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[PMID]: 29400026 [Au] Autor: El Bakkouri W; Blanc R; Benzakin S; Abdellaoui A; Boyeldieu L; Ayache D [Ti] Título: [Innovations in interventional radiology applied to the field of otolaryngology: A pictorial essay]. [So] Source: Rev Laryngol Otol Rhinol (Bord);136(3):91-5, 2015. [Is] ISSN: 0035-1334 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: The management of hypervascular ENT tumors is usually complex and requires a multidisciplinary approach because of the risk of serious intra-operative bleeding and of potential injuries to cranial nerves and/or large cervical vessels. Over the last four decades, advances in neuro-interventional radio­logical procedures have produced a range of adjunctive endo­vascular techniques in addition to conventional surgery. A pictorial essay in ENT specialty is presented in this article highlighting the most relevant innovations in interventional radiology. [Mh] Termos MeSH primário: Otolaringologia Radiologia Intervencionista [Mh] Termos MeSH secundário: Hemorragia/terapia Seres Humanos Artéria Oftálmica Neoplasias da Retina/tratamento farmacológico Retinoblastoma/tratamento farmacológico Zumbido/terapia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180206 [St] Status: MEDLINE

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[PMID]: 28954302 [Au] Autor: Fidler MM; Reulen RC; Winter DL; Allodji RS; Bagnasco F; Bárdi E; Bautz A; Bright CJ; Byrne J; Feijen EAM; Garwicz S; Grabow D; Gudmundsdottir T; Guha J; Haddy N; Jankovic M; Kaatsch P; Kaiser M; Kuonen R; Linge H; Maule M; Merletti F; Øfstaas H; Ronckers CM; Skinner R; Teepen J; Terenziani M; Vu-Bezin G; Wesenberg F; Wiebe T; Jakab Z; Haupt R; Lähteenmäki P; Zaletel LZ; Kuehni CE; Winther JF; de Vathaire F; Kremer LC; Hjorth L; Hawkins MM [Ad] Endereço: Centre for Childhood Cancer Survivor Studies, Institute of Applied Health Research, University of Birmingham, Birmingham, UK; Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France; Cancer and Radiation Team, U1018 INSERM, Villejuif, France; Epidemiology and Biosta [Ti] Título: Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe. [So] Source: J Natl Cancer Inst;110(2), 2018 Feb 01. [Is] ISSN: 1460-2105 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Introduction: We investigate the risks of subsequent primary bone cancers after childhood and adolescent cancer in 12 European countries. For the first time, we satisfactorily address the risks beyond 40 years from diagnosis and beyond 40 years of age among all survivors. Methods: This largest-ever assembled cohort comprises 69 460 five-year survivors of cancer diagnosed before age 20 years. Standardized incidence ratios, absolute excess risks, and multivariable-adjusted relative risks and relative excess risks were calculated. All statistical tests were two-sided. Results: Overall, survivors were 21.65 times (95% confidence interval = 18.97 to 24.60 times) more likely to be diagnosed with a subsequent primary bone cancer than expected from the general population. The greatest excess numbers of bone cancers were observed after retinoblastoma, bone sarcoma, and soft tissue sarcoma. The excess number of bone cancers declined linearly with both years since diagnosis and attained age (all P < .05). Beyond 40 years from diagnosis and age 40 years, there were at most 0.45 excess bone cancers among all survivors per 10 000 person-years at risk; beyond 30 years from diagnosis and age 30 years, there were at most 5.02 excess bone cancers after each of retinoblastoma, bone sarcoma, and soft tissue sarcoma, per 10 000 person-years at risk. Conclusions: For all survivors combined and the cancer groups with the greatest excess number of bone cancers, the excess numbers observed declined with both age and years from diagnosis. These results provide novel, reliable, and unbiased information about risks and risk factors among long-term survivors of childhood and adolescent cancer. [Mh] Termos MeSH primário: Neoplasias Ósseas/epidemiologia Segunda Neoplasia Primária/epidemiologia Sobreviventes/estatística & dados numéricos [Mh] Termos MeSH secundário: Adolescente Adulto Criança Estudos de Coortes Europa (Continente)/epidemiologia Feminino Seguimentos Seres Humanos Masculino Osteossarcoma/epidemiologia Retinoblastoma/epidemiologia Sarcoma/epidemiologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170928 [St] Status: MEDLINE [do] DOI: 10.1093/jnci/djx165

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[PMID]: 29261756 [Au] Autor: Parma D; Ferrer M; Luce L; Giliberto F; Szijan I [Ad] Endereço: Cátedra de Genética, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires. Buenos Aires. Argentina. [Ti] Título: RB1 gene mutations in Argentine retinoblastoma patients. Implications for genetic counseling. [So] Source: PLoS One;12(12):e0189736, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Retinoblastoma (RB) is an inherited childhood ocular cancer caused by mutations in the tumor suppressor RB1 gene. Identification of RB1 mutations is essential to assess the risk of developing retinoblastoma in the patients´ relatives. Retinoblastoma is a potentially curable cancer and an early diagnosis is critical for survival and eye preservation. Unilateral retinoblastoma is mostly non-heritable and results from two somatic mutations whereas bilateral retinoblastoma is heritable and results from one germline and one somatic mutation, both have high penetrance, 90%. The purpose of this study was to identify causative RB1 mutations in RB patients with different clinical presentations. A comprehensive approach was used to study a cohort of 34 patients with unilateral, bilateral and trilateral retinoblastoma. Blood and tumor DNA was analyzed by sequencing and multiplex ligation-dependent probe amplification (MLPA) assay. Validation of an insertion mutation was performed by cloning the PCR product. Most of the patients in our cohort had unilateral RB, eight patients had bilateral RB and one patient had a trilateral tumor with ocular and suprasellar/sellar locations. Other tumors in addition to retinoblastoma were also found in the affected families. One patient had two syndromes, retinoblastoma and schwannomatosis, and another RB patient had a father with a retinoma. Five out of the 25 unilateral RB patients carried germinal mutations (20%), which were mostly missense mutations. The bilateral and trilateral patients carried splice-site, nonsense and frameshift mutations as well as a whole RB1 gene deletion. Missense mutations were associated with mild phenotype: unilateral retinoblastoma, retinoma or no tumor. In this study we identified causative RB1 mutations in most bilateral RB patients and in some unilateral RB patients, including five novel mutations. These data are crucial for genetic counseling and confirm the need to perform complete genetic screening for RB1 mutations in both constitutional and tumor tissues. [Mh] Termos MeSH primário: Aconselhamento Genético Mutação/genética Proteína do Retinoblastoma/genética Retinoblastoma/genética [Mh] Termos MeSH secundário: Argentina Pareamento de Bases Sequência de Bases Pré-Escolar Éxons/genética Feminino Heterozigoto Seres Humanos Lactente Recém-Nascido Masculino Linhagem Penetrância Resultado do Tratamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Retinoblastoma Protein) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180108 [Lr] Data última revisão: 180108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171221 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0189736

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[PMID]: 29237430 [Au] Autor: Liu H; Zhou M [Ad] Endereço: Department of Ophthalmology, Affiliated zhongshan hospital of dalian university, Jiefang Road 6, Dalian, Liao Ning, 116001, China. [Ti] Título: Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways. [So] Source: BMC Complement Altern Med;17(1):531, 2017 Dec 13. [Is] ISSN: 1472-6882 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Quercetin (QCT) is a flavonol present in many vegetables, it is proved to show chemo preventive effect against lung, cervical, prostate, breast and colon cancer due to its anti-inflammatory, anti-tumor and anti-oxidant property. Looking into the reported chemo-preventive effect we speculated antitumor activity in retinoblastoma (RB) Y79 cells, we also studied the molecular mechanism for antitumor activity. METHODS: The effect of QCT on Y79 cell viability count was done by cell counting kit, cell cycle distribution, apoptosis studies and mitochondrial membrane potential was evaluated by flow cytometry. Protein expression was done by western blot analysis. RESULTS: The outcomes of study showed that QCT reduced Y79 cell viability and caused arrest of G1 phase in cell cycle via decreasing the expression levels of cyclin-dependent kinase (CDK)2/6 and cyclin D3 and by increasing the levels of both CDK inhibitor proteins p21 and p27. Apoptosis of Y79 cells mediated by QCT occurred via activation of both caspases-3/-9. Flow cytometry studies showed that QCT caused collapse in mitochondrial membrane potential (ΔΨm) in Y79 cells. Western blot studies confirmed that QCT brought about phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK). We also established that inhibitors of JNK and p38 MAPK suppressed QCT mediated activation of both caspases-3/-9 and subdued the apoptosis of cancerous Y79 cells. CONCLUSION: All the results of the study suggest that QCT induced the apoptosis of Y79 cells via activation of JNK and p38 MAPK pathways, providing a novel treatment approach for human RB. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo Sistema de Sinalização das MAP Quinases/efeitos dos fármacos Quercetina/farmacologia Retinoblastoma/metabolismo [Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos Linhagem Celular Tumoral Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 9IKM0I5T1E (Quercetin); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180108 [Lr] Data última revisão: 180108 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171215 [St] Status: MEDLINE [do] DOI: 10.1186/s12906-017-2023-6

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[PMID]: 29246122 [Au] Autor: Said AMA; Elbayomi AM; Shaat AAK [Ad] Endereço: Ophthalmology Department, Faculty of Medicine, Ain Shams University, Corresponding author address: 10 th Fawzy Elmoteay street, Heliopolis, Cairo, Postal code: 11736, Egypt. dr_azza_22@hotmail.com. [Ti] Título: Structural changes of the macula and optic nerve head in the remaining eyes after enucleation for retinoblastoma: an optical coherence tomography study. [So] Source: BMC Ophthalmol;17(1):251, 2017 Dec 16. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: To describe objectively the possible structural changes of the macula and optic nerve head in the free eyes of unilateral cured retinoblastoma patients and, also after enucleation using spectral domain optical coherence tomography. METHODS: A cross sectional study involving 60 patients subdivided into three groups; 15 unilateral RB patients in whom enucleation was indicated as a sole treatment performed earlier in life [(study group (I)], 15 unilateral RB patients who had completely regressed disease with a preserved eye [(study group (II)] and 30 age and sex matched healthy controls. The remaining and free eyes in study groups and right eyes of control group had full ophthalmological examination, static automated perimetry and optical coherence tomography of the macula and optic nerve head. RESULTS: In study group (II); a significant thinning of total macula, central fovea, ganglion cell layer (GCL), ganglion cell complex (GCC), and some sectors of outer nuclear layer (P- values ≤0.05) was found with no significant difference in peripapillary nerve fiber layer (pRNFL) thickness and optic nerve head parameters compared to the control group and the study group (I). A significantly thickened total macula, GCL, GCC, and pRNFL in study group (I) compared to study group (II). Thickened pRNFL was significantly correlated to standard automated perimetry pattern deviations. No significant difference was found between study group (I) and control group. CONCLUSION: Retinoblastoma eyes characterized by thinning of central fovea, GCL, GCC compared to the control group. After unilateral enucleation, increased GCC and pRNFL thicknesses were detected compared to retinoblastoma group. [Mh] Termos MeSH primário: Enucleação Ocular Macula Lutea/patologia Disco Óptico/patologia Neoplasias da Retina/patologia Retinoblastoma/patologia [Mh] Termos MeSH secundário: Adolescente Adulto Estudos de Casos e Controles Criança Pré-Escolar Estudos Transversais Feminino Seres Humanos Masculino Fibras Nervosas/patologia Células Ganglionares da Retina/patologia Neoplasias da Retina/cirurgia Retinoblastoma/cirurgia Tomografia de Coerência Óptica/métodos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180105 [Lr] Data última revisão: 180105 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171217 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-017-0650-9

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[PMID]: 29217028 [Au] Autor: Andreoli MT; Chau FY; Shapiro MJ; Leiderman YI [Ad] Endereço: Illinois Eye and Ear Infirmary, UIC Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL.. Electronic address: michaelandreoli@gmail.com. [Ti] Título: Epidemiological trends in 1452 cases of retinoblastoma from the Surveillance, Epidemiology, and End Results (SEER) registry. [So] Source: Can J Ophthalmol;52(6):592-598, 2017 Dec. [Is] ISSN: 1715-3360 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To assess retinoblastoma epidemiological trends in the Surveillance, Epidemiology, and End Results (SEER) registry. METHODS: All cases of retinoblastoma in the SEER database from 1973 to 2009 were identified. Kaplan-Meier survival analyses were performed for pathological grade, patient age, sex, year of diagnosis, and treatment modality. Cox proportional hazards regression assessed the impact of patient and tumour characteristics on survival. RESULTS: 1452 cases of retinoblastoma were analyzed. The mean patient age at diagnosis was 1.44 years. The tumour was unilateral in 71.0% and bilateral in 29.0%. The mean follow-up was 129.1 months. Overall survival increased during the study interval. Patients with bilateral tumours were diagnosed at an earlier age (0.46 years) than patients with unilateral disease (1.77 years; p < 0.0001). Bilateral retinoblastoma (90.3% 10-year overall survival) was associated with decreased overall survival than unilateral retinoblastoma (96.1% 10-year overall survival). Bilateral retinoblastoma was also associated with an increased incidence of nonocular malignancies (7.8%) compared with unilateral retinoblastoma (1.3%; p < 0.0001). Grade 1 tumours were diagnosed at a younger age (0.94 years) than grade 3 (2.24 years) and grade 4 tumours (2.14 years; p < 0.0001). Lower grade and lower stage tumours were independently associated with increased survival. In multivariate Cox proportional hazards analysis, T stage and laterality were the only covariates that correlated with overall survival. CONCLUSIONS: There appear to be associations between retinoblastoma tumour features such as tumour stage, pathological grade, and laterality with patient characteristics such as age at diagnosis, overall survival, and second malignancies. [Mh] Termos MeSH primário: Sistema de Registros Neoplasias da Retina/epidemiologia Retinoblastoma/epidemiologia Programa de SEER/estatística & dados numéricos [Mh] Termos MeSH secundário: Adolescente Adulto Criança Pré-Escolar Bases de Dados Factuais Estudos Epidemiológicos Feminino Seres Humanos Incidência Lactente Estimativa de Kaplan-Meier Masculino Estadiamento de Neoplasias Neoplasias da Retina/patologia Neoplasias da Retina/radioterapia Retinoblastoma/patologia Retinoblastoma/radioterapia Taxa de Sobrevida Estados Unidos/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171226 [Lr] Data última revisão: 171226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171209 [St] Status: MEDLINE

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[PMID]: 29230267 [Au] Autor: Shifa JZ; Gezmu AM [Ad] Endereço: Department of Surgery, Faculty of Medicine, University of Botswana, Gaborone, Botswana. [Ti] Título: Presenting signs of retinoblastoma at a tertiary level teaching hospital in Ethiopia. [So] Source: Pan Afr Med J;28:66, 2017. [Is] ISSN: 1937-8688 [Cp] País de publicação: Uganda [La] Idioma: eng [Ab] Resumo: Introduction: Retinoblastoma is a primary malignant intraocular neoplasm that arise from immature retinoblasts with in developing retina. The commonest presenting sign in developing country is proptosis which is the late presenting sign. We report presenting signs of retinoblastoma in Ethiopian children seen at a tertiary level teaching hospitals in Ethiopia. Methods: Prospective case series study was done on children who presented with retinoblastoma between May 1, 2005 and September 1, 2006. This study was done as part of requirement for partial fulfilment of certificate of specialty study in ophthalmology during the year 2005 to 2006. SPSS 11 statistical package was used to analyse the data. Results: Among 41 patients seen during the study period, 24 (58.5%) were males and 17(41%) were females. Unilateral retinoblastoma was found in 32 (78%) patients and bilateral cases were found in 9(22%). Mean age of onset for right eye was 27.5 months and left eye 33.7 months. The mean ages of presentation at time of diagnosis for right and left eye were 34.4 and 40.2 months, respectively .In bilateral retinoblastoma mean age of presentation was 33.3 months. The commonest presenting sign was proptosis 22(53.7%) followed by leucocorea nine (22%),ocular inflammation four (9.0 %), strabismus three (7.3%), glaucoma one (2.4%), loss of vision one (2.4%)and hyphemaone (2.4%). Conclusion: The commonest presenting signs of retinoblastoma in our set up were Proptosis followed by leucocorea. This is due to late presentation of patient and late referral by medical professionals. Health education to the public and health professionals will help early detection of retinoblastoma. [Mh] Termos MeSH primário: Exoftalmia/etiologia Neoplasias da Retina/diagnóstico Retinoblastoma/diagnóstico [Mh] Termos MeSH secundário: Idade de Início Pré-Escolar Detecção Precoce de Câncer Etiópia Exoftalmia/epidemiologia Feminino Hospitais de Ensino Seres Humanos Masculino Estudos Prospectivos Encaminhamento e Consulta Neoplasias da Retina/epidemiologia Neoplasias da Retina/patologia Retinoblastoma/epidemiologia Retinoblastoma/patologia Estrabismo/epidemiologia Estrabismo/etiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171222 [Lr] Data última revisão: 171222 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE [do] DOI: 10.11604/pamj.2017.28.66.11199

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[PMID]: 29197363 [Au] Autor: Wang P; Li YJ; Zhang SB; Cheng QL; Zhang Q; He LS [Ad] Endereço: Department of Ophthalmology, Tangdu Hospital of Fourth Military Medical University, Xi'an, Shaanxi, China. [Ti] Título: Metastatic retinoblastoma of the parotid and submandibular glands: a rare case report. [So] Source: BMC Ophthalmol;17(1):229, 2017 Dec 02. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Retinoblastoma is the most common intraocular malignancy occurring in children. It can metastasize to the regional lymph nodes, central nervous system and distant organs usually the bones and bone marrow and very rarely to the soft tissue. Here, we report a case of unilateral retinoblastoma in a 4-year-old girl accompanied by a large metastasis of the parotid and submandibular glands that developed about 6 months previously and gradually increased in size 5 months after enucleation of the left eye. CASE PRESENTATION: A 4-year-old girl with a history of unilateral retinoblastoma presented with a large, painful and worsening mass (about 20 × 23 cm) of the left side of the neck. Following surgery, the orbital tumour was completely resected, and the large tumour invasion range in the left side of the neck was not resected completely. Histopathological examination revealed retinoblastoma of the orbit and the parotid and submandibular glands. After chemotherapy and additional local radiotherapy on the parotid and submandibular glands, the tumour was inactive and stable. CONCLUSIONS: Delayed detection and inappropriate management contribute to poor outcomes. Fundus examinations, education regarding the early signs of RB, and optimization of the therapeutic strategy for RB may play important roles in ocular health. [Mh] Termos MeSH primário: Neoplasias Mandibulares/secundário Neoplasias Orbitárias/patologia Neoplasias Parotídeas/secundário Neoplasias da Retina/patologia Retinoblastoma/patologia [Mh] Termos MeSH secundário: Pré-Escolar Feminino Seres Humanos Glândula Submandibular/patologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171220 [Lr] Data última revisão: 171220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171204 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-017-0627-8

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[PMID]: 28906322 [Au] Autor: Fischer C; Petriccione M; Vitolano S; Guarini E; Davis ME; Dunkel IJ [Ad] Endereço: Departments of *Pediatrics †Nursing, Memorial Sloan Kettering Cancer Center ‡Department of Pediatrics, Weill Cornell Medical College, New York, NY. [Ti] Título: The Effect of Ophthalmic Artery Chemosurgery on Immune Function in Retinoblastoma Patients: A Single Institution Retrospective Analysis. [So] Source: J Pediatr Hematol Oncol;39(7):555-559, 2017 Oct. [Is] ISSN: 1536-3678 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Ophthalmic artery chemosurgery (OAC) is associated with grade 3 and 4 neutropenia, however the effect on T-cell number and function is unknown. The purpose of this retrospective review was to confirm that patients treated with OAC do not develop immunosuppression warranting Pneumocystis pneumonia prophylaxis. PROCEDURE: IRB approval was obtained for a single center retrospective review of immune function tests in retinoblastoma patients who received OAC. RESULTS: Twenty-three patients received ≥3 cycles of OAC and had immune function testing (absolute CD4 count) performed at a median of 34 days postcompletion of therapy (range, 15 to 63 d). Only 1 patient had a low absolute CD4 count of 189 cells/µL (normal, 359 to 1570 cells/µL) 2 and a half months after IV carboplatin and 28 days after their third dose of OAC. This patient was found to have coexisting hypogammaglobulinemia. Repeat immune function testing normalized through continued OAC treatment. CONCLUSIONS: Clinically significant immune suppression appears rare following OAC alone, but patients previously treated with IV chemotherapy may be immunosuppressed and may benefit from pneumocystis pneumonia prophylaxis until the CD4 count recovers. [Mh] Termos MeSH primário: Neoplasias Oculares/imunologia Artéria Oftálmica/efeitos dos fármacos Retinoblastoma/imunologia [Mh] Termos MeSH secundário: Contagem de Linfócito CD4 Carboplatina/uso terapêutico Criança Pré-Escolar Neoplasias Oculares/terapia Seres Humanos Tolerância Imunológica/efeitos dos fármacos Imunidade/efeitos dos fármacos Lactente Infusões Intra-Arteriais/efeitos adversos Neutropenia/induzido quimicamente Retinoblastoma/terapia Estudos Retrospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: BG3F62OND5 (Carboplatin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171028 [Lr] Data última revisão: 171028 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170915 [St] Status: MEDLINE [do] DOI: 10.1097/MPH.0000000000000968

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[PMID]: 28903151 [Au] Autor: Sreelakshmi KV; Chandra A; Krishnakumar S; Natarajan V; Khetan V [Ad] Endereço: Shri Bhagawan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, India. [Ti] Título: Anterior Chamber Invasion in Retinoblastoma: Not an Indication for Adjuvant Chemotherapy. [So] Source: Invest Ophthalmol Vis Sci;58(11):4654-4661, 2017 Sep 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: In retinoblastoma, adjuvant chemotherapy after enucleation is given in eyes with histopathological high-risk features (HRFs) to reduced mortality. Anterior chamber seeds (AC seeds) on histopathological evaluation are a contentious finding. This study attempts to determine the effect of AC seeds on the survival rate. Methods: This is a retrospective case record review. Eyes were divided into four groups: those with neither AC seeds nor HRFs, those with only HRFs, those with only AC seeds, and those with both HRFs and AC seeds. The groups were compared for demographic and clinical features and survival curves were plotted for each. Results: For the 212 eyes included in the study, mean age was 30.5 ± 36.8 months. Children with only AC seeds were significantly older (75.3 ± 94.6 months) (P = 0.004). Chemotherapy was administered in 81 (38.2%) of 212 eyes; 16 (13.7%) of 117 eyes without HRF and in 65 (68.4%) of 95 eyes with HRFs (P < 0.001). The survival rate at 1, 3, and 5 years was the highest for the group with only AC seeds, although the difference was not statistically significant. Conclusions: We conclude that AC seeds do not, by themselves, constitute an independent risk factor for metastasis. These children need not be treated with immediate adjuvant chemotherapy, but, instead, can be followed with regular screening for metastasis. However, AC seeds are seen in only a small proportion of enucleated eyes. A larger study would better validate our study results. [Mh] Termos MeSH primário: Câmara Anterior/patologia Inoculação de Neoplasia Neoplasias da Retina/patologia Retinoblastoma/patologia [Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Carboplatina/uso terapêutico Quimioterapia Adjuvante Criança Pré-Escolar Etoposídeo/uso terapêutico Enucleação Ocular Feminino Seres Humanos Lactente Masculino Invasividade Neoplásica Neoplasias da Retina/tratamento farmacológico Neoplasias da Retina/mortalidade Retinoblastoma/tratamento farmacológico Retinoblastoma/mortalidade Estudos Retrospectivos Fatores de Risco Taxa de Sobrevida Vincristina/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 5J49Q6B70F (Vincristine); 6PLQ3CP4P3 (Etoposide); BG3F62OND5 (Carboplatin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170922 [Lr] Data última revisão: 170922 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170914 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.17-22111

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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