of thrombus extending from the left spermatic vein and bilateral external iliac veins to the hepatic vein, and multiple lymph node and lung metastases. 3 cycles of chemotherapy were given after the left high inguinal orchiectomy. Pathological examination demonstrated a pure yolk sac carcinoma with lymphovascular invasion and direct tumor extension into the left spermatic cord. CT and positron emission tompgraphy-CT obtained no findings of metastasis or recurrence at 3 months after the chemotherapy. CONCLUSION: We review this seldom case and discuss the literature with regard to its diagnosis and treatment.
[Mh] Termos MeSH primário: Carcinoma Embrionário/patologia
Neoplasias Testiculares/patologia
Veia Cava Inferior/patologia
Trombose Venosa/patologia
Saco Vitelino/patologia
[Mh] Termos MeSH secundário: Adulto
Veias Hepáticas/diagnóstico por imagem
Seres Humanos
Veia Ilíaca/diagnóstico por imagem
Masculino
Veia Cava Inferior/diagnóstico por imagem
Trombose Venosa/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27803451
[Au] Autor:Han MH; Park SW; Do HJ; Chung HJ; Song H; Kim JH; Kim NH; Park KH; Kim JH
[Ad] Endereço:Department of Biomedical Science, College of Life Science, CHA University.
[Ti] Título:Growth and Differentiation Factor 3 Is Transcriptionally Regulated by OCT4 in Human Embryonic Carcinoma Cells.
[So] Source:Biol Pharm Bull;39(11):1802-1808, 2016.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Growth and differentiation factor 3 (GDF3), a mammalian-specific transforming growth factor ß ligand, and OCT4, one of key stem cell transcription factors, are expressed in testicular germ cell tumors (TGCTs) as well as pluripotent stem cells. To understand the molecular mechanism by which OCT4 and GDF3 function in tumorigenesis as well as stemness, we investigated the transcriptional regulation of GDF3 mediated by OCT4 in human embryonic carcinoma (EC) NCCIT cells, which are pluripotent stem cells of TGCTs. GDF3 and OCT4 was highly expressed in undifferentiated NCCIT cells and then significantly decreased upon retinoic acid-induced differentiation in a time-dependent manner. Moreover, GDF3 expression was reduced by short hairpin RNA-mediated knockdown of OCT4 and increased by OCT4 overexpression, suggesting that GDF3 and OCT4 have a functional relationship in pluripotent stem cells. A promoter-reporter assay revealed that the GDF3 promoter (-1721-Luc) activity was significantly activated by OCT4 in a dose-dependent manner. Moreover, the minimal promoter (-183-Luc) was sufficient for OCT4-mediated transcriptional activation and provided a potential binding site for the direct interaction with OCT4. Collectively, this study provides the evidence about the regulatory mechanism of GDF3 mediated by OCT4 in pluripotent EC cells.
[Mh] Termos MeSH primário: Carcinoma Embrionário/genética
Fator 3 de Diferenciação de Crescimento/genética
Fator 3 de Transcrição de Octâmero/genética
Neoplasias Testiculares/genética
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Regulação Neoplásica da Expressão Gênica
Células HEK293
Seres Humanos
Masculino
Fator 3 de Transcrição de Octâmero/metabolismo
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Growth Differentiation Factor 3); 0 (Octamer Transcription Factor-3); 0 (POU5F1 protein, human)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE


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[PMID]:27567571
[Au] Autor:Zhang S; Liang G; Ju Y; You C
[Ad] Endereço:Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Clinical and Radiologic Features of Pediatric Basal Ganglia Germ Cell Tumors.
[So] Source:World Neurosurg;95:516-524.e1, 2016 Nov.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Pediatric basal ganglia germ cell tumors (GCTs) represent a rare subset of tumors about which little is known. We aimed to summarize the clinical features and radiological findings of this special subgroup of GCTs. METHODS: From January 2010 to January 2015, 12 pediatric patients with basal ganglia GCTs were treated in our hospital. The clinical features, radiologic findings, diagnosis, treatment, and outcome of these patients were analyzed retrospectively. Our institutional diagnostic principle and treatment strategy of this disease were discussed. RESULTS: GCTs accounted for 25.5% of all the pediatric basal ganglia tumors treated in our hospital. There were 9 male and 3 female patients with a mean age of 11.5 ± 2.1 years. The most common symptom was progressive hemiparesis (n = 9, 75%). The radiologic findings showed that the lesions predominately located in caput of caudate nucleus (n = 9, 75.0%), followed by lenticular nucleus (n = 3, 25.0%). Hemiatrophy was commonly observed (n = 8, 66.7%). Eight patients were diagnosed as having germinomas, and 4 patients as having nongerminomatous germ cell tumors. During the follow-up period, preoperative neurologic dysfunctions improved in 7 patients and remained stable in 3. Two patients developed new onset of neurologic dysfunction after the treatment. Two patients suffered from tumor recurrence. CONCLUSIONS: GCTs are not as rare as considered in pediatric basal ganglia tumors. They bear some distinctive clinical and radiologic features, which can help with the accurate diagnosis and successful management of such tumors.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Doenças dos Gânglios da Base/terapia
Neoplasias Encefálicas/terapia
Neoplasias Embrionárias de Células Germinativas/terapia
[Mh] Termos MeSH secundário: Adolescente
Assistência ao Convalescente
Doenças dos Gânglios da Base/complicações
Doenças dos Gânglios da Base/diagnóstico por imagem
Doenças dos Gânglios da Base/metabolismo
Neoplasias Encefálicas/complicações
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/metabolismo
Carboplatina/administração & dosagem
Carcinoma Embrionário/complicações
Carcinoma Embrionário/diagnóstico por imagem
Carcinoma Embrionário/metabolismo
Carcinoma Embrionário/terapia
Núcleo Caudado/diagnóstico por imagem
Núcleo Caudado/cirurgia
Criança
Coriocarcinoma não Gestacional/complicações
Coriocarcinoma não Gestacional/diagnóstico por imagem
Coriocarcinoma não Gestacional/metabolismo
Coriocarcinoma não Gestacional/terapia
Gonadotropina Coriônica Humana Subunidade beta/metabolismo
Cisplatino/administração & dosagem
Disfunção Cognitiva/etiologia
Corpo Estriado/diagnóstico por imagem
Corpo Estriado/cirurgia
Irradiação Craniana
Imagem de Tensor de Difusão
Tumor do Seio Endodérmico/complicações
Tumor do Seio Endodérmico/diagnóstico por imagem
Tumor do Seio Endodérmico/metabolismo
Tumor do Seio Endodérmico/terapia
Etoposídeo/administração & dosagem
Feminino
Germinoma/complicações
Germinoma/diagnóstico por imagem
Germinoma/metabolismo
Germinoma/terapia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Terapia Neoadjuvante
Neoplasias Embrionárias de Células Germinativas/complicações
Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem
Neoplasias Embrionárias de Células Germinativas/metabolismo
Procedimentos Neurocirúrgicos
Paresia/etiologia
Estudos Retrospectivos
Cirurgia de Second-Look
Convulsões/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chorionic Gonadotropin, beta Subunit, Human); 0 (alpha-Fetoproteins); 6PLQ3CP4P3 (Etoposide); BG3F62OND5 (Carboplatin); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE


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[PMID]:27490988
[Au] Autor:Reekhaye A; Harris A; Nagarajan S; Chadwick D
[Ad] Endereço:James Cook University Hospital , Middlesbrough , UK.
[Ti] Título:A giant testicular mixed germ cell tumour.
[So] Source:Ann R Coll Surg Engl;98(8):e171-e172, 2016 Nov.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present a case that we believe to be the largest mixed germ cell testicular tumour reported in the United Kingdom. A 23-year-old male was admitted to our urology department with a large scrotal swelling. The patient was found to have a giant left testicular tumour and a solitary lung metastasis at presentation. He underwent an emergency radical orchidectomy and subsequently received four cycles of bleomycin, etoposide and cisplatin chemotherapy. Four months after starting treatment, the tumour markers had normalised and a repeat staging computed tomography showed no active disease. The tumour reached that size because of the patient's failure to seek medical attention due to fear and embarrassment.
[Mh] Termos MeSH primário: Carcinoma Embrionário/diagnóstico
Tumor do Seio Endodérmico/diagnóstico
Neoplasias Testiculares/diagnóstico
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Carcinoma Embrionário/patologia
Carcinoma Embrionário/cirurgia
Terapia Combinada
Tumor do Seio Endodérmico/patologia
Tumor do Seio Endodérmico/cirurgia
Seres Humanos
Neoplasias Pulmonares/secundário
Masculino
Orquiectomia
Neoplasias Testiculares/patologia
Neoplasias Testiculares/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE


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[PMID]:27416669
[Au] Autor:Wang JZ; Hu SS; Zhang LM; Chen TF
[Ti] Título:[Treatments of stage-Is testicular mixed germ cell tumors: A report of 3 cases].
[So] Source:Zhonghua Nan Ke Xue;22(5):437-41, 2016 May.
[Is] ISSN:1009-3591
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate different treatment methods for stage-Is testicular mixed germ cell tumors (TMGCTs). METHODS: We retrospectively analyzed the clinical data about 3'cases of stage-Is TMGCTs (aged 26-39 years) treated in the 175th Hospital of PLA, reviewed relevant literature, and explored the clinical characteristics of TMGCTs. RESULTS: Of the 3 patients, 1 was treated by radical orchiectomy, 1 by radical orchiectomy + retroperitoneal lymph node dissection + BEP chemotherapy scheme, and the other by radical orchiectomy + radiotherapy. The pathological components of TMGCTs were immature teratoma, seminoma, spermatocytoma, chorioepithelioma, embryonal carcinoma, and yolk sac tumor. No recurrence or distant metastasis was found during the 24-month follow-up after surgery. CONCLUSION: The diagnosis of TMGCTs primarily depends on physical examination, ultrasonography, MRI, and measurement of serum tumor markers, while its confirmation necessitates pathological examination, and its treatment is basically radical orchiectomy.
[Mh] Termos MeSH primário: Neoplasias Embrionárias de Células Germinativas/cirurgia
Neoplasias Testiculares/cirurgia
[Mh] Termos MeSH secundário: Adulto
Carcinoma Embrionário/patologia
Tumor do Seio Endodérmico/patologia
Seres Humanos
Excisão de Linfonodo
Masculino
Recidiva Local de Neoplasia
Estadiamento de Neoplasias
Neoplasias Embrionárias de Células Germinativas/patologia
Orquiectomia
Estudos Retrospectivos
Seminoma/patologia
Teratoma/patologia
Neoplasias Testiculares/patologia
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160715
[Lr] Data última revisão:
160715
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE



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