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  1 / 2537 MEDLINE  
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[PMID]:29411910
[Au] Autor:Palicelli A; Neri P; Marchioro G; De Angelis P; Bondonno G; Ramponi A
[Ad] Endereço:Department of Health Science, School of Medicine, University of Eastern Piedmont 'Amedeo Avogadro', Novara, Italy.
[Ti] Título:Paratesticular seminoma: echographic features and histological diagnosis with review of the literature.
[So] Source:APMIS;126(3):267-272, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Primary extratesticular seminomas exceptionally occur in the epididymis or in the paratesticular region/spermatic cord. Some old papers included poor histological description or insufficient photographic documentation, reducing the number of faithful cases: an up-to-date systematic review is lacking. We report the 4th primary seminoma of the paratesticular region/spermatic cord in a 35-year-old man, including the first echographic description. We provide review of the literature and etiopathogenetic discussion. Ultrasound examination showed a right paratesticular, solid, heterogeneous mass (iso-hypoechoic with hyperechoic striae; peri- and intra-lesional vascular signals) with no testicular involvement: the paratesticular origin was confirmed by pathological examination. Despite careful gross examination and extensive sampling, the 6.5-cm extratesticular tumor revealed only one microscopic focus with minimal invasion (<2 mm) of the atrophic testicular parenchyma. Intratubular germ cell neoplasia or morphologic features of a regressed testicular tumor (fibrosis/scar, necrosis, hyalinization, calcification, inflammation) were not found. Primary seminomas of the paratesticular region/spermatic cord occurred at an older mean age and presented as bigger lesions if compared to the 9 primary epididymal seminomas reported in literature. Clinical-pathological correlation and accurate sampling are mandatory for a correct diagnosis.
[Mh] Termos MeSH primário: Epididimo/patologia
Seminoma/patologia
Cordão Espermático/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Adulto
Epididimo/diagnóstico por imagem
Seres Humanos
Masculino
Seminoma/diagnóstico por imagem
Cordão Espermático/diagnóstico por imagem
Neoplasias Testiculares/diagnóstico por imagem
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12806


  2 / 2537 MEDLINE  
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[PMID]:29197138
[Au] Autor:Chen Y; Lu J; Xia L; Xue D; Yu X; Shen D; Xu L; Li G
[Ad] Endereço:Department of Urology and Chawnshang Chang Liver Cancer Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
[Ti] Título:Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma.
[So] Source:Cancer Sci;109(2):384-394, 2018 Feb.
[Is] ISSN:1349-7006
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seminoma is the most common testicular germ cell tumor worldwide and mainly occurs in 15-35-year-old young men. Early studies have indicated that testicular nuclear receptor 4 (TR4) first cloned from testis is involved in the invasion and metastasis of several human tumors; however, little attention is paid to the function of TR4 in seminoma. Our immunohistochemical (IHC) staining results showed that patients with advanced stage tumors tended to have higher expression of TR4. Importantly, there was a significant association between elevated TR4 expression and reduced overall survival in seminoma patients. In vitro MTS, western blot and transwell assays, after manipulating TR4 expression in Tcam-2 cells, revealed that TR4 induced epithelial-to-mesenchymal transition (EMT) and promoted Tcam-2 cell proliferation and invasion. Mechanism dissection demonstrated that AKT3, a critical component in the signaling pathway, played a crucial role in mediating TR4-promoted Tcam-2 cell proliferation and invasion. We further revealed that TR4 modulated AKT3 at the transcriptional level via chromatin immunoprecipitation and luciferase assays. Meanwhile, addition of the AKT3 siRNA blocked the function of TR4. Overall, these findings first elucidate that TR4 is a novel prognostic marker and plays a critical role in the metastatic capacity of Tcam-2 cells by EMT regulation and, consequently, targeting TR4-AKT3 pathway may serve as a potential therapeutic approach for seminoma.
[Mh] Termos MeSH primário: Proteínas Proto-Oncogênicas c-akt/genética
Receptores de Esteroides/metabolismo
Receptores dos Hormônios Tireóideos/metabolismo
Seminoma/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Células COS
Linhagem Celular Tumoral
Proliferação Celular
Cercopithecus aethiops
Progressão da Doença
Transição Epitelial-Mesenquimal
Regulação Neoplásica da Expressão Gênica
Células HEK293
Seres Humanos
Masculino
Meia-Idade
Invasividade Neoplásica
Estadiamento de Neoplasias
Prognóstico
Proteínas Proto-Oncogênicas c-akt/metabolismo
Seminoma/genética
Seminoma/metabolismo
Transdução de Sinais
Neoplasias Testiculares/genética
Neoplasias Testiculares/metabolismo
Regulação para Cima
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NR2C2 protein, human); 0 (Receptors, Steroid); 0 (Receptors, Thyroid Hormone); EC 2.7.11.1 (AKT3 protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1111/cas.13461


  3 / 2537 MEDLINE  
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[PMID]:29314802
[Au] Autor:Prelevic R; Milev B; Milovic N; Ignjatovic M; Spasic A; Petrovic N
[Ti] Título:Gigantic spermatocytic seminoma: A rare tumor of germ cell origin.
[So] Source:Vojnosanit Pregl;73(7):679-81, 2016 Jul.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Spermatocytic seminoma represents a rare hystologic type of malignant testicular germ cell tumor with slow course and low malignant potential. Case report: We presented a 69-year-old patient with atypical clinical presentation of spermatocytic seminoma initially diagnosed as gigantic hydrocoellae which compromised walking. After long term evolution clincal picture presented with signs and symptoms of acute scrotum. Preoperative echosonography was performed and the diagnosis of testicular infiltrative tumor was established. After that left scrotal orchiectomy was performed. Patohistological examination revealed spermatocytic seminoma Conclusion: Inspite good prognosis there is a low probability of development of high grade malignancy sinchronous sarcoma within the testis with a high potential for lymphogenic and hematogenic dissemination. Individual approach is necessary in accordance with the pathohistological diagnosis.
[Mh] Termos MeSH primário: Seminoma/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Masculino
Orquiectomia/métodos
Seminoma/cirurgia
Hidrocele Testicular/diagnóstico
Neoplasias Testiculares/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150527081P


  4 / 2537 MEDLINE  
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[PMID]:28467339
[Au] Autor:Saba L
[Ad] Endereço:. lukas_red@hotmail.it.
[Ti] Título:The primitive extratesticular seminoma: diagnosis of a rare pathology.
[So] Source:Acta Biomed;88(1):82-85, 2017 Apr 28.
[Is] ISSN:0392-4203
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo: Background: The Primitive Extratesticular Seminoma is a very rare condition and represents 3% of germ cell tumors; it is an indeterminate origin disease, whose diagnosis is often complicated by a nonspecific and highly variable clinical finding. CASE PRESENTATION: A caucasian 55 years old male, non-smoker, arrived to our centre with cough, severe respiratory distress and dysphagia, in a context of the superior vena cava syndrome. A Computed Tomography was performed, which shows the presence of a mediastinal anterior mass with aorto-pulmonary window and left paracardiac invasion. A biopsy of the mediastinal mass was performed with mediastinoscopy; the hystological diagnosis was seminoma. After, first of all the 18FDG PET-CT is performed, which shows the presence of an intense hypermetabolism (SUV max=20.3 and metabolic volume 867 cc) at the level of bulky mediastinal mass, with paratracheal, aorto-pulmonary window and left paracardiac invasion. The mass presents also a sternal manubrium invasion. There were no other detectable tissue metabolic alterations with the 18FDG PET-CT and, in particular, the testicles examination was negative. A bilateral testicular ultrasound (US) was executed, which confirms the absence of testicular germ tumor. Clinical laboratory tests show a significant increase of beta-HCG (123 IU/L); AFP is negative. A final diagnosis of primitive extratesticular seminoma was carried. CONCLUSIONS: The Primitive Extratesticolar Seminoma is a rare patology, and, for its massive size at the onset diagnosis, curable in early stage often only with radiochemotherapy. The Diagnostic Imaging and Nuclear Medicine, as Testicular Ultrasound, the CT with contrast medium and the 18FDG PET-CT total body examination, are fundamental to the staging and localisation. MRI sometimes is useful for testicular evaluation. The biopsy is needed for tissue characterization.
[Mh] Termos MeSH primário: Neoplasias do Mediastino/patologia
Seminoma/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Neoplasias do Mediastino/diagnóstico por imagem
Meia-Idade
Invasividade Neoplásica
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
Doenças Raras
Seminoma/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.23750/abm.v88i1.5601


  5 / 2537 MEDLINE  
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[PMID]:28506050
[Au] Autor:Kandori S; Kawai K; Tanaka K; Kawahara T; Ikeda A; Ishitsuka R; Kimura T; Kojima T; Joraku A; Miyazaki J; Nishiyama H
[Ad] Endereço:The Department of Urology, Faculty of Medicine, University of Tsukuba.
[Ti] Título:[A Clinicopathologic Study of 6 Patients with Histologically Pure Seminoma But Elevated Serum Alpha-Fetoprotein].
[So] Source:Hinyokika Kiyo;63(4):139-143, 2017 Apr.
[Is] ISSN:0018-1994
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Histologically pure seminoma with elevated alpha-fetoprotein (AFP), so-called AFP-positive seminoma, is rare. It is recommended that patients with AFP-positive seminoma be managed as non-seminoma, but the clinical features and prognosis of this disease are not fully understood. In this study, we retrospectively analyzed 6 cases of metastatic AFP-positive seminoma at Tsukuba University Hospital (TUH). AFP was elevated before induction chemotherapy in 4 patients with an average of 1,372 ng/ml. In the remaining 2 patients, AFP became elevated during or after induction chemotherapy. In all 4 patients examined, AFPL3% was abnormally increased. As induction chemotherapy, all patients received bleomycin, etoposide and cisplatin (BEP), which was then followed by etoposide, ifosfamide and cisplatin (VIP) in 3 patients. After or during induction chemotherapy, 3 patients suffered from disease progression accompanied by AFP elevation. All 3 were treated by salvage chemotherapy and surgery. Four patients underwent retroperitoneal lymph node dissection (RPLND) after induction chemotherapy ; the pathological findings were necrosis in 3 patients, and viable nonseminomatous cancer in 1 patient. Furthermore, RPLND was performed as salvage surgery in 3 patients ; the pathological findings were necrosis, viable nonseminomatous cancer and teratoma with malignant transformation, respectively. The 5-year progression-free survival rate of the 6 patients was 50%, which is somewhat inferior to that of poor-prognosis non-seminoma patients treated at TUH. One patient ultimately died of cancer, and the remaining 5 are in remission with a median follow-up of 58 months. The present study demonstrates that AFP-positive seminoma patients have a higher risk of relapse compared to non-seminoma patients.
[Mh] Termos MeSH primário: Seminoma
Neoplasias Testiculares/patologia
alfa-Fetoproteínas/análise
[Mh] Termos MeSH secundário: Adulto
Progressão da Doença
Seres Humanos
Masculino
Meia-Idade
Recidiva
Seminoma/química
Seminoma/diagnóstico
Seminoma/terapia
Neoplasias Testiculares/química
Neoplasias Testiculares/diagnóstico
Neoplasias Testiculares/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (alpha-Fetoproteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.14989/ActaUrolJap_63_4_139


  6 / 2537 MEDLINE  
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[PMID]:28407803
[Au] Autor:Tampakis A; Tampaki EC; Damaskos C; Feretis T; Thymara I; Kontzoglou K; Tomos P; Kouraklis G
[Ad] Endereço:Department of Visceral Surgery, University Hospital of Basel, Spitalstrasse 21, 4056, Basel, Switzerland. athantamp@hotmail.com.
[Ti] Título:Orchitis reveals an extragonadal primary mediastinal thymic seminoma: a coincidence or not?
[So] Source:World J Surg Oncol;15(1):85, 2017 Apr 13.
[Is] ISSN:1477-7819
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mediastinal thymic seminomas are rare male germ cell tumors with extragonadal origin that appear predominately with a cystic appearance. CASE PRESENTATION: A 22-year-old male was referred to our department for further investigation of a mediastinal mass discovered incidentally during routine chest X-ray. The patient has denied any symptoms including dyspnea, chest pain, cough, fever, dysphagia, hemoptysis, weight loss, and weakness. His past medical history was remarkable for orchitis, for which he had undergone a bilateral testicular biopsy, without the latter however, indicating the presence of a germ cell tumor or a premalignant lesion. Contrast-enhanced chest computed tomography revealed a lobulated and well-marginated cystic lesion in the anterior mediastinum. Differential diagnosis included mostly a multilocular thymic cyst, a lymphoma, a seminoma, or a soft tissue tumor. Resection of the mass revealed a primary thymic seminoma. CONCLUSIONS: A surgical approach for the management of these tumors might be reasonable considering that an extensive sampling is mandatory to gain an appropriate biopsy preoperatively in order to securely confirm or refute the presence of a mediastinal extragonadal tumor. Orchitis might be a sign of a general disorder of the germ cells which might transform in time.
[Mh] Termos MeSH primário: Neoplasias do Mediastino/diagnóstico
Orquite/patologia
Seminoma/diagnóstico
Neoplasias do Timo/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Seres Humanos
Masculino
Neoplasias do Mediastino/cirurgia
Orquite/cirurgia
Prognóstico
Seminoma/cirurgia
Neoplasias do Timo/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1186/s12957-017-1146-z


  7 / 2537 MEDLINE  
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[PMID]:28362157
[Au] Autor:McCleskey BC; Epstein JI; Albany C; Hashemi-Sadraei N; Idrees MT; Jorns JM; Lu DY; Matoso A; Rais-Bahrami S; Schwartz LE; Ulbright TM; Gordetsky J
[Ti] Título:The Significance of Lymphovascular Invasion of the Spermatic Cord in the Absence of Cord Soft Tissue Invasion.
[So] Source:Arch Pathol Lab Med;141(6):824-829, 2017 Jun.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: - Testicular germ cell tumors with lymphovascular invasion (LVI) are staged pT2, and those with spermatic cord involvement are staged pT3. OBJECTIVE: - To study the clinical significance of LVI within the spermatic cord without direct involvement of the cord soft tissues. DESIGN: - A retrospective, multi-institutional review was performed on testicular GCTs with spermatic cord LVI in the absence of cord soft tissue invasion. RESULTS: - Forty-four germ cell tumors had LVI in the spermatic cord without soft tissue invasion; 37 of 44 patients (84%) had nonseminomatous germ cell tumors (NSGCT), and 7 (16%) had pure seminomas. Patients with NSGCTs and spermatic cord LVI had worse clinical outcomes compared with patients with pure seminoma and spermatic cord LVI (P = .008). We then compared patients with NSGCTs and spermatic cord LVI (n = 37) to patients with NSGCTs and LVI limited to the testis (n = 32). A significantly greater percentage of patients with LVI in the spermatic cord presented with advanced clinical stage (76% versus 50%; P = .01). There was no statistically significant difference in disease recurrence/progression or death between patients with spermatic cord LVI and patients with LVI limited to the testis (P = .40; P = .50). There was no significant difference in the presence of embryonal dominant histology (P = .30) or rete testis invasion (P = .50) between the 2 groups. More hilar soft tissue invasion was seen in patients with LVI present in the spermatic cord (P = .004). CONCLUSIONS: - In patients with NSGCTs, LVI in the spermatic cord, without soft tissue invasion, is associated with worse clinical stage at presentation compared with patients with LVI confined to the testis.
[Mh] Termos MeSH primário: Neoplasias Embrionárias de Células Germinativas/patologia
Seminoma/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Seres Humanos
Masculino
Meia-Idade
Invasividade Neoplásica
Estadiamento de Neoplasias
Cordão Espermático/patologia
Testículo/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2016-0226-OA


  8 / 2537 MEDLINE  
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[PMID]:28302141
[Au] Autor:Benesová M; Trejbalová K; Kovárová D; Vernerová Z; Hron T; Kucerová D; Hejnar J
[Ad] Endereço:Institute of Molecular Genetics, Czech Academy of Sciences, Videnska 1083, 14220, Prague 4, Czech Republic.
[Ti] Título:DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas.
[So] Source:Retrovirology;14(1):20, 2017 Mar 17.
[Is] ISSN:1742-4690
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Syncytin-1 and 2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotrophoblast in chorionic villi. In non-trophoblastic cells, however, the expression of syncytins has to be suppressed to avoid potential pathogenic effects. Previously, we have shown that the transcriptional suppression of ERVWE1 promoter is controlled epigenetically by DNA methylation and chromatin modifications. In this study, we describe the aberrant expression of syncytin-1 in biopsies of testicular germ cell tumors. RESULTS: We found efficient expression and splicing of syncytin-1 in seminomas and mixed germ cell tumors with seminoma component. Although another fusogenic gene, syncytin-2 was also derepressed in seminomas, its expression was significantly lower than that of syncytin-1. Neither the transcription factor GCM1 nor the increased copy number of ERVWE1 were sufficient for this aberrant expression of syncytin-1 in seminomas. In accordance with our recent finding of the highly increased expression of TET1 dioxygenase in most seminomas, the ERVWE1 promoter was significantly hypomethylated in comparison with the matched controls. In contrast, 5-hydroxymethylcytosine levels were not detectable at the ERVWE1 promoter. We further describe that another endogenous retroviral element adjacent to ERVWE1 remains transcriptionally suppressed and two additional HERV-W family members are only slightly upregulated in seminomas. CONCLUSIONS: We conclude that DNA demethylation of the ERVWE1 promoter in seminomas is a prerequisite for syncytin-1 derepression. We propose the spliced syncytin-1 expression as a marker of seminoma and suggest that aberrant expression of endogenous retroviruses might be a correlate of the hypomethylated genome of seminomas.
[Mh] Termos MeSH primário: DNA Viral/metabolismo
Retrovirus Endógenos/genética
Regulação da Expressão Gênica
Produtos do Gene env/biossíntese
Proteínas da Gravidez/biossíntese
Seminoma/patologia
Neoplasias Testiculares/patologia
[Mh] Termos MeSH secundário: Metilação de DNA
Epigênese Genética
Seres Humanos
Masculino
Seminoma/virologia
Neoplasias Testiculares/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral); 0 (Gene Products, env); 0 (Pregnancy Proteins); 0 (syncytin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1186/s12977-017-0342-9


  9 / 2537 MEDLINE  
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Cedenho, Agnaldo Pereira
Texto completo SciELO Brasil
[PMID]:28266817
[Au] Autor:Sposito C; Camargo M; Tibaldi DS; Barradas V; Cedenho AP; Nichi M; Bertolla RP; Spaine DM
[Ad] Endereço:Departamento de Cirurgia, Divisão de Urologia, Setor de Reprodução Humana, Universidade Federal de São Paulo, SP, Brasil.
[Ti] Título:Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy.
[So] Source:Int Braz J Urol;43(4):644-651, 2017 Jul-Aug.
[Is] ISSN:1677-6119
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine enzymatic antioxidant and lipid peroxidation levels in seminal plasma of patients orchiectomized for testicular tumors. MATERIALS AND METHODS: The study included 52 patients: 26 control men and 26 orchiectomized patients for testicular tumor, of which 12 men had seminoma tumor and 14 men non-seminoma tumor. After semen analysis performed according to the WHO guidelines, an aliquot of semen was centrifuged and the seminal plasma was collected. Lipid peroxidation was performed by thiobarbituric acid reactive substances(TBARS) assay and antioxidant profile was assessed by analyzing catalase, glutathione per-oxidase (GPx) and superoxide anion (SOD) activities using colorimetric assays with a standard spectrophotometer. Data were tested for normality and compared using one-way ANOVA (p<0.05). RESULTS: Seminoma and non-seminoma groups presented lower sperm concentration and morphology when compared to control group (p=0.0001). Both study groups (seminoma and non-seminoma) presented higher TBARS levels when compared to control group (p=0.0000013). No differences were observed for SOD (p=0.646) and GPx (p=0.328). It was not possible to access the enzymatic activity of catalase in any group. CONCLUSION: Patients with testicular tumor present increased semen oxidative stress, but no differences were observed in antioxidant levels, even after orchiectomy. This indicates that most likely an increased generation of oxidative products takes place in these patients.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Peroxidação de Lipídeos/fisiologia
Sêmen/enzimologia
Seminoma/metabolismo
Neoplasias Testiculares/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Casos e Controles
Catalase/metabolismo
Estudos Transversais
Glutationa Peroxidase/metabolismo
Seres Humanos
Masculino
Meia-Idade
Oligospermia
Orquiectomia
Estresse Oxidativo/fisiologia
Análise do Sêmen
Contagem de Espermatozoides
Superóxido Dismutase/metabolismo
Neoplasias Testiculares/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


  10 / 2537 MEDLINE  
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[PMID]:28262583
[Au] Autor:Zschäbitz S; Lasitschka F; Hadaschik B; Hofheinz RD; Jentsch-Ullrich K; Grüner M; Jäger D; Grüllich C
[Ad] Endereço:Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. Electronic address: Stefanie.Zschaebitz@med.uni-heidelberg.de.
[Ti] Título:Response to anti-programmed cell death protein-1 antibodies in men treated for platinum refractory germ cell cancer relapsed after high-dose chemotherapy and stem cell transplantation.
[So] Source:Eur J Cancer;76:1-7, 2017 May.
[Is] ISSN:1879-0852
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Treatment options for patients with platinum refractory metastatic germ cell tumours (GCT) relapsing after high-dose chemotherapy and autologous stem cell transplantation are limited and survival is poor. Antibodies directed against programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) are currently assessed within clinical trials. We present updated data on our experience with checkpoint inhibitors as a compassionate use off-label treatment attempt for highly-pretreated patients with GCT and provide an overview of the current literature on PD-L1 expression in this rare tumour entity. PATIENTS AND METHODS: We analysed all patients with platinum refractory GCT treated with checkpoint inhibitors at our institutions between 2015 and 2017. Data were retrieved retrospectively from the patient charts. RESULTS: Seven patients were treated with nivolumab or pembrolizumab. Four patients received single-dose treatment and died shortly afterwards due to tumour progression; the remaining three patients received treatment for at least 6 months. No significant treatment toxicity was observed. Long-term tumour response was achieved in two of the three patients, both of them highly positive for PD-L1 staining. INTERPRETATION: We consider checkpoint inhibition to be efficient in carefully selected patients with platinum refractory GCT. However, predictive markers associated with tumour response are not yet known and larger prospective clinical trials are warranted.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/uso terapêutico
Anticorpos Monoclonais/uso terapêutico
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias do Mediastino/tratamento farmacológico
Recidiva Local de Neoplasia/tratamento farmacológico
Neoplasias Embrionárias de Células Germinativas/tratamento farmacológico
Neoplasias Testiculares/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Coriocarcinoma não Gestacional/diagnóstico por imagem
Coriocarcinoma não Gestacional/tratamento farmacológico
Coriocarcinoma não Gestacional/metabolismo
Coriocarcinoma não Gestacional/secundário
Cisplatino/uso terapêutico
Ensaios de Uso Compassivo
Tumor do Seio Endodérmico/diagnóstico por imagem
Tumor do Seio Endodérmico/tratamento farmacológico
Tumor do Seio Endodérmico/metabolismo
Tumor do Seio Endodérmico/secundário
Etoposídeo/uso terapêutico
Seres Humanos
Ifosfamida/uso terapêutico
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/secundário
Masculino
Neoplasias do Mediastino/metabolismo
Neoplasias do Mediastino/patologia
Meia-Idade
Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem
Neoplasias Embrionárias de Células Germinativas/metabolismo
Neoplasias Embrionárias de Células Germinativas/secundário
Compostos de Platina/administração & dosagem
Receptor de Morte Celular Programada 1/metabolismo
Estudos Retrospectivos
Seminoma/diagnóstico por imagem
Seminoma/tratamento farmacológico
Seminoma/metabolismo
Seminoma/secundário
Transplante de Células-Tronco
Teratoma
Neoplasias Testiculares/metabolismo
Neoplasias Testiculares/patologia
Tomografia Computadorizada por Raios X
Transplante Autólogo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Monoclonal, Humanized); 0 (PDCD1 protein, human); 0 (Platinum Compounds); 0 (Programmed Cell Death 1 Receptor); 31YO63LBSN (nivolumab); 6PLQ3CP4P3 (Etoposide); DPT0O3T46P (pembrolizumab); Q20Q21Q62J (Cisplatin); UM20QQM95Y (Ifosfamide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE



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