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[PMID]:28538899
[Au] Autor:Martinez-Cabriales SA; Miranda-Maldonado I; Ocampo-Candiani J
[Ad] Endereço:Department of Dermatology - University Hospital "Dr. José Eleuterio González" Autonomous University of Nuevo León - Monterrey (N.L), México.
[Ti] Título:Case for diagnosis. A bluish nodule on the scalp.
[So] Source:An Bras Dermatol;92(2):275-276, 2017 Mar-Apr.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Acrospiroma, also known as hidradenoma, is a rare cutaneous tumor that has several histological characteristics. As a consequence, a high index of suspicion is necessary for its diagnosis. Here we report a case that illustrates the importance of a good clinical-pathologic correlation in order to recognize this disease.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Neoplasias de Cabeça e Pescoço/patologia
Couro Cabeludo/patologia
Neoplasias Cutâneas/patologia
Neoplasias das Glândulas Sudoríparas/patologia
[Mh] Termos MeSH secundário: Adulto
Dermoscopia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


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[PMID]:28295007
[Au] Autor:Konstantinova AM; Belousova IE; Kacerovska D; Michal M; Shelekhova KV; Kazakov DV
[Ad] Endereço:Pathology Department, Saint Petersburg Clinical Research and Practical Center for Specialized Types of Medical Care, Saint Petersburg, Russia; Pathology Department, Medical Faculty, Saint Petersburg State University, Saint Petersburg, Russia; Department of Pathology, Saint Petersburg Sociomedical In
[Ti] Título:[Anogenital mammary-like glands and related lesions. Part 1. Benign tumors and tumor-like disorders].
[Ti] Título:Anogenital'nye mammaropodobnye zhelezy i svyazannye s nimi zabolevaniya. Chast' 1. Dobrokachestvennye opukholi i opukholepodobnye protsessy anogenital'nykh zhelez..
[So] Source:Arkh Patol;79(1):43-51, 2017.
[Is] ISSN:0004-1955
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Anogenital mammary-like glands represent a normal anatomic constituent of the anogenital area and may give rise to many benign and malignant tumors that morphologically mimic similar breast diseases. The literature review is complemented by a description of 286 cases of benign tumors and tumor-like processes in the mammary-like glands. The paper presents the clinical and morphological characteristics of papillary hidradenoma, fibroadenoma, benign phyllodes tumor, lactating adenoma, sclerosing adenosis, pseudoangiomatous stromal hyperplasia, etc.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Neoplasias da Mama/patologia
Mama/patologia
Neoplasias/patologia
[Mh] Termos MeSH secundário: Acrospiroma/diagnóstico
Adenoma/diagnóstico
Adenoma/patologia
Neoplasias da Mama/classificação
Neoplasias da Mama/diagnóstico
Feminino
Fibroadenoma/diagnóstico
Fibroadenoma/patologia
Seres Humanos
Lactação/fisiologia
Neoplasias/classificação
Neoplasias/diagnóstico
Tumor Filoide/diagnóstico
Tumor Filoide/patologia
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.17116/patol201779143-51


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[PMID]:28087028
[Au] Autor:Robles-Mendez JC; Martínez-Cabriales SA; Villarreal-Martínez A; Ayala-Cortés AS; Miranda-Maldonado I; Vázquez-Martínez O; Ocampo-Candiani J
[Ad] Endereço:Department of Dermatology, University Hospital "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, Mexico.
[Ti] Título:Nodular hidradenoma: Dermoscopic presentation.
[So] Source:J Am Acad Dermatol;76(2S1):S46-S48, 2017 Feb.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Acrospiroma/patologia
Dermoscopia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE


  4 / 336 MEDLINE  
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[PMID]:28035705
[Au] Autor:Reddy SP; Chong K; Cassarino DS
[Ad] Endereço:School of Medicine, University of Illinois at Chicago College of Medicine, Chicago, Illinois.
[Ti] Título:A rare case of cutaneous oncocytic hidradenoma.
[So] Source:J Cutan Pathol;44(3):289-291, 2017 Mar.
[Is] ISSN:1600-0560
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oncocytes are epithelial cells characterized by their abundant eosinophilic and finely granular cytoplasm. Their histologic appearance is due to excessive amounts of cytoplasmic mitochondria. Oncocytes generally occur in the setting of benign neoplasms. Oncocytomas, or tumors composed primarily of oncocytes, are typically found in the kidneys. Other common sites include the salivary, thyroid, and parathyroid glands. Oncocytic metaplasia has only been rarely reported in various cutaneous neoplasms. We report a case of an elderly male presenting with a 5 mm erythematous papule on his left scalp, who underwent a shave biopsy showing a nodular, dermal-based adnexal tumor with prominent ductal differentiation, composed of multiple small, well-formed lumina surrounded by enlarged and bland-appearing epithelioid cells. Cytokeratin 7 (CK7), epithelial membrane antigen (EMA) and monoclonal carcinoembryonic antigen (mCEA) immunohistochemical stains were positive, consistent with adnexal differentiation. Phosphotungstic acid-hematoxylin (PTAH) and Luxol fast blue (LFB) stains highlighted the cytoplasmic granules, consistent with mitochondria. The overall findings were consistent with an oncocytic nodular hidradenoma. Oncocytic hidradenoma is a very rare entity, with only 1 previously reported case in the literature.
[Mh] Termos MeSH primário: Acrospiroma/patologia
Células Oxífilas/patologia
Neoplasias das Glândulas Sudoríparas/patologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores Tumorais/análise
Carcinoma Basocelular/patologia
Seres Humanos
Imuno-Histoquímica
Masculino
Segunda Neoplasia Primária/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE
[do] DOI:10.1111/cup.12883


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[PMID]:27914681
[Au] Autor:Hsieh MS; Lien HC; Hua SF; Kuo WH; Lee YH
[Ad] Endereço:Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan.
[Ti] Título:Clear cell hidradenoma of the breast with MAML2 gene rearrangement.
[So] Source:Pathology;49(1):84-87, 2017 Jan.
[Is] ISSN:1465-3931
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acrospiroma/genética
Acrospiroma/patologia
Neoplasias da Mama/genética
Proteínas de Ligação a DNA/genética
Rearranjo Gênico/genética
Predisposição Genética para Doença
Proteínas Nucleares/genética
Fatores de Transcrição/genética
[Mh] Termos MeSH secundário: Acrospiroma/diagnóstico
Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (DNA-Binding Proteins); 0 (MAML2 protein, human); 0 (Nuclear Proteins); 0 (Transcription Factors)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27742746
[Au] Autor:Goto K; Maeda D; Kudo-Asabe Y; Hibiya T; Hayashi A; Fukayama M; Ohashi K; Goto A
[Ad] Endereço:Department of Diagnostic Pathology, Kainan Hospital, Aichi, Japan.
[Ti] Título: and mutations in hidradenoma papilliferum.
[So] Source:J Clin Pathol;70(5):424-427, 2017 May.
[Is] ISSN:1472-4146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Hidradenoma papilliferum (HP) is a benign vulvar neoplasm that arises from anogenital mammary-like glands, and its morphology is similar to mammary intraductal papilloma. The aim of this study was to investigate oncogenic mutations involved in the tumourigenesis of HP. We focused specifically on and mutations, which are both reported to be detected in 33% of mammary intraductal papillomas. METHODS: In total, seven HP cases were analysed. Clinicopathological analyses and immunohistochemistry for oestrogen receptor, p63, smooth muscle actin (SMA), p53 and ß-catenin were performed. Furthermore, , and hot spot mutations were examined by Sanger sequencing. RESULTS: Morphologically, all HPs had a papillary and tubular architecture with a biphasic pattern of epithelial and myoepithelial cells. Immunohistochemistry revealed that oestrogen receptor expression was restricted to epithelial cells, whereas p63 and SMA were exclusively expressed in myoepithelial cells. The patterns of p53 and ß-catenin immunostaining suggested wild-type genotypes. Direct sequencing revealed the presence of somatic mutations (Ex9. c.1633G>A, p.E545K and Ex20. c.3140A>G, p.H1047R) in two of the HPs and an (c.49G>A, p.E17K) mutation in one. and mutations were not found in any of the HP cases. CONCLUSIONS: and are frequently mutated in HP tumours (29% and 14%, respectively). PIK3CA/AKT1 pathway alterations in HP further support the hypothesis that HP is the vulvar (anogenital mammary-like gland) analogue of breast intraductal papilloma.
[Mh] Termos MeSH primário: Acrospiroma/genética
Biomarcadores Tumorais/genética
Fosfatidilinositol 3-Quinases/genética
Proteínas Proto-Oncogênicas c-akt/genética
Neoplasias Cutâneas/genética
Neoplasias das Glândulas Sudoríparas/genética
Neoplasias Vulvares/genética
[Mh] Termos MeSH secundário: Acrospiroma/diagnóstico
Acrospiroma/patologia
Adulto
Biomarcadores Tumorais/metabolismo
Transformação Celular Neoplásica
Classe I de Fosfatidilinositol 3-Quinases
Feminino
Genótipo
Seres Humanos
Imuno-Histoquímica
Meia-Idade
Mutação
Fenótipo
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Análise de Sequência de DNA
Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/patologia
Neoplasias das Glândulas Sudoríparas/diagnóstico
Neoplasias das Glândulas Sudoríparas/patologia
Neoplasias Vulvares/diagnóstico
Neoplasias Vulvares/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (PIK3CA protein, human); EC 2.7.11.1 (AKT1 protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161016
[St] Status:MEDLINE
[do] DOI:10.1136/jclinpath-2016-204003


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[PMID]:28329616
[Au] Autor:Tarantino I; Fraga G; Fischer R
[Ti] Título:A chronic, bleeding, and painful nodule on the chest.
[So] Source:Dermatol Online J;22(9), 2016 Sep 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An 81-year-old man presented to the dermatology clinic with a painful lesion on his chest. The nodule would occasionally bleed and leak serous fluid for 10 years. Physical examination revealed an unspecified nodule with two superimposed nodules. A deep shave biopsy of the lesion was obtained and expressed a solid-cystic dermal neoplasm that was comprised of an admixture of cell types. Through the presenting clinical and histological features seen, a final diagnosis of nodular hidradenoma was made.
[Mh] Termos MeSH primário: Acrospiroma/diagnóstico
Neoplasias das Glândulas Sudoríparas/diagnóstico
Parede Torácica
[Mh] Termos MeSH secundário: Acrospiroma/complicações
Acrospiroma/patologia
Idoso
Hemorragia/etiologia
Seres Humanos
Masculino
Dor/etiologia
Neoplasias das Glândulas Sudoríparas/complicações
Neoplasias das Glândulas Sudoríparas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:27477180
[Au] Autor:di Meo N; Stinco G; Gatti A; Fadel M; Vichi S; Trevisan G
[Ti] Título:Dermoscopy of Skin Adnexal Neoplasms:A Continuous Challenge.
[So] Source:Acta Dermatovenerol Croat;24(2):158-60, 2016 Jun.
[Is] ISSN:1847-6538
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm. A 70-year-old woman in fair general condition was referred to our Department for an asymptomatic 10×8 mm single nodule on her left scapula. This nodule was red, dome shaped, well circumscribed, firm, and mildly tender (Figure 1). The patient reported that it had been present since approximately 7 months. The lesion was neither painful nor itchy and there was no bleeding. A skin examination did not show any other lesions with the same features or other suspicious lesions. Dermatoscopy revealed milky-pinkish areas with dotted vessels, linear-irregular vessels, and hairpin vessels: some of these aspects can also be found in amelanotic melanoma (1). There were also homogeneous blue areas similar to lacunae, characteristic but not exclusive to vascular or sarcomatous neoplasms and basal cell carcinoma (1,2). Furthermore, small ulcerations covered by an amber crust were identified, which can usually be found in basal cell carcinoma. Regarding the background of the lesion, we noticed peculiar, translucent, pinkish, soft, large lobular areas (Figure 2). On the basis of this analysis, we suspected an atypical presentation of a basal cell carcinoma, an amelanotic melanoma, or a sarcomatous skin neoplasm. A metastasis of an unknown solid tumor was also taken into consideration. The histological examination revealed an adnexal neoplasm and specifically an apocrine hidradenoma. The neoplasm had variably sized nests and nodules of neoplastic epithelial cells, with a small ductular lumens confined within the upper dermis. The lesion was composed mainly of two cell types: polygonal and smaller, elongated, and darker cells. The cuboidal/polygonal cells were seen lining the duct-like spaces and slots and resembled those of poroma (Figure 3). The adnexal skin tumors group includes a complex variety of uncommon tumors that can be distinguished only histologically, and most of them are benign (3). Searching the literature for "hidradenoma dermoscopy" and "adnexal dermoscopy" yields multiple descriptions of poromas but few dermatoscopic descriptions of hidradenoma (4). There was only one report of the presence of "arborizing vessels"(5), and another described "reddish purple areas and some linear or hairpin-like vessels on the surface of the tumor" (6). In another paper we found: "irregular scar like whitish areas and a polymorphous vascular pattern including irregular reddish-purple areas mimicking lacunar appearance of hemangiomas with thick hairpin vessels at the periphery" (7). It is very difficult make use of such scant data especially in order to detect a leading pattern for a specific diagnosis. Moreover, the described structures lack in specificity, being also present in many other lesions. Analyzing our dermatoscopic image and comparing it to the other ones available in the literature, we identified a peculiar background. It consisted in the presence of multilobular translucent and pinkish soft areas, which fit the previously described dermatoscopic criteria. We hypothesize there is a correlation between this feature and the histopathological presentation with variably sized nests and nodules. Of course, further case reports of hidradenoma are needed to identify the soft lobular background as a distinctive dermatoscopic feature. Due to the lack of specific features both clinically than dermatoscopically, histopathological analysis remains the only gold standard for diagnosis of these benign mimicking lesions.
[Mh] Termos MeSH primário: Acrospiroma/diagnóstico por imagem
Dermoscopia
Neoplasias Cutâneas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Acrospiroma/patologia
Idoso
Feminino
Seres Humanos
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170331
[Lr] Data última revisão:
170331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


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[PMID]:27350422
[Au] Autor:Nakazato S; Yanagi T; Inamura Y; Kitamura S; Hata H; Shimizu H
[Ad] Endereço:Department of Dermatology, Hokkaido University Graduate School of Medicine North 15 West 7, Sapporo 060-8638, Japan.
[Ti] Título:A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma.
[Ti] Título:A case of nodular hidradenoma of the auricle mimicking squamous cell carcinoma..
[So] Source:Eur J Dermatol;26(4):409-10, 2016 Aug 01.
[Is] ISSN:1952-4013
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Acrospiroma/diagnóstico
Carcinoma de Células Escamosas/diagnóstico
Neoplasias da Orelha/diagnóstico
Neoplasias das Glândulas Sudoríparas/diagnóstico
[Mh] Termos MeSH secundário: Acrospiroma/patologia
Idoso
Carcinoma de Células Escamosas/patologia
Diagnóstico Diferencial
Pavilhão Auricular
Neoplasias da Orelha/patologia
Feminino
Seres Humanos
Neoplasias das Glândulas Sudoríparas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE
[do] DOI:10.1684/ejd.2016.2810


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[PMID]:27184479
[Au] Autor:Liau JY; Lan J; Hong JB; Tsai JH; Kuo KT; Chu CY; Sheen YS; Huang WC
[Ad] Endereço:Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10002, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10051, Taiwan.
[Ti] Título:Frequent PIK3CA-activating mutations in hidradenoma papilliferums.
[So] Source:Hum Pathol;55:57-62, 2016 Sep.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hidradenoma papilliferum (HP) is a benign epithelial tumor most commonly seen in the vulva. It is proposed to be derived from the anogenital mammary-like glands and is histologically very similar to the mammary intraductal papilloma (IP). Approximately 60% of mammary IPs have activating mutations in either PIK3CA or AKT1, with each gene accounting for 30% of cases. In this study, we screened the mutation statuses of PIK3CA, AKT1, RAS, and BRAF in 30 HPs. The results showed that activating mutations in either PIK3CA or AKT1 were identified in 20 tumors (67%); 19 tumors had PIK3CA mutations (63%; 13 in exon 20 and 6 in exon 9), and 1 had an AKT1 E17K mutation (3%). BRAF V600E mutation was found in an HP that also had a PIK3CA H1047R mutation. No RAS mutation was found. The mutation status was not correlated with the degree of epithelial cell hyperplasia. We conclude that although there might be site-related variations in the mutation frequencies of PIK3CA and AKT1 genes, HP is histologically and also genetically very similar to the mammary IP, suggesting that HP can be viewed as the extramammary counterpart of mammary IP.
[Mh] Termos MeSH primário: Acrospiroma/genética
Biomarcadores Tumorais/genética
Mutação
Fosfatidilinositol 3-Quinases/genética
Neoplasias das Glândulas Sudoríparas/genética
Neoplasias Vulvares/genética
[Mh] Termos MeSH secundário: Acrospiroma/enzimologia
Acrospiroma/patologia
Acrospiroma/cirurgia
Adulto
Idoso
Classe I de Fosfatidilinositol 3-Quinases
Análise Mutacional de DNA
Éxons
Feminino
Frequência do Gene
Genes ras
Predisposição Genética para Doença
Seres Humanos
Hiperplasia
Meia-Idade
Fenótipo
Proteínas Proto-Oncogênicas B-raf/genética
Proteínas Proto-Oncogênicas c-akt/genética
Neoplasias das Glândulas Sudoríparas/enzimologia
Neoplasias das Glândulas Sudoríparas/patologia
Neoplasias das Glândulas Sudoríparas/cirurgia
Neoplasias Vulvares/enzimologia
Neoplasias Vulvares/patologia
Neoplasias Vulvares/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (PIK3CA protein, human); EC 2.7.11.1 (AKT1 protein, human); EC 2.7.11.1 (BRAF protein, human); EC 2.7.11.1 (Proto-Oncogene Proteins B-raf); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160518
[St] Status:MEDLINE



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