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[PMID]:29480846
[Au] Autor:Cai J; Li W; Du J; Xu N; Gao P; Zhou J; Li X
[Ad] Endereço:Department of Radiology, Beijing Tiantan Hospital affiliated to Capital Medical University.
[Ti] Título:Supratentorial intracerebral cerebellar liponeurocytoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(2):e9556, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Cerebellar liponeurocytoma is a rare tumor of the central nervous system (CNS) characterized by low proliferation but high likelihood of recurrence. Because of its rarity and the paucity of systematic follow-up, the biological behaviors and clinical features of this tumor are still poorly understood. We herein reported a case of cerebellar liponeurocytoma originating in the cerebral hemisphere. PATIENT CONCERNS: A 11-year-old male with intermittent headache, nausea, and vomiting. The first computed tomography revealed a large mass in the right cerebral hemisphere. He was transferred to our institution for neurosurgical treatment. DIAGNOSIS: Magnetic resonance imaging showed a large cystic-solid mass in the right frontal lobe with obvious contrast enhancement. Histopathological examinations showed sheets of isomorphic small neoplastic cells with clear cytoplasm and focal lipomatous differentiation. On immunohistochemistry, tumor cells were positive for synaptophysin, microtubule-associated protein 2, and neuronal nuclei antigen. INTERVENTIONS: The patient was performed a right fronto-parietal craniotomy, and gross total resection of the tumor was achieved without adjuvant therapy. OUTCOMES: No clinical or neuroradiological evidence of recurrence or residual of the tumor was found 6 years and 2 months after initial surgery. LESSONS: Cerebellar liponeurocytoma developing in supratentorial cerebral hemisphere was first reported in the present study. The radiological and histopathological features may be useful in differentiating this rare tumor from other tumors at similar locations. A change in the nomenclature of cerebellar liponeurocytomas should be considered in future World Health Organization (WHO) classifications.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/diagnóstico por imagem
Neoplasias Cerebelares/cirurgia
Neurocitoma/diagnóstico por imagem
Neurocitoma/cirurgia
Neoplasias Supratentoriais/diagnóstico por imagem
Neoplasias Supratentoriais/cirurgia
[Mh] Termos MeSH secundário: Neoplasias Cerebelares/patologia
Criança
Diagnóstico Diferencial
Seres Humanos
Masculino
Neurocitoma/patologia
Neoplasias Supratentoriais/patologia
Terminologia como Assunto
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009556


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[PMID]:28979624
[Au] Autor:Abbad F; Sellami S; Hazmiri F; Idriss Ganouni NE; Benali SA; Khouchani M; Rais H
[Ad] Endereço:Service d'Anatomie et Cytologie Pathologiques, Hôpital Ar Razi, CHU Mohammed VI, Marrakech, Maroc.
[Ti] Título:[Central neurocytomas: clinical and radiopathological correlations: about 12 cases].
[Ti] Título:Neurocytomes centraux: corrélations cliniques et radiopathologiques à propos de 12 observations..
[So] Source:Pan Afr Med J;27:222, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Central neurocytomas are defined as neoplasms composed of round, uniform cells, with neural immunophenotypic profile and low proliferation index. They account for 0.5% of intracranial tumors. They usually occur near the foramen of Monro and can cause obstructive hydrocephaly. We conducted a retrospective data collection from records of 12 patients with central neurocytomas in the Anatomopathological Laboratory at the Mohammed VI University Hospital, Marrakech, between January 2006 and June 2015. This study aimed to report and describe the radiopathological features of this rare histologic type. The male/female sex-ratio was 1.4. The average age at diagnosis was 22.3 years. The revealing symptomatology was dominated by intracranial hypertension associated with decreased visual acuity and diplopia in all patients. Our study concerned about simple biopsy in one case, subtotal resection in seven cases and total resection in four cases. Histopathological examination showed tumor proliferation with endocrine architecture. Tumor cells are more often small and uniform. Mitotic index was low. Tumor proliferation was associated with fibrillary fundus and vascular network with three types of trees. Immunohistochemical examination was identical in all patients. It showed tumor cells positive for anti-synaptophysin antibodies, chromogranine and NSE. In all patients the radio-pathologic correlation suggested central neurocytoma (grade II - WHO 2016). This study highlights the anatomo-clinical, radiological and evolutionary features of these rare tumors.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico
Hipertensão Intracraniana/etiologia
Neurocitoma/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anticorpos Monoclonais/imunologia
Biópsia
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/patologia
Diplopia/etiologia
Feminino
Seres Humanos
Masculino
Marrocos
Neurocitoma/diagnóstico por imagem
Neurocitoma/patologia
Estudos Retrospectivos
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (anti-synaptophysin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.222.12016


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[PMID]:28408259
[Au] Autor:Fu W; Ju Y; Zhang S; You C
[Ad] Endereço:Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Pediatric Basal Ganglia Region Tumors: Clinical and Radiologic Features Correlated with Histopathologic Findings.
[So] Source:World Neurosurg;103:504-516, 2017 Jul.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To summarize the clinical and radiologic features of pediatric basal ganglia region tumors (PBGRT) in correlation with their histopathologic findings to reduce inappropriate surgery and identify tumors that can benefit from maximal safe resection. METHODS: The records of 35 children with PBGRT treated in our hospital from December 2011 to December 2015 were analyzed retrospectively. The clinical and radiologic features of these tumors were summarized and correlated with their histopathologic diagnosis. RESULTS: Our series included 15 astrocytomas and 11 germ cell tumors (GCTs). Basal ganglia astrocytomas were characterized by various clinical presentations and an ill-circumscribed mass with the involvement of surrounding structures on neuroimaging and mostly occurred in the first decade of life (n = 10; 66.7%). Basal ganglia GCT mostly occurred in the second decade of life (n = 8; 72.7%) with hemiparesis as the most common symptom (n = 9; 81.8%). The tumors were located predominantly in the caput of caudate nucleus (n = 8; 72.7%) with hemiatrophy as the typical sign (n = 8; 72.7%). Occasionally, other tumors also could occur in this region, including primitive neuroectodermal tumor (n = 1), atypical teratoid/rhabdoid tumor (n = 1), anaplastic ependymoma (n = 1), lymphoma (n = 1), extraventricular neurocytoma (n = 1), gangliogliomas (n = 2), oligodendroglioma (n = 1), and dysembryoplastic neuroepithelial tumor (n = 1). CONCLUSIONS: Astrocytoma and GCT are the most common PBGRTs. Low-grade astrocytomas could benefit from maximal surgical resection, whereas GCTs merit neoadjuvant chemoradiation therapy followed by second-look surgery. We advocate routine testing of tumor markers and analysis of their clinical and radiologic features to optimize the therapeutic strategy.
[Mh] Termos MeSH primário: Astrocitoma/terapia
Doenças dos Gânglios da Base/terapia
Biomarcadores Tumorais/metabolismo
Neoplasias Encefálicas/terapia
Quimiorradioterapia
Terapia Neoadjuvante
Neoplasias Embrionárias de Células Germinativas/terapia
Procedimentos Neurocirúrgicos
[Mh] Termos MeSH secundário: Adolescente
Astrocitoma/complicações
Astrocitoma/diagnóstico por imagem
Astrocitoma/metabolismo
Doenças dos Gânglios da Base/complicações
Doenças dos Gânglios da Base/diagnóstico por imagem
Doenças dos Gânglios da Base/metabolismo
Neoplasias Encefálicas/complicações
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/metabolismo
Núcleo Caudado/diagnóstico por imagem
Núcleo Caudado/cirurgia
Criança
Pré-Escolar
Tontura/etiologia
Ependimoma/complicações
Ependimoma/diagnóstico por imagem
Ependimoma/metabolismo
Ependimoma/terapia
Feminino
Ganglioglioma/complicações
Ganglioglioma/diagnóstico por imagem
Ganglioglioma/metabolismo
Ganglioglioma/terapia
Cefaleia/etiologia
Seres Humanos
Lactente
Linfoma/complicações
Linfoma/diagnóstico por imagem
Linfoma/metabolismo
Linfoma/terapia
Masculino
Técnicas de Diagnóstico Molecular
Neoplasias Embrionárias de Células Germinativas/complicações
Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem
Neoplasias Embrionárias de Células Germinativas/metabolismo
Neoplasias Neuroepiteliomatosas/complicações
Neoplasias Neuroepiteliomatosas/diagnóstico por imagem
Neoplasias Neuroepiteliomatosas/terapia
Neurocitoma/complicações
Neurocitoma/diagnóstico por imagem
Neurocitoma/metabolismo
Neurocitoma/terapia
Tumores Neuroectodérmicos Primitivos/complicações
Tumores Neuroectodérmicos Primitivos/diagnóstico por imagem
Tumores Neuroectodérmicos Primitivos/metabolismo
Tumores Neuroectodérmicos Primitivos/terapia
Oligodendroglioma/complicações
Oligodendroglioma/diagnóstico por imagem
Oligodendroglioma/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28236115
[Au] Autor:Xu L; Du J; Wang J; Fang J; Liu Z; He Y; Li G
[Ad] Endereço:Department of Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Brain Tumor, Beiji
[Ti] Título:The clinicopathological features of liponeurocytoma.
[So] Source:Brain Tumor Pathol;34(1):28-35, 2017 Jan.
[Is] ISSN:1861-387X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:To discuss the clinicopathological features of liponeurocytoma, we retrospectively reviewed three liponeurocytoma cases and compared their immunophenotypes and genotypes with those of similar tumors. Furthermore, we reviewed the literature and compared the similarities and differences between cerebellar and intraventricular liponeurocytomas. Two cerebellar and one intraventricular liponeurocytomas were included in the present study. The liponeurocytomas comprised small tumor cells and lipomatous cells. The tumor cells expressed SYN, MAP-2, and NeuN. One case showed atypical histological features. By reviewing the literature, we found that cerebellar liponeurocytoma tended to be more common in females, whereas the converse was true for intraventricular liponeurocytoma. Compared with cerebellar liponeurocytoma, intraventricular liponeurocytoma was more commonly noted in younger adult patients. A high MIB-1 index (>10%) and incomplete tumor resection might represent adverse prognostic factors in patients with liponeurocytoma. We suggest that 'central liponeurocytoma' should be used to include all putative liponeurocytoma sites. The present study identified several morphological, immunohistochemical, and genetic features that may aid in the differential diagnosis of liponeurocytoma. In addition, surgery should be the preferred treatment, and complete tumor resection should be the goal. Additional cases with long-term follow-up are needed to develop optimal management protocols for liponeurocytoma.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/patologia
Neurocitoma/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/análise
Linhagem Celular Tumoral
Neoplasias Cerebelares/diagnóstico
Diagnóstico Diferencial
Feminino
Seres Humanos
Imuno-Histoquímica/métodos
Masculino
Meia-Idade
Neurocitoma/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE
[do] DOI:10.1007/s10014-017-0279-7


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[PMID]:28120072
[Au] Autor:Soliman WS
[Ad] Endereço:Faculty of Medicine, Cairo University, Cairo, Egypt. wessamsoliman75@yahoo.com.
[Ti] Título:Ventricular Central Neurocytoma: Rate of Shunting and Outcome 2 Years After Total and Subtotal Excision.
[So] Source:Acta Neurochir Suppl;124:179-185, 2017.
[Is] ISSN:0065-1419
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Central neurocytoma is an intraventricular tumor that affects young adults. It has a favorable prognosis after adequate surgical intervention; however, an aggressive course may take place in some cases. OBJECTIVE: The objective of the study was to evaluate the rate of shunting and the outcome of control measures in patients with central neurocytoma submitted to total and subtotal excision. METHODS: Twelve patients were included in this study, with a follow-up of 24 months. Data collected included: age, sex, clinical presentation, early morbidity and mortality, radiological findings (tumor location, features, residual, recurrence, and hydrocephalus). All patients underwent surgery for total or subtotal excision through a transcortical approach. External Ventricular Drain (EVD) was inserted then removed or replaced by a shunt. Histopathology and the MIB index were used to confirm diagnosis and guide the follow-up; adjuvant radiotherapy or Gamma Knife radiosurgery were used for residual tumor or recurrence. RESULTS: The ages of the patients ranged from 14 to 48 years. Two patients died early, after total and subtotal excision, from sepsis and thalamic infarction, respectively. Six patients (60 %) had a total excision; two of them had a high MIB index and showed small recurrence at 12 months and 18 months, respectively, and received Gamma Knife radiosurgery. One of the six patients with total excision needed a shunt, and no shunt was needed in the four otherpatients; a subtotal excision was done for four patients (40 %). An early shunt was inserted for two of these patients, radiosurgery-controlled for one patient, while radiotherapy was used for control in the other three patients; radiotherapy control failed in one patient, who underwent a second surgery at 18 months. CONCLUSION: Central neurocytoma may have a favorable prognosis, with a lower incidence of shunt insertion throughout its course than that for other intraventricular tumors, if total removal is achieved.
[Mh] Termos MeSH primário: Neoplasias do Ventrículo Cerebral/cirurgia
Hidrocefalia/cirurgia
Neurocitoma/cirurgia
Procedimentos Neurocirúrgicos/métodos
Derivação Ventriculoperitoneal/utilização
[Mh] Termos MeSH secundário: Adolescente
Adulto
Neoplasias do Ventrículo Cerebral/complicações
Neoplasias do Ventrículo Cerebral/diagnóstico por imagem
Drenagem
Feminino
Seguimentos
Seres Humanos
Hidrocefalia/etiologia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Recidiva Local de Neoplasia/radioterapia
Neoplasia Residual
Neurocitoma/complicações
Neurocitoma/diagnóstico por imagem
Radiocirurgia
Radioterapia Adjuvante
Ventriculostomia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-39546-3_28


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[PMID]:27597523
[Au] Autor:Rusiecki D; Lach B; Manoranjan B; Fleming A; Ajani O; Singh SK
[Ad] Endereço:School of Interdisciplinary Sciences, Faculty of Science, McMaster University, Hamilton, Ontario, Canada L8S-4L8. Electronic address: rusiecdr@mcmaster.ca.
[Ti] Título:Progression of atypical extraventricular neurocytoma to anaplastic ganglioglioma.
[So] Source:Hum Pathol;59:125-130, 2017 Jan.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report a childhood case of thalamic atypical extraventricular neurocytoma that progressed to highly anaplastic ganglioglioma after 8 years of dormancy after subtotal resection and chemotherapy. The neurocytoma displayed immunoreactivity only for synaptophysin, ß-catenin, S100, and CD56. The ganglioglioma acquired strong immunoreactivity for chromogranin, glial fibrillary acidic protein, neuron-specific enolase, and p53 and showed a very high proliferation rate approaching 50% in some areas. Tumor transformation was associated with overexpression of components of the sonic hedgehog and Wnt developmental signaling pathways, which are known to regulate tumor-initiating cells in malignant brain neoplasms.
[Mh] Termos MeSH primário: Neoplasias do Tronco Encefálico/patologia
Transformação Celular Neoplásica/patologia
Ganglioglioma/patologia
Neurocitoma/patologia
Tálamo/patologia
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Neoplasias do Tronco Encefálico/química
Neoplasias do Tronco Encefálico/genética
Neoplasias do Tronco Encefálico/terapia
Proliferação Celular
Transformação Celular Neoplásica/química
Transformação Celular Neoplásica/genética
Criança
Progressão da Doença
Evolução Fatal
Feminino
Ganglioglioma/química
Ganglioglioma/genética
Seres Humanos
Imuno-Histoquímica
Lactente
Imagem por Ressonância Magnética
Neoplasia Residual
Neurocitoma/química
Neurocitoma/genética
Neurocitoma/terapia
Tálamo/química
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE


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[PMID]:27450443
[Au] Autor:Nayyar M; Mayo MC; Shiroishi M; Commins D; Liu CY; Go JL; Kim PE; Zee CS; Law M; Lerner A
[Ad] Endereço:Department of Radiology, Keck School of Medicine of the University of Southern California, 1500 San Pablo Street Second Floor Imaging, Los Angeles, CA 90033, USA. Electronic address: mnayyar@usc.edu.
[Ti] Título:Atypical central neurocytoma with metastatic craniospinal dissemination: a case report.
[So] Source:Clin Imaging;40(6):1108-1111, 2016 Nov - Dec.
[Is] ISSN:1873-4499
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Central neurocytomas comprise nearly half of adult intraventricular neoplasms. The median age of onset is 34 years. It is typically a low-grade neoplasm (World Health Organization grade II), although some cases of malignant neurocytomas have been described. We present a rare case of an atypical central neurocytoma with craniospinal dissemination, including both imaging and pathologic findings.
[Mh] Termos MeSH primário: Neoplasias do Ventrículo Cerebral/patologia
Neurocitoma/patologia
Neoplasias da Medula Espinal/etiologia
[Mh] Termos MeSH secundário: Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Invasividade Neoplásica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27438020
[Au] Autor:Zacharoulis S; Morales La Madrid A; Bandopadhayay P; Chi SN; Manley P; Ullrich NN; Marcus K; Goumnerova L; Scott RM; Proctor M; Young-Poussaint T; De Girolami U; Kieran MW
[Ad] Endereço:*Children and Young People's Unit, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK†Pediatric Neuro-Oncology, Dana-Farber Cancer InstituteDepartments of ‡Pediatric Hematology/Oncology§Neurology∥Radiation Oncology¶Neurosurgery#Radiology, Boston Children's Hospital**Department of Pathology, Brigham and Women's Hospital, Boston, MA.
[Ti] Título:Central Versus Extraventricular Neurocytoma in Children: A Clinicopathologic Comparison and Review of the Literature.
[So] Source:J Pediatr Hematol Oncol;38(6):479-85, 2016 Aug.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Central neurocytomas (CN) are rare pediatric CNS tumors most often with a benign clinical course. Occasionally, these tumors occur outside the ventricles and are called extraventricular neurocytomas (EVN). We present a retrospective institutional analysis of children with neurocytoma with prolonged follow-up. PROCEDURE: Twelve patients were diagnosed with neurocytoma at our institution between 1993 and 2004. RESULTS: Six patients were male and the median age at diagnosis was 12 years (1.5 to 16 y). Seven patients had CN and 5 had EVN. Presenting symptoms included headaches (67%), vomiting (50%), nausea (33%), seizures (33%), and mental status changes (25%). Obstructive hydrocephalus was present at diagnosis in 42% of the cases. Younger age and seizures were more common in patients with EVN. Gross total resection (GTR) was achieved in 42% (5/12) of the patients. Patients with GTR received no adjuvant therapy upfront; 1 patient subsequently had recurrence with leptomeningeal disease. Patients with subtotal resection received additional treatment: 1 underwent reoperation (GTR), 2 patients received focal radiation, 2 patients received adjuvant chemotherapy, and 2 patients received craniospinal irradiation followed by chemotherapy. The 20-year overall survival for this cohort was 83% with event free survival of 56%. Overall survival for CNs was 100%, versus 40% for EVN. Event free survival for CNs was 57% and 53% for the EVNs. An MIB-1 fraction >2% was associated with worse prognosis. CONCLUSIONS: Neurocytomas are rare brain tumors in children usually cured with GTR. Adjuvant focal radiation therapy and/or chemotherapy may improve disease control in cases with subtotal resection, but case-by-case analysis should be done. EVNs might be associated with worse outcome due to a higher proliferative index.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Neurocitoma/patologia
[Mh] Termos MeSH secundário: Adolescente
Neoplasias Encefálicas/mortalidade
Neoplasias Encefálicas/terapia
Criança
Pré-Escolar
Terapia Combinada
Feminino
Seres Humanos
Lactente
Masculino
Neurocitoma/mortalidade
Neurocitoma/terapia
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000627


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[PMID]:27349466
[Au] Autor:Pikis S; Fellig Y; Margolin E
[Ad] Endereço:Department of Neurosurgery, "Korgialenio Benakio" Red Cross Hospital of Athens, Athens 11526, Greece.
[Ti] Título:Cerebellar liponeurocytoma in two siblings suggests a possible familial predisposition.
[So] Source:J Clin Neurosci;32:154-6, 2016 Oct.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:There is limited data on the genetic origin and natural history of cerebellar liponeurocytoma. To the best of our knowledge there has been only one report of a familial presentation of this rare entity. We report a 72-year-old female with a posterior fossa tumor presenting with progressive cerebellar signs and symptoms. The patient underwent total tumor resection via an uncomplicated sub-occipital craniotomy. Histopathologic examination was diagnostic for cerebellar liponeurocytoma. Her sister was previously treated for a similar tumor. Our report provides further evidence for the possible existence of a hereditary abnormality predisposing afflicted families to cerebellar liponeurocytoma development.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/patologia
Neurocitoma/patologia
Irmãos
[Mh] Termos MeSH secundário: Idoso
Neoplasias Cerebelares/diagnóstico por imagem
Neoplasias Cerebelares/cirurgia
Feminino
Seres Humanos
Lipoma/patologia
Imagem por Ressonância Magnética
Neurocitoma/diagnóstico por imagem
Neurocitoma/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE


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[PMID]:27242062
[Au] Autor:Tanaka H; Sasayama T; Yamashita H; Hara Y; Hayashi S; Yamamoto Y; Fujita Y; Okino T; Mizowaki T; Yamaguchi Y; Tanaka K; Kohmura E
[Ad] Endereço:Department of Neurosurgery, Hyogo Emergency Medical Center/Kobe Red Cross Hospital, Chuo-ku, Kobe, Japan.
[Ti] Título:Rapid tumor growth with glial differentiation of central neurocytoma after stereotactic radiosurgery.
[So] Source:J Clin Neurosci;31:188-92, 2016 Sep.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Although stereotactic radiosurgery (SRS) is effective for central neurocytoma (CN), the long-term outcome of SRS remains unclear. We present a case of recurrent CN that was diagnosed 10years after surgical resection and consecutive stereotactic radiotherapy. The patient was treated with SRS for the recurrent tumor, but underwent two-staged surgery once again due to rapid tumor growth. Histological features of the recurrent tumor were consistent with the diagnosis of CN. However, an increased Ki-67 proliferation index (3.4%), aberrant angiogenesis and glial differentiation of the tumor cells were observed, which were not identified in the initial CN. In addition, vascular endothelial growth factor (VEGF) and VEGF receptor were highly expressed in the recurrent tumor cells, as well as in the vascular endothelial cells. Our case suggests that malignant transition with aberrant angiogenesis and glial differentiation may be attributable to SRS.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Recidiva Local de Neoplasia/patologia
Neovascularização Patológica/patologia
Neurocitoma/patologia
Neuroglia/patologia
Complicações Pós-Operatórias/patologia
Radiocirurgia
[Mh] Termos MeSH secundário: Adulto
Neoplasias Encefálicas/radioterapia
Feminino
Proteína Glial Fibrilar Ácida/genética
Proteína Glial Fibrilar Ácida/metabolismo
Seres Humanos
Recidiva Local de Neoplasia/diagnóstico por imagem
Recidiva Local de Neoplasia/metabolismo
Neovascularização Patológica/diagnóstico por imagem
Neovascularização Patológica/metabolismo
Neurocitoma/radioterapia
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/metabolismo
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glial Fibrillary Acidic Protein); 0 (Vascular Endothelial Growth Factor A)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160601
[St] Status:MEDLINE



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