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[PMID]:29232814
[Au] Autor:Ciappetta P; Pescatori L
[Ad] Endereço:University of Bari, Bari, Italy.
[Ti] Título:In Reply to the Letter to the Editor Regarding "Anatomic Dissection of Arachnoid Membranes Encircling the Pituitary Stalk on Fresh Non-Formalin-Fixed Specimens: Anatomoradiologic Correlations and Clinical Applications in Craniopharyngioma Surgery".
[So] Source:World Neurosurg;109:507, 2018 01.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Craniofaringioma
Hipófise
[Mh] Termos MeSH secundário: Aracnoide-Máter
Dissecação
Seres Humanos
Neoplasias Hipofisárias
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29232813
[Au] Autor:Kurucz P; Ganslandt O
[Ad] Endereço:Department of Neurosurery, Klinikum Stuttgart, Stuttgart, Germany. Electronic address: p.kurucz@klinikum-stuttgart.de.
[Ti] Título:Letter to the Editor Regarding "Anatomic Dissection of Arachnoid Membranes Encircling the Pituitary Stalk on Fresh Non-Formalin-Fixed Specimens: Anatomoradiologic Correlations and Clinical Applications in Craniopharyngioma Surgery".
[So] Source:World Neurosurg;109:505-506, 2018 01.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Craniofaringioma
Hipófise
[Mh] Termos MeSH secundário: Aracnoide-Máter
Dissecação
Seres Humanos
Neoplasias Hipofisárias
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29046325
[Au] Autor:Wijnen M; Olsson DS; van den Heuvel-Eibrink MM; Hammarstrand C; Janssen JAMJL; van der Lely AJ; Johannsson G; Neggers SJCMM
[Ad] Endereço:Department of Medicine Section Endocrinology, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, The Netherlands m.wijnen.1@erasmusmc.nl.
[Ti] Título:Excess morbidity and mortality in patients with craniopharyngioma: a hospital-based retrospective cohort study.
[So] Source:Eur J Endocrinol;178(1):95-104, 2018 Jan.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Most studies in patients with craniopharyngioma did not investigate morbidity and mortality relative to the general population nor evaluated risk factors for excess morbidity and mortality. Therefore, the objective of this study was to examine excess morbidity and mortality, as well as their determinants in patients with craniopharyngioma. DESIGN: Hospital-based retrospective cohort study conducted between 1987 and 2014. METHODS: We included 144 Dutch and 80 Swedish patients with craniopharyngioma identified by a computer-based search in the medical records (105 females (47%), 112 patients with childhood-onset craniopharyngioma (50%), 3153 person-years of follow-up). Excess morbidity and mortality were analysed using standardized incidence and mortality ratios (SIRs and SMRs). Risk factors were evaluated univariably by comparing SIRs and SMRs between non-overlapping subgroups. RESULTS: Patients with craniopharyngioma experienced excess morbidity due to type 2 diabetes mellitus (T2DM) (SIR: 4.4, 95% confidence interval (CI): 2.8-6.8) and cerebral infarction (SIR: 4.9, 95% CI: 3.1-8.0) compared to the general population. Risks for malignant neoplasms, myocardial infarctions and fractures were not increased. Patients with craniopharyngioma also had excessive total mortality (SMR: 2.7, 95% CI: 2.0-3.8), and mortality due to circulatory (SMR: 2.3, 95% CI: 1.1-4.5) and respiratory (SMR: 6.0, 95% CI: 2.5-14.5) diseases. Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence were identified as risk factors for excess T2DM, cerebral infarction and total mortality. CONCLUSIONS: Patients with craniopharyngioma are at an increased risk for T2DM, cerebral infarction, total mortality and mortality due to circulatory and respiratory diseases. Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence are important risk factors.
[Mh] Termos MeSH primário: Craniofaringioma/epidemiologia
Craniofaringioma/mortalidade
Neoplasias Hipofisárias/epidemiologia
Neoplasias Hipofisárias/mortalidade
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idade de Início
Infarto Cerebral/complicações
Infarto Cerebral/epidemiologia
Criança
Estudos de Coortes
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/epidemiologia
Feminino
Mortalidade Hospitalar
Seres Humanos
Hidrocefalia/complicações
Hidrocefalia/epidemiologia
Hidrocefalia/mortalidade
Incidência
Masculino
Meia-Idade
Morbidade
Países Baixos/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Fatores Sexuais
Suécia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0707


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[PMID]:28882980
[Au] Autor:Wijnen M; Olsson DS; van den Heuvel-Eibrink MM; Hammarstrand C; Janssen JAMJL; van der Lely AJ; Johannsson G; Neggers SJCMM
[Ad] Endereço:Department of MedicineSection Endocrinology, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands m.wijnen.1@erasmusmc.nl.
[Ti] Título:The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up.
[So] Source:Eur J Endocrinol;178(1):11-22, 2018 Jan.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Patients with craniopharyngioma are at an increased risk for cardio- and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its components in patients with craniopharyngioma. DESIGN: Cross-sectional study with retrospective data. METHODS: We studied the prevalence of and risk factors for the MetS and its components in 110 Dutch (median age 47 years, range 18-92) and 68 Swedish (median age 50 years, range 20-81) patients with craniopharyngioma with ≥3 years of follow-up (90 females (51%); 83 patients with childhood-onset craniopharyngioma (47%); median follow-up after craniopharyngioma diagnosis 16 years (range 3-62)). In Dutch patients aged 30-70 years and Swedish patients aged 45-69 years, we examined the prevalence of the MetS and its components relative to the general population. RESULTS: Sixty-nine (46%) of 149 patients with complete data demonstrated the MetS. Prevalence of the MetS was significantly higher in patients with craniopharyngioma compared with the general population (40% vs 26% ( < 0.05) for Dutch patients; 52% vs 15% ( < 0.05) for Swedish patients). Multivariable logistic regression analysis identified visual impairment as a borderline significant predictor of the MetS (OR 2.54, 95% CI 0.95-6.81; = 0.06) after adjustment for glucocorticoid replacement therapy and follow-up duration. Age, female sex, tumor location, radiological hypothalamic damage, Yttrium brachytherapy, glucocorticoid replacement therapy and follow-up duration significantly predicted components of the MetS. CONCLUSIONS: Patients with craniopharyngioma are at an increased risk for the MetS, especially patients with visual impairment.
[Mh] Termos MeSH primário: Craniofaringioma/diagnóstico por imagem
Craniofaringioma/epidemiologia
Síndrome Metabólica/diagnóstico por imagem
Síndrome Metabólica/epidemiologia
Transtornos da Visão/diagnóstico por imagem
Transtornos da Visão/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Craniofaringioma/terapia
Estudos Transversais
Feminino
Seguimentos
Seres Humanos
Masculino
Síndrome Metabólica/terapia
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Resultado do Tratamento
Transtornos da Visão/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0387


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[PMID]:28867358
[Au] Autor:Kralik SF; Watson GA; Shih CS; Ho CY; Finke W; Buchsbaum J
[Ad] Endereço:Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: steve.kralik@gmail.com.
[Ti] Título:Radiation-Induced Large Vessel Cerebral Vasculopathy in Pediatric Patients With Brain Tumors Treated With Proton Radiation Therapy.
[So] Source:Int J Radiat Oncol Biol Phys;99(4):817-824, 2017 Nov 15.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this research was to evaluate the incidence, time to development, imaging patterns, risk factors, and clinical significance of large vessel cerebral vasculopathy in pediatric patients with brain tumors treated with proton radiation therapy. METHODS AND MATERIALS: A retrospective study was performed on 75 consecutive pediatric patients with primary brain tumors treated with proton radiation therapy. Radiation-induced large vessel cerebral vasculopathy (RLVCV) was defined as intracranial large vessel arterial stenosis or occlusion confirmed on magnetic resonance angiography, computed tomographic angiography, catheter angiography, or a combination of these within an anatomic region with previous exposure to proton beam therapy and not present before radiation therapy. Clinical records were used to determine the incidence, timing, radiation dose to the large vessels, and clinical significance associated with the development of large vessel vasculopathy in these patients. RESULTS: RLVCV was present in 5 of 75 (6.7%) patients and included tumor pathologic features of craniopharyngioma (n=2), ATRT (n=1), medulloblastoma (n=1), and anaplastic astrocytoma (n=1). The median time from completion of radiation therapy to development was 1.5 years (mean, 3.0 years; range, 1.0-7.5 years). Neither mean age at the time of radiation therapy (5.1 years) nor mean radiation therapy dose to the large vessels (54.5 Gy) was a statistically significant risk factor. Four of the 5 patients with RLVCV presented with acute stroke and demonstrated magnetic resonance imaging evidence of acute infarcts in the expected vascular distributions. Angiography studies demonstrated collateral vessel formation in only 2 of the patients with RLVCV. No patients demonstrated acute hemorrhage or aneurysm. Two patients were treated with pial synangiomatosis surgery. CONCLUSIONS: RLVCV can occur in pediatric patients with brain tumors treated with proton radiation therapy. Further studies are necessary to determine potential risk factors for large vessel vasculopathy with proton radiation therapy in comparison with conventional photon radiation therapy.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Doenças Arteriais Cerebrais/etiologia
Artérias Cerebrais/efeitos da radiação
Terapia com Prótons/efeitos adversos
Lesões por Radiação/complicações
[Mh] Termos MeSH secundário: Adolescente
Astrocitoma/irrigação sanguínea
Astrocitoma/tratamento farmacológico
Neoplasias Encefálicas/irrigação sanguínea
Doenças Arteriais Cerebrais/diagnóstico por imagem
Artérias Cerebrais/diagnóstico por imagem
Criança
Pré-Escolar
Constrição Patológica/diagnóstico por imagem
Constrição Patológica/etiologia
Craniofaringioma/irrigação sanguínea
Craniofaringioma/radioterapia
Feminino
Seres Humanos
Lactente
Masculino
Meduloblastoma/irrigação sanguínea
Meduloblastoma/tratamento farmacológico
Lesões por Radiação/diagnóstico por imagem
Dosagem Radioterapêutica
Estudos Retrospectivos
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/etiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28859336
[Au] Autor:Donson AM; Apps J; Griesinger AM; Amani V; Witt DA; Anderson RCE; Niazi TN; Grant G; Souweidane M; Johnston JM; Jackson EM; Kleinschmidt-DeMasters BK; Handler MH; Tan AC; Gore L; Virasami A; Gonzalez-Meljem JM; Jacques TS; Martinez-Barbera JP; Foreman NK; Hankinson TC; Advancing Treatment for Pediatric Craniopharyngioma Consortium
[Ad] Endereço:Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Developmental Biology and Cancer Programme, Great Ormond Street UCL Institute of Child Health, London, UK; Department of Neurological Surgery, Columbia University Medical Center, New York, New York; Division
[Ti] Título:Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.
[So] Source:J Neuropathol Exp Neurol;76(9):779-788, 2017 Sep 01.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling mechanisms driving tumor behavior have been hypothesized, with IL-6R overexpression identified as a potential therapeutic target. To identify potential novel therapies, we characterized inflammatory and immunomodulatory factors in ACP cyst fluid and solid tumor components. Cytometric bead analysis revealed a highly pro-inflammatory cytokine pattern in fluid from ACP compared to fluids from another cystic pediatric brain tumor, pilocytic astrocytoma. Cytokines and chemokines with particularly elevated concentrations in ACPs were IL-6, CXCL1 (GRO), CXCL8 (IL-8) and the immunosuppressive cytokine IL-10. These data were concordant with solid tumor compartment transcriptomic data from a larger cohort of ACPs, other pediatric brain tumors and normal brain. The majority of receptors for these cytokines and chemokines were also over-expressed in ACPs. In addition to IL-10, the established immunosuppressive factor IDO-1 was overexpressed by ACPs at the mRNA and protein levels. These data indicate that ACP cyst fluids and solid tumor components are characterized by an inflammatory cytokine and chemokine expression pattern. Further study regarding selective cytokine blockade may inform novel therapeutic interventions.
[Mh] Termos MeSH primário: Craniofaringioma/metabolismo
Líquido Cístico/metabolismo
Citocinas/metabolismo
Neoplasias Hipofisárias/metabolismo
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Estudos de Coortes
Craniofaringioma/genética
Craniofaringioma/patologia
Líquido Cístico/imunologia
Feminino
Perfilação da Expressão Gênica
Regulação Neoplásica da Expressão Gênica/fisiologia
Seres Humanos
Indolamina-Pirrol 2,3,-Dioxigenase/genética
Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo
Masculino
Análise em Microsséries
Neoplasias Hipofisárias/genética
Neoplasias Hipofisárias/patologia
RNA Mensageiro/metabolismo
Receptores de Interleucina-6/genética
Receptores de Interleucina-6/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Cytokines); 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase); 0 (RNA, Messenger); 0 (Receptors, Interleukin-6); 0 (indoleamine 2,3-dioxygenase 1, human)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1093/jnen/nlx061


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[PMID]:28732411
[Au] Autor:Yano S; Hide T; Shinojima N
[Ad] Endereço:Faculty of Life Sciences Research, Kumamoto University Graduate School, Neurosurgery, Kumamoto, Japan. Electronic address: yanoshige7@gmail.com.
[Ti] Título:In Reply to "Craniopharyngioma: Surgical Outcome as Related to the Degree of Hypothalamic Involvement".
[So] Source:World Neurosurg;104:1011-1013, 2017 08.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Craniofaringioma/cirurgia
Hipotálamo/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Hipofisárias/cirurgia
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28732410
[Au] Autor:Prieto R; Pascual JM; Castro-Dufourny I; Carrasco R; Barrios L
[Ad] Endereço:Department of Neurosurgery, Puerta de Hierro University Hospital, Madrid, Spain. Electronic address: rprieto29@hotmail.com.
[Ti] Título:Craniopharyngioma: Surgical Outcome as Related to the Degree of Hypothalamic Involvement.
[So] Source:World Neurosurg;104:1006-1010, 2017 08.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Craniofaringioma/cirurgia
Hipotálamo/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias Hipofisárias/cirurgia
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28604190
[Au] Autor:Bhogal P; Paraskevopoulos D; Makalanda HL
[Ad] Endereço:1 Neuroradiology Clinic, Klinikum Stuttgart, Stuttgart, Germany.
[Ti] Título:The use of a stent-retriever to cause mechanical dilatation of a vasospasm secondary to iatrogenic subarachnoid haemorrhage.
[So] Source:Interv Neuroradiol;23(3):330-335, 2017 Jun.
[Is] ISSN:2385-2011
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objective To report the use of a stent-retriever in the management of vasospasm secondary to craniopharyngioma resection. Postoperative improvement was seen both clinically and on perfusion imaging. Methods A patient was admitted for resection of a large craniopharygioma. On day 6 postoperatively the patient had an acute hemiparesis. A computed tomography angiogram and perfusion scan demonstrated acute right-sided cerebral vasospasm and a perfusion defect in the territory of the middle cerebral artery (MCA). Results A pREset 4 × 20 mm stent-retriever was used to dilate the M1 and proximal M2 segments of the right MCA mechanically. This resulted in immediate dilatation of the spastic segment and improvement in the transit time on the angiogram. There was an improvement in the clinical status post-procedure and a computed tomography perfusion performed 24 hours after the procedure showed symmetrical perfusion. A computed tomography angiogram and magnetic resonance imaging performed 1 week later showed a symmetrical appearance to the MCA and no evidence of restricted diffusion. Conclusion The use of commercially available stent-retrievers can cause mechanical dilatation of vasospastic vessels. The stents do not need to be deployed for a prolonged period nor do they need to be implanted to have a prolonged dilatory effect on the spastic vessels.
[Mh] Termos MeSH primário: Stents
Hemorragia Subaracnóidea/complicações
Vasoespasmo Intracraniano/etiologia
Vasoespasmo Intracraniano/terapia
[Mh] Termos MeSH secundário: Adulto
Angiografia Cerebral
Angiografia por Tomografia Computadorizada
Craniofaringioma/complicações
Craniofaringioma/diagnóstico por imagem
Remoção de Dispositivo
Dilatação
Feminino
Seres Humanos
Doença Iatrogênica
Imagem por Ressonância Magnética
Artéria Cerebral Média
Neoplasias Hipofisárias/complicações
Neoplasias Hipofisárias/diagnóstico por imagem
Hemorragia Subaracnóidea/diagnóstico por imagem
Vasoespasmo Intracraniano/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1177/1591019917694838


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[PMID]:28506993
[Au] Autor:Haston S; Pozzi S; Carreno G; Manshaei S; Panousopoulos L; Gonzalez-Meljem JM; Apps JR; Virasami A; Thavaraj S; Gutteridge A; Forshew T; Marais R; Brandner S; Jacques TS; Andoniadou CL; Martinez-Barbera JP
[Ad] Endereço:Developmental Biology and Cancer Programme, Birth Defects Research Centre, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK scott.haston.13@ucl.ac.uk j.martinez-barbera@ucl.ac.uk.
[Ti] Título:MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.
[So] Source:Development;144(12):2141-2152, 2017 06 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here, we show that the over-activation of the MAPK pathway, through conditional expression of the gain-of-function alleles and in the developing mouse pituitary, results in severe hyperplasia and abnormal morphogenesis of the gland by the end of gestation. Cell-lineage commitment and terminal differentiation are disrupted, leading to a significant reduction in numbers of most of the hormone-producing cells before birth, with the exception of corticotrophs. Of note, Sox2 stem cells and clonogenic potential are drastically increased in the mutant pituitaries. Finally, we reveal that papillary craniopharyngioma (PCP), a benign human pituitary tumour harbouring also contains Sox2 cells with sustained proliferative capacity and disrupted pituitary differentiation. Together, our data demonstrate a crucial function of the MAPK pathway in controlling the balance between proliferation and differentiation of Sox2 cells and suggest that persistent proliferative capacity of Sox2 cells may underlie the pathogenesis of PCP.
[Mh] Termos MeSH primário: Craniofaringioma/fisiopatologia
Sistema de Sinalização das MAP Quinases/fisiologia
Neoplasias Hipofisárias/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Proliferação Celular
Craniofaringioma/genética
Craniofaringioma/patologia
Células-Tronco Embrionárias/patologia
Células-Tronco Embrionárias/fisiologia
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Proteínas de Homeodomínio/genética
Proteínas de Homeodomínio/metabolismo
Seres Humanos
Sistema de Sinalização das MAP Quinases/genética
Camundongos
Camundongos Mutantes
Camundongos Transgênicos
Proteínas Mutantes/genética
Proteínas Mutantes/metabolismo
Hipófise/citologia
Hipófise/embriologia
Hipófise/enzimologia
Neoplasias Hipofisárias/genética
Neoplasias Hipofisárias/patologia
Gravidez
Proteínas Proto-Oncogênicas B-raf/genética
Proteínas Proto-Oncogênicas B-raf/metabolismo
Proteínas Proto-Oncogênicas p21(ras)/genética
Proteínas Proto-Oncogênicas p21(ras)/metabolismo
Proteínas Repressoras/genética
Proteínas Repressoras/metabolismo
Fatores de Transcrição SOXB1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hesx1 protein, mouse); 0 (Homeodomain Proteins); 0 (Mutant Proteins); 0 (Repressor Proteins); 0 (SOX2 protein, human); 0 (SOXB1 Transcription Factors); 0 (Sox2 protein, mouse); EC 2.7.11.1 (Braf protein, mouse); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf); EC 3.6.5.2 (Kras2 protein, mouse); EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1242/dev.150490



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