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[PMID]:28647963
[Au] Autor:Jiang SY; Li L; Zhao J; Xiang Y; Wan XR; Feng FZ; Ren T; Yang JJ
[Ad] Endereço:Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
[Ti] Título:[Effects of prophylactic chemotherapy on outcomes and prognosis of patients older than 40 years with invasive mole].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;52(6):398-402, 2017 Jun 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To discuss the effects of prophylactic chemotherapy on the outcomes and prognosis of invasive mole patients. One hundred and fifteen invasive mole (IM) patients older than 40 years were registered in Peking Union Medical Collage Hospital.Eleven of them were treated with prophylactic chemotherapy before diagnosed as IM prophylactic chemotherapy group, while the other 104 cases received therapeutic chemotherapy after diagnosed as IM (non-prophylactic chemotherapy group). The general clinical data (including age, clinical stage, risk factor score), treatment, outcomes and relapse of patients were retrospectively compared between two groups. (1) The age of prophylactic chemotherapy group and non-prophylactic chemotherapy group were (47±5) versus (46±4) years old. Ratio of clinical stageâ… -â…¡ were 3/11 versus 29.8% (31/104), clinical stage â…¢-â…£ were 8/11 versus 70.2% (73/104). Ratio of risk factor score 0-6 were 11/11 versus 84.6% (88/104), risk factor score >6 were 0 versus 15.4% (16/104). There were no significant statistical differences between two groups in age, clinical stage or risk factor score (all 0.05). (2) Treatment: the total chemotherapy courses between prophylactic chemotherapy group and non-prophylactic chemotherapy group (median 7 versus 5) were significantly different ( 3.071, 0.002). There were no significant statistical differences between two groups in the chemotherapy courses until negative conversion of ß-hCG, consolidation chemotherapy courses, total therapeutic chemotherapy courses or ratio of hysterectomy (all 0.05). (3) Outcomes and relapse: between the prophylactic chemotherapy group and the non-prophylactic chemotherapy group, the complete remission rate were 11/11 versus 98.1%(102/104), the relapse rate were 0 versus 1.0%(1/102). There were no significant difference between the two groups in outcomes or relapse rate ( 0.05). Prophylactic chemotherapy does not substantially benefit the IM patients older than 40 years. Prophylactic chemotherapy may not significantly improve patients' prognosis, in which increased sample size is required in further study.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Mola Hidatiforme Invasiva/tratamento farmacológico
Mola Hidatiforme Invasiva/prevenção & controle
Idade Materna
Neoplasias Uterinas/tratamento farmacológico
Neoplasias Uterinas/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Gonadotropina Coriônica Humana Subunidade beta/sangue
Feminino
Seres Humanos
Mola Hidatiforme Invasiva/patologia
Histerectomia
Recidiva Local de Neoplasia
Gravidez
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Resultado do Tratamento
Neoplasias Uterinas/patologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chorionic Gonadotropin, beta Subunit, Human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2017.06.008


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[PMID]:27544879
[Au] Autor:Grin L; Namazov A; Volodarsky M; Anteby E; Lavie O; Gemer O
[Ad] Endereço:Department of Obstetrics and Gynecology, Barziali Medical Center, Ben-Gurion University, Ashkelon, Israel. Electronic address: Leonti.grin@gmail.com.
[Ti] Título:Laparoscopic Management of an Invasive Mole Perforating the Uterus.
[So] Source:J Minim Invasive Gynecol;24(2):199-200, 2017 Feb.
[Is] ISSN:1553-4669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:STUDY OBJECTIVE: To show the possibility of conservative laparoscopic management in a case of invasive mole perforating the uterus. DESIGN: Video with explanations. SETTING: An invasive mole is a potentially life-threatening complication of gestational trophoblastic disease [1]. This is a case of a 24-year-old female presenting with abdominal pain and vaginal bleeding. There have been several previous reports of cases of uterine perforation by an invasive mole, all of which were managed with abdominal hysterectomy [2-7]. To our knowledge, this is the first report of an invasive mole perforation with active bleeding managed by laparoscopy without hysterectomy. INTERVENTIONS: Sonography revealed a large amount of fluid and a 3 × 3-cm heterogeneous lesion next to the posterior uterine wall. Her hemoglobin level dropped from 10.6 mg/dL to 8.6 mg/dL, and her ß-human chorionic gonadotropin level was 19,004 mIU/mL. On laparoscopy, ∼2500 mL of hemoperitoneum was found, along with an actively bleeding bulging mass in the posterior uterine wall. This mass was dissected, and hemostasis was secured with sutures and electrocoagulation. Pathology confirmed the diagnosis of a complete mole. After surgery, the patient was treated with 5 courses of a methotrexate-folinic acid regimen. Her recovery was uneventful. CONCLUSION: Uterine perforation by an invasive mole can be managed conservatively with laparoscopic surgery and postoperative chemotherapy. The transmural lesion will increase the risk of future uterine rupture during pregnancy in this patient.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos em Ginecologia/métodos
Mola Hidatiforme Invasiva/cirurgia
Laparoscopia/métodos
Neoplasias Uterinas/cirurgia
Ruptura Uterina/cirurgia
[Mh] Termos MeSH secundário: Adulto
Gonadotropina Coriônica Humana Subunidade beta
Feminino
Hemoperitônio/etiologia
Hemoperitônio/cirurgia
Seres Humanos
Mola Hidatiforme Invasiva/complicações
Mola Hidatiforme Invasiva/patologia
Metotrexato/uso terapêutico
Gravidez
Hemorragia Uterina/etiologia
Hemorragia Uterina/cirurgia
Neoplasias Uterinas/complicações
Neoplasias Uterinas/patologia
Ruptura Uterina/etiologia
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Chorionic Gonadotropin, beta Subunit, Human); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160822
[St] Status:MEDLINE


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[PMID]:27353688
[Au] Autor:Vimercati A; de Gennaro AC; Resta L; Cormio G; Cicinelli E
[Ad] Endereço:Department of Obstetrics and Gynecology, University Hospital Policlinico of Bari, University of Bari "Aldo Moro", Bari, Italy.
[Ti] Título:Sonographic and Power Doppler Evaluation of an Invasive Mole Located in a Cesarean Scar Pregnancy.
[So] Source:J Ultrasound Med;35(7):1608-12, 2016 Jul.
[Is] ISSN:1550-9613
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Cesárea
Cicatriz/diagnóstico por imagem
Mola Hidatiforme Invasiva/diagnóstico por imagem
Ultrassonografia/métodos
Neoplasias Uterinas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Gravidez
Ultrassonografia Doppler/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE
[do] DOI:10.7863/ultra.15.08010


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[PMID]:27352577
[Au] Autor:Xiao S; Mu Q; Wan Y; Xue M
[Ti] Título:Spontaneous renal hemorrhage caused by invasive mole: a case report.
[So] Source:Eur J Gynaecol Oncol;37(3):417-9, 2016.
[Is] ISSN:0392-2936
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:CASE: The authors report a case with spontaneous renal hemorrhage caused by invasive mole. The diagnosis was gestational trophoblastic disease (GTD), with metastasis to brain, kidneys, and lungs at Stage IV. The patient was given etoposide-methotrexate-actinomycin D plus cyclophosphamide-vincristine (EMACO) treatment regimen for 11 times including three times with consolidation chemotherapies. Laparoscopically-assisted vaginal hysterectomy (LAVH) + laparoscopic-assisted left renal excision + evacuation of the left perirenal hematoma were performed during the eighth chemotherapy. CONCLUSION: Post-operational pathological examination revealed trophoblasts within the lesions present in uterine fundus and the residue images of a few trophoblasts present in the left renal mass.
[Mh] Termos MeSH primário: Hemorragia/etiologia
Mola Hidatiforme Invasiva/complicações
Nefropatias/etiologia
Neoplasias Uterinas/complicações
[Mh] Termos MeSH secundário: Adulto
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Dactinomicina/administração & dosagem
Doxorrubicina/administração & dosagem
Etoposídeo/administração & dosagem
Feminino
Seres Humanos
Mola Hidatiforme Invasiva/tratamento farmacológico
Leucovorina/administração & dosagem
Metotrexato/administração & dosagem
Gravidez
Neoplasias Uterinas/tratamento farmacológico
Vincristina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1CC1JFE158 (Dactinomycin); 5J49Q6B70F (Vincristine); 6PLQ3CP4P3 (Etoposide); 80168379AG (Doxorubicin); Q573I9DVLP (Leucovorin); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160629
[Lr] Data última revisão:
160629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE


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[PMID]:26781485
[Au] Autor:Mikami Y; Nagai T; Gomi Y; Takai Y; Saito M; Baba K; Seki H
[Ad] Endereço:Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe-shi, Saitama, 350-8550, Japan. ymikami@saitama-med.ac.jp.
[Ti] Título:Methotrexate and actinomycin D chemotherapy in a patient with porphyria: a case report.
[So] Source:J Med Case Rep;10:9, 2016 Jan 18.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite their broadly recommended use as chemotherapeutic agents, the porphyrogenicity of methotrexate and actinomycin D have not been confirmed. Accordingly, it is not known whether these agents are safe for use in patients with porphyria. CASE PRESENTATION: In this report, we present a case of an invasive mole with lung metastasis in a 49-year-old Japanese woman who had previously been diagnosed with acute intermittent porphyria at 27 years of age but had no recent history of acute intermittent porphyria attacks. Her serum human chorionic gonadotropin level was elevated 1 month after hysterectomy, and she was referred to our center for chemotherapy. After she received 100 mg of methotrexate, drug eruptions were observed starting on day 3 and grew progressively worse. Erythema and mucosal erosion spread throughout her body, whereupon she was administered prednisolone. In addition, our patient experienced febrile neutropenia and required granulocyte colony- stimulating factor treatment. No changes in our patient's urinary coproporphyrin or uroporphyrin levels were detected during this entire episode. Methotrexate was replaced by actinomycin D (0.5 mg/body intravenously on days 1-5 every 2 weeks). After five uneventful cycles of actinomycin D, our patient achieved and maintained a normal serum human chorionic gonadotropin level for 3 years. CONCLUSIONS: Methotrexate and actinomycin D did not induce acute porphyric attacks in this patient with acute intermittent porphyria; however, severe adverse effects were noted with methotrexate. Although further investigation is required, our data suggest that these agents are nonporphyrinogenic and can therefore be used to treat patients with comorbid porphyria.
[Mh] Termos MeSH primário: Antibióticos Antineoplásicos/uso terapêutico
Antineoplásicos/efeitos adversos
Gonadotropina Coriônica/sangue
Dactinomicina/uso terapêutico
Mola Hidatiforme Invasiva/tratamento farmacológico
Histerectomia
Neoplasias Pulmonares/tratamento farmacológico
Metotrexato/efeitos adversos
Porfiria Aguda Intermitente/complicações
Neoplasias Uterinas/tratamento farmacológico
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Erupção por Droga/tratamento farmacológico
Erupção por Droga/etiologia
Feminino
Seres Humanos
Mola Hidatiforme Invasiva/secundário
Mola Hidatiforme Invasiva/cirurgia
Neoplasias Pulmonares/secundário
Metotrexato/administração & dosagem
Meia-Idade
Gravidez
Resultado do Tratamento
Neoplasias Uterinas/patologia
Neoplasias Uterinas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (Antineoplastic Agents); 0 (Chorionic Gonadotropin); 1CC1JFE158 (Dactinomycin); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160120
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-015-0790-6


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[PMID]:26887874
[Au] Autor:Li X; Feng F; Xiang Y; Wan X; Ren T; Yang J
[Ad] Endereço:Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
[Ti] Título:[Value of laparoscopic surgery in the diagnosis of suspected gestational trophoblastic neoplasia cases with uterine mass].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;50(12):910-4, 2015 Dec.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To evaluate the value of laparoscopic surgery in the diagnosis of suspected gestational trophoblastic neoplasia (GTN) cases with uterine mass. METHODS: The clinical characteristics of patients underwent laparoscopic surgery for a suspected diagnosis of GTN with uterine mass in Peking Union Medical College Hospital from November 2009 to November 2014 were retrospectively reviewed and analyzed. GTN and other pregnant-related disease were definitely diagnosed by pathological findings. The prognoses of the GTN cases were also investigated. RESULTS: Sixty-two patients with a suspected diagnosis of GTN with uterine mass were studied. Among them, 17 cases were definitely diagnosed as GTN, including 8 choriocarcinoma, 5 invasive mole and 4 placental site trophoblastic tumor (PSTT). The other 45 cases were diagnosed as benign pregnancy-related diseases, including 29 cornual pregnancy, 6 cesarean scar pregnancy, 5 placenta accreta, 4 intramural uterine pregnancy and 1 exaggerated placental site. There were no significantly differences between the two groups in average age, preoperative value or tendency of ß-hCG, and location or size of lesions (P>0.05). More GTN patients showed a history of hydatidiform mole [5/17 vs 4% (2/45) , P>0.05], and more patients with benign pregnancy-related disease showed a history of cesarean section [38% (17/45) vs 1/17, P>0.05]. No serious perioperative complication was found in these patients received laparoscopic surgery. All GTN patients achieved complete remission by chemotherapy later. Except for 1 case loss, no recurrence was found in 11 low-risk stage I cases with an average follow-up period of 11- 66 months, 1 high-risk stage I case with a follow-up period of 61 months and 4 cases PSTT with a follow-up period of 13-66 months. CONCLUSIONS: There were some atypical GTN cases with uterine mass, which were difficult to be differentiated from benign pregnancy-related diseases according to the clinical characteristics. Laparoscopic surgery with a pathologic diagnosis could be an essential way with efficiency and safety.
[Mh] Termos MeSH primário: Coriocarcinoma/cirurgia
Gonadotropina Coriônica Humana Subunidade beta/sangue
Doença Trofoblástica Gestacional/cirurgia
Laparoscopia/métodos
Tumor Trofoblástico de Localização Placentária/cirurgia
[Mh] Termos MeSH secundário: Adulto
Antineoplásicos/uso terapêutico
China
Coriocarcinoma/diagnóstico
Feminino
Doença Trofoblástica Gestacional/diagnóstico
Seres Humanos
Mola Hidatiforme/cirurgia
Mola Hidatiforme Invasiva/cirurgia
Recidiva Local de Neoplasia
Gravidez
Prognóstico
Estudos Retrospectivos
Resultado do Tratamento
Tumor Trofoblástico de Localização Placentária/diagnóstico
Neoplasias Uterinas
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Chorionic Gonadotropin, beta Subunit, Human)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160218
[Lr] Data última revisão:
160218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160219
[St] Status:MEDLINE


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[PMID]:26664525
[Au] Autor:Boubess I; Filali A; Benbrahim F; Ouassour S; Tazi M; Alami MH
[Ad] Endereço:Centre National de la Santé Reproductive, CHU Ibn Sina, Rabat, Maroc.
[Ti] Título:[Twin pregnancy involving a molar pregnancy and living fetus with progression to invasive mole: about two cases].
[Ti] Título:Grossesse gémellaire associant une grossesse molaire et un fÅ“tus vivant avec évolution vers mole invasive: à propos de deux cas..
[So] Source:Pan Afr Med J;22:24, 2015.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Mh] Termos MeSH primário: Mola Hidatiforme Invasiva/patologia
Mola Hidatiforme/patologia
Resultado da Gravidez
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Adulto
Progressão da Doença
Feminino
Seres Humanos
Mola Hidatiforme/diagnóstico
Mola Hidatiforme Invasiva/diagnóstico
Gravidez
Gravidez de Gêmeos
Ultrassonografia Pré-Natal/métodos
Neoplasias Uterinas/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2015.22.24.7150


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[PMID]:26050078
[Au] Autor:von Welser SF; Grube M; Ortmann O
[Ad] Endereço:Department of Gynecology and Obstetrics, University Medical Center, Caritas Hospital St. Josef, University of Regensburg, Landshuter Strasse 65, 93053, Regensburg, Germany. sophievonwelser@aol.com.
[Ti] Título:Invasive mole in a perimenopausal woman: a case report and systematic review.
[So] Source:Arch Gynecol Obstet;292(6):1193-9, 2015 Dec.
[Is] ISSN:1432-0711
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumors. We present a case of a perimenopausal woman with invasive mole. A systematic review was performed to identify reports on GTD in older women and to determine adequate treatment options. CASE: A 51-year-old perimenopausal woman was admitted to hospital with abdominal feeling of pressure and nausea. Diagnostic curettage revealed hydatidiform mole. She also presented symptomatic hyperthyroidism with hypertensive blood pressure and uneasiness. After treatment with beta blockers and carbimazole, the patient underwent abdominal hysterectomy and bilateral oophorosalpingectomy. Histopathological examination confirmed an invasive hydatidiform mole (IHM). Serum ß-hCG has decreased from initially 300,000-100 unit/L after 4 weeks. DATA SOURCES: A systematic review was performed to identify all prior cases of GTD in women over 50. We searched in Medline, The Cochrane Library and Embase, to identify any articles published in the English language after 1970 and before Oct 31, 2013 pertaining to GTD in older woman (50 years or older). TABULATION, INTEGRATION, AND RESULTS: Ten records were included in the systematic review, involving 203 cases of trophoblastic disease in older women. Although the diagnosis of GTD in older women is rare, it should be considered especially in patients with suspicious intrauterine findings in transvaginal ultrasound examinations. Different treatments were performed. In a limited number of reports, older women with GTD underwent initial hysterectomy. Benefits are avoidance of chemotherapy-induced toxicity and reduced risk of recurrence. Hysterectomy should be performed by an experienced surgeon. CONCLUSION: It is concluded that GTD is very rare in peri- or postmenopausal women. Treatment has to be individualized, and hysterectomy can be considered as an appropriate option.
[Mh] Termos MeSH primário: Mola Hidatiforme Invasiva/patologia
Neoplasias Uterinas/patologia
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/uso terapêutico
Antitireóideos/uso terapêutico
Carbimazol/uso terapêutico
Curetagem
Feminino
Seres Humanos
Mola Hidatiforme Invasiva/cirurgia
Hipertensão/complicações
Hipertensão/tratamento farmacológico
Hipertireoidismo/complicações
Hipertireoidismo/tratamento farmacológico
Histerectomia
Meia-Idade
Perimenopausa
Gravidez
Resultado do Tratamento
Neoplasias Uterinas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Antithyroid Agents); 8KQ660G60G (Carbimazole)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:151015
[Lr] Data última revisão:
151015
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150608
[St] Status:MEDLINE
[do] DOI:10.1007/s00404-015-3777-z


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[PMID]:25736137
[Au] Autor:Mu Q; Xiao S; Wan Y
[Ad] Endereço:Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.E-mail: muqingling1@163.com.
[Ti] Título:[Spontaneous renal hemorrhage caused by invasive mole: a case report].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;35(2):309-11, 2015 Feb.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Gestational trophoblastic tumors (GTTs) are malignant lesions that often cause abnormal genital bleeding and may present with hemoptysis, intraperitoneal bleeding or acute neurologic deficits. GTTs are generally highly chemosensitive with more favorable outcomes than other comparable malignancies. Here we report a rare case of invasive mole (FIGO stage IV, WHO score16) presenting with renal subcapsular hematoma due to bleeding renal metastasis. The patient had a pretreatment ß-human chorionic gonadotrophin (ß-HCG) level of 462 047 mIU/ml and received combined chemotherapy with etoposide, methotrexate, actinomycin-D, cyclophosphamide and vincristine with also adjuvant surgeries including hysterectomy and nephrectomy. The patient recovered well and the tumor has remained in complete remission for one year and a half.
[Mh] Termos MeSH primário: Hemorragia/etiologia
Mola Hidatiforme Invasiva/complicações
[Mh] Termos MeSH secundário: Protocolos de Quimioterapia Combinada Antineoplásica
Feminino
Seres Humanos
Rim/patologia
Gravidez
Neoplasias Uterinas/complicações
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150304
[Lr] Data última revisão:
150304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150305
[St] Status:MEDLINE


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[PMID]:25492410
[Au] Autor:Wu X; Zhu J; Zhao A
[Ad] Endereço:Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Gynecologic Oncology, Shanghai, China.
[Ti] Título:Ovarian hyperstimulation syndrome in a spontaneous pregnancy with invasive mole.
[So] Source:J Obstet Gynaecol Res;41(5):817-22, 2015 May.
[Is] ISSN:1447-0756
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Spontaneous ovarian hyperstimulation syndrome (sOHSS) is an extremely rare event. Herein, we report a case of severe sOHSS with invasive mole in a 29-year-old woman. In this case the full-blown OHSS developed after evacuation when the serum ß-hCG value was declining. Also noticeable was a very high level of cancer antigen-125. Molecular biology study of the follicle-stimulating hormone (FSHR) gene did not detect exonic mutations, but revealed the presence of c.-29G>A (rs1394205) in the 5'-non-coding region of exon 1. The A307T and S680N polymorphisms of exon 10 of FSHR was Thr307 Asn680. Although sOHSS is a rare entity, clinicians must bear the differential diagnosis of sOHSS in mind if a patient presents with gross ascites and other symptoms of ovarian cancer, which also may be signs of OHSS. Whether the single nucleotide polymorphism rs1394205 affects the level of transcriptional activity of the FSHR gene needs to be studied in the future.
[Mh] Termos MeSH primário: Mola Hidatiforme Invasiva/complicações
Síndrome de Hiperestimulação Ovariana/complicações
Neoplasias Uterinas/complicações
[Mh] Termos MeSH secundário: Adulto
Éxons
Feminino
Seres Humanos
Mola Hidatiforme Invasiva/diagnóstico por imagem
Mola Hidatiforme Invasiva/genética
Mutação
Síndrome de Hiperestimulação Ovariana/diagnóstico por imagem
Síndrome de Hiperestimulação Ovariana/genética
Gravidez
Receptores do FSH/genética
Tomografia Computadorizada por Raios X
Ultrassonografia
Neoplasias Uterinas/diagnóstico por imagem
Neoplasias Uterinas/genética
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, FSH)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141211
[St] Status:MEDLINE
[do] DOI:10.1111/jog.12606



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