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  1 / 1795 MEDLINE  
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[PMID]:29310387
[Au] Autor:Liu G; Li Y; Li Z; Zhou J; Huo Z; Ji Z
[Ad] Endereço:Department of Urology.
[Ti] Título:Renal hybrid oncocytic/chromophobe tumor associated with multiple schwannomas: Case report and literature review.
[So] Source:Medicine (Baltimore);96(48):e8939, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Renal hybrid oncocytic/chromophobe tumors (HOCTs) are benign tumors containing a mixture of cells with features of chromophobe renal cell carcinoma (CHRCC) and renal oncocytoma (RO). Sporadic HOCT, which means HOCT occurs in patients without Birt-Hogg-Dubé syndrome (BHDS) or renal oncocytosis, is extremely rare. In this article, we would report a new case of a patient with both sporadic HOCT and multiple Schwannomas, which is even rarer than simplex sporadic HOCT. PATIENT CONCERNS: A 48-year-old female was noted with multiple left-kidney masses and a history of multiple Schwannomas. She had no complaints of urological symptoms, abdominal pain, and osphyalgia. The vital sign was stable and blood biochemistry test showed normal renal function. Enhanced computed tomography (CT) found multiple lesions occupying parenchyma of the left kidney. The largest one was measured 3.5 × 3.1 × 3.2 cm. It showed apparently enhancement in arterial phase and low-density in venous phase. DIAGNOSES: The preoperative diagnosis was renal cell carcinomas. INTERVENTIONS: The masses were removed by laparoscopic partial left nephrectomy. OUTCOMES: The diagnosis of HOCT was made by histopathology after surgery. No evidence of local recurrence or distant metastasis was noted on imaging after 2-month follow-up. LESSONS: We searched PubMed for cases of sporadic HOCT and a total of 26 patients were evaluated. Our case was the first one involving sporadic HOCT and multiple Schwannomas. Although rare, sporadic HOCT does exist in patients presented with renal mass. Urological surgeons should be aware of the existence of HOCT when considering masses on kidney due to the different prognosis between HOCT and renal cell carcinoma. Further, a possible genetic relationship between HOCT and Schwannoma may contribute to a common pathogenesis in these 2 tumors.
[Mh] Termos MeSH primário: Adenoma Oxífilo/diagnóstico
Carcinoma de Células Renais/diagnóstico
Neoplasias Renais/diagnóstico
Neoplasias Primárias Múltiplas/diagnóstico
Neurilemoma/diagnóstico
[Mh] Termos MeSH secundário: Adenoma Oxífilo/patologia
Carcinoma de Células Renais/patologia
Carcinoma de Células Renais/cirurgia
Diagnóstico Diferencial
Feminino
Seres Humanos
Neoplasias Renais/patologia
Neoplasias Renais/cirurgia
Meia-Idade
Neoplasias Primárias Múltiplas/patologia
Neoplasias Primárias Múltiplas/cirurgia
Neurilemoma/patologia
Neurilemoma/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008939


  2 / 1795 MEDLINE  
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[PMID]:29310349
[Au] Autor:Hong Y; Hao Y; Hu J; Xu B; Shan H; Wang X
[Ad] Endereço:Department of Urology.
[Ti] Título:Adrenocortical oncocytoma: 11 Case reports and review of the literature.
[So] Source:Medicine (Baltimore);96(48):e8750, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Adrenocortical oncocytoma is an extremely rare tumor of the adrenal gland. Its diagnostic criteria and biological behavior has not yet reached a consensus. The purpose of this study is to investigate the clinical characteristics of adrenocortical oncocytoma. PATIENT CONCERNS: The clinical data from 11 cases of adrenocortical oncocytoma were retrospectively analyzed. Five patients found the tumor incidentally during the healthy examination, and 3 cases found the tumor during the diagnostic work-up for the evaluation of flank pain or hypertension. A female patient manifested virilization, and Cushing's syndrome showed in two patients. The tumor diameter was ranging from 2.0-13.0 cm. DIAGNOSES: The serum cortisol, plasma aldosterone and catecholamine metabolites were used to evaluate the function of the tumors, and enhanced CT scan was used to confirm the tumor boundary, enhancement, and lymph nodes condition. INTERVENTIONS: Seven cases underwent laparoscopic adrenal tumor resection, 4 patients underwent open surgery. Pathological report indicated adrenocortical oncocytoma in all cases, three of which were potentially malignant. OUTCOMES: The patients were followed up for 19-72 months, no local recurrence and distant metastases were detected in 3 cases of malignant potential cases. LESSONS: The majority of adrenocortical oncocytoma with or without function are benign, and close follow-up observation is essential.
[Mh] Termos MeSH primário: Adenoma Oxífilo/patologia
Neoplasias do Córtex Suprarrenal/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores Tumorais/sangue
Pré-Escolar
Feminino
Seres Humanos
Achados Incidentais
Masculino
Meia-Idade
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008750


  3 / 1795 MEDLINE  
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[PMID]:28968156
[Au] Autor:Wu A
[Ti] Título:Oncocytic Renal Neoplasms on Resections and Core Biopsies: Our Approach to This Challenging Differential Diagnosis.
[So] Source:Arch Pathol Lab Med;141(10):1336-1341, 2017 Oct.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Distinguishing oncocytomas from their malignant mimics is very challenging. This review highlights our approach to classifying low-grade oncocytic tumors on both resections and biopsies. We also discuss how we use immunohistochemical stains in this challenging differential diagnosis.
[Mh] Termos MeSH primário: Adenoma Oxífilo/classificação
Adenoma Oxífilo/diagnóstico
Adenoma Oxífilo/patologia
Neoplasias Renais/classificação
Neoplasias Renais/diagnóstico
Neoplasias Renais/patologia
[Mh] Termos MeSH secundário: Biópsia
Diagnóstico Diferencial
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0240-RA


  4 / 1795 MEDLINE  
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[PMID]:28668830
[Au] Autor:Shackelford RE; Abdulsattar J; Wei EX; Cotelingam J; Coppola D; Herrera GA
[Ad] Endereço:Department of Pathology and Translational Pathobiology, LSU Health Shreveport, Shreveport, LA, U.S.A. rshack@lsuhsc.edu.
[Ti] Título:Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-ß-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.
[So] Source:Anticancer Res;37(7):3423-3427, 2017 07.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H S)-synthesizing enzyme levels, including cystathionine-ß-synthase (CBS). MATERIALS AND METHODS: We used tissue microarrays to examine Nampt and the H S-synthesizing enzyme CBS protein levels in benign kidney, RCC, UC and ROs. RESULTS: Compared to benign kidney, all three neoplasms showed increased Nampt and CBS protein levels, with the levels increasing in RCC at higher Fuhrman grades. CONCLUSION: H S is known to ameliorate chronic renal failure but, as yet, no role for H S in renal neoplasia has been demonstrated. Here, we showed, for the first time, that Nampt, CBS and, likely, H S likely play a role in malignant and benign neoplastic renal disease.
[Mh] Termos MeSH primário: Adenoma Oxífilo/metabolismo
Carcinoma de Células Renais/metabolismo
Cistationina beta-Sintase/metabolismo
Citocinas/metabolismo
Neoplasias Renais/metabolismo
Nicotinamida Fosforribosiltransferase/metabolismo
[Mh] Termos MeSH secundário: Seres Humanos
Sulfeto de Hidrogênio/metabolismo
Rim/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase); EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human); EC 4.2.1.22 (Cystathionine beta-Synthase); YY9FVM7NSN (Hydrogen Sulfide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  5 / 1795 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28591289
[Au] Autor:Fenelon EM; Balby IT; Neves NTD; Figueiredo F; Duarte ECB; Tzelikis PF
[Ad] Endereço:Hospital Oftalmológico de Brasília (HOB), Brasília, DF, Brazil.
[Ti] Título:Oncocytoma of the lacrimal gland: a case report.
[So] Source:Arq Bras Oftalmol;80(2):128-130, 2017 Mar-Apr.
[Is] ISSN:1678-2925
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Here we describe a rare case of a benign tumor in the lacrimal gland of a healthy 4-year-old girl. Mild proptosis was the only abnormality observed on clinical examination. Magnetic resonance imaging of the right orbit revealed an oval, solid, well-circumscribed, homogeneous mass extending from the lacrimal gland and measuring 2.5 × 2.3 × 1.7 cm without any evidence of invasion into adjacent bones. The lesion was surgically excised and histological analyses defined the diagnosis of oncocytoma of the lacrimal gland. Although rare, oncocytoma should be included in the differential diagnosis of lacrimal gland tumors.
[Mh] Termos MeSH primário: Adenoma Oxífilo/diagnóstico por imagem
Neoplasias Oculares/diagnóstico por imagem
Doenças do Aparelho Lacrimal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma Oxífilo/patologia
Pré-Escolar
Diagnóstico Diferencial
Eosinófilos/patologia
Neoplasias Oculares/patologia
Feminino
Seres Humanos
Doenças do Aparelho Lacrimal/patologia
Imagem por Ressonância Magnética
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  6 / 1795 MEDLINE  
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[PMID]:28411376
[Au] Autor:Rooper LM; Onenerk M; Siddiqui MT; Faquin WC; Bishop JA; Ali SZ
[Ad] Endereço:Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
[Ti] Título:Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
[So] Source:Cancer;125(8):627-634, 2017 Aug.
[Is] ISSN:1097-0142
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nodular oncocytic hyperplasia (oncocytosis) of the salivary glands is a benign process that does not inherently require surgical excision. However, cytologic findings in fine-needle aspiration (FNA) of oncocytosis cases have not been well characterized previously, limiting preoperative identification. METHODS: All available cases of oncocytosis with corresponding FNA specimens were identified from the pathology archives of 3 academic institutions. Clinical, cytologic, and histologic findings were tabulated for all cases. RESULTS: Twelve cases of oncocytosis were identified from 11 patients, including 11 parotid FNA specimens and 1 submandibular FNA specimen. On the original diagnoses, 6 specimens were classified as benign, 4 as atypical, and 2 as nondiagnostic. Oncocytosis was listed in the differential diagnosis in only 1 case. Among diagnostic aspirates, 8 demonstrated low cellularity and 2 demonstrated moderate cellularity. All 10 cases demonstrated oncocytic cells in small to medium groups, with single cells in just 1 case. Spindled and squamous morphology were each noted in 3 cases. Four cases demonstrated cystic change and 1 showed background mucin without goblet cells. No necrosis or mitoses were observed. CONCLUSIONS: Although oncocytosis demonstrates some overlap with Warthin tumor and oncocytoma, it lacks the diagnostic findings specific to oncocytic salivary gland malignancies such as salivary duct carcinoma, acinic cell carcinoma, mammary analog secretory carcinoma, and mucoepidermoid carcinoma. Despite current limitations in the understanding of oncocytic salivary gland lesions, the presence of a paucicellular specimen comprised of small groups of oncocytic cells should raise the possibility of oncocytosis in the differential diagnosis and can favor it in elderly patients with multiple salivary nodules. Cancer Cytopathol 2017;125:627-34. © 2017 American Cancer Society.
[Mh] Termos MeSH primário: Células Oxífilas/patologia
Doenças Parotídeas/patologia
Doenças da Glândula Submandibular/patologia
[Mh] Termos MeSH secundário: Adenolinfoma/diagnóstico
Adenolinfoma/patologia
Adenoma Oxífilo/diagnóstico
Adenoma Oxífilo/patologia
Idoso
Idoso de 80 Anos ou mais
Biópsia por Agulha Fina
Carcinoma/diagnóstico
Carcinoma/patologia
Carcinoma de Células Acinares/diagnóstico
Carcinoma de Células Acinares/patologia
Carcinoma Mucoepidermoide/diagnóstico
Carcinoma Mucoepidermoide/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças Parotídeas/diagnóstico
Doenças das Glândulas Salivares/diagnóstico
Doenças das Glândulas Salivares/patologia
Neoplasias das Glândulas Salivares/diagnóstico
Neoplasias das Glândulas Salivares/patologia
Doenças da Glândula Submandibular/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE
[do] DOI:10.1002/cncy.21865


  7 / 1795 MEDLINE  
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[PMID]:28325361
[Au] Autor:Skenderi F; Ulamec M; Vanecek T; Martinek P; Alaghehbandan R; Foix MP; Babankova I; Montiel DP; Alvarado-Cabrero I; Svajdler M; Dubinský P; Cempirkova D; Pavlovsky M; Vranic S; Daum O; Ondic O; Pivovarcikova K; Michalova K; Hora M; Rotterova P; Stehlikova A; Dusek M; Michal M; Hes O
[Ad] Endereço:Department of Pathology, University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina.
[Ti] Título:Warthin-like papillary renal cell carcinoma: Clinicopathologic, morphologic, immunohistochemical and molecular genetic analysis of 11 cases.
[So] Source:Ann Diagn Pathol;27:48-56, 2017 Apr.
[Is] ISSN:1532-8198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oncocytic papillary renal cell carcinoma (PRCC) is a distinct subtype of PRCC, listed as a possible new variant of PRCC in the 2016 WHO classification. It is composed of papillae aligned by large single-layered eosinophilic cells showing linearly arranged oncocytoma-like nuclei. We analyzed clinicopathologic, morphologic, immunohistochemical and molecular-genetic characteristics of 11 oncocytic PRCCs with prominent tumor lymphocytic infiltrate, morphologically resembling Warthin's tumor. The patients were predominantly males (8/11, 73%), with an average age of 59years (range 14-76), and a mean tumor size of 7cm (range 1-22cm). Tumors had the features of oncocytic PRCCs with focal pseudostratification in 8/11 cases and showed dense stromal inflammatory infiltration in all cases. Papillary growth pattern was predominant, comprising more than 60% of tumor volume. Tubular and solid components were present in 5 and 3 cases, respectively. Uniform immunohistochemical positivity was found for AMACR, PAX-8, MIA, vimentin, and OSCAR. Tumors were mostly negative for carboanhydrase 9, CD117, CK20, and TTF-1. Immunohistochemical stains for DNA mismatch repair proteins MLH1 and PMS2 were retained in all cases, while MSH2 and MSH6 were negative in 1 case. Tumor infiltrating lymphocytes (TILs) consisted of both B and T cells. Chromosomal copy number variation analysis showed great variability in 5 cases, ranging from a loss of one single chromosome to complex genome rearrangements. Only one case showed gains of chromosomes 7 and 17, among other aberrations. In 4 cases no numerical imbalance was found. Follow up data was available for 9 patients (median 47.6months, range 1-132). In 6 patients no lethal progression was noted, while 3 died of disease. In conclusion, Warthin-like PRCC is morphologically very close to oncocytic PRCC, from which it differs by the presence of dense lymphoid stroma. Chromosomal numerical aberration pattern of these tumors is variable; only one case showed gains of chromosomes 7 and 17. Warthin-like PRCC is a potentially aggressive tumor since a lethal outcome was recorded in 3/9 cases.
[Mh] Termos MeSH primário: Carcinoma Papilar/patologia
Carcinoma de Células Renais/genética
Carcinoma de Células Renais/patologia
Neoplasias Renais/genética
Neoplasias Renais/patologia
[Mh] Termos MeSH secundário: Adenoma Oxífilo/genética
Adenoma Oxífilo/patologia
Adolescente
Idoso
Biomarcadores Tumorais/análise
Carcinoma Papilar/genética
Carcinoma de Células Renais/diagnóstico
Variações do Número de Cópias de DNA/genética
Feminino
Predisposição Genética para Doença
Testes Genéticos/métodos
Seres Humanos
Imuno-Histoquímica/métodos
Hibridização in Situ Fluorescente/métodos
Neoplasias Renais/diagnóstico
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  8 / 1795 MEDLINE  
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[PMID]:28315424
[Au] Autor:Williamson SR; Gadde R; Trpkov K; Hirsch MS; Srigley JR; Reuter VE; Cheng L; Kunju LP; Barod R; Rogers CG; Delahunt B; Hes O; Eble JN; Zhou M; McKenney JK; Martignoni G; Fleming S; Grignon DJ; Moch H; Gupta NS
[Ad] Endereço:Department of Pathology and Laboratory Medicine, Detroit, MI, 48202, United States; Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, 48202, United States; Department of Pathology, Wayne State University School of Medicine, Detroit, MI, 48202, United States. Electronic address: sea
[Ti] Título:Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists.
[So] Source:Hum Pathol;63:149-156, 2017 May.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Renal oncocytoma and chromophobe renal cell carcinoma have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17 of 26 invitees. Histologically, more than 1 mitotic figure was regarded as most worrisome (n=10) or incompatible (n=6) with oncocytoma diagnosis. Interpretation of focal nuclear wrinkling, focal perinuclear clearing, and multinucleation depended on extent and did not necessarily exclude oncocytoma if minor. Staining techniques most commonly used included the following: cytokeratin 7 (94%), KIT (71%), vimentin (65%), colloidal iron (59%), CD10 (53%), and AMACR (41%). Rare cytokeratin 7-positive cells (≤5%) were regarded as most supportive of oncocytoma, although an extent excluding oncocytoma was not universal. Multiple chromosomal losses were most strongly supportive for chromophobe renal cell carcinoma diagnosis (65%). Less certainty was reported for chromosomal gain or a single loss. For tumors with mixed or inconclusive features, many participants use an intermediate diagnostic category (82%) that does not label the tumor as unequivocally benign or malignant, typically "oncocytic neoplasm" or "tumor" with comment. The term "hybrid tumor" was used variably in several scenarios. A slight majority (65%) report outright diagnosis of oncocytoma in needle biopsies. The morphologic, immunohistochemical, and genetic characteristics that define oncocytic renal tumors remain incompletely understood. Further studies correlating genetics, behavior, and histology are needed to define which tumors truly warrant classification as carcinomas for patient counseling and follow-up strategies.
[Mh] Termos MeSH primário: Adenoma Oxífilo/patologia
Carcinoma de Células Renais/patologia
Neoplasias Renais/patologia
Patologistas
Urologistas
[Mh] Termos MeSH secundário: Adenoma Oxífilo/química
Adenoma Oxífilo/genética
Biomarcadores Tumorais/análise
Biomarcadores Tumorais/genética
Biópsia
Carcinoma de Células Renais/química
Carcinoma de Células Renais/genética
Proliferação Celular
Diagnóstico Diferencial
Pesquisas sobre Serviços de Saúde
Seres Humanos
Imuno-Histoquímica
Queratina-7/análise
Neoplasias Renais/química
Neoplasias Renais/genética
Índice Mitótico
Técnicas de Diagnóstico Molecular
Valor Preditivo dos Testes
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (KRT7 protein, human); 0 (Keratin-7)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170319
[St] Status:MEDLINE


  9 / 1795 MEDLINE  
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[PMID]:28286028
[Au] Autor:Billeci D; Marton E; Giordan E; Carraro V; Ronzon M; Rossi S
[Ad] Endereço:Department of Neurosurgery, Treviso Regional Hospital, University of Padova, Treviso, Italy.
[Ti] Título:Spindle cell oncocytoma: Report of two cases with massive bleeding and review of the literature.
[So] Source:J Clin Neurosci;39:39-44, 2017 May.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Spindle cell oncocytoma (SCO) is a rare pituitary tumor, classified as a WHO grade I neoplasm. Due to its rarity, SCO is often preoperatively misdiagnosed as a pituitary macroadenoma. In the present study we report two recent cases of SCO, a 61-year-old male and a 65-year-old female presenting at Treviso General Hospital between March 2014 and April 2015. Tumor resection was achieved by endoscopic transsphenoidal approach but massive hemorrhagic events hampered surgery, endangering the patient's life in both cases. Both tumors featured fascicles of spindle cells with eosiniphilic cytoplasm expressing vimentin, S-100 and thyroid transcription factor-1 (TTF-1). The diagnosis of SCO was confirmed by second opinion in both cases. Extensive review of available literature, about 30 cases from 2002 to 2015, provided valuable clinical data for preoperative diagnosis and surgical removal of SCO tumors.
[Mh] Termos MeSH primário: Adenoma Oxífilo/diagnóstico por imagem
Hemorragia Cerebral/diagnóstico por imagem
Neoplasias Hipofisárias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma Oxífilo/complicações
Adenoma Oxífilo/cirurgia
Idoso
Hemorragia Cerebral/complicações
Hemorragia Cerebral/cirurgia
Diagnóstico Diferencial
Erros de Diagnóstico
Feminino
Seres Humanos
Masculino
Meia-Idade
Adeno-Hipófise/diagnóstico por imagem
Adeno-Hipófise/cirurgia
Neoplasias Hipofisárias/complicações
Neoplasias Hipofisárias/cirurgia
Encaminhamento e Consulta
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


  10 / 1795 MEDLINE  
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[PMID]:28280876
[Au] Autor:Coy H; Young JR; Douek ML; Brown MS; Sayre J; Raman SS
[Ad] Endereço:Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Ronald Reagan-UCLA Medical Center, 924 Westwood Boulevard, Suite 650, Los Angeles, CA, 90024, USA. hcoy@mednet.ucla.edu.
[Ti] Título:Quantitative computer-aided diagnostic algorithm for automated detection of peak lesion attenuation in differentiating clear cell from papillary and chromophobe renal cell carcinoma, oncocytoma, and fat-poor angiomyolipoma on multiphasic multidetector computed tomography.
[So] Source:Abdom Radiol (NY);42(7):1919-1928, 2017 Jul.
[Is] ISSN:2366-0058
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the performance of a novel, quantitative computer-aided diagnostic (CAD) algorithm on four-phase multidetector computed tomography (MDCT) to detect peak lesion attenuation to enable differentiation of clear cell renal cell carcinoma (ccRCC) from chromophobe RCC (chRCC), papillary RCC (pRCC), oncocytoma, and fat-poor angiomyolipoma (fp-AML). MATERIALS AND METHODS: We queried our clinical databases to obtain a cohort of histologically proven renal masses with preoperative MDCT with four phases [unenhanced (U), corticomedullary (CM), nephrographic (NP), and excretory (E)]. A whole lesion 3D contour was obtained in all four phases. The CAD algorithm determined a region of interest (ROI) of peak lesion attenuation within the 3D lesion contour. For comparison, a manual ROI was separately placed in the most enhancing portion of the lesion by visual inspection for a reference standard, and in uninvolved renal cortex. Relative lesion attenuation for both CAD and manual methods was obtained by normalizing the CAD peak lesion attenuation ROI (and the reference standard manually placed ROI) to uninvolved renal cortex with the formula [(peak lesion attenuation ROI - cortex ROI)/cortex ROI] × 100%. ROC analysis and area under the curve (AUC) were used to assess diagnostic performance. Bland-Altman analysis was used to compare peak ROI between CAD and manual method. RESULTS: The study cohort comprised 200 patients with 200 unique renal masses: 106 (53%) ccRCC, 32 (16%) oncocytomas, 18 (9%) chRCCs, 34 (17%) pRCCs, and 10 (5%) fp-AMLs. In the CM phase, CAD-derived ROI enabled characterization of ccRCC from chRCC, pRCC, oncocytoma, and fp-AML with AUCs of 0.850 (95% CI 0.732-0.968), 0.959 (95% CI 0.930-0.989), 0.792 (95% CI 0.716-0.869), and 0.825 (95% CI 0.703-0.948), respectively. On Bland-Altman analysis, there was excellent agreement of CAD and manual methods with mean differences between 14 and 26 HU in each phase. CONCLUSION: A novel, quantitative CAD algorithm enabled robust peak HU lesion detection and discrimination of ccRCC from other renal lesions with similar performance compared to the manual method.
[Mh] Termos MeSH primário: Adenoma Oxífilo/diagnóstico por imagem
Angiomiolipoma/diagnóstico por imagem
Carcinoma Papilar/diagnóstico por imagem
Carcinoma de Células Renais/diagnóstico por imagem
Neoplasias Renais/diagnóstico por imagem
Tomografia Computadorizada Multidetectores/métodos
[Mh] Termos MeSH secundário: Adenoma Oxífilo/patologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Algoritmos
Angiomiolipoma/patologia
Biópsia
Carcinoma Papilar/patologia
Carcinoma de Células Renais/patologia
Meios de Contraste
Diagnóstico por Computador
Diagnóstico Diferencial
Feminino
Seres Humanos
Imagem Tridimensional
Iohexol
Neoplasias Renais/patologia
Masculino
Meia-Idade
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 4419T9MX03 (Iohexol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1007/s00261-017-1095-6



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