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[PMID]:28960912
[Au] Autor:van Engelen K; Villani A; Wasserman JD; Aronoff L; Greer MC; Tijerin Bueno M; Gallinger B; Kim RH; Grant R; Meyn MS; Malkin D; Druker H
[Ad] Endereço:Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
[Ti] Título:DICER1 syndrome: Approach to testing and management at a large pediatric tertiary care center.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To expand the current knowledge of DICER1 syndrome and to propose criteria for genetic testing based on experience at a pediatric tertiary care center. PROCEDURE: This study involved a retrospective chart review of the 78 patients (47 probands and 31 family members) seen in the Cancer Genetics Program at The Hospital for Sick Children (SickKids) who were offered genetic testing for DICER1. RESULTS: Of 47 probands offered genetic testing for DICER1, 46 pursued testing: 11 (23.9%) carried a pathogenic variant and one proband (2.1%) carried a missense variant of uncertain significance with evidence for pathogenicity. Thirty-one family members of variant-positive probands were offered testing: eight of the 25 who agreed to testing carried their familial variant (32.0%). Overall, 20 patients were identified to have a variant in DICER1 (eight males, 12 females). Of these, 13 (65.0%) presented with clinical manifestations associated with the syndrome. The most common lesions were pleuropulmonary blastoma (PPB) (five of 20 patients, 25.0%) and pineoblastoma (three of 20 patients, 15.0%). The average age at which individuals were diagnosed with a primary neoplasm was 5.2 years (range 0.8-20 years, median 3.0). Surveillance at our institution, with a median follow-up time of 23 months, has identified PPB in two asymptomatic individuals. These lesions were identified at early stages, thus potentially reducing treatment-related morbidity and mortality. CONCLUSION: This study further delineates the DICER1 syndrome phenotype and demonstrates the feasibility of a DICER1 syndrome surveillance protocol for the early detection of tumors.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/genética
Síndromes Neoplásicas Hereditárias/genética
Glândula Pineal
Pinealoma/genética
Blastoma Pulmonar/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Síndromes Neoplásicas Hereditárias/mortalidade
Síndromes Neoplásicas Hereditárias/patologia
Pinealoma/mortalidade
Pinealoma/patologia
Blastoma Pulmonar/mortalidade
Blastoma Pulmonar/patologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26720


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[PMID]:28777035
[Au] Autor:Roland JL; Price RL; Kamath AA; Akbari SH; Leuthardt EC; Miller BA; Smyth MD
[Ad] Endereço:Departments of 1 Neurological Surgery.
[Ti] Título:Hydrocephalus presenting as idiopathic aqueductal stenosis with subsequent development of obstructive tumor: report of 2 cases demonstrating the importance of serial imaging.
[So] Source:J Neurosurg Pediatr;20(4):329-333, 2017 Oct.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The authors describe 2 cases of triventricular hydrocephalus initially presenting as aqueductal stenosis that subsequently developed tumors of the pineal and tectal region. The first case resembled late-onset idiopathic aqueductal stenosis on serial imaging. Subsequent imaging revealed a new tumor in the pineal region causing mass effect on the midbrain. The second case presented in a more typical pattern of aqueductal stenosis during infancy. On delayed follow-up imaging, an enlarging tectal mass was discovered. In both cases hydrocephalus was successfully treated by cerebrospinal fluid diversion prior to tumor presentation. The differential diagnoses, diagnostic testing, and treatment course for these unusual cases are discussed. The importance of follow-up MRI in cases of idiopathic aqueductal stenosis is emphasized by these exemplar cases.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/etiologia
Hidrocefalia/complicações
Hidrocefalia/cirurgia
Glândula Pineal/patologia
Terceiro Ventrículo/cirurgia
Ventriculostomia/métodos
[Mh] Termos MeSH secundário: Criança
Progressão da Doença
Feminino
Seguimentos
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Lactente
Imagem por Ressonância Magnética
Masculino
Glândula Pineal/diagnóstico por imagem
Pinealoma/diagnóstico por imagem
Pinealoma/etiologia
Teto do Mesencéfalo/diagnóstico por imagem
Teto do Mesencéfalo/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.3171/2017.5.PEDS1779


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[PMID]:28719464
[Au] Autor:Coy S; Dubuc AM; Dahiya S; Ligon KL; Vasiljevic A; Santagata S
[Ad] Endereço:*Department of Pathology, Brigham and Women's Hospital, Harvard Medical School ‡Department of Pathology, Boston Children's Hospital, Harvard Medical School Departments of §Medical Oncology ¶Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA †Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO ∥East Pathology and Neuropathology Center, East Hospital Group, University Hospital of Lyon Bron, France.
[Ti] Título:Nuclear CRX and FOXJ1 Expression Differentiates Non-Germ Cell Pineal Region Tumors and Supports the Ependymal Differentiation of Papillary Tumor of the Pineal Region.
[So] Source:Am J Surg Pathol;41(10):1410-1421, 2017 Oct.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Papillary tumor of the pineal region (PTPR) is a neuroepithelial neoplasm first described in 2003. Despite the anatomic association of PTPR with the pineal gland, the features of these tumors resemble those of the ependymal circumventricular subcommissural organ (SCO) of the posterior third ventricle. Given the presumed distinct derivation of PTPR and pineal parenchymal tumors, we hypothesized that expression of lineage-specific transcription factors could distinguish these tumors and provide additional insight into the differentiation of PTPR. A broad series of pineal region samples was reviewed, including 7 benign pineal glands, 4 pineal cysts, 13 pineocytomas, 28 pineal parenchymal tumors of intermediate differentiation, 11 pineoblastomas, and 18 PTPR. All samples were evaluated by immunohistochemistry for expression of CRX, a master transcriptional regulator of photoreceptor differentiation expressed in pineal gland and retina and/or FOXJ1, a master transcriptional regulator of ciliogenesis expressed in normal ependymal cells and ependymal neoplasms. Diffuse nuclear CRX expression is present in 100% of pineal samples. FOXJ1 is negative in all pineal samples. CRX staining is present in 53% of PTPR, though expression is nearly always limited to rare cells. Diffuse nuclear FOXJ1 expression is present in 100% of PTPR. Fetal human SCO diffusely expressed FOXJ1 but was negative for CRX. Immunohistochemistry for FOXJ1 and CRX differentiates non-germ cell pineal region tumors with high sensitivity and specificity, including pineal parenchymal tumors and PTPR. Our findings support the hypothesis that PTPR have ependymal differentiation and are phenotypically more similar to SCO than pineal gland.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Fatores de Transcrição Forkhead
Proteínas de Homeodomínio
Glândula Pineal
Pinealoma/patologia
Transativadores
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/química
Neoplasias Encefálicas/metabolismo
Diferenciação Celular
Núcleo Celular/metabolismo
Fatores de Transcrição Forkhead/análise
Fatores de Transcrição Forkhead/biossíntese
Proteínas de Homeodomínio/análise
Proteínas de Homeodomínio/biossíntese
Seres Humanos
Pinealoma/química
Pinealoma/metabolismo
Transativadores/análise
Transativadores/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FOXJ1 protein, human); 0 (Forkhead Transcription Factors); 0 (Homeodomain Proteins); 0 (Trans-Activators); 0 (cone rod homeobox protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000903


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[PMID]:28602925
[Au] Autor:Choque-Velasquez J; Colasanti R; Resendiz-Nieves JC; Jahromi BR; Kozyrev DA; Thiarawat P; Hernesniemi J
[Ad] Endereço:Department of Neurosurgery, Helsinki University Hospital, Helsinki, Finland. Electronic address: johchove@hotmail.com.
[Ti] Título:Supracerebellar Infratentorial Paramedian Approach in Helsinki Neurosurgery: Cornerstones of a Safe and Effective Route to the Pineal Region.
[So] Source:World Neurosurg;105:534-542, 2017 Sep.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The supracerebellar infratentorial (SCIT) paramedian approach in sitting position represents one of the most used surgical routes for dealing with pineal region lesions. The purpose of this study is to determine the cornerstones to perform this approach in a simple, safe, and effective way, so that it could be easily reproduced in other neurosurgical centers, particularly in those with modest resources. METHODS: We reviewed and analyzed the surgical videos of 24 pineal region lesions that were operated on through an SCIT approach between June 2012 and October 2015. The SCIT approach may be divided into 3 main steps: 1) skin-muscle incision; 2) craniotomy; and 3) dura opening and access to the pineal region. RESULTS: Complete lesion removal was accomplished in 23 cases, and subtotal removal was accomplished in 1 case. The pineal region was effectively and safely reached through the SCIT approach in the sitting position with a mean time of 14 minutes, using a basic set of microsurgical instruments. Cornerstones and potential delaying events were carefully recorded for each of the 3 main steps of the approach. Moreover, we present in a short video a step-by-step guide to perform the SCIT approach in a fast and safe way. CONCLUSIONS: A correct application of microsurgical principles may allow to safely and rapidly perform the SCIT approach, therefore offering an effective and relatively atraumatic route for dealing with pineal region lesions.
[Mh] Termos MeSH primário: Cerebelo/cirurgia
Neoplasias Infratentoriais/cirurgia
Microcirurgia/métodos
Procedimentos Neurocirúrgicos/métodos
Glândula Pineal/cirurgia
Pinealoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Cerebelo/diagnóstico por imagem
Criança
Pré-Escolar
Feminino
Seres Humanos
Neoplasias Infratentoriais/diagnóstico por imagem
Masculino
Meia-Idade
Posicionamento do Paciente/métodos
Glândula Pineal/diagnóstico por imagem
Pinealoma/diagnóstico por imagem
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28215583
[Au] Autor:Flanagan ME; Williams JR; Emerson SN; Chiarelli PA; Ellenbogen RG; Cimino PJ
[Ad] Endereço:Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA.
[Ti] Título:Clinicopathologic characteristics of metastatic esophageal carcinoma isolated to the pineal region: A case report and review of the literature.
[So] Source:Exp Mol Pathol;102(2):247-250, 2017 Apr.
[Is] ISSN:1096-0945
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Metastasis to the pineal region is a rare event, and esophageal adenocarcinoma metastatic to the pineal region is exceptionally rare, with only two cases reported in the current literature. Here, we characterize a third case of metastatic esophageal adenocarcinoma to the pineal region, and compare clinicopathological characteristics among all three cases. The three patients were men, with ages at neurological presentation ranging from 48 to 65years. Time from initial esophageal adenocarcinoma diagnosis to development of neurologic symptoms ranged from 12 to 23months. Neuroimaging in all cases showed an isolated enhancing pineal region mass with sizes ranging from 1.8 to 2.2cm. All cases were believed to have local control of esophageal disease prior to metastatic sequela, with initial treatment including esophageal resection with or without chemoradiation therapy. No cases had evidence of primary site disease progression at time of metastatic presentation, nor were there signs of other sites of metastasis. All patients underwent tumor excision and were referred for subsequent radiotherapy. Overall, all three cases demonstrate similar demographics, histology, and clinical presentations. In the appropriate clinical setting it is important to keep esophageal metastasis in the differential diagnosis, particularly in the setting of isolated pineal lesions.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Neoplasias Encefálicas/secundário
Neoplasias Esofágicas/patologia
Glândula Pineal/patologia
Pinealoma/secundário
[Mh] Termos MeSH secundário: Adenocarcinoma/terapia
Idoso
Neoplasias Encefálicas/terapia
Neoplasias Esofágicas/terapia
Evolução Fatal
Feminino
Seres Humanos
Masculino
Meia-Idade
Pinealoma/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:27742368
[Au] Autor:Hakar M; Chandler JP; Bigio EH; Mao Q
[Ad] Endereço:Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States.
[Ti] Título:Neuroendocrine carcinoma of the pineal parenchyma. The first reported case.
[So] Source:J Clin Neurosci;35:68-70, 2017 Jan.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:We report a case of a 35-year-old female patient who presented with worsening headaches, vertigo, and vision changes. MRI of the brain showed an enhancing lesion in the pineal region. The patient was taken for resection of the lesion which was classified as neuroendocrine carcinoma of the pineal parenchyma, intermediate grade. Histologically, the neoplasm was cellular, mitotically active, and composed of tightly packed cells with high nuclear cytoplasmic ratio, scant cytoplasm, and ill-defined cell borders. Immunohistochemically the tumor cells were positive for chromogranin, synaptophysin and AE1/AE3, and negative for CK-7, CK-20, and TTF1. Possible metastasis from any other primary sites was ruled out clinically. This represents the first reported case of neuroendocrine carcinoma of the pineal parenchyma.
[Mh] Termos MeSH primário: Carcinoma Neuroendócrino/diagnóstico por imagem
Glândula Pineal/diagnóstico por imagem
Pinealoma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Encéfalo/diagnóstico por imagem
Carcinoma Neuroendócrino/patologia
Núcleo Celular/patologia
Citoplasma/imunologia
Feminino
Seres Humanos
Imuno-Histoquímica
Imagem por Ressonância Magnética
Proteínas de Neoplasias/genética
Glândula Pineal/patologia
Pinealoma/patologia
Tomografia por Emissão de Pósitrons
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neoplasm Proteins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161016
[St] Status:MEDLINE


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[PMID]:27282397
[Au] Autor:Raleigh DR; Solomon DA; Lloyd SA; Lazar A; Garcia MA; Sneed PK; Clarke JL; McDermott MW; Berger MS; Tihan T; Haas-Kogan DA
[Ad] Endereço:Department of Radiation Oncology, University of California San Francisco, San Francisco, California (D.R.R., S.A.L., A.L., M.A.G., P.K.S., D.A.H.-K.); Division of Neuropathology, Department of Pathology, University of California San Francisco, San Francisco, California (D.A.S., T.T.); Department of
[Ti] Título:Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.
[So] Source:Neuro Oncol;19(1):78-88, 2017 Jan.
[Is] ISSN:1523-5866
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pineal parenchymal tumors (PPTs) are rare neoplasms of the central nervous system, and data concerning clinical outcomes are limited. The purpose of this study was to define the clinical behavior of PPT according to current histopathologic criteria and identify prognostic factors to guide therapeutic decisions. METHODS: Seventy-five patients treated for PPT at a single institution between 1992 and 2015 were retrospectively identified. Forty-five resection specimens were available and re-reviewed. Freedom from progression (FFP) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using log-rank tests. RESULTS: Median follow-up was 4.1 years. All patients initially underwent surgery; 78% of patients with PPT of intermediate differentiation (PPTID) and all patients with pineoblastoma received adjuvant therapy. Pathologic re-review refined classification in 27% of cases, with the majority of these being adult patients with pineal tumors originally classified as pineoblastomas that more accurately resembled PPTID based on the 2007 WHO classification. CLASSIFICATION: Our histologic review also identified that PPTIDs can be classified into small-cell and large-cell morphologic subtypes, which have distinct clinical outcomes. Tumor grade, extent of resection, and neuraxis spread were prognostic for FFP. PPTID subtype, extent of resection, and neuraxis spread were prognostic for OS. Genetic analysis of a pineoblastoma case identified somatic mutations of DICER1, ARID1A, and KDM5C genes. CONCLUSIONS: PPTIDs can be classified into 1 of 2 novel morphologic subtypes that are associated with distinct clinical outcomes. Tumor grade, neuraxis spread, and extent of resection also influence outcome for patients with PPT.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Neoplasias Encefálicas/patologia
Glândula Pineal/patologia
Pinealoma/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Neoplasias Encefálicas/genética
Neoplasias Encefálicas/terapia
Criança
Pré-Escolar
Terapia Combinada
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Mutação/genética
Estadiamento de Neoplasias
Glândula Pineal/metabolismo
Pinealoma/genética
Pinealoma/terapia
Prognóstico
Estudos Retrospectivos
Taxa de Sobrevida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE
[do] DOI:10.1093/neuonc/now105


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[PMID]:27866682
[Au] Autor:Frappaz D; Sunyach MP; Le Rhun E; Blonski M; Laurence V; Bonneville Levard A; Loiseau H; Meyronnet D; Callies A; Laigle-Donadey F; Faure Conter C; au nom de l'ANOCEF, GO-AJA, de la SFCE
[Ad] Endereço:Centre Léon-Bérard, 28, Prom. Léa-et-Napoléon-Bullukian, 69008 Lyon, France; Association des neuro-oncologues d'expression française (ANOCEF), 54035 Nancy cedex, France; Société française du cancer de l'enfant (SFCE), 35203 Rennes cedex 2, France; Groupe onco-hématologie adolescents jeunes adultes (
[Ti] Título:[Adolescent and Young Adults (AYAS) brain tumor national Web conference. On behalf of ANOCEF, GO-AJA and SFCE societies].
[Ti] Título:La neuro-oncologie des adolescents et adultes jeunes (AJAS) : place d'une RCP nationale. Au nom de l'ANOCEF, GO-AJA et de la SFCE..
[So] Source:Bull Cancer;103(12):1050-1056, 2016 Dec.
[Is] ISSN:1769-6917
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The skills of adult versus pediatric neuro-oncologists are not completely similar though additive. Because the tumors and their protocols are different and the tolerance and expected sequelae are specific. Multidisciplinary meetings including adult and pediatric neuro-oncologists are warranted to share expertise. Since 2008, a weekly national web based conference was held in France. Any patient with the following criteria could be discussed: Adolescent and Young Adults aged between 15 and 25 years, and any adult with a pediatric type pathology, including medulloblastoma, germ cell tumors, embryonic tumors, ependymoma, pilocytic astrocytoma. RESULTS: Attendance during the year 2015 was as follows: 42 meetings were held; the median number of cases discussed at each meeting was 4 (1 to 8); the mean number of attendants was 7 (2 to 12). One hundred and sixty-eight cases concerning 121 patients were discussed. Mean age was 30 years old (7 to 67). Forty-eight percent were discussed at diagnosis. The patients had mostly medulloblastomas (40%), germ cell tumors (11%), ependymomas (11%), pineal tumors (7%) and embryonal tumors (8%). The rate of inclusion in protocols was increased since the opening of this web conference, especially for the germ cell tumor SIOP protocol that is opened without age restriction, and in RSMA standard risk or MEVITEM relapse adult medulloblastoma protocols. CONCLUSION: Multidisciplinary Web conference for AYAs is feasible and increases the inclusion rate in protocols. It should be developed further.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/terapia
Comunicação Interdisciplinar
Oncologia
Neurologia
Telecomunicações/organização & administração
[Mh] Termos MeSH secundário: Adolescente
Adulto
Astrocitoma/terapia
Criança
Ependimoma/terapia
Estudos de Viabilidade
França
Seres Humanos
Meduloblastoma/terapia
Meia-Idade
Neoplasias Embrionárias de Células Germinativas/terapia
Pinealoma/terapia
Telecomunicações/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161122
[St] Status:MEDLINE


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[PMID]:27712799
[Au] Autor:Causil LD; Ames R; Puac P; Castillo M
[Ad] Endereço:Neuroradiology Section, Department of Radiology, University of North Carolina School of Medicine, Room 3326, Old Infirmary Building, Manning Drive, Chapel Hill, NC 27599-7510, USA. Electronic address: Lazaro_causil@med.unc.edu.
[Ti] Título:Adult Brain Tumors and Pseudotumors: Interesting (Bizarre) Cases.
[So] Source:Neuroimaging Clin N Am;26(4):667-689, 2016 Nov.
[Is] ISSN:1557-9867
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Some brain tumors results are interesting due to their rarity at presentation and overwhelming imaging characteristics, posing a diagnostic challenge in the eyes of any experienced neuroradiologist. This article focuses on the most important features regarding epidemiology, location, clinical presentation, histopathology, and imaging findings of cases considered "bizarre." A review of the most recent literature dealing with these unusual tumors and pseudotumors is presented, highlighting key points related to the diagnosis, treatments, outcomes, and differential diagnosis.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Neuroimagem/métodos
Pinealoma/diagnóstico por imagem
Malformações Vasculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Encéfalo/diagnóstico por imagem
Encefalopatias/diagnóstico por imagem
Diagnóstico Diferencial
Diagnóstico por Imagem/métodos
Seres Humanos
Glândula Pineal/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27689687
[Au] Autor:Gupta AK; Jones M; Prelog K; Bui J; Zhu J; Ng A; Dalla-Pozza L
[Ad] Endereço:a Department of Oncology , Children's Hospital at Westmead , Sydney , New South Wales , Australia.
[Ti] Título:Pineal cysts-A benign association with familial retinoblastoma.
[So] Source:Pediatr Hematol Oncol;33(6):408-414, 2016 Sep.
[Is] ISSN:1521-0669
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Patients with familial/heritable retinoblastoma (RB) are at increased risk of developing second malignancies throughout life, including a pineoblastoma (trilateral RB [TRB]) in early childhood. Current guidelines recommend regular surveillance brain imaging for those with heritable RB until 5 years of age. The presence of pineal cysts has been reported in patients with RB. Pineal cysts are thought to arise due to focal degeneration of the pineal gland and can be found incidentally. The finding of pineal abnormalities including cysts in children with RB on imaging is disconcerting, as it raises the possibility of an underlying malignancy, specifically a pinealoblastoma. The authors reviewed the imaging findings and clinical significance of pineal cysts in 69 patients diagnosed with RB at our center between December 1999 and November 2015. Twenty-six patients had pineal cysts found on brain magnetic resonance imaging (MRI) scans performed either at diagnosis or follow-up. Thirty-eight of 69 patients had underlying heritable RB. Nineteen of 38 familial RB patients had a pineal cyst compared with 3 out of 26 with sporadic RB (P = .004). In the majority, the imaging characteristics and size of the cysts remained stable or resolved. In this cohort, pineal cysts were detected at significantly increased frequency in heritable RB. This may be a benign association or may reflect abnormal underlying biology of pineal tissue in individuals highly susceptible to malignancy. Imaging characteristics can be helpful in distinguishing between benign and malignant lesions. The presence of a pineal cyst in patients with unilateral disease may be a useful indicator of underlying heritable RB.
[Mh] Termos MeSH primário: Segunda Neoplasia Primária/diagnóstico por imagem
Segunda Neoplasia Primária/epidemiologia
Pinealoma/diagnóstico por imagem
Pinealoma/epidemiologia
Retinoblastoma/diagnóstico por imagem
Retinoblastoma/epidemiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Glândula Pineal/diagnóstico por imagem
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE



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