[PMID]: | 28654578 |
[Au] Autor: | Gordon S; Fischer C; Martin A; Rosman IS; Council ML |
[Ad] Endereço: | *Division of Dermatology, Department of Internal Medicine, Washington University, St. Louis, Missouri; †Department of Pathology and Immunology, Washington University, St. Louis, Missouri. |
[Ti] Título: | Microcystic Adnexal Carcinoma: A Review of the Literature. |
[So] Source: | Dermatol Surg;43(8):1012-1016, 2017 Aug. |
[Is] ISSN: | 1524-4725 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive cutaneous neoplasm that commonly occurs on the face. OBJECTIVE: The purpose of this article is to comprehensively review the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment. MATERIALS AND METHODS: An extensive literature review was conducted using OVID MEDLINE and PubMed to identify articles relating to MAC. RESULTS: Microcystic adnexal carcinoma typically presents as a skin-colored nodule on the face. The pathogenesis is mostly related to pilar and eccrine differentiation. Histologically, MAC can mimic syringoma, desmoplastic trichoepithelioma, and infiltrative basal cell carcinoma. Diagnosis is challenging because superficial shave biopsies may reveal only benign findings that do not warrant further management. A deep biopsy is mandatory for the correct diagnosis, and Mohs micrographic surgery provides the highest cure rate. CONCLUSION: Microcystic adnexal carcinoma is a locally aggressive disease with histological margins that often far surpass what is clinically suspected. Mohs micrographic surgery is the standard of care for removal of these lesions. Patients with a history of MAC should be examined at least every 6 months for recurrence, metastasis, and development of additional skin cancers. |
[Mh] Termos MeSH primário: |
Neoplasias Faciais Neoplasias Cutâneas Siringoma
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[Mh] Termos MeSH secundário: |
Neoplasias Faciais/epidemiologia Neoplasias Faciais/metabolismo Neoplasias Faciais/patologia Neoplasias Faciais/cirurgia Seres Humanos Imuno-Histoquímica Prognóstico Neoplasias Cutâneas/epidemiologia Neoplasias Cutâneas/metabolismo Neoplasias Cutâneas/patologia Neoplasias Cutâneas/cirurgia Siringoma/epidemiologia Siringoma/metabolismo Siringoma/patologia Siringoma/cirurgia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; REVIEW |
[Em] Mês de entrada: | 1708 |
[Cu] Atualização por classe: | 170830 |
[Lr] Data última revisão:
| 170830 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170628 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1097/DSS.0000000000001142 |
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