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[PMID]:29399882
[Au] Autor:Mitra S; Chatterjee D; Das A; Gupta K; Radotra BD; Mandal AK
[Ad] Endereço:Department of Histopathology, PGIMER, Chandigarh, India.
[Ti] Título:Urothelial tumors with villous morphology: Histomorphology and role of immunohistochemistry in diagnosis.
[So] Source:APMIS;126(3):191-200, 2018 Mar.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Villous adenoma and urothelial carcinoma with villoglandular differentiation (UCVGD) are rare urothelial tumours showing villous morphology, the former being a preneoplastic entity and the latter being a malignant one. The detailed immunohistochemistry of these entities is previously not described in the literature. Moreover, a limited biopsy sample of UCVGD or a villous adenoma with or without adenocarcinoma may be difficult to distinguish on the basis of the histomorphology alone. An immunohistochemical panel comprising of GATA3, p63, ß-catenin, CK7 and CK20 was performed on five cases of UCVGD and three cases of villous adenoma with the aim of studying the expression of the proteins thereby aiding in the diagnosis of these entities in a limited surgical pathology specimen. The mean age of UCVGD was 66.8 years and all the patients were male. All the cases of UCVGD were associated with high grade papillary urothelial carcinoma with lamina propria invasion. The immunohistochemical panel showed strong nuclear GATA3 expression in the urothelial component of UCVGD. Interestingly, the high grade and the low grade villoglandular components of UCVGD also expressed GATA3 (nuclear) with a progressive loss of expression from the high grade to the low grade component. The villous adenomas showed negativity or aberrant cytoplasmic positivity for GATA3. The ß-catenin showed a gradual loss of membranous expression from villous adenoma to low grade and high grade villoglandular components of UCVGD with a patchy membranous expression in the urothelial component of the UCVGD. p63 showed strong nuclear positivity in the urothelial component and uniform negativity in the villous adenoma and villoglandular component of UCVGD irrespective of its grade, thereby distinguishing the villoglandular component from the urothelial component. The urothelial component of UCVGD showed strong membranous CK7 expression and was higher than the CK20 expression in the urothelial component. In contrast, CK20 expression was higher in villous adenoma as compared to CK7. There was no difference in the expression of CK7 and CK20 in the villoglandular components and low grade and high grade villoglandular areas. The above-mentioned immunohistochemical pattern may help to distinguish the UCVGD from the villous adenoma.
[Mh] Termos MeSH primário: Adenoma Viloso/diagnóstico
Fator de Transcrição GATA3/metabolismo
Queratina-7/metabolismo
Proteínas de Membrana/metabolismo
Neoplasias Urológicas/diagnóstico
beta Catenina/metabolismo
[Mh] Termos MeSH secundário: Adenoma Viloso/patologia
Idoso
Biomarcadores Tumorais/metabolismo
Feminino
Hematúria/patologia
Seres Humanos
Imuno-Histoquímica
Queratina-20/metabolismo
Masculino
Meia-Idade
Neoplasias Urológicas/patologia
Urotélio/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (CKAP4 protein, human); 0 (GATA3 Transcription Factor); 0 (GATA3 protein, human); 0 (KRT20 protein, human); 0 (KRT7 protein, human); 0 (Keratin-20); 0 (Keratin-7); 0 (Membrane Proteins); 0 (beta Catenin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180206
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12799


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[PMID]:28188165
[Au] Autor:Kagan MD; Schmidt K; Sangha G
[Ad] Endereço:Department of Psychiatry, Kern Medical, Bakersfield, California, USA.
[Ti] Título:Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma.
[So] Source:BMJ Case Rep;2017, 2017 Feb 10.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin. Villous adenomas are benign neoplasms with a high incidence of becoming malignant. A small percentage of villous adenomas are known to cause depletion syndrome, also referred to as the McKittrick-Wheelock syndrome, a condition characterised by secretory diarrhoea, dehydration, hyponatremia, hypokalaemia, hypochloraemia, metabolic acidosis and acute renal failure. Prostaglandin-E2 mediates the hypersecretion mechanism observed in depletion syndrome, and can be inhibited by cyclo-oxygenase inhibitors. This case study measured the effectiveness of prostaglandin inhibition on a patient with oral and parenteral electrolyte replacement refractory depletion syndrome. Fluid loss and prostaglandin levels were measured before and after pharmacological treatment. This case demonstrates a 49% decrease in rectal effluent and a marked commensurate decrease in daily replenishment requirements within 48 hours of indomethacin treatment initiation, resulting in subsequent electrolyte stabilisation.
[Mh] Termos MeSH primário: Adenoma Viloso/complicações
Inibidores de Ciclo-Oxigenase/uso terapêutico
Hipopotassemia/tratamento farmacológico
Hiponatremia/tratamento farmacológico
Indometacina/uso terapêutico
Neoplasias Retais/complicações
[Mh] Termos MeSH secundário: Adulto
Diuréticos/uso terapêutico
Quimioterapia Combinada
Feminino
Seres Humanos
Hipopotassemia/etiologia
Hiponatremia/etiologia
Potássio/uso terapêutico
Prostaglandinas/análise
Reto/química
Espironolactona/uso terapêutico
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclooxygenase Inhibitors); 0 (Diuretics); 0 (Prostaglandins); 27O7W4T232 (Spironolactone); RWP5GA015D (Potassium); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE


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[PMID]:28104721
[Au] Autor:Massani M; Capovilla G; Ruffolo C; Bassi N
[Ad] Endereço:Regional Center for HPB Surgery, Regional Hospital of Treviso, Treviso, Italy.
[Ti] Título:Gastrointestinal stromal tumour (GIST) presenting as a strangulated inguinal hernia with small bowel obstruction.
[So] Source:BMJ Case Rep;2017, 2017 Jan 19.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Gastrointestinal stromal tumours (GISTs) can arise everywhere along the gastrointestinal (GI) tract. Their presentation in unusual locations should always be taken into account. A 74-year-old man referred to the emergency department for small bowel obstruction caused by an incarcerated inguinal hernia. A CT scan showed a mesenchymal tumour originating from the herniated bowel loop and a mass in the ascending colon. Laparoscopic resection of the mass and laparoscopic right hemicolectomy were performed. The histology showed a ruptured GIST arising from the herniated small bowel and a high-grade dysplasia villous adenoma of the right colon. GISTs can present with symptoms spanning from vague abdominal discomfort to surgical urgencies. Strangulated hernia is an extremely rare presentation, with only two cases described in the literature. A safe surgical approach was obtained with laparoscopy, maintaining surgical radicality. The ileal localisation and the pseudocapsule rupture were the main risk factors on prognostic stratification.
[Mh] Termos MeSH primário: Adenoma Viloso/diagnóstico por imagem
Neoplasias do Colo/diagnóstico por imagem
Tumores do Estroma Gastrointestinal/diagnóstico por imagem
Hérnia Inguinal/diagnóstico por imagem
Neoplasias do Íleo/diagnóstico por imagem
Obstrução Intestinal/diagnóstico por imagem
Neoplasias Primárias Múltiplas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma Viloso/complicações
Adenoma Viloso/patologia
Adenoma Viloso/cirurgia
Idoso
Colectomia
Neoplasias do Colo/complicações
Neoplasias do Colo/patologia
Neoplasias do Colo/cirurgia
Tumores do Estroma Gastrointestinal/complicações
Tumores do Estroma Gastrointestinal/patologia
Tumores do Estroma Gastrointestinal/cirurgia
Hérnia Inguinal/complicações
Seres Humanos
Neoplasias do Íleo/classificação
Neoplasias do Íleo/patologia
Neoplasias do Íleo/cirurgia
Obstrução Intestinal/etiologia
Masculino
Neoplasias Primárias Múltiplas/complicações
Neoplasias Primárias Múltiplas/patologia
Neoplasias Primárias Múltiplas/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:28133119
[Au] Autor:Okano M; Okuyama M; Nishino M; Hoshino H; Kawada J; Kim Y; Tsujinaka T
[Ad] Endereço:Dept. of Surgery, Kaizuka City Hospital.
[Ti] Título:[A Case of Large Rectal Villous Adenoma Associated with Tenesmus and Body Weight Loss].
[So] Source:Gan To Kagaku Ryoho;43(12):1748-1750, 2016 Nov.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The patient was a 78-year-old man who was hospitalized with a 1-month history of tenesmus and body weight loss. Blood tests revealed a mild increase in tumor markers(CEA 9.7 ng/mL)and an elevation of the inflammatory response. Colonoscopic examination disclosed a full circular lateral spreading tumor(LST)extending from the second Houston valve to the rectosigmoidal region with a more than 10 cm length. Since invasion to the SM layer was suspected, endoscopic resection was judged inapplicable and laparoscopic low anterior resection with D2 lymph node dissection was performed, along with covering ileostomy. The final pathology diagnosis was villous adenoma with carcinoma in adenoma, showing multiple villous structures categorized as high dysplasia. Postoperatively, he was free from tenesmus and his body weight increased. In addition, normalization of the tumor markers occurred.
[Mh] Termos MeSH primário: Adenoma Viloso
Neoplasias Retais/patologia
Perda de Peso
[Mh] Termos MeSH secundário: Adenoma Viloso/complicações
Adenoma Viloso/cirurgia
Idoso
Colectomia
Colonoscopia
Seres Humanos
Masculino
Neoplasias Retais/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


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[PMID]:27852534
[Au] Autor:Akabah P; Boeriu A; Bartha JR; Dobru D
[Ad] Endereço:Department of Gastroenterology, Mures County Hospital, Targu Mures, Romania. akabahpeter@gmail.com.
[Ti] Título:Prediction of the histotype of a rectal polyp with the help of an underwater examination.
[So] Source:Turk J Gastroenterol;27(6):484-485, 2016 Nov.
[Is] ISSN:2148-5607
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Mh] Termos MeSH primário: Adenoma Viloso/diagnóstico por imagem
Hemorragia Gastrointestinal/etiologia
Pólipos Intestinais/diagnóstico por imagem
Neoplasias Retais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenoma Viloso/patologia
Idoso
Colonoscopia
Seres Humanos
Imersão
Pólipos Intestinais/patologia
Masculino
Imagem de Banda Estreita
Valor Preditivo dos Testes
Neoplasias Retais/patologia
Água
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE
[do] DOI:10.5152/tjg.2016.16430


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[PMID]:27406827
[Au] Autor:Rao P; Sikora SS; Ghosal N
[Ad] Endereço:Department of Histopathology, Sakra World Hospital, Sy No 52/2 &52/3, Deverbeesanahalli, Varthur Hobli, Bangalore, 560103, India. drpallavirao@gmail.com.
[Ti] Título:Villous Adenoma Arising at the Hepaticojejunostomy Site (HJ Site): First Report of an Unusual Case.
[So] Source:J Gastrointest Cancer;47(3):338-40, 2016 Sep.
[Is] ISSN:1941-6636
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Adenoma Viloso/etiologia
Fígado/patologia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Meia-Idade
Pancreaticoduodenectomia/efeitos adversos
Pancreaticoduodenectomia/métodos
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160714
[St] Status:MEDLINE
[do] DOI:10.1007/s12029-016-9857-x


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[PMID]:27281826
[Au] Autor:Väyrynen SA; Väyrynen JP; Klintrup K; Mäkelä J; Tuomisto A; Mäkinen MJ
[Ad] Endereço:Cancer and Translational Medicine Research Unit, University of Oulu, Oulu, Finland.
[Ti] Título:Ectopic crypt foci in conventional and serrated colorectal polyps.
[So] Source:J Clin Pathol;69(12):1063-1069, 2016 Dec.
[Is] ISSN:1472-4146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Despite almost pathognomonic status of ectopic crypt foci (ECF) in the diagnosis of traditional serrated adenoma (TSA), there are few systematic studies on their prevalence in other types of colon polyps or in adenomas adjacent to colorectal cancer (CRC). METHODS: We calculated ECF in all the polyps (n=922) removed in the colonoscopy in Oulu University Hospital in 2001. Moreover, to study ECF in precursor lesions next to CRCs, we re-examined a previously described cohort of 148 CRCs. RESULTS: ECF were seen in 53 (5.7%) polyps representing 28 (6.5%) tubular adenomas (TAs), 14 (53.8%) tubulovillous adenomas (TVAs), 2 (100.0%) villous adenomas (VAs) and 9 (100.0%) TSAs. In all TSAs and VAs, the density of ECF was higher than in TVAs and TAs. An adjacent precursor lesion was recognised in 28 of 148 (18.9%) CRCs. Twenty-four (85.7%) of these contained ECF. CONCLUSIONS: ECF can most frequently be observed in TSAs but also in many TVAs, VAs and TAs, reflecting a histological overlap between serrated and conventional polyps. Especially, precursor lesions adjacent to CRC frequently contain ECF.
[Mh] Termos MeSH primário: Adenoma Viloso/classificação
Adenoma/classificação
Neoplasias do Colo/classificação
Pólipos do Colo/classificação
Neoplasias Colorretais/classificação
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Colo/patologia
Pólipos do Colo/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.1136/jclinpath-2015-203593


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[PMID]:27267899
[Au] Autor:Agnes A; Novelli D; Doglietto GB; Papa V
[Ad] Endereço:Division of Surgery, Miulli General Hospital, S.P. 127 Acquaviva-Santeramo km 4, 70021, Acquaviva delle Fonti, Italy. annamaria.agnes@gmail.com.
[Ti] Título:A case report of a giant rectal adenoma causing secretory diarrhea and acute renal failure: McKittrick-Wheelock syndrome.
[So] Source:BMC Surg;16(1):39, 2016 Jun 07.
[Is] ISSN:1471-2482
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The McKittrick-Wheelock syndrome is a rare depletion syndrome caused by a secretory villous adenoma or a carcinoma of the rectosigmoid tract. An aggressive hydroelectrolyte rebalancing is often needed, and curative treatment is obtained only with complete removal of the lesion, by endoscopy or surgery. Low clinical suspicion often delays the diagnosis, resulting in detrimental complications. CASE PRESENTATION: We report the case of a 75-year-old woman, presenting to the emergency department with acute renal failure and electrolyte imbalance, reporting an history of recurrent episodes of dehydration and chronic diarrhea. After being admitted to the nephrology department she underwent diagnostic investigation that revealed the presence of a giant adenoma of the rectum. The patients received supportive therapy and was subsequently treated with surgery, with a favorable outcome. CONCLUSIONS: A prompt diagnosis plays an important role in the treatment of McKittrick-Wheelock syndrome. We describe a case of this condition in detail and review the related literature, underlining the typical diagnostic features and exploring the possible therapeutic options.
[Mh] Termos MeSH primário: Lesão Renal Aguda/etiologia
Adenocarcinoma/complicações
Adenoma Viloso/complicações
Diarreia/etiologia
Cardiopatias Congênitas/complicações
Hidrocolpos/complicações
Polidactilia/complicações
Neoplasias Retais/complicações
Doenças Uterinas/complicações
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/diagnóstico
Anormalidades Múltiplas/cirurgia
Lesão Renal Aguda/diagnóstico
Adenocarcinoma/diagnóstico
Adenocarcinoma/cirurgia
Adenoma Viloso/diagnóstico
Idoso
Biópsia
Colonoscopia
Diagnóstico Diferencial
Diarreia/diagnóstico
Feminino
Cardiopatias Congênitas/diagnóstico
Cardiopatias Congênitas/cirurgia
Seres Humanos
Hidrocolpos/diagnóstico
Hidrocolpos/cirurgia
Polidactilia/diagnóstico
Polidactilia/cirurgia
Neoplasias Retais/diagnóstico
Tomografia Computadorizada por Raios X
Doenças Uterinas/diagnóstico
Doenças Uterinas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1186/s12893-016-0153-2


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[PMID]:27121034
[Au] Autor:Ishikawa R; Kadota K; Hayashi T; Motoyama M; Matsunaga T; Miyai Y; Katsuki N; Kushida Y; Haba R
[Ad] Endereço:Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
[Ti] Título:Cytopathological features of villous adenoma of the urinary bladder in urine: A rare case report.
[So] Source:Diagn Cytopathol;44(7):632-5, 2016 Jul.
[Is] ISSN:1097-0339
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Villous adenoma of the urinary bladder is a rare tumor that histologically mimics its enteric counterpart. Patients with an isolated villous adenoma have an excellent prognosis, but associated adenocarcinomas can frequently be identified in them as well. There is no literature that discusses the cytopathologic features of villous adenoma. Here we report a case which was diagnosed as villous adenoma histologically, which has been followed up with urine cytology. In urine cytology, many mucin producing cells are recognized. Few cell clusters show glandular formation or arrangement along the basement membrane. When glandular cells with columnar mucin-filled goblet cells are seen in urine cytology, the presence of a primary glandular lesion of the urinary bladder, such as villous adenoma, should be considered possible. Diagn. Cytopathol. 2016;44:632-635. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Adenoma Viloso/patologia
Neoplasias da Bexiga Urinária/patologia
Urina/citologia
[Mh] Termos MeSH secundário: Feminino
Células Caliciformes/metabolismo
Células Caliciformes/patologia
Seres Humanos
Meia-Idade
Mucinas/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mucins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160429
[St] Status:MEDLINE
[do] DOI:10.1002/dc.23488


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[PMID]:27025396
[Au] Autor:Cipolla C; Ferro G; Graceffa G; Morini L; Guercio G; Vieni S; Pantuso G
[Ti] Título:Transanal endoscopic video-assisted (TEVA) resection of early rectal lesions using a SILS port A single center experience.
[So] Source:Ann Ital Chir;87:36-40, 2016.
[Is] ISSN:2239-253X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: represents a safe and complete technique to remove benign lesions of the rectum not treatable by endoscopy and malignant rectal lesions at early stage. It is a valid alternative to transanal endoscopic microsurgery (TEM), to conventional transanal surgery and to transabdominal resection. METHODS: In our operating Unit we performed a resection of 8 voluminous adenoma in the rectal ampulla with SILSTM-Port. RESULTS: The mean age of the patients was of 51.1 years, the mean BMI was 23. There were not intra or post-operative complications nor conversions to conventional transanal excision or major resective surgery. The postoperative course was normal. The average time of hospitalization was 3 days. CONCLUSIONS: TEVA is easier to perform than TEM and does not require a long training and specific and expensive material as the TEM does. TEVA might go to replace completely TEM. KEY WORDS: Rectal tumours, SILS, TEVA.
[Mh] Termos MeSH primário: Adenoma/cirurgia
Neoplasias Retais/cirurgia
Cirurgia Endoscópica Transanal/métodos
Cirurgia Vídeoassistida/métodos
[Mh] Termos MeSH secundário: Adenoma Viloso/cirurgia
Adulto
Idoso
Feminino
Hospitais Universitários
Seres Humanos
Itália
Tempo de Internação/estatística & dados numéricos
Masculino
Meia-Idade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE



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